Abstract:
BACKGROUND:Human Rhinovirus (HRV) is responsible for the majority of common colds and is frequently accompanied by secondary bacterial infections through poorly understood mechanisms. We investigated the effects of experimental human HRV serotype 16 infection on the upper respiratory tract microbiota. METHODS:Six healthy volunteers were infected with HRV16. We performed 16S ribosomal RNA-targeted pyrosequencing on throat swabs taken prior, during and after infection. We compared overall community diversity, phylogenetic structure of the ecosystem and relative abundances of the different bacteria between time points. RESULTS:During acute infection strong trends towards increases in the relative abundances of Haemophilus parainfluenzae and Neisseria subflava were observed, as well as a weaker trend towards increases of Staphylococcus aureus. No major differences were observed between day-1 and day 60, whereas differences between subjects were very high. CONCLUSIONS:HRV16 infection is associated with the increase of three genera known to be associated with secondary infections following HRV infections. The observed changes of upper respiratory tract microbiota could help explain why HRV infection predisposes to bacterial otitis media, sinusitis and pneumonia.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Hofstra JJ,Matamoros S,van de Pol MA,de Wever B,Tanck MW,Wendt-Knol H,Deijs M,van der Hoek L,Wolthers KC,Molenkamp R,Visser CE,Sterk PJ,Lutter R,de Jong MDdoi
10.1186/s12879-015-1081-ysubject
Has Abstractpub_date
2015-08-14 00:00:00pages
336issn
1471-2334pii
10.1186/s12879-015-1081-yjournal_volume
15pub_type
杂志文章abstract:BACKGROUND:To reach non-participants, reluctant to undergo clinician-based cervical cancer screening and vaginal self-sampling, urine collection for high-risk human papillomavirus detection (hrHPV) may be valuable. Using two hrHPV DNA assays, we evaluated the concordance of hrHPV positivity in urine samples in comparis...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05663-7
更新日期:2020-12-04 00:00:00
abstract:BACKGROUND:The urine lipoarabinomannan (LAM) strip test has been suggested as a new point-of-care test for active tuberculosis (TB) among human immunodeficiency virus (HIV) infected individuals. It has been questioned if infections with nontuberculous mycobacteria (NTM) affect assay specificity. We set forth to investi...
journal_title:BMC infectious diseases
pub_type: 临床试验,杂志文章
doi:10.1186/s12879-014-0655-4
更新日期:2014-12-04 00:00:00
abstract:BACKGROUND:Self-reported antiretroviral therapy (ART) adherence measures that are associated with plasma viral load (VL) are valuable to clinicians and researchers, but are rarely examined among groups vulnerable to dropping out of care. One-seventh of all those living with HIV pass through incarceration annually and c...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4443-z
更新日期:2019-10-29 00:00:00
abstract:BACKGROUND:After antibiotic treatment of Lyme borreliosis, a subset of patients report persistent symptoms, also referred to as post-treatment Lyme disease syndrome. The reported prevalence of persistent symptoms varies considerably, and its pathophysiology is under debate. The LymeProspect study has been designed to i...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3949-8
更新日期:2019-04-15 00:00:00
abstract:BACKGROUND:The tuberculin skin test (TST) has limitations for latent tuberculosis infection (LTBI) diagnosis in low-prevalence settings. Previously, all TST-positive individuals referred from the community to Baltimore City Health Department (BCHD) were offered LTBI treatment, after active TB was excluded. In 2010, BCH...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-360
更新日期:2012-12-19 00:00:00
abstract:BACKGROUND:The real burden of smear-positive (PTB+) and bacteriologically confirmed tuberculosis (BCTB) in Ethiopia is not known. Thus, the aim of this community-based study was to measure the prevalence and incidence of tuberculosis in the Hetosa District of Oromia Region, Ethiopia. METHODS:First, a population-based ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2321-0
更新日期:2017-03-16 00:00:00
abstract:BACKGROUND:The effects of helminth co-infection on malaria in humans remain uncertain. This study aimed to evaluate the nature of association of intestinal helminths with prevalence and clinical outcomes of Plasmodium infection. METHODS:A cross-sectional study involving 1,065 malaria suspected febrile patients was con...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-291
更新日期:2012-11-09 00:00:00
