Recent advances in our understanding of human host responses to tuberculosis.

Abstract:

:Tuberculosis remains one of the world's greatest public health challenges: 2 billion persons have latent infection, 8 million people develop active tuberculosis annually, and 2-3 million die. Recently, significant advances in our understanding of the human immune response against tuberculosis have occurred. The present review focuses on recent work in macrophage and T-cell biology that sheds light on the human immune response to tuberculosis. The role of key cytokines such as interferon-gamma is discussed, as is the role of CD4+ and CD8+ T cells in immune regulation in tuberculosis, particularly with regard to implications for vaccine development and evaluation.

journal_name

Respir Res

journal_title

Respiratory research

authors

Schluger NW

doi

10.1186/rr53

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

157-63

issue

3

eissn

1465-9921

issn

1465-993X

journal_volume

2

pub_type

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