VEGFR3 inhibition chemosensitizes ovarian cancer stemlike cells through down-regulation of BRCA1 and BRCA2.

abstract：:During normal sympathetic nervous system (SNS) development, cells of the ganglionic lineage can malignantly transform and develop into the childhood tumor neuroblastoma. Hypoxia-inducible transcription factors (HIFs) mediate cellular responses during normal development and are central in the adaptation to oxygen short...

journal_title：Neoplasia (New York, N.Y.)

authors： Mohlin S,Hamidian A,Påhlman S

更新日期：2013-03-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is an intrinsically chemotherapy refractory malignancy. Development of effective therapeutic regimens would be facilitated by improved preclinical HCC models. Currently, most models consist of subcutaneous human tumor transplants in immunodeficient mice; however, these do not reproduce t...

journal_title：Neoplasia (New York, N.Y.)

authors： Tang TC,Man S,Lee CR,Xu P,Kerbel RS

更新日期：2010-03-01 00:00:00

abstract：:Neurofibromatosis type 2 (NF2) is an inherited predisposition cancer syndrome characterized by the development of multiple benign tumors in the nervous system including schwannomas, meningiomas, and ependymomas. Using a disease model comprising primary human schwannoma cells, we previously demonstrated that adherens j...

journal_title：Neoplasia (New York, N.Y.)

authors： Zhou L,Ercolano E,Ammoun S,Schmid MC,Barczyk MA,Hanemann CO

更新日期：2011-12-01 00:00:00

abstract：:Activation of the insulin-like growth factor-1 receptor (IGF-1R) by IGF-1 is associated with the risk and progression of many types of cancer, although despite this it remains unclear how activated IGF-1R contributes to cancer progression. In this study, gene expression changes elicited by IGF-1 were profiled in breas...

journal_title：Neoplasia (New York, N.Y.)

authors： Oh JS,Kucab JE,Bushel PR,Martin K,Bennett L,Collins J,DiAugustine RP,Barrett JC,Afshari CA,Dunn SE

更新日期：2002-05-01 00:00:00

abstract：:Pancreatic carcinoma has an extremely bad prognosis due to lack of early diagnostic markers and lack of effective therapeutic strategies. Recently, we have established an in vitro model recapitulating the first steps in the carcinogenesis of the pancreas. SV40 large T antigen-immortalized bovine pancreatic duct cells ...

journal_title：Neoplasia (New York, N.Y.)

authors： Jesnowski R,Zubakov D,Faissner R,Ringel J,Hoheisel JD,Lösel R,Schnölzer M,Löhr M

更新日期：2007-02-01 00:00:00

abstract：:Monocytes/macrophages are an influential component of the glioma microenvironment. However, understanding their diversity and plasticity constitute one of the most challenging areas of research due to the paucity of models to study these cells' inherent complexity. Herein, we analyzed the role of monocytes/macrophages...

journal_title：Neoplasia (New York, N.Y.)

authors： Gabrusiewicz K,Hossain MB,Cortes-Santiago N,Fan X,Kaminska B,Marini FC,Fueyo J,Gomez-Manzano C

更新日期：2015-04-01 00:00:00

abstract：:Global molecular profiling of cancers has shown broad utility in delineating pathways and processes underlying disease, in predicting prognosis and response to therapy, and in suggesting novel treatments. To gain further insights from such data, we have integrated and analyzed a comprehensive collection of "molecular ...

journal_title：Neoplasia (New York, N.Y.)

authors： Rhodes DR,Kalyana-Sundaram S,Tomlins SA,Mahavisno V,Kasper N,Varambally R,Barrette TR,Ghosh D,Varambally S,Chinnaiyan AM

更新日期：2007-05-01 00:00:00

abstract：:Pancreatic cancer patients have an abysmal prognosis because of late diagnosis and lack of therapeutic options. Pancreatic intraepithelial neoplasias (PanINs), the precursor lesions, are a potential target for chemoprevention. Targeting eicosanoid pathways is an obvious choice because 5-lipoxygenase (5-LOX) has been s...

journal_title：Neoplasia (New York, N.Y.)

