Abstract：
:Despite much information on their catalytic properties and gene regulation, we actually know very little of what matrix metalloproteinases (MMPs) do in tissues. The catalytic activity of these enzymes has been implicated to function in normal lung biology by participating in branching morphogenesis, homeostasis, and repair, among other events. Overexpression of MMPs, however, has also been blamed for much of the tissue destruction associated with lung inflammation and disease. Beyond their role in the turnover and degradation of extracellular matrix proteins, MMPs also process, activate, and deactivate a variety of soluble factors, and seldom is it readily apparent by presence alone if a specific proteinase in an inflammatory setting is contributing to a reparative or disease process. An important goal of MMP research will be to identify the actual substrates upon which specific enzymes act. This information, in turn, will lead to a clearer understanding of how these extracellular proteinases function in lung development, repair, and disease.
journal_name
Respir Resjournal_title
Respiratory researchauthors
Parks WC,Shapiro SDdoi
10.1186/rr33keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
10-9issue
1eissn
1465-9921issn
1465-993Xjournal_volume
2pub_type
杂志文章,评审abstract：BACKGROUND:Numerous studies have demonstrated associations between genetic markers and COPD, but results have been inconsistent. One reason may be heterogeneity in disease definition. Unsupervised learning approaches may assist in understanding disease heterogeneity. METHODS:We selected 31 phenotypic variables and 12 ...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-11-30
更新日期：2010-03-16 00:00:00
abstract：:Pulmonary surfactant is a complex fluid that comprises phospholipids and four proteins (SP-A, SP-B, SP-C, and SP-D) with different biological functions. SP-B, SP-C, and SP-D are essential for the lungs' surface tension function and for the organization, stability and metabolism of lung parenchyma. SP-A and SP-D, which...
journal_title：Respiratory research
pub_type： 杂志文章,评审
doi：10.1186/s12931-016-0385-9
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:Emphysema is a crucial pathological characteristic of chronic obstructive pulmonary disease (COPD). Oxidative stress, apoptosis and epigenetic mechanisms contribute to the pathogenesis of emphysema. However, an attempt to accurately identify whether these mechanisms interact with each other and how they are ...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-020-01495-w
更新日期：2020-09-03 00:00:00
abstract：BACKGROUND:Fibrocytes are implicated in Idiopathic Pulmonary Fibrosis (IPF) pathogenesis and increased proportions in the circulation are associated with poor prognosis. Upon tissue injury, fibrocytes migrate to the affected organ. In IPF patients, circulating fibrocytes are increased especially during exacerbations, h...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-018-0798-8
更新日期：2018-05-10 00:00:00
abstract：BACKGROUND:Extended culture of monocytes and fibroblasts in three-dimensional collagen gels leads to degradation of the gels (see linked study in this issue, "Fibroblasts and monocytes contract and degrade three-dimensional collagen gels in extended co-culture"). The current study, therefore, was designed to evaluate p...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/rr73
更新日期：2001-01-01 00:00:00
abstract：RESEARCH QUESTION:There is no widely accepted grading system for IPF disease severity, although physiologic impairment based on pulmonary function testing is frequently employed. We sought to describe clinical and functional characteristics as well as outcomes of patients with severe physiologic impairment. PATIENTS A...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-020-01600-z
更新日期：2021-01-06 00:00:00
abstract：BACKGROUND:Functional deterioration in cystic fibrosis (CF) may be reflected by increasing bronchial obstruction and, as recently shown, by ventilation inhomogeneities. This study investigated which physiological factors (airway obstruction, ventilation inhomogeneities, pulmonary hyperinflation, development of trapped ...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-7-138
更新日期：2006-11-30 00:00:00
abstract：BACKGROUND:Adherence to tuberculosis (TB) treatment is troublesome, due to long therapy duration, quick therapeutic response which allows the patient to disregard about the rest of their treatment and the lack of motivation on behalf of the patient for improved. The objective of this study was to develop and validate a...
