Would screening for lung cancer benefit 75- to 84-year-old residents of the United States?

abstract：Objective:The effectiveness of various strategies for the post-treatment monitoring of cervical cancer is unclear. This pilot study was conducted to explore recurrence patterns in and diagnostic strategies for patients with uterine cervical cancer who were meticulously followed using a customized monitoring plan. Meth...

journal_title：Frontiers in oncology

authors： Chao X,Fan J,Song X,You Y,Wu H,Wu M,Li L

更新日期：2020-12-07 00:00:00

abstract：:Background: The number of retrieved lymph nodes (RLNs) affects the likelihood of detecting metastatic lymph nodes (MLNs) for gastric cancer (GC), but the retrieval of LNs is not satisfactory worldwide. There is no standard for LN examination. Methods: We retrospectively analyzed 2,163 patients diagnosed with GC who un...

journal_title：Frontiers in oncology

authors： Chen X,Chen Y,Hu Y,Lin T,Luo J,Li T,Li T,Huang H,Zhu Y,Li T,Chen H,Liu H,Li G,Yu J

更新日期：2020-02-12 00:00:00

abstract：:Lung cancer is a leading cause of cancer death all around the world. Long non-coding RNAs (lncRNAs) have been confirmed to be involved in carcinogenesis of malignancies. However, the molecular mechanism of most lncRNAs in various kinds of cancers remains unclear. LncRNA HOTAIR and HNRNPA1 are reported to play an oncog...

journal_title：Frontiers in oncology

authors： Li H,Cui Z,Lv X,Li J,Gao M,Yang Z,Bi Y,Zhang Z,Wang S,Li S,Zhou B,Yin Z

更新日期：2020-09-25 00:00:00

abstract：:Neuroblastoma is a common extracranial solid tumor of neural crest (NC) origin that accounts for up to 15% of all pediatric cancer deaths. The disease arises from a transient population of NC cells that undergo an epithelial-mesenchymal transition (EMT) and generate diverse cell-types and tissues. Patients with neurob...

journal_title：Frontiers in oncology

authors： Uemura S,Ishida T,Thwin KKM,Yamamoto N,Tamura A,Kishimoto K,Hasegawa D,Kosaka Y,Nino N,Lin KS,Takafuji S,Mori T,Iijima K,Nishimura N

更新日期：2019-06-04 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is a rare, aggressive cancer of the pleural surface associated with asbestos exposure. The median survival of MPM patients is a mere 8-14 months, and there are few biomarkers and no cure available. It is hoped that, eventually, the incidence of MPM will drop and remain low and cons...

journal_title：Frontiers in oncology

authors： Nicolini F,Bocchini M,Bronte G,Delmonte A,Guidoboni M,Crinò L,Mazza M

更新日期：2020-01-24 00:00:00

abstract：:The clinical benefit of a multidisciplinary clinic practice model has been well described in a variety of medical specialties and cancer types. It proves particularly valuable when an integrated team is needed to optimally manage patients with rare or complex neoplasms. However, the ideal implementation of an integrat...

journal_title：Frontiers in oncology

authors： Tyler KH,Haverkos BM,Hastings J,Hu E,Philips R,Gru AA,Welliver MX,Mishra A,Wong HK,Porcu P

更新日期：2015-06-17 00:00:00

abstract：:Mechanisms of dysfunctional T cell immunity in Hepatocellular Carcinoma (HCC) need to be well defined. B7 family molecules provide both co-stimulatory and co-inhibitory signals to T cells while tryptophan degrading enzymes like Indoleamine 2,3 dioxygenase (IDO) and Tryptophan 2,3 Dioxygenase (TDO) mediate tumor immune...

journal_title：Frontiers in oncology

authors： Chinnadurai R,Scandolara R,Alese OB,Arafat D,Ravindranathan D,Farris AB,El-Rayes BF,Gibson G

更新日期：2020-09-03 00:00:00

abstract：:Signaling via the intrinsic (mitochondrial) pathway of apoptosis represents one of the critical signal transduction cascades that control the regulation of cell death. This pathway is typically altered in human cancers, thereby providing a suitable target for therapeutic intervention. Members of the Bcl-2 family of pr...

journal_title：Frontiers in oncology

authors： Fulda S

更新日期：2012-10-08 00:00:00

abstract：:Meningiomas are relatively common, and typically benign intracranial tumors, which in many cases can be cured by surgical resection. However, less prevalent, high grade meningiomas, grow quickly, and recur frequently despite treatment, leading to poor patient outcomes. Across tumor grades, subjective guidelines for hi...

journal_title：Frontiers in oncology

authors： Al-Rashed M,Foshay K,Abedalthagafi M

更新日期：2020-01-08 00:00:00

abstract：Purpose:Gynecological melanomas (GMs) are rare tumors with a poor prognosis. Here, we performed exome sequencing to generate the mutational landscape of GMs. Methods:Next-generation sequencing was carried out on mucosal melanoma samples (n = 35) obtained from gynecological sites. The alternative telomere lengthening (...

