Update on HER-2 as a target for cancer therapy: intracellular signaling pathways of ErbB2/HER-2 and family members.


:ErbB (also termed HER) receptors are expressed in various tissues of epithelial, mesenchymal and neuronal origin, in which they are involved in the control of diverse biological processes such as proliferation, differentiation, migration and apoptosis. Furthermore, their deregulated expression has been implicated in many types of human cancers and is associated with poor clinical prognosis. Owing to the importance of ErbB proteins in both development and cellular transformation, a lot of attention has been drawn to the intracellular signals initiated by the engagement of this family of receptor tyrosine kinases. This review will focus on the membrane proximal events triggered by the ErbB receptor network and will address questions of how receptor heterodimerization may contribute to signal specification and diversification.


Breast Cancer Res


Olayioye MA





Has Abstract


2001-01-01 00:00:00












  • Breast cancer in association with thyroid disorders.

    abstract:BACKGROUND:The relationship between breast cancer and thyroid diseases is controversial. Discrepant results have been reported in the literature. The incidences of autoimmune and nonautoimmune thyroid diseases were investigated in patients with breast cancer and age-matched control individuals without breast or thyroid...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Turken O,NarIn Y,DemIrbas S,Onde ME,Sayan O,KandemIr EG,YaylacI M,Ozturk A

    更新日期:2003-01-01 00:00:00

  • A whole slide image-based machine learning approach to predict ductal carcinoma in situ (DCIS) recurrence risk.

    abstract:BACKGROUND:Breast ductal carcinoma in situ (DCIS) represent approximately 20% of screen-detected breast cancers. The overall risk for DCIS patients treated with breast-conserving surgery stems almost exclusively from local recurrence. Although a mastectomy or adjuvant radiation can reduce recurrence risk, there are sig...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Klimov S,Miligy IM,Gertych A,Jiang Y,Toss MS,Rida P,Ellis IO,Green A,Krishnamurti U,Rakha EA,Aneja R

    更新日期:2019-07-29 00:00:00

  • Association of functional polymorphisms in CYP19A1 with aromatase inhibitor associated arthralgia in breast cancer survivors.

    abstract:INTRODUCTION:Aromatase inhibitor-associated arthralgia (AIAA) is a common and often debilitating symptom in breast cancer survivors. Since joint symptoms have been related to estrogen deprivation through the menopausal transition, we hypothesized that genetic polymorphisms in CYP19A1, the final enzyme in estrogen synth...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Mao JJ,Su HI,Feng R,Donelson ML,Aplenc R,Rebbeck TR,Stanczyk F,DeMichele A

    更新日期:2011-01-20 00:00:00

  • Measuring proliferation in breast cancer: practicalities and applications.

    abstract::Various methods are available for the measurement of proliferation rates in tumours, including mitotic counts, estimation of the fraction of cells in S-phase of the cell cycle and immunohistochemistry of proliferation-associated antigens. The evidence, advantages and disadvantages for each of these methods along with ...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,评审


    authors: Beresford MJ,Wilson GD,Makris A

    更新日期:2006-01-01 00:00:00

  • Hypoxia and oxidative stress in breast cancer. Hypoxia signalling pathways.

    abstract::Hypoxia-inducible factor-1 (HIF), which is centrally involved in physiological oxygen homeostasis, is also activated in the majority of tumours. Activation of HIF can occur through genetic mechanisms or as a result of hypoxia within the tumour microenvironment. In some cases HIF activation appears to be intimately lin...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,评审


    authors: Pugh CW,Gleadle J,Maxwell PH

    更新日期:2001-01-01 00:00:00

  • Addition of T2-guided optical tomography improves noncontrast breast magnetic resonance imaging diagnosis.

    abstract:BACKGROUND:While dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) is recognized as the most sensitive examination for breast cancer detection, it has a substantial false positive rate and gadolinium (Gd) contrast agents are not universally well tolerated. As a result, alternatives to diagnosing breast can...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Feng J,Xu J,Jiang S,Yin H,Zhao Y,Gui J,Wang K,Lv X,Ren F,Pogue BW,Paulsen KD

    更新日期:2017-10-24 00:00:00

  • Circulating DNA as biomarker in breast cancer.

