Abstract:
:Two cases of zinc deficiency in breastfed neonates were investigated where zinc levels in the mothers' milk were reduced by more than 75 % compared to normal. The objective of this study was to find the molecular basis of the maternal zinc deficiency condition. Significant reductions in mRNA expression and protein levels of the zinc transporters SLC30A5 and SLC30A6 were found in maternal tissue, suggesting a causal link to the zinc-deficient milk. Novel splice variants of the SLC30A6 transcript were detected. No modifications were found in coding regions, or in transcription binding sites of promoter regions or in 5' and 3' untranslated regions of both transporters in lymphoblasts and fibroblasts isolated from both mothers. Altered DNA methylation in SLC30A5 at two CpG sites was detected and may account for the reduced levels of SLC30A5 mRNA and protein in lymphoblasts. Reduced SLC30A6 mRNA and protein levels in lymphoblasts may be secondary to reduced SLC30A5 expression, as they function as a heterodimer in zinc transport. In conclusion, two cases of zinc deficiency are linked to low levels of the SLC30A5 and SLC30A6 zinc transporters. These two zinc transporters have not been previously associated with zinc deficiency in milk.
journal_name
Genes Nutrjournal_title
Genes & nutritionauthors
Kumar L,Michalczyk A,McKay J,Ford D,Kambe T,Hudek L,Varigios G,Taylor PE,Ackland MLdoi
10.1007/s12263-015-0487-xsubject
Has Abstractpub_date
2015-09-01 00:00:00pages
487issue
5eissn
1555-8932issn
1865-3499journal_volume
10pub_type
杂志文章abstract::The goal of this study was to investigate the effect of a short-term nutritional intervention on gene expression in adipose tissue from lean and overweight subjects. Gene expression profiles were measured after consumption of an intervention spread (increased levels of polyunsaturated fatty acids, conjugated linoleic ...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-008-0096-z
更新日期:2008-12-01 00:00:00
abstract::Anthocyanins (AC) are water-soluble natural pigments found in various parts of higher plants. Despite their limited oral bioavailability and very low post-absorption plasma concentrations, the dietary consumption of these pigments has been proposed to be associated with a significant protection against several human p...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-014-0404-8
更新日期:2014-07-01 00:00:00
abstract:Background:The multidisciplinary nature of nutrition research is one of its main strengths. At the same time, however, it presents a major obstacle to integrate data analysis, especially for the terminological and semantic interpretations that specific research fields or communities are used to. To date, a proper ontol...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-018-0601-y
更新日期:2018-04-30 00:00:00
abstract::Moderate maternal calorie restriction during lactation protects rat offspring against obesity development in adulthood, due to an improved ability to handle and store excess dietary fuel. We used this model to identify early transcriptome-based biomarkers of metabolic health using peripheral blood mononuclear cells (P...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-013-0366-2
更新日期:2014-01-01 00:00:00
abstract::Phytosterol (PS) intake may be used for hypercholesterolaemia in some groups although the presence of non-responders is well known. Carotenoids and PS/cholesterol may compete for the same transporters during absorption. As part of a randomized, double-blind, crossover, multiple-dose supplementation study with β-crypto...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-014-0428-0
更新日期:2014-09-01 00:00:00
abstract::Vitamin C is known to protect mucosal tissues from oxidative stress and inhibit nitrosamine formation in the stomach. High consumption of fruits, particularly citrus, and higher circulating vitamin C concentrations may be inversely associated with gastric cancer (GC) risk. We investigated 20 polymorphisms in vitamin C...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-013-0346-6
更新日期:2013-11-01 00:00:00
abstract:Background:We investigated whether the long-term consumption of a symbiotic formulation with Lactobacillus fermentum (probiotic) and β-glucan from cauliflower mushroom (prebiotic) would delay the progression of post-menopausal symptoms in ovariectomized (OVX) rats and explored their mechanisms of action, including chan...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-017-0585-z