authors： Hennig R,Kehl T,Noor S,Ding XZ,Rao SM,Bergmann F,Fürstenberger G,Büchler MW,Friess H,Krieg P,Adrian TE

更新日期：2007-11-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) invade the tumor stroma in many cancers, yet their role is incompletely understood. To visualize and better understand these critical cells in tumor progression, we screened a portfolio of rationally selected, injectable agents to image endogenous TAMs ubiquitously in three differen...

journal_title：Neoplasia (New York, N.Y.)

authors： Leimgruber A,Berger C,Cortez-Retamozo V,Etzrodt M,Newton AP,Waterman P,Figueiredo JL,Kohler RH,Elpek N,Mempel TR,Swirski FK,Nahrendorf M,Weissleder R,Pittet MJ

更新日期：2009-05-01 00:00:00

abstract：:Modulation of the antitumor immune response through the engagement of NKG2D receptors with their ligands (L) on targets represents a promising therapeutic approach against cancer. In this study, we tested the effect of valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, on the expression of NKG2D ligands in m...

journal_title：Neoplasia (New York, N.Y.)

authors： Wu X,Tao Y,Hou J,Meng X,Shi J

更新日期：2012-12-01 00:00:00

abstract：:Bone morphogenetic protein 7 (BMP-7) belongs to the superfamily of transforming growth factor β-like cytokines, which can act either as tumor suppressors or as tumor promoters depending on cell type and differentiation. Our investigations focused on analyzing the effects of BMP-7 during glioma cell proliferation in vi...

journal_title：Neoplasia (New York, N.Y.)

authors： Klose A,Waerzeggers Y,Monfared P,Vukicevic S,Kaijzel EL,Winkeler A,Wickenhauser C,Löwik CW,Jacobs AH

更新日期：2011-03-01 00:00:00

abstract：:Tel is an Ets transcription factor that is the target of chromosome translocations in lymphoid and myeloid leukemias and in solid tumors. It contains two functional domains, a pointed oligomerization domain and a DNA-binding domain. Retroviral transduction of a wild-type Tel cDNA into a clonal subline of NIH3T3 fibrob...

journal_title：Neoplasia (New York, N.Y.)

authors： Van Rompaey L,Dou W,Buijs A,Grosveld G

更新日期：1999-12-01 00:00:00

abstract：:Upper urinary tract transitional cell carcinoma (UUT-TCC) is quite an uncommon disease, and its prognosis differs among individuals irrespective of tumor stage. DNA repair gene polymorphisms are reported to result in the modulation of the repair capacity and might influence the prognosis of UUT-TCC. We examined the as...

journal_title：Neoplasia (New York, N.Y.)

authors： Sasaki M,Sakano S,Okayama N,Akao J,Hara T,Kawai Y,Ohmi C,Hinoda Y,Naito K

更新日期：2008-03-01 00:00:00

abstract：:The progression of ovarian cancer, from cell transformation through invasion of normal tissue, relies on communication between tumor cells and their adjacent stromal microenvironment. Through a natural selection process, an autocrine-paracrine communication loop establishes reciprocal reinforcement of growth and migra...

journal_title：Neoplasia (New York, N.Y.)

authors： Schauer IG,Sood AK,Mok S,Liu J

更新日期：2011-05-01 00:00:00

abstract：:We previously discovered that a fat-metabolizing enzyme, 15-lipoxygenase-1 (15-LO-1), is high in human prostate cancer (PCa) and correlates with disease progression. The biologic link between the aberrant 15-LO-1/linoleic acid (LA) metabolism and fat (which is a rich source of growth factors) in PCa is unknown. Theref...

journal_title：Neoplasia (New York, N.Y.)

authors： Kelavkar UP,Cohen C

更新日期：2004-01-01 00:00:00

abstract：:Recent studies have demonstrated that the chemokine receptor CXCR4 plays a crucial role in organ-specific metastasis formation. Although a variety of studies showed the expression of chemokine receptors, in particular, CXCR4, by gastrointestinal tumors, the precise mechanisms of chemokine receptor-mediated homing of c...

journal_title：Neoplasia (New York, N.Y.)

