Abstract：
:The regulation of GH secretion involves the harmonious integration of factors acting at the hypothalamic and pituitary levels summating to produce the peripheral patterns of intermittent GH secretion observed in man and experimental animals under physiologic and experimental conditions. SRIH and GHRH act primarily at the pituitary to regulate the secretion of GH, while monaminergic, cholinergic and peptidergic neurotransmitters act centrally and/or at the pituitary level. In addition IGF-I, the anabolic effector of GH has inhibitory feedback effects at both the pituitary and hypothalamus. The control of GH secretion often differs between species and is dependent on the sex, nutritional state and physiologic condition being studied. In vivo and in vitro effects may differ as the complex, multilayered regulatory mechanisms of GH secretion in the intact subject override the direct effects of an individual controlling factor.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Root AWsubject
Has Abstractpub_date
1989-01-01 00:00:00pages
3-7issue
8 Suppl 3eissn
0391-4097issn
1720-8386journal_volume
12pub_type
杂志文章,评审abstract：PURPOSE:Iodine plays a pivotal role in adaptation during the transition from intrauterine to extrauterine life. Although it is well known that the placenta plays a role in iodine storage, a relationship between the neonatal thyroid stimulating hormone (TSH) peak and placental iodine concentration has not been establish...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-020-01399-y
更新日期：2020-08-28 00:00:00
abstract：:Severe bleeding into the peritoneal cavity from a ruptured ovulatory follicle is a rare complication in women receiving anticoagulation therapy. A number of both surgical and non surgical methods have been proposed to solve this problem. We adopted a novel therapeutic approach in a 40-year old patient who presented wi...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348998
更新日期：1994-05-01 00:00:00
abstract：:Cushing's Syndrome (CS) may sometimes lead to dilated cardiomyopathy, even though this condition can be partially or completely reversed after treatment. In this article we report the case of a 28-yr-old woman with CS secondary to adrenal adenoma who exhibited congestive heart failure as an initial symptom. Two weeks ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346339
更新日期：2007-06-01 00:00:00
abstract：:We studied the possibility of an association between serum somatomedin-C (Sm-C) and thyroid hormone concentrations. For this purpose 34 hyperthyroid patients, 39 patients with primary hypothyroidism, 36 patients with severe nonthyroidal illnesses (NTI), and 63 euthyroid healthy control subjects were examined. The mean...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349528
更新日期：1990-02-01 00:00:00
abstract：:Isolated hypothyroxinemia (IH) is defined as a thyroxine level in the lower 5th (severe IH) or 10th percentile (mild IH) of the pregnancy-related reference range and a normal TSH. The etiology of IH remains unknown. This review aims to evaluate the biochemical criteria used to define IH in different published studies ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/s40618-014-0203-5
更新日期：2015-02-01 00:00:00
abstract：:Liquid-chromatography - tandem mass spectrometry (LC-MS/MS) is becoming the method of choice for clinical steroid analysis. In most instances, it has the advantage of higher sensitivity, better reproducibility and greater specificity than commercial immunoassay techniques. The method requires only minimal sample prepa...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.3275/7843
更新日期：2011-10-01 00:00:00
abstract：:The unlimited availability of GH obtained by recombinant DNA technology has allowed optimization of treatment in GH-deficient (GHD) children. At the same time it has prompted a number of studies in conditions not characterized by GHD such as Turner syndrome, intrauterine growth retardation, chronic renal failure and o...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03345367
更新日期：2005-02-01 00:00:00
abstract：:Final height was evaluated in 47 patients with classical 21-hydroxylase treated since diagnosis, and in 29 patients with nonclassical (NC) 21-hydroxylase deficiency who had never been treated before reaching final adult height. Classical patients achieved final heights consistently below the mean for the general popul...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Two radioimmunological techniques for the measurement of anti-alpha-galactosyl (anti-Gal) antibodies were developed and we demonstrated that this antibody is present in the serum of most untreated patients with Graves' disease, thyroid-associated ophthalmopathy (TAO) and autoimmune thyroiditis. Thyrotropin-binding inh...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349806
更新日期：1995-11-01 00:00:00
abstract：:The aim of this prospective study was to investigate the effects of thyroid hormone levels on the sepsis criteria and mortality in septic newborns. This study was performed at the Firat University Hospital Neonatal Intensive Care Unit. A group of septic newborns and a control group of healthy non-infected newborns wer...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347098
更新日期：2011-04-01 00:00:00
abstract：:Insulin degradation in IM-9 cultured human lymphocytes occurs extracellularly. In the presence of 0.1% bovine serum albumin, insulin degradation products are formed that are soluble in 5% trichloroacetic acid. In the presence of 5% bovine serum albumin, the major products of insulin degradation are insoluble in 5% tri...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348223
更新日期：1980-01-01 00:00:00
abstract：OBJECTIVE:Although two studies have shown that Addison's disease (AD) is still a potentially lethal condition for cardiovascular, malignant, and infectious diseases, a recent retrospective study showed a normal overall mortality rate. Differently from secondary hypoadrenalism, scanty data exist on the role of conventio...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345773
更新日期：2009-12-01 00:00:00
abstract：:The behavior of serum anti-thyroglobulin (Abs-Tg) and antimicrosomal antibodies (Abs-Mc) was examined during and after normal pregnancies. The antibodies titer decreases as pregnancy progresses; they cross the placenta and are present in the fetal serum. Infants' thyroid function is not affected by this transplacentar...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349385
更新日期：1980-10-01 00:00:00