更新日期:2017-11-09 00:00:00
abstract::Personalized nutrition has the potential to enhance individual health control. It could be seen as a means to strengthen people's autonomy as they learn more about their personal health risks, and receive dietary advice accordingly. We examine in what sense personalized nutrition strengthens or weakens individual auto...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-013-0337-7
更新日期:2013-07-01 00:00:00
abstract::Current evidence indicates that genetic testing for obesity risk has limited affective or behavioral impact, but few studies have explored the effects among individuals who self-identify as having weight problems. Here, we report findings from in-depth telephone interviews with seven overweight or obese volunteers who...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-013-0374-2
更新日期:2014-01-01 00:00:00
abstract::Folic acid is an essential nutrient that is required for one-carbon biosynthetic processes and for methylation of biomolecules. Deficiency of this micronutrient leads to disturbances in normal physiology of cell. Chronic alcoholism is well known to be associated with folate deficiency, which is due in part to folate m...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-012-0318-2
更新日期:2013-03-01 00:00:00
abstract::A substantial and growing consumer demand exists for plant-based functional foods that improve general health and wellbeing. Amongst consumed phytochemicals, the polyphenolic compounds tend to be the most bioactive. Many commonly consumed polyphenols have been shown to have specific and potent health-promoting activit...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-009-0148-z
更新日期:2010-03-01 00:00:00
abstract::The nuclear factor (NF)-kappaB is a primary regulator of inflammatory responses and may be linked to pathology associated with obesity. We investigated the progression of NF-kappaB activity during a 12-week feeding period on a high-fat diet (HFD) or a low-fat diet (LFD) using NF-kappaB luciferase reporter mice. In viv...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-009-0133-6
更新日期:2009-09-01 00:00:00
abstract::Breast cancer is the second most frequent cancer affecting women worldwide after lung cancer. The toxicity factor associated with synthetic drugs has turned the attention toward natural compounds as the primary focus of interest as anticancer agents. Vitamin E derivatives consisting of the well-established tocopherols...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-011-0224-z
更新日期:2012-01-01 00:00:00
abstract:UNLABELLED:Intake of anthocyanin-rich foods has been associated with a reduced risk of cardiovascular diseases. Supplementation with anthocyanin-rich extracts from black rice or purple sweet potato was reported to attenuate atherosclerotic lesion development in apolipoprotein E-deficient (apo E(-/-)) mice. However, the...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-010-0171-0
更新日期:2010-12-01 00:00:00
abstract::Identification of new biomarkers of food and nutrient intake has developed fast over the past two decades and could potentially provide important new tools for compliance monitoring and dietary intake assessment in nutrition and health science. In recent years, metabolomics has played an important role in identifying ...
journal_title:Genes & nutrition
pub_type: 杂志文章,评审
doi:10.1186/s12263-018-0592-8
更新日期:2018-02-20 00:00:00
abstract::The long latency and high incidence of prostate carcinogenesis provides the opportunity to intervene with chemoprevention in order to prevent or eradicate prostate malignancies. We present here an overview of the chemopreventive potential of curcumin (diferuloylmethane), a well-known natural compound that exhibits the...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-009-0152-3
更新日期:2010-03-01 00:00:00
abstract::Biomarkers of food intake (BFIs) are a promising tool for limiting misclassification in nutrition research where more subjective dietary assessment instruments are used. They may also be used to assess compliance to dietary guidelines or to a dietary intervention. Biomarkers therefore hold promise for direct and objec...
