Matrix metalloproteinases in lung biology.


:Despite much information on their catalytic properties and gene regulation, we actually know very little of what matrix metalloproteinases (MMPs) do in tissues. The catalytic activity of these enzymes has been implicated to function in normal lung biology by participating in branching morphogenesis, homeostasis, and repair, among other events. Overexpression of MMPs, however, has also been blamed for much of the tissue destruction associated with lung inflammation and disease. Beyond their role in the turnover and degradation of extracellular matrix proteins, MMPs also process, activate, and deactivate a variety of soluble factors, and seldom is it readily apparent by presence alone if a specific proteinase in an inflammatory setting is contributing to a reparative or disease process. An important goal of MMP research will be to identify the actual substrates upon which specific enzymes act. This information, in turn, will lead to a clearer understanding of how these extracellular proteinases function in lung development, repair, and disease.


Respir Res


Respiratory research


Parks WC,Shapiro SD





Has Abstract


2001-01-01 00:00:00












  • Monitoring mandibular movements to detect Cheyne-Stokes Breathing.

    abstract:BACKGROUND:The patterns of mandibular movements (MM) during sleep can be used to identify increased respiratory effort periodic large-amplitude MM (LPM), and cortical arousals associated with "sharp" large-amplitude MM (SPM). We hypothesized that Cheyne Stokes breathing (CSB) may be identified by periodic abnormal MM p...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Martinot JB,Borel JC,Le-Dong NN,Guénard HJ,Cuthbert V,Silkoff PE,Gozal D,Pepin JL

    更新日期:2017-04-20 00:00:00

  • Abnormal pulmonary function tests predict the development of radiation-induced pneumonitis in advanced non-small cell lung Cancer.

    abstract:BACKGROUND:Radiation pneumonitis (RP) is a frequent complication of concurrent chemoradiotherapy (CCRT) and is associated with severe symptoms that decrease quality of life and might result in pulmonary fibrosis or death. The aim of this study is to identify whether pulmonary function test (PFT) abnormalities may predi...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究


    authors: Torre-Bouscoulet L,Muñoz-Montaño WR,Martínez-Briseño D,Lozano-Ruiz FJ,Fernández-Plata R,Beck-Magaña JA,García-Sancho C,Guzmán-Barragán A,Vergara E,Blake-Cerda M,Gochicoa-Rangel L,Maldonado F,Arroyo-Hernández M,Arrieta O

    更新日期:2018-04-24 00:00:00

  • Psychometric properties and minimal important differences of SF-36 in Idiopathic Pulmonary Fibrosis.

    abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a rare disease with a median survival of 3-5 years after diagnosis with limited treatment options. The aim of this study is to assess the psychometric characteristics of the Short Form 36 Health Status Questionnaire (SF-36) in IPF and to provide disease specific minimal...

    journal_title:Respiratory research

    pub_type: 临床试验,杂志文章


    authors: Witt S,Krauss E,Barbero MAN,Müller V,Bonniaud P,Vancheri C,Wells AU,Vasakova M,Pesci A,Klepetko W,Seeger W,Crestani B,Leidl R,Holle R,Schwarzkopf L,Guenther A

    更新日期:2019-03-01 00:00:00

  • 24-h bronchodilation and inspiratory capacity improvements with glycopyrrolate/formoterol fumarate via co-suspension delivery technology in COPD.

    abstract:BACKGROUND:Symptoms of chronic obstructive pulmonary disease may vary throughout the day and it is important that therapeutic approaches provide 24-h symptom control. We report the results of two phase IIIb crossover studies, PT003011 and PT003012, investigating the 24-h lung function profile of GFF MDI (glycopyrrolate...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Reisner C,Gottschlich G,Fakih F,Koser A,Krainson J,Delacruz L,Arora S,Feldman G,Pudi K,Siddiqui S,Orevillo C,Maes A,St Rose E,Martin U

    更新日期:2017-08-18 00:00:00

  • Nebulization of the acidified sodium nitrite formulation attenuates acute hypoxic pulmonary vasoconstriction.

    abstract:BACKGROUND:Generalized hypoxic pulmonary vasoconstriction (HPV) occurring during exposure to hypoxia is a detrimental process resulting in an increase in lung vascular resistance. Nebulization of sodium nitrite has been shown to inhibit HPV. The aim of this project was to investigate and compare the effects of nebuliza...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Egemnazarov B,Schermuly RT,Dahal BK,Elliott GT,Hoglen NC,Surber MW,Weissmann N,Grimminger F,Seeger W,Ghofrani HA

    更新日期:2010-06-21 00:00:00

  • The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19.

    abstract::Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and mortality. This commentary discusses the limitations of the evidence around BCG and COVID-19. We argue that hig...

