EphA2 as a Diagnostic Imaging Target in Glioblastoma: A Positron Emission Tomography/Magnetic Resonance Imaging Study.

abstract：:For clinical application of stem cell-based therapies, noninvasive detection of applied stem cells is of high importance. We report on the feasibility of detecting implanted neural progenitor cells (NPCs) noninvasively and follow their fate and functional status by sequential multimodal molecular imaging and reporter ...

journal_title：Molecular imaging

authors： Waerzeggers Y,Klein M,Miletic H,Himmelreich U,Li H,Monfared P,Herrlinger U,Hoehn M,Coenen HH,Weller M,Winkeler A,Jacobs AH

更新日期：2008-03-01 00:00:00

abstract：:Surgical biopsy of potential tumor recurrence is a common challenge facing oncologists, surgeons, and cancer patients. Imaging modalities have limited ability to accurately detect recurrent cancer in fields affected by previous surgery, chemotherapy, or radiation. However, definitive tissue diagnosis is often needed t...

journal_title：Molecular imaging

authors： Okusanya OT,Deshpande C,Barbosa EM Jr,Aggarwal C,Simone CB 2nd,Jiang J,Judy R,DeJesus E,Albelda S,Nie S,Low PS,Singhal S

更新日期：2014-01-01 00:00:00

abstract：:We investigated the capacity of normalized transillumination methods in imaging fluorescent proteins in visible light, in phantoms and in live mice. We demonstrate significant imaging improvements over epi-illumination imaging, as commonly applied today. Of particular importance is the significant betterment in contra...

journal_title：Molecular imaging

authors： Zacharakis G,Shih H,Ripoll J,Weissleder R,Ntziachristos V

更新日期：2006-07-01 00:00:00

abstract：:The aim of this study is to determine and characterize factors influencing in vivo bioluminescence imaging (BLI) and apply them to the specific application of imaging transplanted pancreatic islets. Noninvasive quantitative assessment of transplanted pancreatic islets poses a formidable challenge. Murine pancreatic is...

journal_title：Molecular imaging

authors： Virostko J,Chen Z,Fowler M,Poffenberger G,Powers AC,Jansen ED

更新日期：2004-10-01 00:00:00

abstract：:The lung remains one of the most challenging organs to image using magnetic resonance imaging (MRI) due to intrinsic rapid signal decay. However, unlike conventional modalities such as computed tomography, MRI does not involve radiation and can provide functional and morphologic information on a regional basis. Here w...

journal_title：Molecular imaging

authors： Tchouala Nofiele J,Cheng W,Haedicke IE,Ganesh T,Zhang XA,Cheng HL

更新日期：2014-01-01 00:00:00

abstract：:The pharmacokinetic properties of radiotracers are crucial for successful in vivo single-photon emission computed tomographic (SPECT) imaging. Our goal was to determine if MDR1A-deficient animals could allow better SPECT imaging outcomes than wild-type (WT) animals for a selection of serotoninergic radioligands. Thus,...

journal_title：Molecular imaging

authors： Dumas N,Moulin-Sallanon M,Ginovart N,Tournier BB,Suzanne P,Cailly T,Fabis F,Rault S,Charnay Y,Millet P

更新日期：2014-01-01 00:00:00

abstract：:The ability of tumor cells to adhere to, migrate on, and remodel extracellular matrices is mediated by cell surface receptors such as beta1-integrins. Here we conducted functional live-cell imaging in real time to investigate the effects of modulating beta1-integrin expression and function on proteolytic remodeling of...

journal_title：Molecular imaging

authors： Sameni M,Dosescu J,Yamada KM,Sloane BF,Cavallo-Medved D

更新日期：2008-09-01 00:00:00

abstract：:β-Glucuronidase (β-GUS) plays an important role in inflammation and degenerative processes. The enzyme has also been investigated as a target in prodrug therapy for cancer. To investigate the role of β-GUS in pathologies and to optimize β-GUS-based prodrug therapies, we recently developed a positron emission tomograph...

journal_title：Molecular imaging

authors： Antunes IF,Haisma HJ,Elsinga PH,van Waarde A,Willemsen AT,Dierckx RA,de Vries EF

更新日期：2012-02-01 00:00:00

abstract：:Imaging of glutamate carboxypeptidase II (GCP II), also known as N-acetylated alpha-linked L-amino dipeptidase (NAALADase), may enable study of glutamatergic transmission, prostate cancer, and tumor neovasculature in vivo. Our goal was to develop a probe for GCP II for use with positron emission tomography (PET). Radi...

journal_title：Molecular imaging

authors： Pomper MG,Musachio JL,Zhang J,Scheffel U,Zhou Y,Hilton J,Maini A,Dannals RF,Wong DF,Kozikowski AP

更新日期：2002-04-01 00:00:00

abstract：:Reporter genes can monitor the status and activity of recombinant genomes in a diverse array of organisms, from bacteria and yeast to plants and animals. We have combined luciferase reporter genes with a conditional gene expression system based on regulatory elements from the lac operon of Escherichia coli to visualiz...