journal_title：Respiratory research
pub_type： 杂志文章,多中心研究
doi：10.1186/1465-9921-13-75
更新日期：2012-09-02 00:00:00
abstract：:The interaction between viruses and dendritic cells (DCs) is varied and complex. DCs are key elements in the development of a host response to pathogens such as viruses, but viruses have developed survival tactics to either evade or diminish the immune system that functions to kill and eliminate these micro-organisms....
journal_title：Respiratory research
pub_type： 杂志文章,评审
doi：10.1186/rr63
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:The effects of corticosteroid-based therapy in patients with idiopathic nonspecific interstitial pneumonia (iNSIP), and factors affecting treatment outcome, are not fully understood. We aimed to investigate the long-term treatment response and factors affecting the treatment outcome in iNSIP patients from a ...
journal_title：Respiratory research
pub_type： 杂志文章,多中心研究
doi：10.1186/s12931-017-0686-7
更新日期：2017-12-06 00:00:00
abstract：:The hygiene hypothesis states that childhood asthma develops as a result of decreased exposure to infectious agents during infancy and early childhood. This results in the persistence of the neonatal T helper lymphocyte 2 immunophenotype, thereby predisposing the child to atopic disease. While multiple studies support...
journal_title：Respiratory research
pub_type： 杂志文章,评审
doi：10.1186/rr81
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:To identify COPD associated gene susceptibility and lung function in a longitudinal cohort including COPD and subjects who were at risk for developing COPD, and to replicate this in two cross-sectional and longitudinal populations in Chinese Han population. METHODS:Three cohorts were recruited in this study...
journal_title：Respiratory research
pub_type： 杂志文章,多中心研究
doi：10.1186/s12931-015-0209-3
更新日期：2015-04-18 00:00:00
abstract：BACKGROUND:It is generally accepted that emphysematous lungs are characterized by an increase in the numbers of neutrophils, macrophages, and CD8+ T lymphocytes, the lasts having increased cytotoxic activity. Because systemic inflammation is also a component of emphysema, we hypothesize that peripheral CD8+ T lymphocyt...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-8-62
更新日期：2007-09-06 00:00:00
abstract：BACKGROUND:Bronchoalveolar lavage (BAL) has proven to be very useful to monitor the lung allograft after transplantation. In addition to allowing detection of infections, multiple BAL analytes have been proposed as potential biomarkers of lung allograft rejection or dysfunction. However, BAL collection is not well stan...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-018-0786-z
更新日期：2018-05-25 00:00:00
abstract：:Reports regarding gender-related differences in COPD expression have provided conflicting results. In the French Initiatives BPCO real-world cohort, which contained 688 patients (146 women) when data were extracted, women were matched with men (1:3 ratio: n = 107:275) on age (5-year intervals) and FEV1 (5% predicted i...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-15-20
更新日期：2014-02-17 00:00:00
abstract：:The role of autoimmunity targeting epithelial antigens in asthma has been suggested, in particular in non-atopic and severe asthma. Periplakin, a desmosomal component, is involved in epithelial cohesion and intracellular signaling. We detected anti-periplakin IgG antibodies in 47/260 (18 %) patients with asthma, with ...
journal_title：Respiratory research
pub_type： 信件
doi：10.1186/s12931-016-0441-5
更新日期：2016-10-07 00:00:00
abstract：:The lung responds to a variety of insults in a remarkably consistent fashion but with inconsistent outcomes that vary from complete resolution and return to normal to the destruction of normal architecture and progressive fibrosis. Increasing evidence indicates that diffuse lung disease results from an imbalance betwe...
