Abstract：
BACKGROUND:Multifocal motor neuropathy (MMN) is characterised by progressive, predominantly distal, asymmetrical limb weakness and usually multiple partial motor nerve conduction blocks. Intravenous immunoglobulin (IVIg) is beneficial but the role of immunosuppressive agents is uncertain. This is an update of a review first published in 2002 and previously updated in 2003, 2005, 2008 and 2011. OBJECTIVES:To assess the effects of immunosuppressive agents for the treatment of multifocal motor neuropathy. SEARCH METHODS:On 22 September 2014 we searched the Cochrane Neuromuscular Disease Group Specialized Register, CENTRAL, MEDLINE, EMBASE and LILACS for trials of MMN. We also searched two trials registers for ongoing studies. SELECTION CRITERIA:We planned to include randomised controlled trials (RCTs) and quasi-RCTs. We considered prospective and retrospective case series and case reports in the Discussion. DATA COLLECTION AND ANALYSIS:Two review authors searched the titles and abstracts of the articles identified and extracted the data independently. MAIN RESULTS:Only one RCT of an immunosuppressive or immunomodulatory agent has been performed in MMN. This study randomised 28 participants and showed that mycophenolate mofetil, when used with IVIg, did not significantly improve strength, function or reduce the need for IVIg. No serious adverse events were observed. The study was deemed at low risk of bias. We summarised the results of retrospective and prospective case series in the discussion. AUTHORS' CONCLUSIONS:According to moderate quality evidence, mycophenolate mofetil did not produce significant benefit in terms of reducing need for IVIg or improving muscle strength in MMN. Trials of other immunosuppressants should be undertaken.
journal_name
Cochrane Database Syst Revjournal_title
The Cochrane database of systematic reviewsauthors
Umapathi T,Hughes RA,Nobile-Orazio E,Léger JMdoi
10.1002/14651858.CD003217.pub5subject
Has Abstractpub_date
2015-03-04 00:00:00pages
CD003217issue
3issn
1469-493Xpub_type
杂志文章,评审abstract：BACKGROUND:It has been suggested that peptides from gluten and casein may have a role in the origins of autism and that the physiology and psychology of autism might be explained by excessive opioid activity linked to these peptides. Research has reported abnormal levels of peptides in the urine and cerebrospinal fluid...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD003498.pub3
更新日期：2008-04-16 00:00:00
abstract：BACKGROUND:Telemedicine is the use of electronic communications technology to provide care for patients when distance separates the practitioner and the patient. As the parents and families of infants admitted to the NICU require major support from health professionals in terms of information and time, telemedicine has...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD006818.pub2
更新日期：2012-06-13 00:00:00
abstract：BACKGROUND:Acute splenic sequestration crises are a complication of sickle cell disease, with high mortality rates and frequent recurrence in survivors of first attacks. Splenectomy and blood transfusion, with their consequences, are the mainstay of long-term management used in different parts of the world. This is a 2...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD003425.pub4
更新日期：2017-11-07 00:00:00
abstract：BACKGROUND:Mechanical ventilation is a potentially painful and discomforting intervention widely used in neonatal intensive care units. Newborn babies (neonates) demonstrate increased sensitivity to pain, which may affect clinical and neurodevelopmental outcomes. The use of drugs that reduce pain might be important in ...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD004212.pub3
更新日期：2008-01-23 00:00:00
abstract：BACKGROUND:A large proportion of patients with anxiety disorders fail to respond to first-line medication interventions, despite evidence of the effectiveness of these agents. OBJECTIVES:To assess the effects of medication versus placebo augmentation in the treatment of patients with anxiety disorders who have failed ...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD005473.pub2
更新日期：2006-10-18 00:00:00
abstract：BACKGROUND:Both peripheral arterial thrombolysis and surgery can be used in the management of peripheral arterial ischaemia. Much is known about the indications, risks, and benefits of thrombolysis. However, whether thrombolysis works better than surgery for initial management of acute limb ischaemia remains unknown. T...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析
doi：10.1002/14651858.CD002784.pub3
更新日期：2018-08-10 00:00:00
abstract：BACKGROUND:Patient surveys have shown that postoperative pain is often not managed well, and there is a need to assess the efficacy and safety of commonly used analgesics as newer treatments become available. Paracetamol (acetaminophen) is an important non-opiate analgesic, commonly prescribed, as well as being availab...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD001547
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:In high-income countries, over the last three decades, the length of hospital stays for people with serious mental illness has reduced drastically although considerable variation remains. In lower-income countries this variation may be greater. Some argue that reduction in hospital stay leads to 'revolving d...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD000384.pub3
