Does SMS 201-995 normalize growth hormone secretion in acromegaly? GH day profiles and GH concentrations after oral glucose loading.

Abstract:

:GH secretion in acromegaly was studied in 8 patients before and during treatment with SMS 201-995, a somatostatin analogue, 100 micrograms twice daily, by evaluating GH day profiles and GH suppressibility after oral glucose tolerance tests (OGTT). Normalization of GH secretion, estimated by OGTT, was only observed in the three patients who had a decrease in plasma GH to less than 2 micrograms/l after SMS 201-995 injection, and who had the lowest mean plasma GH levels during the day and the largest percent decline of mean plasma GH levels. We conclude that real normalization of GH secretion during SMS 201-995 therapy only occurs in a subset of patients. The data illustrate that the applicability of the generally held cut-off value of 5 micrograms/l, between normal and abnormal plasma GH, has to be reconsidered in the case of chronic intermittent subcutaneous therapy with SMS 201-995.

journal_name

J Endocrinol Invest

authors

van Liessum PA,Pieters GF,Smals AG,Swinkels LM,Benraad TJ,Kloppenborg PW

doi

10.1007/BF03350758

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

553-7

issue

8

eissn

0391-4097

issn

1720-8386

journal_volume

12

pub_type

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