The many essential interfaces of clinical pharmacology.

abstract：:1. Antinociceptive activity of hen egg white lysozyme (Fleming's lysozyme) was determined against abdominal contractions provoked by irritants injected intraperitoneally into mice. Carrageenan (2 mg) (CA) injected with arachidonic acid (15 micrograms) (AA) or prostaglandins PGE1 or PGF2 alpha (0.04 ng), brewer's yeast...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bianchi C

更新日期：1983-01-01 00:00:00

abstract：:1. The intrinsic sympathomimetic activity of a range of beta-adrenoceptor antagonists and its relationship to beta-adrenoceptor blockade was studied in pentobarbitone-anaesthetized, vagotomized rats which had been depleted of catecholamines by pretreatment with syrosingopine. Dichlorisoprenaline, practolol, oxprenolol...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bilski A,Robertson HH,Wale JL

更新日期：1979-01-01 00:00:00

abstract：:Central administration of choline increases blood pressure in normotensive and hypotensive states by increasing plasma concentrations of vasopressin and catecholamines. We hypothesized that choline could also modulate the renin-angiotensin pathway, the third main pressor system in the body. Plasma renin activity (PRA)...

journal_title：Clinical and experimental pharmacology & physiology

authors： Isbil-Buyukcoskun N,Ilcol YO,Cansev M,Hamurtekin E,Ozluk K,Ulus IH

更新日期：2008-09-01 00:00:00

abstract：:Nucleocytoplasmic protein shuttling is integral to the transmission of signals between the nucleus and the cytoplasm. The nuclear/cytoplasmic distribution of proteins of interest can be determined via fluorescence microscopy, following labelling of the target protein with fluorophore-conjugated antibodies (immunofluor...

journal_title：Clinical and experimental pharmacology & physiology

authors： Molenaar C,Weeks KL

更新日期：2018-10-01 00:00:00

abstract：:1. This study aimed to characterize the effect of nicorandil (NC) on myocardial stunning and the role of ATP-sensitive K+ (KATP) channel opening property in its cardioprotective action. 2. In open-chest anaesthetized rabbits, myocardial stunning was induced by 10 min of coronary occlusion followed by 30 min of reperfu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iwamoto T,Miura T,Urabe K,Itoya M,Shimamoto K,Iimura O

更新日期：1993-09-01 00:00:00

abstract：:1. The hypothesis that adrenocorticotrophin (ACTH)-induced hypertension is a consequence of steroid-induced hyperinsulinaemia was tested using the somatostatin analogue (sandostatin, octreotide) to inhibit insulin release in Sprague-Dawley (SD) rats (n = 41). 2. Octreotide (20 micrograms, twice daily) did not modify b...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li M,Wong KS,Whitworth JA

更新日期：1993-10-01 00:00:00

abstract：:1. Chronic alcohol treatment has been reported to be associated with liver and kidney damage. The insulin-like growth factor (IGF) is the major growth factor related to alcohol consumption. However, the effect of alcohol on the IGF system in the liver and kidney has not been fully elucidated. Thus, the present study w...

journal_title：Clinical and experimental pharmacology & physiology

authors： Park SH,Heo JS,Kang CW

更新日期：2004-01-01 00:00:00

abstract：:The antihypertensive agent rilmenidine has threefold higher affinity for I(1) imidazoline receptors compared with alpha(2)-adrenoceptors and acts on the central nervous system by reducing sympathetic activity and in the kidney by inhibiting Na(+)/H(+) exchange activity. In the present study, we examined: (i) the effec...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jovanovska V,Eitle E,Harris PJ

更新日期：2004-05-01 00:00:00

abstract：:1. The clinical observation that hypertension is more common in males and postmenopausal women than in premenopausal women suggests vascular protective effects of female sex hormones, including hormone-mediated inhibition of vascular tone. The purpose of the present study was to investigate whether the Ca2+ mobilizati...

journal_title：Clinical and experimental pharmacology & physiology

authors： Crews JK,Khalil RA

更新日期：1999-09-01 00:00:00

abstract：:1. We examined the effects of torasemide (0.3 and 1 mg/kg i.v.) on renal haemodynamics and function employing renal clearance and stop-flow techniques in anaesthetized dogs and compared these with furosemide (1 and 3 mg/kg i.v.). 2. Torasemide and furosemide did not influence renal haemodynamics, in the renal clearanc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Uchida T,Hayashi K,Suzuki Y,Matsumura Y

