Abstract：
BACKGROUND:To compare the long-term efficacy of ranibizumab versus bevacizumab for myopic choroidal neovascularization (CNV). METHODS:This was a retrospective, multicenter, comparative, non-randomized study of 64 consecutive patients with myopic CNV treated with ranibizumab (22 patients) or bevacizumab (42 patients). Best-corrected visual acuity (BCVA) and central foveal thickness (CFT) on optical coherence tomography were evaluated before and after treatment. All the patients were followed for at least 12 months. RESULTS:BCVA (logarithm of the minimal angle of resolution) improved from 0.63 ± 0.30 to 0.43 ± 0.27, 0.41 ± 0.37, 0.40 ± 0.39, 0.39 ± 0.43, and 0.39 ± 0.42 at 1, 2, 3, 6, and 12 months after treatment in the ranibizumab group, and from 0.67 ± 0.28 to 0.52 ± 0.31, 0.49 ± 0.31, 0.47 ± 0.31, 0.42 ± 0.32, and 0.46 ± 0.43 in the bevacizumab group (all P < 0.05 compared with baseline BCVA in each group). CFT decreased by 20.21%, 19.58%, and 22.43% from the baseline 304 ± 76 μm at 3, 6, and 12 months after treatment in the former group, and by 15.20%, 15.67%, and 15.56% from the baseline 297 ± 62 μm in the latter group (all P < 0.05 compared with baseline CFT in each group). BCVA improvement and CFT reduction did not statistically differ when compared at the same periods from treatment between 2 groups. Neither ocular nor systemic safety problems appeared during follow up. CONCLUSIONS:This study showed a similar functional and anatomical improvement after treatment of ranibizumab and bevacizumab for myopic CNV over a 12-month follow-up period.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Cha DM,Kim TW,Heo JW,Woo SJ,Park KH,Yu HG,Chung Hdoi
10.1186/1471-2415-14-69subject
Has Abstractpub_date
2014-05-21 00:00:00pages
69issn
1471-2415pii
1471-2415-14-69journal_volume
14pub_type
临床试验,杂志文章,多中心研究abstract：BACKGROUND:The influence of serous retinal detachment (SRD) on retinal sensitivity in patients with branch retinal vein occlusion (BRVO) and macular edema remains unclear. This is despite the frequent co-existence of SRD and cystoid macular edema (CME) in BRVO patients on optical coherence tomography (OCT) and the fact...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-11-29
更新日期：2011-09-26 00:00:00
abstract：BACKGROUND:To report a case series in which a modified technique was used to remove retained submacular perfluorocarbon liquid (PFCL) secondary to vitreoretinal surgery for rhegmatogenous retinal detachment. CASE PRESENTATION:Four patients who had undergone pars plana vitrectomy for rhegmatogenous retinal detachment w...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-0798-y
更新日期：2018-06-04 00:00:00
abstract：BACKGROUND:The Heimann-Bielschowsky phenomenon (HBP) is an underrecognized condition characterized by slow, pendular, vertical oscillations of the eye accompanying monocular vision loss. Hypotropic dissociated vertical deviation (DVD) is another rare condition induced by asymmetric visual input. This report documents a...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01502-0
更新日期：2020-06-26 00:00:00
abstract：BACKGROUND:Glaucoma is one of the most leading causes of permanent visual impairments in Korea, and social expenses spent for the glaucoma are increasing. This study is to identify association between socioeconomic status and the visual impairments caused by primary glaucoma in Korea. METHODS:This study is based on a ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-017-0551-y
更新日期：2017-08-23 00:00:00
abstract：BACKGROUND:This objective of the review and analysis is to demonstrate that acyclovir (ACV) 3% ophthalmic ointment is superior to idoxuridine (IDU) in treating herpetic keratitis (HK) presenting as dendritic and geographic ulcer sub-types. METHODS: DATA SOURCES:Publications in human subjects were identified by search...
journal_title：BMC ophthalmology
pub_type： 杂志文章,meta分析,评审
doi：10.1186/s12886-015-0022-2
更新日期：2015-04-17 00:00:00
abstract：BACKGROUND:Patients' feedback is of great importance in health care policy decisions. The Consumer Quality Index Cataract Questionnaire (CQI Cataract) was used to measure patients' experiences with quality of care after a cataract operation. This study aims to evaluate the reliability and the dimensional structure of t...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-7-14
更新日期：2007-09-19 00:00:00
abstract：BACKGROUND:Iridoschisis is a rare condition that is characterized by the separation of the iris stroma into layers, with portions of the anterior layer floating freely in the aqueous humour. Here, we report three cases of iridoschisis that were complicated by either a cataract or glaucoma. Based on these cases, we spec...