    abstract::As the release of tumor-associated DNA into blood circulation is a common event in patients with cancer, screening of plasma or serum DNA may provide information on genetic and epigenetic profiles associated with breast cancer development, progression, and response to therapy. Quantitative testing of circulating DNA c...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,评审


    authors: Schwarzenbach H,Pantel K

    更新日期:2015-10-09 00:00:00

  • Identification of chemokine receptors as potential modulators of endocrine resistance in oestrogen receptor-positive breast cancers.

    abstract:INTRODUCTION:Endocrine therapies target oestrogenic stimulation of breast cancer (BC) growth, but resistance remains problematic. Our aims in this study were (1) to identify genes most strongly associated with resistance to endocrine therapy by intersecting global gene transcription data from patients treated presurgic...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Ribas R,Ghazoui Z,Gao Q,Pancholi S,Rani A,Dunbier A,Dowsett M,Martin LA

    更新日期:2014-10-31 00:00:00

  • Transforming growth factor-beta and breast cancer: Transforming growth factor-beta/SMAD signaling defects and cancer.

    abstract::Transforming growth factor-beta (TGF-beta) is a tumor suppressor, the function of which is compromised in many types of human cancer, including breast cancer. The tumor suppressive effects of TGF-beta are caused by potent inhibition of cell proliferation due to cell cycle arrest in the G1 phase. Such antiproliferative...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,评审


    authors: Kretzschmar M

    更新日期:2000-01-01 00:00:00

  • Finding the needle in the haystack: why high-throughput screening is good for your health.

    abstract::High-throughput screening is an essential component of the toolbox of modern technologies that improve speed and efficiency in contemporary cancer drug development. This is particularly important as we seek to exploit, for maximum therapeutic benefit, the large number of new molecular targets emerging from the Human G...

    journal_title:Breast cancer research : BCR

    pub_type: 社论


    authors: Aherne GW,McDonald E,Workman P

    更新日期:2002-01-01 00:00:00

  • Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer.

    abstract:INTRODUCTION:The amplification event occurring at chromosome locus 11q13, reported in several different cancers, includes a number of potential oncogenes. We have previously reported amplification of one such oncogene, namely CCND1, to be correlated with an adverse effect of tamoxifen in premenopausal breast cancer pat...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Lundgren K,Holm K,Nordenskjöld B,Borg A,Landberg G

    更新日期:2008-01-01 00:00:00

  • A novel approach for the generation of genetically modified mammary epithelial cell cultures yields new insights into TGFβ signaling in the mammary gland.

    abstract:INTRODUCTION:Molecular dissection of the signaling pathways that underlie complex biological responses in the mammary epithelium is limited by the difficulty of propagating large numbers of mouse mammary epithelial cells, and by the inability of ribonucleic acid interference (RNAi)-based knockdown approaches to fully a...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Kohn EA,Du Z,Sato M,Van Schyndle CM,Welsh MA,Yang YA,Stuelten CH,Tang B,Ju W,Bottinger EP,Wakefield LM

    更新日期:2010-01-01 00:00:00

  • Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.

    abstract:INTRODUCTION:Human epidermal growth factor receptor HER3 has been implicated in promoting the aggressiveness and metastatic potential of breast cancer. Upregulation of HER3 has been found to be a major mechanism underlying drug resistance to EGFR and HER2 tyrosine kinase inhibitors and to endocrine therapy in the treat...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Ren XR,Wang J,Osada T,Mook RA Jr,Morse MA,Barak LS,Lyerly HK,Chen W

    更新日期:2015-02-15 00:00:00

  • Chromogenic in situ hybridization (CISH): a novel alternative in screening archival breast cancer tissue samples for HER-2/neu status.

    abstract:BACKGROUND:Chromogenic in situ hybridization (CISH) is emerging as a practical, cost-effective, and valid alternative to fluorescent in situ hybridization in testing for gene alteration, especially in centers primarily working with immunohistochemistry (IHC). METHODS:We assessed Her-2/neu alteration using CISH on form...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Madrid MA,Lo RW

    更新日期:2004-01-01 00:00:00

  • Gene expression in murine mammary epithelial stem cell-like cells shows similarities to human breast cancer gene expression.

    abstract:INTRODUCTION:Mammary stem cells are bipotential and suggested to be the origin of breast cancer development, but are elusive and vaguely characterized. Breast tumors can be divided into subgroups, each one requiring specific treatment. To determine a possible association between mammary stem cells and breast cancer, a ...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Williams C,Helguero L,Edvardsson K,Haldosén LA,Gustafsson JA