abstract:BACKGROUND:Healthy condition and chronic diseases may be associated with microbiota composition and its properties. The prevalence of respiratory haemophili with respect to their phenotypes including the ability to biofilm formation in patients with sarcoidosis was assayed. METHODS:Nasopharynx and sputum specimens wer...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1793-7
更新日期:2016-08-26 00:00:00
abstract:BACKGROUND:In developing countries rotavirus is the leading cause of severe diarrhoea and diarrhoeal deaths in children under 5. Vaccination could greatly alleviate that burden, but in Mexico as in most low- and middle-income countries the decision to add rotavirus vaccine to the national immunisation program will depe...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-8-103
更新日期:2008-07-29 00:00:00
abstract:BACKGROUND:Lemierre's syndrome presents a classic clinical picture, the pathophysiology of which remains obscure. Attempts have been made to trace genetic predispositions that modify the host detection of pathogen or the resultant systemic reaction. CASE PRESENTATION:A 17-year old female, with no previous medical hist...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-6-115
更新日期:2006-07-17 00:00:00
abstract:BACKGROUND:In Ethiopia a tiebreaker algorithm using 3 rapid diagnostic tests (RDTs) in series is used to diagnose HIV. Discordant results between the first 2 RDTs are resolved by a third 'tiebreaker' RDT. Médecins Sans Frontières uses an alternate serial algorithm of 2 RDTs followed by a confirmation test for all doubl...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0769-3
更新日期:2015-02-03 00:00:00
abstract:BACKGROUND:Hand, foot and mouth disease (HFMD) is a transmissible infectious disease caused by human enteroviruses (EV). Here, we described features of children with severe HFMD caused by EV-A71 or coxsackievirus A16 (CV-A16) in Shanghai, China. METHODS:Severe EV-A71 or CV-A16 caused HFMD children admitted to the Xinh...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3878-6
更新日期:2019-03-27 00:00:00
abstract:BACKGROUND:Lassa fever has been a public health concern in the West African sub-region where it is endemic and a latent threat to the world at large. We investigated the trend in Lassa fever research using bibliometric approach. METHODS:We used the SCOPUS database employing "Lassa fever" as search descriptor. The most...
journal_title:BMC infectious diseases
pub_type: 历史文章,杂志文章
doi:10.1186/s12879-018-3526-6
更新日期:2018-12-10 00:00:00
abstract:BACKGROUND:Compliance to anti-TB treatment is crucial in achieving cure and avoiding the emergence of drug resistance. Electronic health (eHealth) interventions are included in the strategy to end the global Tuberculosis (TB) epidemic by 2035. Evidences showed that mobile messaging systems could improve patient adheren...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析
doi:10.1186/s12879-020-4765-x
更新日期:2020-01-14 00:00:00
abstract:BACKGROUND:The major factors contributing for nerve damage and permanent disabilities in leprosy are type 1 or reversal reactions (RR) and type 2 or erythema nodosum leprosum (ENL). Gene profiling of leprosy reactions have shown that different pathways are activated during the course of reactions, which is consistent w...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3348-6
更新日期:2018-08-24 00:00:00
abstract:BACKGROUND:Invasive pneumococcal disease (IPD) is responsible for significant mortality and morbidity worldwide. There are however few longitudinal studies on the changes in case fatality rate of IPD in recent years. We carried out a prospective observational study of patients with IPD in Nord Trøndelag county in Norwa...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1553-8
更新日期:2016-05-23 00:00:00
abstract:BACKGROUND:High prevalence of risky sexual behaviors and lack of information, skills and preventive support mean that, adolescents face high risks of HIV/AIDS. This study applied the information-motivation-behavioral skills (IMB) model to examine the predictors of consistent condom use among senior high school students...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-262
更新日期:2013-06-04 00:00:00
abstract:BACKGROUND:Brain abscesses, a severe infectious disease of the CNS, are usually caused by a variety of different pathogens, which include Streptococcus intermedius (S. intermedius). Pulmonary arteriovenous fistulas (PAVFs), characterized by abnormal direct communication between pulmonary artery and vein, are a rare und...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05092-6
更新日期:2020-05-24 00:00:00
abstract:BACKGROUND:Why human tick-borne encephalitis (TBE) cases differ from year to year, in some years more 100%, has not been clarified, yet. The cause of the increasing or decreasing trends is also controversial. Austria is the only country in Europe where a 40-year TBE time series and an official vaccine coverage time ser...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05156-7
