Recent advances in our understanding of human host responses to tuberculosis.


:Tuberculosis remains one of the world's greatest public health challenges: 2 billion persons have latent infection, 8 million people develop active tuberculosis annually, and 2-3 million die. Recently, significant advances in our understanding of the human immune response against tuberculosis have occurred. The present review focuses on recent work in macrophage and T-cell biology that sheds light on the human immune response to tuberculosis. The role of key cytokines such as interferon-gamma is discussed, as is the role of CD4+ and CD8+ T cells in immune regulation in tuberculosis, particularly with regard to implications for vaccine development and evaluation.


Respir Res


Respiratory research


Schluger NW





Has Abstract


2001-01-01 00:00:00












  • Maintained inspiratory activity during proportional assist ventilation in surfactant-depleted cats early after surfactant instillation: phrenic nerve and pulmonary stretch receptor activity.

    abstract:BACKGROUND:Inspiratory activity is a prerequisite for successful application of patient triggered ventilation such as proportional assist ventilation (PAV). It has recently been reported that surfactant instillation increases the activity of slowly adapting pulmonary stretch receptors (PSRs) followed by a shorter inspi...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Sindelar R,Rieger-Fackeldey E,Jonzon A,Schaller P,Schulze A,Sedin G

    更新日期:2006-03-10 00:00:00

  • Neutrophil cannibalism--a back up when the macrophage clearance system is insufficient.

    abstract:BACKGROUND:During a lipopolysaccharide-induced lung inflammation, a massive accumulation of neutrophils occurs, which is normally cleared by macrophage phagocytosis following neutrophil apoptosis. However, in cases of extensive apoptosis the normal clearance system may fail, resulting in extensive neutrophil secondary ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Rydell-Törmänen K,Uller L,Erjefält JS

    更新日期:2006-12-14 00:00:00

  • A probabilistic model of biological ageing of the lungs for analysing the effects of smoking, asthma and COPD.

    abstract:BACKGROUND:Although a large body of literature is available that describes the effects of smoking, asthma and COPD on lung function, most studies are restricted to a small age range and to one factor. As a consequence, available results are incomplete and often difficult to compare, also due to the ways the effects are...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Chiappa S,Winn J,Viñuela A,Tipney H,Spector TD

    更新日期:2013-05-30 00:00:00

  • Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma.

    abstract:BACKGROUND:Using guinea pig tracheal preparations, we have recently shown that endogenous arginase activity attenuates inhibitory nonadrenergic noncholinergic (iNANC) nerve-mediated airway smooth muscle relaxation by reducing nitric oxide (NO) production--due to competition with neuronal NO-synthase (nNOS) for the comm...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Maarsingh H,Leusink J,Bos IS,Zaagsma J,Meurs H

    更新日期:2006-01-12 00:00:00

  • Abnormal pulmonary function tests predict the development of radiation-induced pneumonitis in advanced non-small cell lung Cancer.

    abstract:BACKGROUND:Radiation pneumonitis (RP) is a frequent complication of concurrent chemoradiotherapy (CCRT) and is associated with severe symptoms that decrease quality of life and might result in pulmonary fibrosis or death. The aim of this study is to identify whether pulmonary function test (PFT) abnormalities may predi...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究


    authors: Torre-Bouscoulet L,Muñoz-Montaño WR,Martínez-Briseño D,Lozano-Ruiz FJ,Fernández-Plata R,Beck-Magaña JA,García-Sancho C,Guzmán-Barragán A,Vergara E,Blake-Cerda M,Gochicoa-Rangel L,Maldonado F,Arroyo-Hernández M,Arrieta O

    更新日期:2018-04-24 00:00:00

  • Weighted Epworth sleepiness scale predicted the apnea-hypopnea index better.

    abstract:BACKGROUND:The relationship between the Epworth sleepiness scale (ESS) and the apnea-hypopnea index (AHI) is uncertain and even poor. The major problem associated with the ESS might be a lack of consideration of weight in prediction in clinical practice. Would awarding different item-scores to the four scales of ESS it...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Guo Q,Song WD,Li W,Zeng C,Li YH,Mo JM,Lü ZD,Jiang M

    更新日期:2020-06-12 00:00:00

  • Gene expression analysis of a murine model with pulmonary vascular remodeling compared to end-stage IPAH lungs.