更新日期：2014-01-30 00:00:00
abstract：BACKGROUND:Radiofrequency (RF) denervation, an invasive treatment for chronic low back pain (CLBP), is used most often for pain suspected to arise from facet joints, sacroiliac (SI) joints or discs. Many (uncontrolled) studies have shown substantial variation in its use between countries and continued uncertainty regar...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD008572.pub2
更新日期：2015-10-23 00:00:00
abstract：BACKGROUND:Venous thromboembolism (VTE) is a prevalent and serious condition. Its medical treatment requires anticoagulation, usually with either unfractionated or low molecular weight heparin (LMWH). Administration of unfractionated heparin (UFH) is usually intravenous (IV) but can be subcutaneous as well. This is an ...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD006771.pub3
更新日期：2017-02-14 00:00:00
abstract：BACKGROUND:Carpal tunnel syndrome is a clinical syndrome manifested by signs and symptoms of irritation of the median nerve at the level of the carpal tunnel in the wrist. Local corticosteroid injection for carpal tunnel syndrome has been studied but its effectiveness and duration of benefit of local corticosteroid inj...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD001554
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:People with asthma who come from minority groups have poorer asthma outcomes and more asthma related visits to Emergency Departments (ED). Various programmes are used to educate and empower people with asthma and these have previously been shown to improve certain asthma outcomes. Models of care for chronic ...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD006580.pub3
更新日期：2009-01-21 00:00:00
abstract：BACKGROUND:The effectiveness and safety of amantadine (AMT) and rimantadine (RMT) for preventing and treating influenza A in adults has been systematically reviewed. However, little is known about these treatments in children and the elderly. OBJECTIVES:To systematically review the effectiveness and safety of AMT and ...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD002745.pub3
更新日期：2012-01-18 00:00:00
abstract：BACKGROUND:Usual-type vulval intraepithelial neoplasia (uVIN) is a pre-cancerous condition of the vulval skin. Also known as high-grade VIN, VIN 2/3 or high-grade vulval squamous intraepithelial lesion (HSIL), uVIN is associated with high-risk subtype human papilloma virus (HPV) infection. The condition causes distress...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD011837.pub2
更新日期：2016-01-05 00:00:00
abstract：BACKGROUND:Self-monitoring of blood glucose is essential to optimise glycaemic control in type 1 diabetes mellitus. Continuous glucose monitoring (CGM) systems measure interstitial fluid glucose levels to provide semi-continuous information about glucose levels, which identifies fluctuations that would not have been id...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD008101.pub2
更新日期：2012-01-18 00:00:00
abstract：BACKGROUND:Patients with chronic kidney disease have significant abnormalities of bone remodelling and calcium homeostasis and are at increased risk of fracture. The fracture risk for a kidney transplant recipient is four times that of the general population and higher than that for a patient on dialysis. Trials report...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD005015.pub2
更新日期：2005-04-18 00:00:00
abstract：BACKGROUND:Endometriomata are endometriotic deposits within the ovary. The surgical management of these blood filled cysts is controversial. The laparoscopic approach to the management of endometriomata is favoured for as it offers the advantage of a shorter hospital stay, faster patient recovery and decreased hospital...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD004992.pub2
更新日期：2005-07-20 00:00:00
abstract：BACKGROUND:Parecoxib was the first COX-2 available for parenteral administration, and may, given intravenously or intramuscularly, offer advantages over oral medication when patients have nausea and vomiting or are unable to swallow, such as in the immediate postoperative period. OBJECTIVES:Assess the efficacy of sing...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD004771.pub4
更新日期：2009-04-15 00:00:00
abstract：BACKGROUND:In response to criticism that epilepsy care for children has little impact, healthcare professionals and administrators have developed various service models and strategies to address perceived inadequacies. OBJECTIVES:To assess the effects of any specialised or dedicated intervention for epilepsy versus us...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD006245.pub4
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:Combination therapies are frequently recommended as maintenance therapy for people with asthma, whose disease is not adequately controlled with inhaled steroids. Fluticasone/salmeterol (FP/SAL) and budesonide/formoterol (BUD/F) have been assessed against their respective monocomponents, but there is a need t...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD004106.pub3
更新日期：2008-07-16 00:00:00
abstract：BACKGROUND:Anticoagulation may improve survival in patients with cancer through an antitumor effect in addition to the perceived antithrombotic effect. OBJECTIVES:To evaluate the efficacy and safety of parenteral anticoagulants in patients with cancer with no therapeutic or prophylactic indication for anticoagulation....
