Identifying roles of "Jun-Chen-Zuo-Shi" component herbs of QiShenYiQi formula in treating acute myocardial ischemia by network pharmacology.

Abstract:

BACKGROUND:The role of "Jun-Chen-Zuo-Shi" (also known as "sovereign-minister-assistant-courier") component herbs of Chinese medicine is not fully understood. This study aims to test the "Jun-Chen-Zuo-Shi" rule with the QiShenYiQi formula (QSYQ) on treating acute myocardial ischemia (AMI) by a network pharmacology approach. METHODS:An Acute Myocardial Ischemia (AMI) specific Organism Disturbed Network (AMI-ODN), was constructed by integrating data of disease-associated genes, protein-protein interaction and microarray experiments. A network-based index, Network Recovery Index for Organism Disturbed Network (NRI-ODN), was developed to measure the therapeutic efficacy of QSYQ and its ingredients, i.e., the ability to recover disturbed AMI network model back to normal state. RESULTS:The whole formula of QSYQ got a NRI-ODN score of 864.48, which outperformed all individual herbs. Additionally, the primary component herbs, Radix Astragalus membranaceus and Radix Salvia miltiorrrhiza showed NRI-DON score of 680.27 and 734.31 respectively, which meant a better performance to recover disturbed AMI network than the supplementary component herbs, Panax notoginseng and Dalbergia sissoo did (545.76 and 584.88, respectively). CONCLUSION:AMI-ODN model and NRI-ODN identified the possible roles of "Jun-Chen-Zuo-Shi" component herbs of QSYQ in treating AMI at molecular network and pathway level.

journal_name

Chin Med

journal_title

Chinese medicine

authors

Wu L,Wang Y,Li Z,Zhang B,Cheng Y,Fan X

doi

10.1186/1749-8546-9-24

subject

Has Abstract

pub_date

2014-09-16 00:00:00

pages

24

issn

1749-8546

pii

1749-8546-9-24

journal_volume

9

pub_type

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