journal_title：Molecular imaging

authors： Ryan A,Scrable H

更新日期：2004-01-01 00:00:00

abstract：:Transfection agent (TFA)-induced magnetic cell labeling with Feridex IV is an attractive method of loading cells because it employs a pharmaceutical source of iron oxide. Although attractive, the method has two significant drawbacks. First, it requires mixing positively charged transfection agents and negatively charg...

journal_title：Molecular imaging

authors： Montet-Abou K,Montet X,Weissleder R,Josephson L

更新日期：2007-01-01 00:00:00

abstract：:We have developed novel proteinase-modulated contrast agents (PCAs) to detect the activity of proteinases in vivo using magnetic resonance imaging. The PCAs are based on the concept of a solubility switch, from hydrophilic to hydrophobic, that significantly modifies the pharmacokinetic properties of the agent as revea...

journal_title：Molecular imaging

authors： Lepage M,Dow WC,Melchior M,You Y,Fingleton B,Quarles CC,Pépin C,Gore JC,Matrisian LM,McIntyre JO

更新日期：2007-11-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are extracellular proteolytic enzymes involved in acute lung inflammation in response to cigarette smoke exposure (CSE). We present the in vivo detection of MMP activity using a specific MMP-activatable, near-infrared, polymer-based proteolytic probe in strains of mice with different s...

journal_title：Molecular imaging

authors： Pérez-Rial S,Del Puerto-Nevado L,González-Mangado N,Peces-Barba G

更新日期：2011-10-01 00:00:00

abstract：:Macrophage infiltration is a prominent feature of abdominal aortic aneurysm (AAA) progression. We used a combined imaging approach with bioluminescence (BLI) and magnetic resonance imaging (MRI) to study macrophage homing and accumulation in experimental AAA disease. Murine AAAs were created via intra-aortic infusion ...

journal_title：Molecular imaging

authors： Miyama N,Dua MM,Schultz GM,Kosuge H,Terashima M,Pisani LJ,Dalman RL,McConnell MV

更新日期：2012-04-01 00:00:00

abstract：:Breast cancer continues to be the most lethal cancer type in women and one of the most diagnosed. Understanding Breast cancer receptor status is one of the most vital processes for determining treatment options. One type of breast cancer, human epidermal growth factor receptor 2 (HER2) positive, has approved receptor-...

journal_title：Molecular imaging

authors： Ducharme M,Lapi SE

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:We evaluated the relationship between isocitrate dehydrogenase 1 (IDH1) mutation status and metabolic imaging in patients with nonenhancing supratentorial diffuse gliomas using 11C-methionine positron emission tomography (11C-MET PET). MATERIALS AND METHODS:Between June 2012 and November 2017, we enrolled 86 (...

journal_title：Molecular imaging

authors： Kudulaiti N,Zhang H,Qiu T,Lu J,Aibaidula A,Zhang Z,Guan Y,Zhuang D

更新日期：2019-01-01 00:00:00

abstract：:High spectral and spatial resolution (HiSS) data, acquired with echo-planar spectroscopic imaging (EPSI), can be used to acquire water spectra from each small image voxel. These images are sensitive to changes in local susceptibility caused by superparamagnetic iron oxide particles (SPIO); therefore, we hypothesized t...

journal_title：Molecular imaging

authors： Haney CR,Pelizzari CA,Foxley S,Zamora MA,Mustafi D,Tretiakova M,Li S,Fan X,Karczmar GS

更新日期：2011-06-01 00:00:00

abstract：:Mutated adenomatous polyposis coli (APC) genes predispose transformations to neoplasia, progressing to colorectal carcinoma. Early detection facilitates clinical management and therapy. Novel lectin-mediated polymerized targeted liposomes (Rh-I-UEA-1), with polyp specificity and incorporated imaging agents were fabric...

journal_title：Molecular imaging

authors： Roney CA,Xu B,Xie J,Yuan S,Wierwille J,Chen CW,Chen Y,Griffiths GL,Summers RM

更新日期：2011-08-01 00:00:00

abstract：:We investigated the effect of diet on abdominal autofluorescence detected by in vivo fluorescence imaging (FLI) of living mice. Groups of mice were fed a regular, alfalfa-free, or purified diet, and whole-body FLI was performed without the administration of fluorescent probes. In addition, quantum dots were injected i...

journal_title：Molecular imaging

authors： Inoue Y,Izawa K,Kiryu S,Tojo A,Ohtomo K

更新日期：2008-01-01 00:00:00

abstract：:The purpose of this study was to validate (99m)Tc-3P-RGD(2) single-photon emission computed tomography/computed tomography (SPECT/CT) as an imaging tool to monitor α(v)β(3) expression and tumor necrosis. The animal model was established by subcutaneous injection of 5 × 10(6) U87MG cells into the shoulder flank of each...

