Abstract：
BACKGROUND:While echocardiographic grading of left ventricular (LV) diastolic dysfunction (DD) is used every day, the relationship between echocardiographic DD grade and hemodynamic abnormalities is uncertain. METHODS:We identified 460 consecutive patients who underwent transthoracic echocardiography within 24 h of elective left heart catheterization and had: normal sinus rhythm, no confounding structural heart disease, no change in medications between catheterization and echo, and complete echocardiographic data. Patients were grouped based on echocardiographic DD grade. Hemodynamic tracings were used to determine time constant of isovolumic pressure decay (Tau), LV end-diastolic pressure (LVEDP) and end-diastolic volume index at a pressure of 20 mmHg (EDVi20). RESULTS:Normal diastolic function was found in 55 (12.0%) patients, while 132 (28.7%) patients had grade 1, 156 (33.9%) grade 2 and 117 (25.4%) grade 3 DD. The median value for Tau was 46.9 ms for the overall population (interquartile range 38.6-58.1 ms), with a prevalence of a prolonged Tau (>48 ms) of 47.5%. While there was an association between DD grade and Tau (p = 0.003), LV dysfunction (ejection fraction <50%) was more strongly associated with increased Tau (p < 0.001) than was DD grade (p = 0.19). There was also an association between DD grade and LVEDP (p < 0.001), with both LV dysfunction (p = 0.029) and DD grade (p < 0.001) independently associated with LVEDP. Calculated EDVi20 was related to DD grade, but this relationship was driven by findings of paradoxically increased compliance in patients with severe DD. CONCLUSIONS:Although echocardiographic grading of DD was related to invasive hemodynamics in this population, the relationship was modest.
journal_name
Cardiovasc Ultrasoundjournal_title
Cardiovascular ultrasoundauthors
Grant AD,Negishi K,Negishi T,Collier P,Kapadia SR,Thomas JD,Marwick TH,Griffin BP,Popović ZBdoi
10.1186/s12947-015-0023-6subject
Has Abstractpub_date
2015-06-24 00:00:00pages
28issn
1476-7120pii
10.1186/s12947-015-0023-6journal_volume
13pub_type
杂志文章abstract：INTRODUCTION:Mitral annulus calcification (MAC) is a common finding on echocardiographic examination. The goal of this study was to evaluate associations between MAC and cardiac abnormalities using a large echocardiographic database. METHODS:For this study we retrospectively reviewed 24,380 echocardiograms performed f...
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