    abstract:BACKGROUND:Idiopathic pulmonary arterial hypertension (IPAH) continues to be one of the most serious intractable diseases that might start with activation of several triggers representing the genetic susceptibility of a patient. To elucidate what essentially contributes to the onset and progression of IPAH, we investig...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Shimodaira K,Okubo Y,Ochiai E,Nakayama H,Katano H,Wakayama M,Shinozaki M,Ishiwatari T,Sasai D,Tochigi N,Nemoto T,Saji T,Kamei K,Shibuya K

    更新日期:2012-11-17 00:00:00

  • A comparison of four different models of acute respiratory distress syndrome in sheep.

    abstract:BACKGROUND:Acute respiratory distress syndrome (ARDS) can have various causes. The study objective was to investigate whether different pathophysiologic models of ARDS would show different respiratory, cardiovascular and inflammatory outcomes. METHODS:We performed a prospective, randomized study in 27 ventilated ewes ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Engel M,Nowacki RME,Jonker EM,Ophelders D,Nikiforou M,Kloosterboer N,Zimmermann LJI,van Waardenburg DA,Kramer BW

    更新日期:2020-08-08 00:00:00

  • Decline of COPD exacerbations in clinical trials over two decades - a systematic review and meta-regression.

    abstract:BACKGROUND:An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. A more systematic understanding would help to improve the design and interpretation of COPD trials. ...

    journal_title:Respiratory research

    pub_type: 杂志文章,meta分析


    authors: Andreas S,Röver C,Heinz J,Straube S,Watz H,Friede T

    更新日期:2019-08-16 00:00:00

  • Abstracts from the 2018 Respiratory Effectiveness Group Summit : Amsterdam, the Netherlands. 22-24 March 2018.

    abstract:: ...

    journal_title:Respiratory research




    更新日期:2018-12-20 00:00:00

  • A confocal microscopic study of solitary pulmonary neuroendocrine cells in human airway epithelium.

    abstract:BACKGROUND:Pulmonary neuroendocrine cells (PNEC) are specialized epithelial cells that are thought to play important roles in lung development and airway function. PNEC occur either singly or in clusters called neuroepithelial bodies. Our aim was to characterize the three dimensional morphology of PNEC, their distribut...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Weichselbaum M,Sparrow MP,Hamilton EJ,Thompson PJ,Knight DA

    更新日期:2005-10-10 00:00:00

  • Inhibition of TNFalpha in vivo prevents hyperoxia-mediated activation of caspase 3 in type II cells.

    abstract:BACKGROUND:The mechanisms during the initial phase of oxygen toxicity leading to pulmonary tissue damage are incompletely known. Increase of tumour necrosis factor alpha (TNFalpha) represents one of the first pulmonary responses to hyperoxia. We hypothesised that, in the initial phase of hyperoxia, TNFalpha activates t...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Guthmann F,Wissel H,Schachtrup C,Tölle A,Rüdiger M,Spener F,Rüstow B

    更新日期:2005-01-21 00:00:00

  • Macrophage CD74 contributes to MIF-induced pulmonary inflammation.

    abstract:BACKGROUND:MIF is a critical mediator of the host defense, and is involved in both acute and chronic responses in the lung. Neutralization of MIF reduces neutrophil accumulation into the lung in animal models. We hypothesized that MIF, in the alveolar space, promotes neutrophil accumulation via activation of the CD74 r...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Takahashi K,Koga K,Linge HM,Zhang Y,Lin X,Metz CN,Al-Abed Y,Ojamaa K,Miller EJ

    更新日期:2009-05-04 00:00:00

  • Arginine deficiency augments inflammatory mediator production by airway epithelial cells in vitro.

    abstract:BACKGROUND:Previously we showed that reduced availability of the essential amino acid tryptophan per se attenuates post-transcriptional control of interleukin (IL)-6 and IL-8 leading to hyperresponsive production of these inflammatory mediators by airway epithelial cells. Availability of the non-essential amino acid ar...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Fan XY,van den Berg A,Snoek M,van der Flier LG,Smids B,Jansen HM,Liu RY,Lutter R

    更新日期:2009-07-03 00:00:00

  • Analysis of comorbid factors that increase the COPD assessment test scores.

    abstract:BACKGROUND:The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) is a concise health status measure for COPD. COPD patients have a variety of comorbidities, but little is known about their impact on quality of life. This study was designed to investigate comorbid factors that may contribute to high CAT...

