当前位置： SCI文献检索 > Environmental Health期刊下所有文献 > Indoor air pollution exposure from use of indoor stoves and fireplaces in association with breast cancer: a case-control study.

Indoor air pollution exposure from use of indoor stoves and fireplaces in association with breast cancer: a case-control study.

Abstract：

BACKGROUND:Previous studies suggest that polycyclic aromatic hydrocarbons (PAHs) may adversely affect breast cancer risk. Indoor air pollution from use of indoor stoves and/or fireplaces is an important source of ambient PAH exposure. However, the association between indoor stove/fireplace use and breast cancer risk is unknown. We hypothesized that indoor stove/fireplace use in a Long Island, New York study population would be positively associated with breast cancer and differ by material burned, and the duration and timing of exposure. We also hypothesized that the association would vary by breast cancer subtype defined by p53 mutation status, and interact with glutathione S-transferases GSTM1, T1, A1 and P1 polymorphisms. METHODS:Population-based, case-control resources (1,508 cases/1,556 controls) were used to conduct unconditional logistic regression to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI). RESULTS:Breast cancer risk was increased among women reporting ever burning synthetic logs (which may also contain wood) in their homes (OR = 1.42, 95% CI 1.11, 1.84), but not for ever burning wood alone (OR = 0.93, 95% CI 0.77, 1.12). For synthetic log use, longer duration >7 years, older age at exposure (>20 years; OR = 1.65, 95% CI 1.02, 2.67) and 2 or more variants in GSTM1, T1, A1 or P1 (OR = 1.71, 95% CI 1.09, 2.69) were associated with increased risk. CONCLUSIONS:Burning wood or synthetic logs are both indoor PAH exposure sources; however, positive associations were only observed for burning synthetic logs, which was stronger for longer exposures, adult exposures, and those with multiple GST variant genotypes. Therefore, our results should be interpreted with care and require replication.

journal_name

Environ Health

journal_title

Environmental health : a global access science source

authors

White AJ,Teitelbaum SL,Stellman SD,Beyea J,Steck SE,Mordukhovich I,McCarty KM,Ahn J,Rossner P Jr,Santella RM,Gammon MD

doi

10.1186/1476-069X-13-108

subject

Has Abstract

pub_date

2014-12-12 00:00:00

pages

108

issn

1476-069X

pii

1476-069X-13-108

journal_volume

pub_type

杂志文章

在线工具

Indoor air pollution exposure from use of indoor stoves and fireplaces in association with breast cancer: a case-control study.