journal_title：Frontiers in oncology

authors： Yuan G,Song J,Li N,Song Q,Li Y,Du Y,Wang X,Jiao Y,Wu L

更新日期：2020-09-02 00:00:00

abstract：:Introduction: Deep Learning (DL) is a machine learning technique that uses deep neural networks to create a model. The application areas of deep learning in radiation oncology include image segmentation and detection, image phenotyping, and radiomic signature discovery, clinical outcome prediction, image dose quantifi...

journal_title：Frontiers in oncology

authors： Boldrini L,Bibault JE,Masciocchi C,Shen Y,Bittner MI

更新日期：2019-10-01 00:00:00

abstract：Background:Recent research has shown that immune-related lncRNA plays a crucial part in the tumor immune microenvironment. This study tried to identify immune-related lncRNAs and construct a robust prediction model to increase the predicted value of lung adenocarcinoma (LUAD). Methods:RNA expression data of LUAD were ...

journal_title：Frontiers in oncology

authors： Li JP,Li R,Liu X,Huo C,Liu TT,Yao J,Qu YQ

更新日期：2020-10-14 00:00:00

abstract：:Celastrol is a natural triterpene isolated from the Chinese plant Thunder God Vine with potent antitumor activity. However, the effect of celastrol on the growth of ovarian cancer cells in vitro and in vivo is still unclear. In this study, we found that celastrol induced cell growth inhibition, cell cycle arrest in G2...

journal_title：Frontiers in oncology

authors： Xu LN,Zhao N,Chen JY,Ye PP,Nan XW,Zhou HH,Jiang QW,Yang Y,Huang JR,Yuan ML,Xing ZH,Wei MN,Li Y,Shi Z,Yan XJ

更新日期：2019-01-28 00:00:00

abstract：:Extranodal natural killer/T-cell lymphoma, nasal type (ENKL), is a rare malignancy of Non-Hodgkin lymphoma characterized by an aggressive clinical course and poor prognosis. It shows strong association with Epstein-Barr virus infection and occurs more commonly in Asia and Latin America. Various genetic alterations hav...

journal_title：Frontiers in oncology

authors： Cai Q,Cai J,Fang Y,Young KH

更新日期：2019-05-14 00:00:00

abstract：:Primary Central Nervous System Lymphoma (PCNSL) and Metastatic (or Secondary) Central Nervous System Lymphoma (MCNSL) are rare central nervous system (CNS) malignancies that exhibit aggressive clinical behavior and have a poor prognosis. The majority of CNS lymphomas are histologically classified as diffuse large-B ce...

journal_title：Frontiers in oncology

authors： Zorofchian S,Lu G,Zhu JJ,Duose DY,Windham J,Esquenazi Y,Ballester LY

更新日期：2018-09-20 00:00:00

abstract：:We present the first validated metabolic network model for analysis of flux through key pathways of tumor intermediary metabolism, including glycolysis, the oxidative and non-oxidative arms of the pentose pyrophosphate shunt, the TCA cycle as well as its anaplerotic pathways, pyruvate-malate shuttling, glutaminolysis,...

journal_title：Frontiers in oncology

authors： Shestov AA,Lee SC,Nath K,Guo L,Nelson DS,Roman JC,Leeper DB,Wasik MA,Blair IA,Glickson JD

更新日期：2016-06-15 00:00:00

abstract：:Recent advances in maximum safe glioma resection have included the introduction of a host of visualization techniques to complement intraoperative white-light imaging of tumors. However, barriers to the effective use of these techniques within the central nervous system remain. In the healthy brain, the blood-brain ba...

journal_title：Frontiers in oncology

authors： Belykh E,Shaffer KV,Lin C,Byvaltsev VA,Preul MC,Chen L

更新日期：2020-06-05 00:00:00

abstract：:Patient-derived xenograft (PDX) models have recently emerged as a highly desirable platform in oncology and are expected to substantially broaden the way in vivo studies are designed and executed and to reshape drug discovery programs. However, acquisition of patient-derived samples, and propagation, annotation and di...

journal_title：Frontiers in oncology

authors： Mattar M,McCarthy CR,Kulick AR,Qeriqi B,Guzman S,de Stanchina E

更新日期：2018-02-19 00:00:00

abstract：:Image guidance allows delivery of very high doses of radiation over a few fractions, known as stereotactic ablative radiotherapy (SABR). This treatment is associated with excellent outcome for early stage non-small cell lung cancer and metastases to the lungs. In the delivery of SABR, central location constantly poses...

journal_title：Frontiers in oncology

authors： Chi A,Nguyen NP,Komaki R

更新日期：2014-06-25 00:00:00

abstract：:Pediatric allogeneic hematopoietic cell transplant (HCT) survival is limited by the development of post-transplant infections. In this overview, we discuss a clinical approach to the prompt recognition and treatment of fever and hypotension in pediatric HCT patients. Special attention is paid to individualized hemodyn...