journal_title：Respiratory research
pub_type： 杂志文章,评审
doi：10.1186/rr177
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:Previously we showed that reduced availability of the essential amino acid tryptophan per se attenuates post-transcriptional control of interleukin (IL)-6 and IL-8 leading to hyperresponsive production of these inflammatory mediators by airway epithelial cells. Availability of the non-essential amino acid ar...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-10-62
更新日期：2009-07-03 00:00:00
abstract：BACKGROUND:Generally, structural destruction of lung parenchyma, such as pulmonary emphysema, is considered to be related to the low diagnostic yields and high complication rates of lung biopsies of peripheral lung lesions. Currently, little is known about the clinical outcomes of using endobronchial ultrasound with a ...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-019-1149-0
更新日期：2019-08-06 00:00:00
abstract：BACKGROUND:Tracheal epithelial cells are anchored to a dynamic basement membrane that contains a variety of extracellular matrix proteins including collagens and laminins. During development, wound repair and disease of the airway epithelium, significant changes in extracellular matrix proteins may directly affect cell...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-7-105
更新日期：2006-08-02 00:00:00
abstract：OBJECTIVES:Swimming is one of the most popular forms of physical activity. Pool water is cleaned with chlorine, which - in combination with compounds contained in water - could form chloramines and trichloromethane in the swimmer's lungs. The aim of the present study was to examine the effect of swimming training in an...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-020-01350-y
更新日期：2020-04-15 00:00:00
abstract：BACKGROUND:Although a large body of literature is available that describes the effects of smoking, asthma and COPD on lung function, most studies are restricted to a small age range and to one factor. As a consequence, available results are incomplete and often difficult to compare, also due to the ways the effects are...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-14-60
更新日期：2013-05-30 00:00:00
abstract：BACKGROUND:In idiopathic pulmonary fibrosis loss of alveolar epithelium induces inflammation of the pulmonary tissue followed by accumulation of pathogenic myofibroblasts leading eventually to respiratory failures. In animal models inflammatory and resident cells have been demonstrated to contribute to pulmonary fibros...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-12-126
更新日期：2011-09-26 00:00:00
abstract：BACKGROUND:Patients with severe uncontrolled asthma may receive oral corticosteroid (OCS) treatment regularly. The present study investigated the health care resource utilization and cost in regularly OCS treated Swedish asthma patients. METHODS:Primary care medical records data were linked to data from Swedish nation...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-018-0855-3
更新日期：2018-09-03 00:00:00
abstract：BACKGROUND:There are limited series concerning Dieulafoy disease of the bronchus. We describe the clinical presentation of a series of 7 patients diagnosed with Dieulafoy disease of the bronchus and provide information about the pathological diagnosis approach. PATIENTS AND METHODS:A retrospective review of patients w...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-9-58
更新日期：2008-08-05 00:00:00
abstract：BACKGROUND:A multitude of epidemiological studies have shown that ambient fine particulate matter 2.5 (diameter < 2.5um; PM2.5) was associated with increased morbidity and mortality of chronic obstructive pulmonary disease (COPD). However, the underlying associated mechanisms have not yet been elucidated. We conducted ...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-019-1081-3
更新日期：2019-06-13 00:00:00
abstract：BACKGROUND:Obstructive sleep apnea syndrome (OSAS) is a common disorder with significant morbidity and mortality. We aimed to evaluate the predictive accuracy of the Berlin questionnaire in patients with suspected OSAS undergoing PSG in the sleep laboratory setting against those going through the Embletta™ portable dia...
journal_title：Respiratory research
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12931-019-1009-y
更新日期：2019-02-22 00:00:00
abstract：BACKGROUND:Impaired skeletal muscle regeneration could contribute to the progression of muscle atrophy in patients with chronic obstructive pulmonary disease (COPD). METHODS:Satellite cells and myogenesis-related proteins were compared between healthy subjects and patients with COPD, with or without muscle atrophy. Sa...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-15-35
更新日期：2014-03-25 00:00:00
abstract：BACKGROUND:Early life impairments leading to lower lung function by adulthood are considered as risk factors for chronic obstructive pulmonary disease (COPD). Recently, we compared the lung transcriptomic profile between two mouse strains with extreme total lung capacities to identify plausible pulmonary function deter...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-018-0795-y
更新日期：2018-06-06 00:00:00
abstract：BACKGROUND:MIF is a critical mediator of the host defense, and is involved in both acute and chronic responses in the lung. Neutralization of MIF reduces neutrophil accumulation into the lung in animal models. We hypothesized that MIF, in the alveolar space, promotes neutrophil accumulation via activation of the CD74 r...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-10-33
更新日期：2009-05-04 00:00:00