journal_title:Genes & nutrition
pub_type: 杂志文章,评审
doi:10.1186/s12263-018-0603-9
更新日期:2018-05-30 00:00:00
abstract::The innate immune receptor toll-like receptor 4 (TLR4) has been implicated in mediating some of the effects of dietary lipids on inflammation and type 2 diabetes (T2D). Similar to TLR4, the nucleotide-binding oligomerization domains (Nods) 1 and 2 are also proteins of innate immunity, which can respond to lipids and i...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-012-0287-5
更新日期:2012-07-01 00:00:00
abstract::Fish aquaculture is considered to be one of the most sustainable sources of protein for humans. Many different species are cultured worldwide, but among them, marine flatfishes comprise a group of teleosts of high commercial interest because of their highly prized white flesh. However, the aquaculture of these fishes ...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-012-0312-8
更新日期:2013-01-01 00:00:00
abstract::The nutraceutical benefits of β-sitosterol (SIT) are well documented. The present study investigated the in vitro effects of SIT on adipogenesis, glucose transport, and lipid mobilization in rat adipocytes. Primary cultures of rat preadipocytes and differentiated adipocytes were used in this study. Glucose uptake was ...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-010-0196-4
更新日期:2011-05-01 00:00:00
abstract::Multiple factors have been implicated in the age-related declines in brain function. Thus, it is unlikely that modulating only a single factor will be effective at slowing this decline. A better approach is to identify small molecules that have multiple biological activities relevant to the maintenance of brain functi...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-009-0142-5
更新日期:2009-12-01 00:00:00
abstract::Transmembrane protease, serine 6 (TMPRSS6), is likely to be involved in iron metabolism through its pleiotropic effect on hepcidin concentrations. Recently, genome-wide association studies have identified common variants in the TMPRSS6 gene to be linked to anaemia and low iron status. To get a more precise evaluation ...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-014-0442-2
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Mitochondria are of major importance in oocyte and early embryo, playing a key role in maintaining energy homeostasis. Epidemiological findings indicate that maternal undernutrition-induced mitochondrial dysfunction during pregnancy is associated with the development of metabolic disorders in offspring. Here...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-016-0535-1
更新日期:2016-06-23 00:00:00
abstract::Phytoestrogens are naturally occurring plantderived polyphenols with estrogenic potency. They are ubiquitous in diet and therefore, generally consumed. Among Europeans, the diet is rich in multiple putative phytoestrogens including flavonoids, tannins, stilbenoids, and lignans. These compounds have been suggested to p...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/BF02829964
更新日期:2006-09-01 00:00:00
abstract::While the effects of chronic ethanol consumption on liver have been well studied and documented, its effect on the cardiovascular system is bimodal. Thus, moderate drinking in many population studies is related to lower prevalence of coronary artery disease (CAD). In contrast, heavy drinking correlates with higher pre...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-009-0161-2
更新日期:2010-06-01 00:00:00
abstract::Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), riboflavin-dependent enzymes, participate in homocysteine metabolism. Reported effects of riboflavin status on the association between the MTHFR 677C>T polymorphism and homocysteine vary, and the effects of the MTRR 66A>G or MTRR 524...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-014-0435-1
更新日期:2014-11-01 00:00:00
abstract::Low plasma levels of high-density lipoprotein cholesterol (HDL-C) are identified as a risk factor for cardiovascular disease (CVD). Sexual dimorphism, however, is widely reported in both HDL-C and CVD, with the underlying explanations of these sexual differences not fully understood. HDL-C is a complex trait influence...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-008-0075-4
更新日期:2008-07-01 00:00:00
abstract::The aim of this study was to examine the relationship between the L55M and Q192R paraoxonase (PON1) polymorphisms and obesity in a population of adult Mexican workers. The study population included 127 adult individuals from the Universidad Autónoma del Estado de Morelos, ranging in age from 20 to 56 years and represe...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-011-0215-0
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Methionine, a central molecule in one-carbon metabolism, is an essential amino acid required for normal growth and development. Despite its importance to biological systems, methionine is toxic when administered at supra-physiological levels. The aim of this study was to investigate the effects of short-term...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-017-0576-0
更新日期:2017-09-06 00:00:00
abstract::Folic acid is the key one-carbon donor required for de novo nucleotide and methionine synthesis. Its deficiency is associated with megaloblastic anemia, cancer and various complications of pregnancy. However, its supplementation results in reduction of neural tube defects and prevention of several types of cancer. The...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-013-0369-z
更新日期:2014-01-01 00:00:00