authors： Gassmann P,Haier J,Schlüter K,Domikowsky B,Wendel C,Wiesner U,Kubitza R,Engers R,Schneider SW,Homey B,Müller A

更新日期：2009-07-01 00:00:00

abstract：:Epidemiological studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) significantly reduce the risk and mortality from colorectal cancer, in part by inhibiting prostaglandin (PG) synthesis. Cyclooxygenase (COX), the rate-limiting enzyme in PG biosynthesis, exists in two isoforms, COX-1 and COX-2. Genetic...

journal_title：Neoplasia (New York, N.Y.)

authors： Tong BJ,Tan J,Tajeda L,Das SK,Chapman JA,DuBois RN,Dey SK

更新日期：2000-11-01 00:00:00

abstract：:Heparanase-1 (HPR1), an endoglycosidase that specifically degrades heparan sulfate (HS) proteoglycans, is overexpressed in a variety of malignancies. Our present study sought to determine whether oncogene BRAF and RAS mutations lead to increased HPR1 expression. Reverse transcription-polymerase chain reaction analysis...

journal_title：Neoplasia (New York, N.Y.)

authors： Rao G,Liu D,Xing M,Tauler J,Prinz RA,Xu X

更新日期：2010-11-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) has been targeted for inhibition using tyrosine kinase inhibitors and monoclonal antibodies, with improvement in outcome in subsets of patients with head and neck, lung, and colorectal carcinomas. We have previously found that EGFR stability plays a key role in cell survival...

journal_title：Neoplasia (New York, N.Y.)

authors： Ahsan A,Ramanand SG,Whitehead C,Hiniker SM,Rehemtulla A,Pratt WB,Jolly S,Gouveia C,Truong K,Van Waes C,Ray D,Lawrence TS,Nyati MK

更新日期：2012-08-01 00:00:00

abstract：:A step toward the molecular classification of prostate cancer was the discovery of recurrent erythroblast transformation-specific rearrangements, most commonly fusing the androgen-regulated TMPRSS2 promoter to ERG. The TMPRSS2-ERG fusion is observed in around 90% of tumors that overexpress the oncogene ERG. The goal o...

journal_title：Neoplasia (New York, N.Y.)

authors： Pflueger D,Rickman DS,Sboner A,Perner S,LaFargue CJ,Svensson MA,Moss BJ,Kitabayashi N,Pan Y,de la Taille A,Kuefer R,Tewari AK,Demichelis F,Chee MS,Gerstein MB,Rubin MA

更新日期：2009-08-01 00:00:00

abstract：:Numerous human tumor types, including ovarian cancer, display a significant expression of the CD44 family of cell surface proteoglycans. To develop tumor-targeted drugs, we have initially evaluated whether the CD44 ligand hyaluronic acid (HA) could serve as a backbone for paclitaxel (TXL) prodrugs. HA-TXL was prepared...

journal_title：Neoplasia (New York, N.Y.)

authors： Auzenne E,Ghosh SC,Khodadadian M,Rivera B,Farquhar D,Price RE,Ravoori M,Kundra V,Freedman RS,Klostergaard J

更新日期：2007-06-01 00:00:00

abstract：:Previously, we identified the transcription factor CUX1 as an important modulator of invasion and resistance to apoptosis. Expression profiles suggested that CUX1 regulates a complex transcriptional program mediating tumor progression. We aimed to identify functionally relevant targets of CUX1 by using RNA interferenc...

journal_title：Neoplasia (New York, N.Y.)

authors： Ripka S,Riedel J,Neesse A,Griesmann H,Buchholz M,Ellenrieder V,Moeller F,Barth P,Gress TM,Michl P

更新日期：2010-08-01 00:00:00

abstract：:A noninvasive method for molecular imaging of T-cell activity in vivo would be of considerable value. It would aid in understanding the role of specific genes and signal transduction pathways in the course of normal and pathologic immune responses, and could elucidate temporal dynamics and immune regulation at differe...

journal_title：Neoplasia (New York, N.Y.)

authors： Ponomarev V,Doubrovin M,Lyddane C,Beresten T,Balatoni J,Bornman W,Finn R,Akhurst T,Larson S,Blasberg R,Sadelain M,Tjuvajev JG