journal_title：BMC ophthalmology
pub_type： 杂志文章,评审
doi：10.1186/s12886-017-0418-2
更新日期：2017-03-14 00:00:00
abstract：BACKGROUND:Physical cooling of the eye surface relieves ocular discomfort, but translating this event to drug treatment of dry eye discomfort not been studied. Here, we synthesized a water-soluble TRPM8 receptor agonist called cryosim-3 (C3, 1-diisopropylphosphorylnonane) which selectively activates TRPM8 (linked to co...
journal_title：BMC ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12886-017-0495-2
更新日期：2017-06-26 00:00:00
abstract：BACKGROUND:P66Shc is partially localised within the mitochondrial fraction. It is primarily related to the generation of mitochondrial reactive oxygen species and apoptosis. Based on previous studies, we hypothesize that in the retina, p66Shc may exist and affect the development of diabetic retinopathy. The purpose of ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-0724-3
更新日期：2018-02-27 00:00:00
abstract：BACKGROUND:The current study compared optical quality before and after implantation of a posterior chamber phakic intraocular lens with a central hole [V4c implantable collamer lens (ICL)] under bright and dark lighting conditions by means of the Optical Quality Analysis System™ (OQAS; Visiometrics, Terrassa, Spain). ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01340-0
更新日期：2020-03-04 00:00:00
abstract：BACKGROUND:Artificial iris anterior chamber implants were originally developed for therapeutic purposes but have been used recently for the cosmetic alteration of eye colour. There is a growing body of evidence surrounding their associated risks. We report a case presenting with complications secondary to bilateral New...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-015-0084-1
更新日期：2015-08-08 00:00:00
abstract：BACKGROUND:To analyze the positions of intraocular posterior Implantable Collamer Lens (ICL) and its possible relationship with vault. METHODS:This cross-sectional study included 72 patients with high myopia (134 eyes) who were followed up after phakic intraocular lens implantation. The postoperative time ranged from ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-0783-5
更新日期：2018-05-09 00:00:00
abstract：BACKGROUND:Monocular infantile blindness may be associated with bilateral horizontal nystagmus, a subtype of fusion maldevelopment nystagmus syndrome (FMNS). Patients often adopt a significant anomalous head posture (AHP) towards the fixing eye in order to dampen the nystagmus. This clinical entity has also been report...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-14-137
更新日期：2014-11-20 00:00:00
abstract：BACKGROUND:To evaluate the retinal function before and soon after an intravitreal injection of an anti-vascular endothelial growth factor (anti-VEGF) agents. METHODS:Seventy-nine eyes of 79 patients that were treated by an intravitreal injection of an anti-VEGF agent for age-related macular degeneration (AMD), diabeti...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-019-1129-7
更新日期：2019-06-17 00:00:00
abstract：BACKGROUND:To screen for visual impairment in Malaysian preschool children. METHODS:Visual screening was conducted in 400 preschool children aged 4 to 6 years. The screening involved two basic procedures; the distant visual acuity test using the Sheridan Gardiner chart and the depth perception test using the Langs ste...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-13-16
更新日期：2013-04-19 00:00:00
abstract：BACKGROUND:To present a case report of a patient with a mixed choroidal neovascular membrane (CNV) with an asymmetric response to ranibizumab diagnosed on optical coherence tomography angiography (OCTa). CASE PRESENTATION:A 61-year-old male was referred to our department in September 2017 due to decreased vision in hi...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-021-01810-z
更新日期：2021-01-15 00:00:00
abstract：BACKGROUND:To describe the characteristics of patients with syphilitic uveitis in northern China. METHODS:A case series of 21 patients (33 eyes) diagnosed with syphilitic uveitis from 2011 to 2016 at a tertiary center in northern China was retrospectively analyzed. RESULTS:Twenty-one patients (33 eyes) were diagnosed...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-017-0491-6
更新日期：2017-06-19 00:00:00
abstract：BACKGROUND:The use of capsular tension ring (CTR) implantation to treat cataract patients with weak zonules is still controversial. The aim of this study was to examine the effects of CTR implantation on capsular stability after phacoemulsification in patients with weak zonules, especially patients who have undergone p...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01772-8
更新日期：2021-01-07 00:00:00
abstract：BACKGROUND:To predict the effectiveness of topical glaucoma medications based on initial uniocular and binocular treatment. To test a traditional hypothesis that effectiveness following a uniocular trial is associated with the change in IOP in the initially treated eye minus the change in the initially untreated eye. T...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-7-17
更新日期：2007-10-05 00:00:00
abstract：BACKGROUND:There is a huge need for the availability of transplantable donor corneas worldwide to reduce the burden of corneal blindness due to corneal opacity. Voluntary eye donation depends on the awareness levels of various stakeholders in the community. This study aimed to assess the awareness level regarding eye d...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-14-25
更新日期：2014-03-06 00:00:00
abstract：BACKGROUND:An eye injury that causes no light perception (NLP) typically carries an unfavorable prognosis, and NLP because of trauma is a common indication for enucleation. With advances in vitreoretinal surgical techniques, however, the indication for enucleation is no longer determined by posttrauma NLP vision alone....