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD006652.pub2
更新日期：2011-01-19 00:00:00
abstract：BACKGROUND:High altitude illness (HAI) is a term used to describe a group of cerebral and pulmonary syndromes that can occur during travel to elevations above 2500 metres (8202 feet). Acute hypoxia, acute mountain sickness (AMS), high altitude cerebral oedema (HACE) and high altitude pulmonary oedema (HAPE) are reporte...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD009761.pub2
更新日期：2017-06-27 00:00:00
abstract：BACKGROUND:Patients with acute asthma treated in the emergency department (ED) are frequently treated with inhaled beta(2)-agonists and systemic corticosteroids after discharge. The use of inhaled corticosteroids (ICS) following discharge may also be beneficial in improving patient outcomes after acute asthma. OBJECTI...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD002316.pub2
更新日期：2012-12-12 00:00:00
abstract：BACKGROUND:Electromechanical- and robot-assisted gait-training devices are used in rehabilitation and might help to improve walking after stroke. This is an update of a Cochrane Review first published in 2007 and previously updated in 2017. OBJECTIVES:Primary • To determine whether electromechanical- and robot-assiste...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析
doi：10.1002/14651858.CD006185.pub5
更新日期：2020-10-22 00:00:00
abstract：BACKGROUND:The number of obese patients requiring general anaesthesia is likely to increase in coming years, and obese patients pose considerable challenges to the anaesthetic team. Tracheal intubation may be more difficult and risk of aspiration of gastric contents into the lungs is increased in obese patients. Suprag...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD010105.pub2
更新日期：2013-09-09 00:00:00
abstract：BACKGROUND:Leprosy causes nerve damage which may result in nerve function impairment and disability. Decompressive surgery is used for treating nerve damage, although the effect is uncertain. OBJECTIVES:To assess the effects of decompressive surgery on nerve damage in leprosy. SEARCH STRATEGY:We searched the Cochrane...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD006983.pub2
更新日期：2009-01-21 00:00:00
abstract：BACKGROUND:Demographic changes are leading to an increase in the number of older drivers: as dementia is an age-related disease, there is also an increase in the numbers of drivers with dementia. Dementia can impact on both the mobility and safety of drivers, and the impact of formal assessment of driving is unknown in...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD006222.pub2
更新日期：2009-01-21 00:00:00
abstract：BACKGROUND:Fluid excess may place patients undergoing surgery at risk for various complications. Hypertonic saline (HS) maintains intravascular volume with less intravenous fluid than isotonic salt (IS) solutions, but may increase serum sodium. OBJECTIVES:To determine the benefits and harms of HS versus IS solutions a...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD005576.pub2
更新日期：2010-01-20 00:00:00
abstract：BACKGROUND:This is an update of a review that was first published in 2002. Female sterilisation is the most popular contraceptive method worldwide. Several techniques exist for interrupting the patency of fallopian tubes, including cutting and tying the tubes, damaging the tube using electric current, applying clips or...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD003034.pub3
更新日期：2015-09-07 00:00:00
abstract：BACKGROUND:The number of people with severe mental illness who receive treatment whilst living at home has increased greatly over the last 30 years. Day centres and day hospitals frequently supplement this treatment. OBJECTIVES:To determine the effects of non-medical day centre care for people with severe mental illne...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD001710
更新日期：2001-01-01 00:00:00