    journal_title:Respiratory research

    pub_type: 信件,评审


    authors: Pereira M,Paixão E,Trajman A,de Souza RA,da Natividade MS,Pescarini JM,Pereira SM,Barreto FR,Ximenes R,Dalcomo M,Ichihara MY,Nunes C,Barral-Netto M,Barreto ML

    更新日期:2020-07-11 00:00:00

  • Exacerbations of chronic obstructive pulmonary disease: when are antibiotics indicated? A systematic review.

    abstract:BACKGROUND:For decades, there is an unresolved debate about adequate prescription of antibiotics for patients suffering from exacerbations of chronic obstructive pulmonary disease (COPD). The aim of this systematic review was to analyse randomised controlled trials investigating the clinical benefit of antibiotics for ...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Puhan MA,Vollenweider D,Latshang T,Steurer J,Steurer-Stey C

    更新日期:2007-04-04 00:00:00

  • Impaired survival of regulatory T cells in pulmonary sarcoidosis.

    abstract:BACKGROUND:Impaired regulatory T cell (Treg) function is thought to contribute to ongoing inflammatory responses in sarcoidosis, but underlying mechanisms remain unclear. Moreover, it is not known if increased apoptotic susceptibility of Tregs may contribute to an impaired immunosuppressive function in sarcoidosis. The...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Broos CE,van Nimwegen M,Kleinjan A,ten Berge B,Muskens F,in 't Veen JC,Annema JT,Lambrecht BN,Hoogsteden HC,Hendriks RW,Kool M,van den Blink B

    更新日期:2015-09-16 00:00:00

  • Surfactant protein D attenuates sub-epithelial fibrosis in allergic airways disease through TGF-β.

    abstract:BACKGROUND:Surfactant protein D (SP-D) can regulate both innate and adaptive immunity. Recently, SP-D has been shown to contribute to the pathogenesis of airway allergic inflammation and bleomycin-induced pulmonary fibrosis. However, in allergic airways disease, the role of SP-D in airway remodeling remains unknown. Th...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Ogawa H,Ledford JG,Mukherjee S,Aono Y,Nishioka Y,Lee JJ,Izumi K,Hollingsworth JW

    更新日期:2014-11-29 00:00:00

  • Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells.

    abstract:BACKGROUND:The elastolytic enzyme matrix metalloproteinase (MMP)-12 has been implicated in the development of airway inflammation and remodeling. We investigated whether human airway smooth muscle cells could express and secrete MMP-12, thereby participating in the pathogenesis of airway inflammatory diseases. METHODS...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Xie S,Issa R,Sukkar MB,Oltmanns U,Bhavsar PK,Papi A,Caramori G,Adcock I,Chung KF

    更新日期:2005-12-16 00:00:00

  • Metformin attenuates lung fibrosis development via NOX4 suppression.

    abstract:BACKGROUND:Accumulation of profibrotic myofibroblasts in fibroblastic foci (FF) is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis (IPF) pathogenesis, and transforming growth factor (TGF)-β plays a key regulatory role in myofibroblast differentiation. Reactive oxygen species (ROS) has...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Sato N,Takasaka N,Yoshida M,Tsubouchi K,Minagawa S,Araya J,Saito N,Fujita Y,Kurita Y,Kobayashi K,Ito S,Hara H,Kadota T,Yanagisawa H,Hashimoto M,Utsumi H,Wakui H,Kojima J,Numata T,Kaneko Y,Odaka M,Morikawa T,Na

    更新日期:2016-08-30 00:00:00

  • Incidence of asthma and mortality in a cohort of young adults: a 7-year prospective study.

    abstract:BACKGROUND:Few longitudinal data exist on the incidence of asthma in young adults and on the overall mortality risk due to asthma. A 7-year follow-up prospective study was performed to assess the incidence of asthma and mortality from all causes in a cohort of young adults. METHODS:The life status of a cohort of 6031 ...

    journal_title:Respiratory research

    pub_type: 临床试验,杂志文章


    authors: de Marco R,Locatelli F,Cazzoletti L,Bugianio M,Carosso A,Marinoni A

    更新日期:2005-08-16 00:00:00

  • Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia.

    abstract:BACKGROUND:ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, resulting in a ventilation-perfusion mismatch and hypoxia. Since increase of vascular KATP channel Kir6.1 ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Turzo M,Vaith J,Lasitschka F,Weigand MA,Busch CJ

    更新日期:2018-02-13 00:00:00

  • Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis.

    abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis. The kinase inhibitor nintedanib specific for vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR) and fibroblast growth factor receptor (FGFR) significantly reduced the rate ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Hostettler KE,Zhong J,Papakonstantinou E,Karakiulakis G,Tamm M,Seidel P,Sun Q,Mandal J,Lardinois D,Lambers C,Roth M

    更新日期:2014-12-12 00:00:00

  • Shifting paradigms of nontuberculous mycobacteria in cystic fibrosis.