    journal_title:Respiratory research

    pub_type: 临床试验,杂志文章


    authors: Miyazaki M,Nakamura H,Chubachi S,Sasaki M,Haraguchi M,Yoshida S,Tsuduki K,Shirahata T,Takahashi S,Minematsu N,Koh H,Nakamura M,Sakamaki F,Terashima T,Sayama K,Jones PW,Asano K,Betsuyaku T,Keio COPD Comorbidity Researc

    更新日期:2014-02-06 00:00:00

  • The influence of chlorine in indoor swimming pools on the composition of breathing phase of professional swimmers.

    abstract:OBJECTIVES:Swimming is one of the most popular forms of physical activity. Pool water is cleaned with chlorine, which - in combination with compounds contained in water - could form chloramines and trichloromethane in the swimmer's lungs. The aim of the present study was to examine the effect of swimming training in an...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Swinarew AS,Stanula AJ,Gabor J,Raif P,Paluch J,Karpiński J,Kubik K,Okła H,Ostrowski A,Tkacz E,Skoczyński S,Waśkiewicz Z,Rosemann T,Nikolaidis PT,Knechtle B

    更新日期:2020-04-15 00:00:00

  • Macrorheology of cystic fibrosis, chronic obstructive pulmonary disease & normal sputum.

    abstract:BACKGROUND:Prior microrheologic assessments of selected, microlitre plugs of cystic fibrosis (CF) sputum suggest no intrinsic rheologic abnormality. However, such analyses may not be representative of CF sputum as a whole. We therefore reassessed this question using whole sputum macrorheology. Additionally, we wished t...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Serisier DJ,Carroll MP,Shute JK,Young SA

    更新日期:2009-07-06 00:00:00

  • Influence of weather and atmospheric pollution on physical activity in patients with COPD.

    abstract:RATIONALE:Information concerning how climate and atmospheric pollutants affects physical activity in COPD patients is lacking and might be valuable in determining when physical activity should be encouraged. METHODS:Seventy-three stable COPD patients recorded on daily diary cards worsening of respiratory symptoms, pea...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Alahmari AD,Mackay AJ,Patel AR,Kowlessar BS,Singh R,Brill SE,Allinson JP,Wedzicha JA,Donaldson GC

    更新日期:2015-06-13 00:00:00

  • Cigarette smoke exposure inhibits extracellular MMP-2 (gelatinase A) activity in human lung fibroblasts.

    abstract:BACKGROUND:Exposure to cigarette smoke is considered a major risk factor for the development of lung diseases, since its causative role has been assessed in the induction and maintenance of an inflamed state in the airways. Lung fibroblasts can contribute to these processes, due to their ability to produce proinflammat...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: La Rocca G,Anzalone R,Magno F,Farina F,Cappello F,Zummo G

    更新日期:2007-03-12 00:00:00

  • The clinical features of the overlap between COPD and asthma.

    abstract:BACKGROUND:The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma. METHODS:We performed a cross-sectional study comparing subjects with COPD and asthma to subjects ...

    journal_title:Respiratory research

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Hardin M,Silverman EK,Barr RG,Hansel NN,Schroeder JD,Make BJ,Crapo JD,Hersh CP,COPDGene Investigators.

    更新日期:2011-09-27 00:00:00

  • Electronic cigarettes: a survey of perceived patient use and attitudes among members of the British thoracic oncology group.

    abstract:BACKGROUND:Smoking cessation following lung cancer diagnosis has been found to improve several patient outcomes. Electronic cigarette (e-cigarette) use is now prevalent within Great Britain, however, use and practice among patients with lung cancer has not as yet been explored. The current study aims to explore e-cigar...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Sherratt FC,Newson L,Field JK

    更新日期:2016-05-17 00:00:00

  • Cigarette smoke alters the ability of human dendritic cells to promote anti-Streptococcus pneumoniae Th17 response.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation and impaired immune response to pathogens leading to bacteria-induced exacerbation of the disease. A defect in Th17 cytokines in response to Streptococcus pneumoniae, a bacteria associated with COPD exacerbations, has been r...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Le Rouzic O,Koné B,Kluza J,Marchetti P,Hennegrave F,Olivier C,Kervoaze G,Vilain E,Mordacq C,Just N,Perez T,Bautin N,Pichavant M,Gosset P

    更新日期:2016-07-26 00:00:00

  • Gender differences in pulmonary arterial hypertension patients with BMPR2 mutation: a meta-analysis.

