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Isolated hyperthyrotropinemia in childhood obesity and its relation with metabolic parameters.

Abstract：

PURPOSE:The aim of the presented study was to evaluate the prevalence of isolated hyperthyrotropinemia (IH) in obese children and the relation between anthropometric and metabolic parameters. METHODS:Hospital records of the children, who presented to the Pediatric Endocrinology outpatient clinic of our institution with obesity, and age and gender-matched healthy children, who had undergone thyroid function test for any reason were retrospectively reviewed. RESULTS:The prevalence of IH was significantly higher in the obese group than in the controls (9.2 and 3.8 %, respectively). Body mass index-standard deviation score (BMI-SDS), thyroid-stimulating hormone (TSH), lipid parameters were significantly different in the obese group than in the control group. A positive correlation between TSH and BMI-SDS and negative correlation between TSH and free T4 (fT4) levels were found in obese subjects. Stepwise multiple linear regression analysis confirmed that BMI-SDS, fT4 and triglyceride levels were the strongest independent variables correlated with TSH level in obese subjects (r (2) = 0.046, p = 0.001). CONCLUSIONS:IH prevalence is higher in obese children as compared to healthy children and the increase in TSH level correlates negatively with serum fT4 and positively with BMI-SDS and triglyceride levels in obese children.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Unüvar T,Anık A,Catlı G,Esen I,Abacı A,Büyükgebiz A,Böber E

doi

10.1007/s40618-014-0100-y

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

799-804

issue

9

eissn

0391-4097

issn

1720-8386

journal_volume

37

pub_type

杂志文章

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