    abstract::Important paradigms of pulmonary disease with nontuberculous mycobacteria (NTM) are currently shifting based on an increasing attention within the field of cystic fibrosis (CF). These shifts are likely to benefit the management of all patients with pulmonary NTM, regardless of underlying pathology. Currently several k...

    journal_title:Respiratory research

    pub_type: 社论


    authors: Qvist T,Pressler T,Høiby N,Katzenstein TL

    更新日期:2014-04-11 00:00:00

  • Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation.

    abstract:BACKGROUND:Numerous studies have demonstrated associations between genetic markers and COPD, but results have been inconsistent. One reason may be heterogeneity in disease definition. Unsupervised learning approaches may assist in understanding disease heterogeneity. METHODS:We selected 31 phenotypic variables and 12 ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Cho MH,Washko GR,Hoffmann TJ,Criner GJ,Hoffman EA,Martinez FJ,Laird N,Reilly JJ,Silverman EK

    更新日期:2010-03-16 00:00:00

  • Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study.

    abstract:BACKGROUND:Asthma is a disease of varying severity and differing disease mechanisms. To date, studies aimed at stratifying asthma into clinically useful phenotypes have produced a number of phenotypes that have yet to be assessed for stability and to be validated in independent cohorts. The aim of this study was to def...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Loza MJ,Djukanovic R,Chung KF,Horowitz D,Ma K,Branigan P,Barnathan ES,Susulic VS,Silkoff PE,Sterk PJ,Baribaud F,ADEPT (Airways Disease Endotyping for Personalized Therapeutics) and U-BIOPRED (Unbiased Biomarkers for the Prediction

    更新日期:2016-12-15 00:00:00

  • Prenatal fine particulate exposure associated with reduced childhood lung function and nasal epithelia GSTP1 hypermethylation: Sex-specific effects.

    abstract:BACKGROUND:In utero exposure to particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) has been linked to child lung function. Overlapping evidence suggests that child sex and exposure timing may modify effects and associations may be mediated through glutathione S-transferase P1 (GSTP1) methylatio...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Lee AG,Le Grand B,Hsu HL,Chiu YM,Brennan KJ,Bose S,Rosa MJ,Brunst KJ,Kloog I,Wilson A,Schwartz J,Morgan W,Coull BA,Wright RO,Baccarelli AA,Wright RJ

    更新日期:2018-04-27 00:00:00

  • Blood and sputum eosinophils in COPD; relationship with bacterial load.

    abstract:BACKGROUND:Sputum and blood eosinophil counts predict corticosteroid effects in COPD patients. Bacterial infection causes increased airway neutrophilic inflammation. The relationship of eosinophil counts with airway bacterial load in COPD patients is uncertain. We tested the hypothesis that bacterial load and eosinophi...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Kolsum U,Donaldson GC,Singh R,Barker BL,Gupta V,George L,Webb AJ,Thurston S,Brookes AJ,McHugh TD,Wedzicha JA,Brightling CE,Singh D

    更新日期:2017-05-08 00:00:00

  • Cigarette smoke-induced accumulation of lung dendritic cells is interleukin-1α-dependent in mice.

    abstract:BACKGROUND:Evidence suggests that dendritic cells accumulate in the lungs of COPD patients and correlate with disease severity. We investigated the importance of IL-1R1 and its ligands IL-1α and β to dendritic cell accumulation and maturation in response to cigarette smoke exposure. METHODS:Mice were exposed to cigare...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Botelho FM,Nikota JK,Bauer CM,Morissette MC,Iwakura Y,Kolbeck R,Finch D,Humbles AA,Stämpfli MR

    更新日期:2012-09-19 00:00:00

  • Superoxide dismutase A antigens derived from molecular analysis of sarcoidosis granulomas elicit systemic Th-1 immune responses.

    abstract:BACKGROUND:Sarcoidosis is an idiopathic granulomatous disease with pathologic and immunologic features similar to tuberculosis. Routine histologic staining and culture fail to identify infectious agents. An alternative means for investigating a role of infectious agents in human pathogenesis involves molecular analysis...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Allen SS,Evans W,Carlisle J,Hajizadeh R,Nadaf M,Shepherd BE,Pride DT,Johnson JE,Drake WP

    更新日期:2008-04-25 00:00:00

  • Endotoxin receptor CD14 in PiZ alpha-1-antitrypsin deficiency individuals.

    abstract:BACKGROUND:CD14, a receptor for lipopolysaccharides (LPS), is found in both a membrane-bound form (mCD14) and a soluble form (sCD14). It is suggested that sCD14 is mainly released from blood monocytes by serine protease-mediated shedding. Because alpha1-antitrypsin (AAT), an inhibitor of serine proteases, has been show...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Sandström CS,Novoradovskaya N,Cilio CM,Piitulainen E,Sveger T,Janciauskiene S