    abstract:OBJECTIVE:To investigate the differences in the proportions of BMPR2 mutations in familial hereditary pulmonary arterial hypertension (HPAH) and idiopathic pulmonary arterial hypertension (IPAH) between males and females and the relationship between BMPR2 mutation and PAH severity. METHODS:A computer was used to searc...

    journal_title:Respiratory research

    pub_type: 杂志文章,meta分析


    authors: Ge X,Zhu T,Zhang X,Liu Y,Wang Y,Zhang W

    更新日期:2020-02-06 00:00:00

  • Profibrotic role of WNT10A via TGF-β signaling in idiopathic pulmonary fibrosis.

    abstract:BACKGROUND:WNT/β-catenin signaling plays an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF); however, the role of WNT10A via transforming growth factor (TGF)-β signaling remains unclear. METHODS:We evaluated the expression of WNT10A and TGF-β in bleomycin (BLM)-treated mice and the interactio...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Oda K,Yatera K,Izumi H,Ishimoto H,Yamada S,Nakao H,Hanaka T,Ogoshi T,Noguchi S,Mukae H

    更新日期:2016-04-12 00:00:00

  • Lung function imaging methods in Cystic Fibrosis pulmonary disease.

    abstract::Monitoring of pulmonary physiology is fundamental to the clinical management of patients with Cystic Fibrosis. The current standard clinical practise uses spirometry to assess lung function which delivers a clinically relevant functional readout of total lung function, however does not supply any visible or localised ...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Kołodziej M,de Veer MJ,Cholewa M,Egan GF,Thompson BR

    更新日期:2017-05-17 00:00:00

  • TLR4 signaling is essential for survival in acute lung injury induced by virulent Pseudomonas aeruginosa secreting type III secretory toxins.

    abstract:BACKGROUND:The relative contributions of the cytotoxic phenotype of P. aeruginosa expressing type III secretory toxins and an immunocompromised condition lacking normal Toll-like receptor 4 (TLR4) signaling in the pathogenesis of acute lung injury and sepsis were evaluated in a mouse model for Pseudomonas aeruginosa pn...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Faure K,Sawa T,Ajayi T,Fujimoto J,Moriyama K,Shime N,Wiener-Kronish JP

    更新日期:2004-02-12 00:00:00

  • Impaired survival of regulatory T cells in pulmonary sarcoidosis.

    abstract:BACKGROUND:Impaired regulatory T cell (Treg) function is thought to contribute to ongoing inflammatory responses in sarcoidosis, but underlying mechanisms remain unclear. Moreover, it is not known if increased apoptotic susceptibility of Tregs may contribute to an impaired immunosuppressive function in sarcoidosis. The...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Broos CE,van Nimwegen M,Kleinjan A,ten Berge B,Muskens F,in 't Veen JC,Annema JT,Lambrecht BN,Hoogsteden HC,Hendriks RW,Kool M,van den Blink B

    更新日期:2015-09-16 00:00:00

  • CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma.

    abstract:BACKGROUND:Patients with severe, uncontrolled asthma, particularly those with a non-eosinophilic phenotype, have a great unmet need for new treatments that act on a broad range of inflammatory pathways in the airway. Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin, an...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Emson C,Diver S,Chachi L,Megally A,Small C,Downie J,Parnes JR,Bowen K,Colice G,Brightling CE

    更新日期:2020-10-13 00:00:00

  • Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats.

    abstract:BACKGROUND:CXCR4 is the receptor for chemokine CXCL12 and reportedly plays an important role in systemic vascular repair and remodeling, but the role of CXCR4 in development of pulmonary hypertension and vascular remodeling has not been fully understood. METHODS:In this study we investigated the role of CXCR4 in the d...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Yu L,Hales CA

    更新日期:2011-02-04 00:00:00

  • IL-4 and IL-13 exposure during mucociliary differentiation of bronchial epithelial cells increases antimicrobial activity and expression of antimicrobial peptides.

    abstract::The airway epithelium forms a barrier against infection but also produces antimicrobial peptides (AMPs) and other inflammatory mediators to activate the immune system. It has been shown that in allergic disorders, Th2 cytokines may hamper the antimicrobial activity of the epithelium. However, the presence of Th2 cytok...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Zuyderduyn S,Ninaber DK,Schrumpf JA,van Sterkenburg MA,Verhoosel RM,Prins FA,van Wetering S,Rabe KF,Hiemstra PS

    更新日期:2011-05-02 00:00:00