journal_title：Frontiers in oncology

authors： Zinter MS,Dvorak CC,Auletta JJ

更新日期：2020-09-16 00:00:00

abstract：:Extramammary Paget's disease (EMPD) is a rare, slow-growing, cutaneous adenocarcinoma that usually originates in the anogenital area and axillae outside the mammary glands. EMPD mostly progresses slowly and is often diagnosed as carcinoma in situ; however, upon becoming invasive, it promptly and frequently metastasize...

journal_title：Frontiers in oncology

authors： Fukuda K,Funakoshi T

更新日期：2018-02-16 00:00:00

abstract：:Immunotherapy has revolutionized the standard of care for a range of malignancies. Accumulating evidence suggests that the success of immunotherapy is likely attributable to neoantigen-specific T cells. Thus, adoptive cell therapy with these neoantigen-specific T cells is highly promising. This strategy has proven to ...

journal_title：Frontiers in oncology

authors： Li Q,Ding ZY

更新日期：2020-08-11 00:00:00

abstract：Objective:To assess the performance of pretreatment 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) radiomics features for predicting EGFR mutation status in patients with non-small cell lung cancer (NSCLC). Patients and Methods:We enrolled total 173 patients with histologicall...

journal_title：Frontiers in oncology

authors： Zhang M,Bao Y,Rui W,Shangguan C,Liu J,Xu J,Lin X,Zhang M,Huang X,Zhou Y,Qu Q,Meng H,Qian D,Li B

更新日期：2020-10-08 00:00:00

abstract：:Mycobacterium bovis bacille Calmette-Guérin (BCG) is listed as an intralesional (IL) therapeutic option for inoperable stage III in-transit melanoma in the National Comprehensive Cancer Network Guidelines. Although the mechanism is unknown, others have reported up to 50% regression of injected lesions, and 17% regress...

journal_title：Frontiers in oncology

authors： Yang J,Jones MS,Ramos RI,Chan AA,Lee AF,Foshag LJ,Sieling PA,Faries MB,Lee DJ

更新日期：2017-04-05 00:00:00

abstract：Objectives:The aim of this study was to identify tumor-derived DNA from Papanicolaou (Pap) smear and plasma specimens collected from patients with endometrial cancer or atypical hyperplasia (EC/AH) or epithelial ovarian cancer (OC). Methods:Tumor tissues, peripheral blood, and Pap smear samples were collected from pat...

journal_title：Frontiers in oncology

authors： Jiang X,Li W,Yang J,Wang S,Cao D,Yu M,Shen K,Bai J,Gao Y

更新日期：2020-12-14 00:00:00

abstract：:Tumor angiogenesis is a process which is traditionally regarded as the tumor's response to low nutrient supply occurring under hypoxic conditions. However, hypoxia is not a pre-requisite for angiogenesis. The fact that even single tumor cells or small tumor cell aggregates are capable of attracting blood vessels revea...

journal_title：Frontiers in oncology

authors： Meierjohann S

更新日期：2015-05-05 00:00:00

abstract：:Purpose: To explore the application value of multiparametric computed tomography (CT) radiomics in non-invasive differentiation between aldosterone-producing and cortisol-producing functional adrenocortical adenomas. Methods: This retrospective review analyzed 83 patients including 41 patients with aldosterone-produci...

journal_title：Frontiers in oncology

authors： Zheng Y,Liu X,Zhong Y,Lv F,Yang H

更新日期：2020-09-29 00:00:00

abstract：:Breast cancer (BC) remains the most frequently diagnosed cancer worldwide. Among breast cancer patients, distant metastasis and invasion is the leading cause of BC related death. Recently, long non-coding RNAs (lncRNAs), which used to be considered a genetic byproduct (owing to their unknown biological function), have...

journal_title：Frontiers in oncology

authors： Wu Y,Shao A,Wang L,Hu K,Yu C,Pan C,Zhang S

更新日期：2019-05-31 00:00:00

abstract：:Currently, immunotherapy has shown great efficacy in clinical trials, and monoclonal antibodies directed against immune checkpoint PD-1/PD-L1 have shown encouraging results in first-line or second-line treatment of non-small cell lung cancer patients. Meanwhile, anti-PD-1/PD-L1 immune checkpoint drugs combined with ot...

journal_title：Frontiers in oncology

authors： Su C,Wang H,Liu Y,Guo Q,Zhang L,Li J,Zhou W,Yan Y,Zhou X,Zhang J

更新日期：2020-09-17 00:00:00

abstract：:Altered networks of gene regulation underlie many pathologies, including cancer. There are several proteins in cancer cells that are turned either on or off, which dramatically alters the metabolism and the overall activity of the cell, with the complex machinery of enzymes involved in the metabolism of glycolipids no...

journal_title：Frontiers in oncology

authors： Daniotti JL,Vilcaes AA,Torres Demichelis V,Ruggiero FM,Rodriguez-Walker M

更新日期：2013-12-19 00:00:00