Spying on organelle Ca²⁺ in living cells: the mitochondrial point of view.

Abstract:

:Over the past years, the use of genetically encoded Ca(2+) indicators (GECIs), derived from aequorin and green fluorescent protein, has profoundly transformed the study of Ca(2+) homeostasis in living cells leading to novel insights into functional aspects of Ca(2+) signalling. Particularly relevant for a deeper understanding of these key aspects of cell pathophysiology has been the possibility of imaging changes in Ca(2+) concentration not only in the cytoplasm, but also inside organelles. In this review, we will provide an overview of the ongoing developments in the use of GECIs, with particular focus on mitochondrially targeted probes. Indeed, due to recent advances in organelle Ca(2+) imaging with GECIs, mitochondria are now at the centre of renewed interest: they play key roles both in the physiology of the cell and in multiple pathological conditions relevant to human health.

journal_name

J Endocrinol Invest

authors

Pendin D,Greotti E,Filadi R,Pozzan T

doi

10.1007/s40618-014-0178-2

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

39-45

issue

1

eissn

0391-4097

issn

1720-8386

pii

10.1007/s40618-014-0178-2

journal_volume

38

pub_type

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