abstract：:A 45-year-old man presented with gynecomastia, hypertension and a large left adrenal mass. Further evaluation revealed elevated serum concentrations of estrogen, estrone sulfate, androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, deoxycorticosterone, and aldosterone and increased 24-hour urinary ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348975
更新日期：1994-04-01 00:00:00
abstract：:In healthy pregnant women, the regulation of thyroid function depends upon several factors. Three factors act independently to increase thyroid hormone requirements: 1) the marked increase in the binding capacity of serum due to high TBG levels; 2) the direct stimulation of the thyroid by human chorionic gonadotropin,...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03348861
更新日期：1993-05-01 00:00:00
abstract：:We report the case of a 17-year-old girl presenting short stature (height 149 cm, below the 3rd percentile), obesity (weight 83.5 kg, body mass index 37 kg/m2) and secondary amenorrhea, in whom endocrinological evaluation disclosed an absolute lack of GH responsiveness to both suprapituitary challenges and repetitive ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347844
更新日期：1995-05-01 00:00:00
abstract：:Our study previously showed that estrogen and progesterone stimulated the production of matrix metalloproteinase-14 [MMP-14, or also named membrane type matrix metalloproteinses-1 (MT1-MMP)] in osteoblastic cells. MMP-14 was implied to regulate the function of osteoblasts by degrading bone matrix or growth factors, bu...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345259
更新日期：2003-11-01 00:00:00
abstract：:The pituitary and peripheral responses to L-T4 and L-T3 therapy were studied in 12 patients with congenital goitrous hypothyroidism, in 10 patients with an ectopic thyroid and onset of hypothyroidism at 3-8 years of age, and in 6 patients with adult-onset hypothyroidism, after they had had their chronic thyroid hormon...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348554
更新日期：1985-12-01 00:00:00
abstract：:Eleven patients with Paget's disease of bone, treated intermittently for 2-4 years with porcine calcitonin (pCT) and clinically resistant to pCT [no modifications of serum alkaline phosphatase (ALP) and urinary hydroxyproline ( uHOP ) during pCT administration] were treated with 0.5-0.25 mg/day of human calcitonin (hC...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348394
更新日期：1984-04-01 00:00:00
abstract：:Unfortunately, the author name and his affiliation were published in the original publication. They have now been removed. ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,已发布勘误
doi：10.1007/s40618-019-01012-x
更新日期：2019-02-01 00:00:00
abstract：AIM:This 3-month study compared the effect on overall glycemic control of adding biphasic insulin aspart 30 (BIAsp30) and premixed human insulin 30/70 (BHI30) to metformin (met) in insulin-naïve, obese patients (30 males/20 females) with Type 2 diabetes (T2DM). MATERIAL/SUBJECTS: At baseline, patients had a mean age of...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345673
更新日期：2009-01-01 00:00:00
abstract：:Effects of primary hypothyroidism (HYPO) on the male gonadal axis are controversial, with only scanty data on the gonadotroph cell response and no information on GnRH tuberoinfundibular neurons, even in animal models. HYPO has been reported to variably induce hypogonadotropic hypogonadism, a hypergonadotropic state, o...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
abstract：:A comparison of peripheral patterns of androstenedione (A), 17 beta-estradiol (E2) and progesterone (P) is reported in ten infertile women during HMG-HCG induction of ovulation, in order to assess the site of ovarian secretion of plasma A and the possible influence on conception. Evidence for both the follicular and l...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03351016
更新日期：1984-08-01 00:00:00
abstract：:A 41-year-old male with primary hypothyroidism and a huge TSH-secreting pituitary tumor presented with a bleeding nasal mass that was initially misdiagnosed as a paraganglioma. Other unique features of the case include lack of complaints related to hypothyroidism, an extremely elevated TSH level of 3474 mU/l, and a lo...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03343584
更新日期：1999-06-01 00:00:00
abstract：:Serial weekly serum samples (for 3 weeks) were obtained from 42 patients with differentiated thyroid cancer (DTC, papillary no.=35, follicular no.=6, Hurthle cell no.=1) for serum thyroid hormone, TSH and TG before and after total thyroidectomy. Serum specimens were also obtained one month after radioiodine (131I) the...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03343973
更新日期：2002-02-01 00:00:00
abstract：:Forty-three euthyroid patients with a single, solid, nonfunctioning thyroid nodule were submitted to fine needle aspiration biopsy and serum thyroglobulin (Tg) was measured before and after (48h) 10 U of bovine TSH. Twenty-two normal subjects were also submitted to the bTSH test. Patients with nonfunctioning nodules w...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348125
更新日期：1987-06-01 00:00:00
abstract：:TSH has been incriminated in Graves' disease for increasing the production of antibodies against TSH receptor (TRAb). It has been, therefore, suggested that T4 administration after successful antithyroid drug (ATD) treatment may indirectly decrease the production of TRAb and, therefore, the frequency of recurrence of ...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF03348195
更新日期：2003-10-01 00:00:00
abstract：:A patient with Graves' disease associated with severe muscle weakness who was finally diagnosed as polymyositis by pathological examination of the muscle is reported. A 28-year-old women was incidentally found to have hyperthyroidism when she consulted a hospital for the evaluation and treatment of anemia in 1979. She...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03350077
更新日期：1989-12-01 00:00:00
abstract：:Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare, but well-defined monogenic disorder that is caused by mutations in the autoimmune regulator (AIRE) gene on chromosome 21q22.3. Patients most often suffer from loss of endocrine function in the parathyroid and adrenal glands but may also...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03345516
更新日期：2002-10-01 00:00:00
abstract：:Volume receptors are situated in many organs and are capable of modulating ADH secretion. We have evaluated the variation of plasma ADH concentration after an experimentally induced increase of cerebrospinal fluid (CSF) pressure (PCSF). The experiment was performed in controlled environmental conditions to avoid pain ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349891
更新日期：1996-07-01 00:00:00