更新日期：1991-07-01 00:00:00

abstract：:Capillary permeability (CP) is elevated in late normal pregnancy, when compared to postpartum values. In women with pregnancy associated hypertension (PAH), pregnancy CP levels are not different from postpartum and are less than in normal pregnancy. These changes in capillary permeability are not explained by alterati...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hunyor SN,McEniery PT,Roberts KA,Bellamy GR,Roffe DJ,Gallery ED,Gyory AZ,Boyce ES

更新日期：1983-05-01 00:00:00

abstract：:1. The present review reports some of the earliest physiological changes that occur in the diabetic retina prior to any clinical or anatomical changes in an animal model of diabetes. 2. Using chemically induced diabetes (by streptozotocin) in rats, retinal blood flow and vitreal and retinal oxygen tension were determi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Alder VA,Su EN,Yu DY,Cringle SJ,Yu PK

更新日期：1997-09-01 00:00:00

abstract：:1. The role of cardiac reflexes in baroreflex control mechanisms and the changes that occur in chronic hypertension is reviewed. The rapid resetting properties of the arterial baroreceptors ensures its role in short-term rather than long-term control of blood pressure. 2. In hypertensive humans and animals, the barore...

journal_title：Clinical and experimental pharmacology & physiology

authors： Head GA

更新日期：1994-10-01 00:00:00

abstract：:1. The present study investigated whether the somatostatin receptor (SSTR) agonist, octreotide, could inhibit the activation of dorsal skin afferent fibres induced by local injection of capsaicin in the rat. 2. Single unit activity from Aδ mechano-heat sensitive (AMH; n = 41) and C mechano-heat sensitive (CMH; n = 30)...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang J,Cao DY,Guo Y,Ma SJ,Luo R,Pickar JG,Zhao Y

更新日期：2011-08-01 00:00:00

abstract：:1. Glucuronidation is the major route of metabolism of dihydrocodeine (DHC) and accounts for 25-30% of an oral dose in urine. The kinetics of DHC-6-glucuronide formation in liver microsomes from five human donors and the effect of a number of potential inhibitor drugs were examined using a newly developed and validate...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kirkwood LC,Nation RL,Somogyi AA

更新日期：1998-03-01 00:00:00

abstract：:1. The aim of the present study was to examine the effect of bacterial lipopolysaccharide (LPS) on the disposition of an organic anion transporting polypeptide and P-glycoprotein substrate in the rat isolated perfused liver. 2. Male Sprague-Dawley rats were divided into four groups. Three of the groups received 1, 2.5...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tong Y,Zhang R,Ngo SN,Davey AK

更新日期：2006-08-01 00:00:00

abstract：:1. In a number of species, high concentrations of angiotensin II (AngII) receptors have been found in the rostral ventrolateral medulla (RVLM) in the hindbrain, which is an important region involved in the modulation of sympathetic vasomotor tone. The present review describes studies in which the contribution of angio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Head GA

更新日期：1996-09-01 00:00:00

abstract：:1. This study was undertaken to evaluate the preventive effects of locally administered argatroban, a competitive inhibitor of thrombin-induced platelet activation, on restenosis after balloon angioplasty. 2. A hydrogel-coated balloon catheter was immersed three times in argatroban/saline solution (1 mg/mL) for 60 s, ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Imanishi T,Arita M,Tomobuchi Y,Hamada M,Hano T,Nishio I

更新日期：1997-11-01 00:00:00

abstract：:1. The differential identification of the angiotensin AT1A and AT1B receptor subtypes is impaired by the existing>96% homology of both receptors. In the present study, we characterized two polyclonal rabbit peptide antibodies, namely alpha-AT1A and alpha-AT1B, that recognize the C-terminal region of mouse AT1A and AT1...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hoffmann A,Cool DR

更新日期：2005-11-01 00:00:00

abstract：:1. The aim of the present study was to examine the role of dopaminergic and glutamatergic receptors on different stages of the amphetamine (AMPH) sensitized effect in schedule-induced polydipsia (SIP) in rats. 2. Three experiments were designed to evaluate the roles of DAD2 receptor antagonist haloperidol (HAL) and gl...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu YP,Tung CS,Lin PJ,Wan FJ