    更新日期:2008-04-21 00:00:00

  • Fluticasone furoate: once-daily evening treatment versus twice-daily treatment in moderate asthma.

    abstract:BACKGROUND:Inhaled corticosteroids are the recommended first-line treatment for asthma but adherence to therapy is suboptimal. The objectives of this study were to compare the efficacy and safety of once-daily (OD) evening and twice-daily (BD) regimens of the novel inhaled corticosteroid fluticasone furoate (FF) in ast...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Woodcock A,Bleecker ER,Busse WW,Lötvall J,Snowise NG,Frith L,Jacques L,Haumann B,Bateman ED

    更新日期:2011-12-21 00:00:00

  • Cell-specific expression of lung disease risk-related genes in the human small airway epithelium.

    abstract:BACKGROUND:The human small airway epithelium (SAE) plays a central role in the early events in the pathogenesis of most inherited and acquired lung disorders. Little is known about the molecular phenotypes of the specific cell populations comprising the SAE in humans, and the contribution of SAE specific cell populatio...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Zuo WL,Rostami MR,Shenoy SA,LeBlanc MG,Salit J,Strulovici-Barel Y,O'Beirne SL,Kaner RJ,Leopold PL,Mezey JG,Schymeinsky J,Quast K,Visvanathan S,Fine JS,Thomas MJ,Crystal RG

    更新日期:2020-07-29 00:00:00

  • Prevalence and risk factors of moderate to severe obstructive sleep apnea syndrome in insomnia sufferers: a study on 1311 subjects.

    abstract:BACKGROUND:Several studies have investigated the prevalence and risk factors of insomnia in subjects with obstructive sleep apnea syndrome. However, few studies have investigated the prevalence and risk factors for obstructive sleep apnea syndrome in insomnia sufferers. Thus, the aim of this study was to examine the pr...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Hein M,Lanquart JP,Loas G,Hubain P,Linkowski P

    更新日期:2017-07-06 00:00:00

  • Recent advances in our understanding of human host responses to tuberculosis.

    abstract::Tuberculosis remains one of the world's greatest public health challenges: 2 billion persons have latent infection, 8 million people develop active tuberculosis annually, and 2-3 million die. Recently, significant advances in our understanding of the human immune response against tuberculosis have occurred. The presen...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Schluger NW

    更新日期:2001-01-01 00:00:00

  • Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis.

    abstract:BACKGROUND:Myofibroblasts play a major role in the synthesis of extracellular matrix (ECM) and the stimulation of these cells is thought to play an important role in the development of silicosis. The present study was undertaken to investigate the anti-fibrotic effects of dibutyryl-cAMP (db-cAMP) on rats induced by sil...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Liu Y,Xu H,Geng Y,Xu D,Zhang L,Yang Y,Wei Z,Zhang B,Li S,Gao X,Wang R,Zhang X,Brann D,Yang F

    更新日期:2017-02-21 00:00:00

  • Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort study.

    abstract:BACKGROUND:The effects of corticosteroid-based therapy in patients with idiopathic nonspecific interstitial pneumonia (iNSIP), and factors affecting treatment outcome, are not fully understood. We aimed to investigate the long-term treatment response and factors affecting the treatment outcome in iNSIP patients from a ...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究


    authors: Lee SH,Park MS,Kim SY,Kim DS,Kim YW,Chung MP,Uh ST,Park CS,Park SW,Jeong SH,Park YB,Lee HL,Shin JW,Lee EJ,Lee JH,Jegal Y,Lee HK,Kim YH,Song JW,Park JS

    更新日期:2017-12-06 00:00:00

  • The efficacy of mesenchymal stromal cell-derived therapies for acute respiratory distress syndrome-a meta-analysis of preclinical trials.

    abstract:BACKGROUND:The investigation of mesenchymal stromal cell (MSC)-conditioned medium or extracellular vesicles (exosomes or microvesicles) as a remedy for acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) has become a fast-growing field in recent years. Our purpose was to conduct a meta-analysis to inv...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Wang F,Fang B,Qiang X,Shao J,Zhou L

    更新日期:2020-11-20 00:00:00

  • MUC1 deficiency mediates corticosteroid resistance in chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Lung inflammation in COPD is poorly controlled by inhaled corticosteroids (ICS). Strategies to improve ICS efficacy or the search of biomarkers who may select those patients candidates to receive ICS in COPD are needed. Recent data indicate that MUC1 cytoplasmic tail (CT) membrane mucin can mediate corticost...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Milara J,Díaz-Platas L,Contreras S,Ribera P,Roger I,Ballester B,Montero P,Cogolludo Á,Morcillo E,Cortijo J

    更新日期:2018-11-20 00:00:00