journal_title：Molecular imaging

authors： Shao G,Zhou Y,Wang F,Liu S

更新日期：2013-01-01 00:00:00

abstract：:18F positron emission tomography (PET) has a number of attributes that make it clinically attractive, including nearly 100% positron efficiency, very high specific radioactivity, and a short half-life of ≈ 110 minutes. However, the short half-life of 18F and the poor nucleophilicity of fluoride introduce challenges fo...

journal_title：Molecular imaging

authors： Liu S,Hassink M,Selvaraj R,Yap LP,Park R,Wang H,Chen X,Fox JM,Li Z,Conti PS

更新日期：2013-03-01 00:00:00

abstract：:Bacterial genes involved in the biomineralization of magnetic nanoparticles in magnetotactic bacteria have recently been proposed as reporters for magnetic resonance imaging (MRI). In such systems, the expression of the bacterial genes in mammalian cells purportedly leads to greater concentrations of intracellular iro...

journal_title：Molecular imaging

authors： Pereira SM,Williams SR,Murray P,Taylor A

更新日期：2016-04-26 00:00:00

abstract：:The reversal effect of multidrug resistance (MDR1) gene expression by adenoviral vector-mediated MDR1 ribonucleic acid interference was assessed in a human colon cancer animal model using bioluminescent imaging with Renilla luciferase (Rluc) gene and coelenterazine, a substrate for Rluc or MDR1 gene expression. A fluo...

journal_title：Molecular imaging

authors： Jeon YH,Bae SA,Lee YJ,Lee YL,Lee SW,Yoon GS,Ahn BC,Ha JH,Lee J

更新日期：2010-12-01 00:00:00

abstract：:Our purpose was to enable an in vivo imaging technology that can assess the anatomy and function of peripheral nerve tissue (neurography). To do this, we designed and tested a fluorescently labeled molecular probe based on the nontoxic C fragment of tetanus toxin (TTc). TTc was purified, labeled, and subjected to immu...

journal_title：Molecular imaging

authors： Schellingerhout D,Le Roux LG,Bredow S,Gelovani JG

更新日期：2009-12-01 00:00:00

abstract：:Transplantation of neural stem cells (NSCs) has been proposed as a treatment for Parkinson disease (PD). The aim of this study was to monitor the viability of transplanted NSCs expressing the enhanced luciferase gene in a mouse model of PD in vivo. The PD animal model was induced by unilateral injection of 6-hydroxydo...

journal_title：Molecular imaging

authors： Im HJ,Hwang DW,Lee HK,Jang J,Lee S,Youn H,Jin Y,Kim SU,Kim EE,Kim YS,Lee DS

更新日期：2013-06-01 00:00:00

abstract：:To explore suitable imaging probes for early and specific detection of pancreatic cancer, we demonstrated that α6β4integrin is a good target and employed single-photon emission computed tomography (SPECT) or near-infrared (NIR) imaging for immunotargeting. Expression levels of α6β4were examined by Western blotting and...

journal_title：Molecular imaging

authors： Aung W,Tsuji AB,Sudo H,Sugyo A,Furukawa T,Ukai Y,Kurosawa Y,Saga T

更新日期：2016-01-29 00:00:00

abstract：:The purpose of this study was to evaluate the time course of contrast enhancement of spleen, liver, and blood using eXIA 160 XL in healthy mice. eXIA 160 XL was intravenously injected in C57bl/6 mice (n  =  12) at a dose of 0.1 mL/20 g (16 mg iodine [I]/20 g) (n  =  6) or 0.2 mL/20 g (32 mg I/20 g) (n  =  6). The dist...

journal_title：Molecular imaging

authors： Willekens I,Buls N,De Maeseneer M,Lahoutte T,de Mey J

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:Melanoma is a lethal skin cancer with unmet clinical needs for targeted imaging and therapy. Nanoscale materials conjugated with targeting components have shown great potential to improve tumor delivery efficiency while minimizing undesirable side effects in vivo. Herein, we proposed to develop targeted nanopar...

journal_title：Molecular imaging

authors： Zhao Y,Pang B,Detering L,Luehmann H,Yang M,Black K,Sultan D,Xia Y,Liu Y

更新日期：2018-01-01 00:00:00

abstract：:Bioluminescence imaging (BLI) of luciferase reporters provides a cost-effective and sensitive means to image biological processes. However, transport of luciferase substrates across the cell membrane does affect BLI readout intensity from intact living cells. To investigate the effect of ATP-binding cassette (ABC) tra...

journal_title：Molecular imaging

authors： Huang R,Vider J,Serganova I,Blasberg RG

更新日期：2011-06-01 00:00:00

abstract：:Bioluminescence imaging (BLI) detects light generated by luciferase-mediated oxidation of substrate and is used widely for evaluating transgene expression in cell-based assays and in vivo in relevant preclinical models. The most commonly used luciferase for in vivo applications is firefly luciferase (fLuc), for which ...

journal_title：Molecular imaging

authors： Zhang Y,Pullambhatla M,Laterra J,Pomper MG

更新日期：2012-11-01 00:00:00