更新日期：2001-11-01 00:00:00

abstract：:Mutations of the NF2 gene on chromosome 22q are thought to initiate tumorigenesis in nearly 50% of meningiomas, and 22q deletion is the earliest and most frequent large-scale chromosomal abnormality observed in these tumors. In aggressive meningiomas, 22q deletions are generally accompanied by the presence of large-sc...

journal_title：Neoplasia (New York, N.Y.)

authors： Yang HW,Kim TM,Song SS,Shrinath N,Park R,Kalamarides M,Park PJ,Black PM,Carroll RS,Johnson MD

更新日期：2012-01-01 00:00:00

abstract：:Recent studies suggest that tumor-infiltrating immune cells can benefit the tumor by producing factors that promote angiogenesis and suppress immunity. Because the tumor microenvironment is characterized by high adenosine levels, we hypothesized that the low-affinity A(2B) adenosine receptor located on host immune cel...

journal_title：Neoplasia (New York, N.Y.)

authors： Ryzhov S,Novitskiy SV,Zaynagetdinov R,Goldstein AE,Carbone DP,Biaggioni I,Dikov MM,Feoktistov I

更新日期：2008-09-01 00:00:00

abstract：:Antagonists of growth hormone-releasing hormone(GH-RH)inhibit the growth of various cancers by mechanisms that involve the suppression of the insulin-like growth factor (IGF)-I and/or IGF-II. In view of the importance of the IGF system in glioma tumorigenesis, the effects of GH-RH antagonists MZ-5-156 and JV-1-36 were...

journal_title：Neoplasia (New York, N.Y.)

authors： Kiaris H,Schally AV,Varga JL

更新日期：2000-05-01 00:00:00

abstract：:The aim of this work was to use phosphorus magnetic resonance spectroscopy ((31)P MRS) to investigate the pharmacodynamic effects of LAQ824, a histone deacetylase (HDAC) inhibitor. Human HT29 colon carcinoma cells were examined by (31)P MRS after treatment with LAQ824 and another HDAC inhibitor, suberoylanilide hydrox...

journal_title：Neoplasia (New York, N.Y.)

authors： Chung YL,Troy H,Kristeleit R,Aherne W,Jackson LE,Atadja P,Griffiths JR,Judson IR,Workman P,Leach MO,Beloueche-Babari M

更新日期：2008-04-01 00:00:00

abstract：:Fbw7 is a tumor suppressor that regulates the degradation of oncogenic substrates such as c-Jun, c-Myc, Notch1 intracellular domain (ICD), and cyclin E by functioning as the substrate recognition protein in the Skp1-Cullin-F-box (SCF) ubiquitin ligase complex. Consequently, low expression or loss of FBXW7 in breast ca...

journal_title：Neoplasia (New York, N.Y.)

authors： Meyer AE,Furumo Q,Stelloh C,Minella AC,Rao S

更新日期：2020-11-01 00:00:00

abstract：:Pediatric rhabdomyosarcoma (RMS) is a morphologically and genetically heterogeneous malignancy commonly classified into three histologic subtypes, namely, alveolar, embryonal, and anaplastic. An issue that continues to challenge effective RMS patient prognosis is the dearth of molecular markers predictive of disease s...

journal_title：Neoplasia (New York, N.Y.)

authors： Jacob AG,O'Brien D,Singh RK,Comiskey DF Jr,Littleton RM,Mohammad F,Gladman JT,Widmann MC,Jeyaraj SC,Bolinger C,Anderson JR,Barkauskas DA,Boris-Lawrie K,Chandler DS

更新日期：2013-09-01 00:00:00

abstract：:SAG (Sensitive to Apoptosis Gene), also known as RBX2 or ROC2, is a RING component of CRL (Cullin-RING ligase), required for its activity. Our previous studies showed that Sag/Rbx2 co-operated with Kras or Pten loss to promote tumorigenesis in the lung and prostate, respectively, but antagonized Kras to inhibit skin t...

journal_title：Neoplasia (New York, N.Y.)

authors： Zhang Q,Wei D,Tan M,Li H,Morgan MA,Sun Y

更新日期：2020-04-24 00:00:00