    更新日期:2009-01-01 00:00:00

  • Metastatic breast cancer cells inhibit osteoblast differentiation through the Runx2/CBFβ-dependent expression of the Wnt antagonist, sclerostin.

    abstract:INTRODUCTION:Breast cancers frequently metastasise to the skeleton where they cause osteolytic bone destruction by stimulating osteoclasts to resorb bone and by preventing osteoblasts from producing new bone. The Runt-related transcription factor 2, Runx2, is an important determinant of bone metastasis in breast cancer...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Mendoza-Villanueva D,Zeef L,Shore P

    更新日期:2011-10-27 00:00:00

  • The effect of psychosocial factors on breast cancer outcome: a systematic review.

    abstract:INTRODUCTION:We sought to review the available evidence regarding the effect of psychosocial factors on the survival of breast cancer patients. METHODS:We systematically searched the PubMed and PsycINFO databases to identify relevant studies. RESULTS:We identified 31 studies examining the association of various psych...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,meta分析


    authors: Falagas ME,Zarkadoulia EA,Ioannidou EN,Peppas G,Christodoulou C,Rafailidis PI

    更新日期:2007-01-01 00:00:00

  • Phosphoinositide 3-kinase targeting by the beta galactoside binding protein cytokine negates akt gene expression and leads aggressive breast cancer cells to apoptotic death.

    abstract:INTRODUCTION:Phosphoinositide 3-kinase (PI3K)-activated signalling has a critical role in the evolution of aggressive tumourigenesis and is therefore a prime target for anticancer therapy. Previously we have shown that the beta galactoside binding protein (betaGBP) cytokine, an antiproliferative molecule, induces funct...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Wells V,Mallucci L

    更新日期:2009-01-01 00:00:00

  • Breast cancer in Marin County.

    abstract::Two articles previously published in Breast Cancer Research illustrate the high rates of breast cancer in Marin County, a wealthy, urban county immediately northwest of the city of San Francisco. I herein comment on these articles, and on the political/psychological/scientific dilemma presented by regions with high ca...

    journal_title:Breast cancer research : BCR

    pub_type: 评论,杂志文章,评审


    authors: Whittemore AS

    更新日期:2003-01-01 00:00:00

  • Sulfatide decreases the resistance to stress-induced apoptosis and increases P-selectin-mediated adhesion: a two-edged sword in breast cancer progression.

    abstract:BACKGROUND:We have previously shown that galactosylceramide (GalCer) affects the tumourigenic and metastatic properties of breast cancer cells by acting as an anti-apoptotic molecule. Since GalCer is a precursor molecule in the synthesis of sulfatides, the present study was aimed to define the role of sulfatides in apo...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Suchanski J,Grzegrzolka J,Owczarek T,Pasikowski P,Piotrowska A,Kocbach B,Nowak A,Dziegiel P,Wojnar A,Ugorski M

    更新日期:2018-11-06 00:00:00

  • Tricho-rhino-phalangeal syndrome 1 protein functions as a scaffold required for ubiquitin-specific protease 4-directed histone deacetylase 2 de-ubiquitination and tumor growth.

    abstract:BACKGROUND:Although numerous studies have reported that tricho-rhino-phalangeal syndrome type I (TRPS1) protein, the only reported atypical GATA transcription factor, is overexpressed in various carcinomas, the underlying mechanism(s) by which it contributes to cancer remain unknown. METHODS:Both overexpression and kn...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Wang Y,Zhang J,Wu L,Liu W,Wei G,Gong X,Liu Y,Ma Z,Ma F,Thiery JP,Chen L

    更新日期:2018-08-02 00:00:00

  • ELF5 isoform expression is tissue-specific and significantly altered in cancer.

    abstract:BACKGROUND:E74-like factor 5 (ELF5) is an epithelial-specific member of the E26 transforming sequence (ETS) transcription factor family and a critical regulator of cell fate in the placenta, pulmonary bronchi, and milk-producing alveoli of the mammary gland. ELF5 also plays key roles in malignancy, particularly in basa...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Piggin CL,Roden DL,Gallego-Ortega D,Lee HJ,Oakes SR,Ormandy CJ

    更新日期:2016-01-07 00:00:00

  • Zoledronic acid effectiveness against breast cancer metastases - a role for estrogen in the microenvironment?