更新日期：2010-09-01 00:00:00

abstract：:1. The effects of clomiphene (CLM) on cardiac outward K+ current components from rat isolated ventricular myocytes were investigated using the whole-cell patch-clamp technique. Clomiphene (10 micromol/L) significantly inhibited both peak (Ipeak) and end-pulse (Ilate) outward currents (elicited by a 500 msec voltage st...

journal_title：Clinical and experimental pharmacology & physiology

authors： Borg JJ,Hancox JC,Hogg DS,James AF,Kozlowski RZ

更新日期：2004-01-01 00:00:00

abstract：:The combined administration of metronidazole and ampicillin increased faecal weights by 198% in normal male subjects on controlled diets with constant energy, protein and dietary fibre content. Intestinal transit times were unaltered despite marked increase in faecal weights. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kurpad AV,Shetty PS

更新日期：1984-09-01 00:00:00

abstract：:Posture changes may differ between types of hypertensive disease. The aim is to evaluate the orthostatic response of impedance cardiography (ICG) measurements in uncomplicated and hypertensive pregnancies. Measurements were performed in supine and standing position in 202 women: 41 uncomplicated pregnancies (UP), 59 g...

journal_title：Clinical and experimental pharmacology & physiology

authors： Staelens AS,Vonck S,Mesens T,Tomsin K,Molenberghs G,Gyselaers W

更新日期：2015-10-01 00:00:00

abstract：:1. Elevated plasma lipoprotein (a) (Lp(a)) concentrations have been correlated with an increased risk of premature cardiovascular disease. The plasma Lp(a) concentration is quantitatively heritable and the apolipoprotein (Apo) A gene is known as a major locus-determining Lp(a) concentration. 2. The aim of the present ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Park HY,Nabika T,Notsu Y,Kobayashi S,Masuda J

更新日期：1999-04-01 00:00:00

abstract：:Urapidil had blocking activity on alpha 1-adrenoceptors in the rat isolated caudal artery (pA2 congruent to 7) and in the anaesthetized rat. Urapidil had no clonidine like agonistic activity on alpha 2-adrenoceptors in preparations of the guinea-pig ileum (prejunctional) or dog saphenous vein (post-junctional). Urapid...

journal_title：Clinical and experimental pharmacology & physiology

authors： Verberne AJ,Rand MJ

更新日期：1984-07-01 00:00:00

abstract：:1. The present study sought to explain the mechanism leading to reduced availability of propranolol when given after a priming dose in the single-pass perfused rat liver. 2. Extracellular sucrose space (as a measure of sinusoidal relaxation) in perfused rat liver before and after propranolol or propranolol and N(G)-ni...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu X,Zou Y,Khlentzos AM,Yang Y,Nikolovski J,Weiss M,Roberts MS

更新日期：2010-10-01 00:00:00

abstract：:1. There has been considerable recent interest in the possibility that increased intake of dietary anti-oxidants may protect against cardiovascular disease. This is partly due to the knowledge that oxidative events in vivo may play a role in the pathogenesis of atherosclerosis. 2. While dietary anti-oxidants, such as ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morton LW,Abu-Amsha Caccetta R,Puddey IB,Croft KD

更新日期：2000-03-01 00:00:00

abstract：:1. Subacute administration of dyflos to guinea-pigs (1.2 mg/kg, s.c., daily for 10 days) led to the development of subsensitivity to carbachol in the ileum but not in the electrically stimulated left atrium. 2. Atria from dyflos-pretreated animals became supersensitive to acetylcholine but the ileum became subsensitiv...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mitchelson F,O'Shea RA

更新日期：1977-11-01 00:00:00

abstract：:1. Neuropeptide Y (NPY) is colocalized with catecholamines in central regions involved in blood pressure regulation and exerts depressor responses in the nucleus tractus solitarius (NTS). Ageing is accompanied by a decline in baroreflex function and a reduction in NPY concentrations in some brain areas. The present st...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morris MJ,Pavia JM

更新日期：1997-02-01 00:00:00

abstract：:Acute kidney injury (AKI) occurs in 5% of hospitalized patients and in 50% of sepsis patients with acute renal dysfunction. However, there have been no safe and effective therapeutic strategies. The hypoxia condition is closely related to renal injury and function under AKI. As hypoxia-inducible factor 1α (HIF-1α) is ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang H,Liu N,Li R,Tian J,Hu W,Zhang J

更新日期：2018-10-01 00:00:00