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-12-16
更新日期：2012-06-19 00:00:00
abstract：:Although the mechanism of dry eye disease is not clearly understood, it is certain that inflammation and the immune response play a major role in determining the health of the ocular surface in dry eye patients. Accurate ocular surface characterization during the early stages of dry eye disease is critical for success...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-015-0133-9
更新日期：2015-12-17 00:00:00
abstract：BACKGROUND:Since the normative value of the retinal macular thickness is undocumented in the Middle East, the aim of this work is to assess the normative values of the macular thickness in healthy eyes in a Middle Eastern population and its relationship with age, sex, and laterality. METHODS:One hundred sixteen indivi...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01391-3
更新日期：2020-04-07 00:00:00
abstract：BACKGROUND:To report patients with age-related macular degeneration and atypical central retinal pigment epithelium (RPE) defects not attributable to geographic atrophy (GA) or RPE-tears with overlying preserved photoreceptor layers. METHODS:Multimodal imaging case-series evaluating the course of atypical RPE- defects...
journal_title：BMC ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1186/s12886-017-0452-0
更新日期：2017-05-15 00:00:00
abstract：BACKGROUND:To evaluate the effectiveness of intravitreal bevacizumab (IVB) and intravitreal ranibizumab (IVR) in actual practice for treating patients with retinal diseases in Thailand. METHODS:A prospective, multi-centre, observational study was conducted among eight hospitals in their ophthalmology outpatient depart...
journal_title：BMC ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1186/s12886-019-1086-1
更新日期：2019-03-29 00:00:00
abstract：BACKGROUND:To study the value and safety of aqueous humor polymerase chain reaction (PCR) analysis for Herpes simplex, varicella zoster, cytomegalovirus, Epstein-Barr virus and Toxoplasma gondii in patients with uveitis. METHODS:Records of 45 consecutive patients with anterior and posterior uveitis who underwent AC pa...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-016-0369-z
更新日期：2016-10-28 00:00:00
abstract：BACKGROUND:To evaluate the efficacy and safety of intravitreal conbercept (KH902) as the primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy. METHODS:This study was a retrospective, consecutive, observational case series. We reviewed medical records of 16 eyes (16 patients) with...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-017-0481-8
更新日期：2017-06-12 00:00:00
abstract：BACKGROUND:Idiopathic orbital pseudotumour is rare in children. We report a case of bilateral paediatric idiopathic orbital pseudotumour and review the characteristics of this case. CASE PRESENTATION:A 14-year-old female patient presented at our Department of Pulmonary and Critical Care Medicine (PCCM) with complaints...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01718-0
更新日期：2020-11-16 00:00:00
abstract：BACKGROUND:To evaluate the differences between the predicted and achieved lenticule thickness (ΔLT) after small incision lenticule extraction (SMILE) surgery and investigate relationships between ΔLT and predicted lenticule thickness in SMILE. METHODS:A total of 184 eyes from 184 consecutive patients who underwent SMI...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01374-4
更新日期：2020-03-17 00:00:00
abstract：BACKGROUND:To report the successful treatment of ocular toxoplasmosis and present the use of multimodal imaging to describe the changes in ocular toxoplasmic lesions subsequent to treatment. CASE PRESENTATION:A 73-year-old female visited the clinic with decreased visual acuity in the left eye. Fundus examination showe...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-019-1209-8
更新日期：2019-09-05 00:00:00