    abstract::Zoledronic acid (ZA) is an imidazole-containing bisphosphonate that has been extensively studied as an osteoclast inhibitor. ZA decreases bone turnover and has been effective in limiting osteolysis in metastatic cancers, including breast cancer. Recent clinical trials that demonstrated enhancement of disease-free surv...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,评审


    authors: Steinman RA,Brufsky AM,Oesterreich S

    更新日期:2012-09-21 00:00:00

  • HER2 expression on tumor-derived extracellular vesicles and circulating tumor cells in metastatic breast cancer.

    abstract:BACKGROUND:Tumor-derived extracellular vesicles (tdEVs) and circulating tumor cells (CTCs) in the blood of metastatic cancer patients associate with poor outcomes. In this study, we explored the human epidermal growth factor receptor 2 (HER2) expression on CTCs and tdEVs of metastatic breast cancer patients. METHODS:B...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Nanou A,Zeune LL,Bidard FC,Pierga JY,Terstappen LWMM

    更新日期:2020-08-12 00:00:00

  • Progesterone receptors--animal models and cell signalling in breast cancer. Diverse activation pathways for the progesterone receptor: possible implications for breast biology and cancer.

    abstract::Progesterone and estradiol, and their nuclear receptors, play essential roles in the physiology of the reproductive tract, the mammary gland and the nervous system. Estrogens have traditionally been considered associated with an increased risk of breast cancer. There is, however, compelling evidence that progesterone ...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,评审


    authors: Lanari C,Molinolo AA

    更新日期:2002-01-01 00:00:00

  • Interaction with adipocyte stromal cells induces breast cancer malignancy via S100A7 upregulation in breast cancer microenvironment.

    abstract:BACKGROUND:Breast adipocytes play important roles in both the development and function of mammary epithelial cells. Therefore, carcinoma-adipose stromal cell (ASC) interactions have been considered pivotal in supporting tumor growth in breast cancer. In addition, it has been demonstrated that the biological features of...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Sakurai M,Miki Y,Takagi K,Suzuki T,Ishida T,Ohuchi N,Sasano H

    更新日期:2017-06-19 00:00:00

  • Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways.

    abstract:INTRODUCTION:Metastasis is the main cause of breast cancer morbidity and mortality. Processes that allow for tumor cell migration and invasion are important therapeutic targets. Here we demonstrate that receptor-interacting protein kinase 2 (RIP2), a kinase known to be involved in inflammatory processes, also has novel...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Singel SM,Batten K,Cornelius C,Jia G,Fasciani G,Barron SL,Wright WE,Shay JW

    更新日期:2014-03-19 00:00:00

  • Vitamin D and breast cancer: interpreting current evidence.

    abstract::Preclinical investigations and selected clinical observational studies support an association between higher vitamin D intake and 25-hydroxyvitamin D levels with lower breast cancer risk. However, the recently updated report from the Institute of Medicine concluded that, for cancer and vitamin D, the evidence was 'inc...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,评审


    authors: Chlebowski RT

    更新日期:2011-08-16 00:00:00

  • Family history of later-onset breast cancer, breast healthy behavior and invasive breast cancer among postmenopausal women: a cohort study.

    abstract:INTRODUCTION:A family history of later-onset breast cancer (FHLBC) may suggest multi-factorial inheritance of breast cancer risk, including unhealthy lifestyle behaviors that may be shared within families. We assessed whether adherence to lifestyle behaviors recommended for breast cancer prevention--including maintaini...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Gramling R,Lash TL,Rothman KJ,Cabral HJ,Silliman R,Roberts M,Stefanick ML,Harrigan R,Bertoia ML,Eaton CB

    更新日期:2010-01-01 00:00:00

  • No evidence for association of inherited variation in genes involved in mitosis and percent mammographic density.

    abstract:INTRODUCTION:Increased mammographic breast density is one of the strongest risk factors for breast cancer. While two-thirds of the variation in mammographic density appears to be genetically influenced, few variants have been identified. We examined the association of inherited variation in genes from pathways that med...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Vachon CM,Li J,Scott CG,Hall P,Czene K,Wang X,Liu J,Fredericksen ZS,Rider DN,Wu FF,Olson JE,Cunningham JM,Stevens KN,Sellers TA,Pankratz SV,Couch FJ

    更新日期:2012-01-07 00:00:00