Hypoxia and oxidative stress in breast cancer. Hypoxia signalling pathways.

Abstract:

:Hypoxia-inducible factor-1 (HIF), which is centrally involved in physiological oxygen homeostasis, is also activated in the majority of tumours. Activation of HIF can occur through genetic mechanisms or as a result of hypoxia within the tumour microenvironment. In some cases HIF activation appears to be intimately linked to the proliferative stimulus itself. HIF affects patterns of gene expression and tumour growth, although precise effects vary between tumour types. Modulation of HIF activity, if correctly applied, may be therapeutically beneficial in tumour therapy.

journal_name

Breast Cancer Res

authors

Pugh CW,Gleadle J,Maxwell PH

doi

10.1186/bcr313

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

313-7

issue

5

eissn

1465-5411

issn

1465-542X

journal_volume

3

pub_type

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