更新日期:2020-06-26 00:00:00
abstract:BACKGROUND:Varicella is a common childhood disease. Only 5% of first varicella-zoster-virus infections occur asymptomatically. Most data on the burden of varicella stem from health service databases. This study aims to provide insight in the burden of varicella from a parent's perspective including cases outside the he...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-320
更新日期:2011-11-17 00:00:00
abstract:BACKGROUND:Cervical cancer is the second most common cancer in women worldwide. Infection with certain human papillomavirus (HPV) genotypes is the most important risk factor associated with cervical cancer. This study analysed the distribution of type-specific HPV infection among women with normal and abnormal cytology...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-316
更新日期:2011-11-15 00:00:00
abstract:BACKGROUND:Microscopic examination of peripheral blood smear produces reliable results both about the malaria infection status and level of parasitemia. However, test results are affected by skill of the laboratory personnel, workload, condition of microscopes and quality of laboratory supplies. Therefore, continuous m...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05077-5
更新日期:2020-05-19 00:00:00
abstract:BACKGROUND:Tétanos Quick Stick® (TQS) is a test for tetanus immunity screening for wounded patients in emergency departments (EDs), but represents additional costs compared with a medical interview on vaccination history. The study objective was to assess the effectiveness and cost of the TQS in French EDs. METHODS:We...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-014-0603-3
更新日期:2014-11-19 00:00:00
abstract:BACKGROUND:Tuberculosis (TB) caused by Mycobacterium tuberculosis is one of the leading causes of death from infectious diseases worldwide. Sputum smear microscopy remains the most widely available pulmonary TB diagnostic tool particularly in resource limited settings. A highly sensitive diagnostic with minimal infrast...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-2140-8
更新日期:2017-01-17 00:00:00
abstract:BACKGROUND:On 18 August 2015, Kyegegwa District reported eight deaths during a measles outbreak to the Uganda Ministry of Health (MoH). We investigated this death cluster to verify the cause, identify risk factors, and inform public health interventions. METHODS:We defined a probable measles case as onset of fever and...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2558-7
更新日期:2017-07-03 00:00:00
abstract:BACKGROUND:Diseases caused by Mycobacterium tuberculosis (TB) among adult patients with hematological malignancies have rarely been investigated. METHODS:Adult patients with hematological malignancies at National Taiwan University Hospital between 1996 and 2009 were retrospectively reviewed. Patients with positive ser...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-324
更新日期:2011-11-23 00:00:00
abstract:BACKGROUND:Schizophyllum commune, a basidiomycetous fungus, is a common invader of rotten wood. This fungus rarely causes mycotic disease in humans, especially cutaneous infection. In this paper, we describe the first case of cutaneous granuloma caused by S. commune in a Chinese woman. CASE PRESENTATION:A 25-year-old ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3187-5
更新日期:2018-06-26 00:00:00
abstract:BACKGROUND:Antiretroviral therapy (ART) has significantly decreased HIV/AIDS-related morbidity and mortality. However, globally, many people living with HIV die from non-AIDS related illnesses including liver diseases which occur partly due to co-infection with HBV and or HCV. The aim of this study was to determine the...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4027-y
更新日期:2019-05-03 00:00:00
abstract:BACKGROUND:Hepatitis B (HBV) and C (HCV) infections are a serious global and national public health problem. Earlier studies have reported increasing rates of hepatitis infection in Pakistan, particularly in rural areas. Pakistan has no active surveillance program to monitor trends of these infections. The objective of...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-8-43
更新日期:2008-04-10 00:00:00
abstract:BACKGROUND:Haemophilus influenzae type b (Hib) vaccination led to a significant decrease in invasive bacterial infections in children. The aim of this study was to assess a potential shift to more non-type b invasive infections in a population with high Hib vaccination coverage and to compare the burden of suffering be...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-9-45
更新日期:2009-04-20 00:00:00