Abstract:
BACKGROUND:Although many of the factors and molecules closely associated with non-alcoholic steatohepatitis (NASH) have been reported, the role of inducible nitric oxide synthase (iNOS)-derived nitric oxide (NO) on the progression of NASH remains unclear. We therefore investigated the role of iNOS-derived NO in NASH pathogenesis with a long-term follow-up study using systemic iNOS-knockout mice under high-fat diet (HFD) conditions. METHODS:iNOS-knockout and wild-type mice were fed a basal or HFD for 10 or 48 weeks. Lipid accumulation, fibrosis, and inflammation were evaluated, and various factors and molecules closely associated with NASH were analyzed. RESULTS:Marked fibrosis and inflammation (indicators of NASH) were observed in the livers of iNOS-knockout mice compared to wild-type mice after 48 weeks of a HFD; however, lipid accumulation in iNOS-knockout mice livers was less than in the wild-type. Increased expressions of various cytokines that are transcriptionally controlled by NF-kB in iNOS-deficient mice livers were observed during HFD conditions. CONCLUSIONS:iNOS-derived NO may play a protective role against the progression to NASH during an HFD by preventing fibrosis and inflammation, which are mediated by NF-kB activation in Kupffer cells. A lack of iNOS-derived NO accelerates progression to NASH without excessive lipid accumulation.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Nozaki Y,Fujita K,Wada K,Yoneda M,Kessoku T,Shinohara Y,Imajo K,Ogawa Y,Nakamuta M,Saito S,Masaki N,Nagashima Y,Terauchi Y,Nakajima Adoi
10.1186/s12876-015-0269-3subject
Has Abstractpub_date
2015-04-01 00:00:00pages
42issn
1471-230Xpii
10.1186/s12876-015-0269-3journal_volume
15pub_type
杂志文章abstract:BACKGROUND:Allergic proctocolitis (APC) in exclusively breast-fed infants is caused by food proteins, deriving from maternal diet, transferred through lactation. In most cases a maternal cow milk-free diet leads to a prompt resolution of rectal bleeding, while in some patients a multiple food allergy can occur. The aim...
journal_title:BMC gastroenterology
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2005-02-18 00:00:00
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更新日期:2010-07-07 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-07-08 00:00:00
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pub_type: 杂志文章
doi:10.1186/1471-230X-12-100
更新日期:2012-08-03 00:00:00
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更新日期:2021-01-26 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:2013-04-15 00:00:00