Abstract：
:Folic acid is the key one-carbon donor required for de novo nucleotide and methionine synthesis. Its deficiency is associated with megaloblastic anemia, cancer and various complications of pregnancy. However, its supplementation results in reduction of neural tube defects and prevention of several types of cancer. The intake of folic acid from fortified food together with the use of nutritional supplements creates a state of folate oversupplementation. Fortification of foods is occurring worldwide with little knowledge of the potential safety and physiologic consequences of intake of such high doses of folic acid. So, we planned to examine the effects of acute and chronic folate oversupplementation on the physiology of renal folate transport in rats. Male Wistar rats were procured and divided into two groups. Rats in group I were given semisynthetic diets containing 2 mg folic acid/kg diet (control) and those in group II were given folate-oversupplemented rat diet, i.e., 20 mg folic acid/kg diet (oversupplemented). Six animals from group I and group II received the treatment for 10 days (acute treatment) and remaining six for 60 days (chronic treatment). In acute folate-oversupplemented rats, 5-[(14)C]-methyltetrahydrofolate uptake was found to be significantly reduced, as compared to chronic folate-oversupplemented and control rats. This reduction in uptake was associated with a significant decrease in the mRNA and protein levels of the folate transporters. Results of the present investigation showed that acute oversupplementation led to a specific and significant down-regulation of renal folate uptake process mediated via transcriptional and translational regulatory mechanism(s).
journal_name
Genes Nutrjournal_title
Genes & nutritionauthors
Thakur S,Thakur SD,Wani NA,Kaur Jdoi
10.1007/s12263-013-0369-zsubject
Has Abstractpub_date
2014-01-01 00:00:00pages
369issue
1eissn
1555-8932issn
1865-3499journal_volume
9pub_type
杂志文章abstract：BACKGROUND:Methionine, a central molecule in one-carbon metabolism, is an essential amino acid required for normal growth and development. Despite its importance to biological systems, methionine is toxic when administered at supra-physiological levels. The aim of this study was to investigate the effects of short-term...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-017-0576-0
更新日期：2017-09-06 00:00:00
abstract：:Biomarkers of food intake (BFIs) are a promising tool for limiting misclassification in nutrition research where more subjective dietary assessment instruments are used. They may also be used to assess compliance to dietary guidelines or to a dietary intervention. Biomarkers therefore hold promise for direct and objec...
journal_title：Genes & nutrition
pub_type： 杂志文章,评审
doi：10.1186/s12263-018-0603-9
更新日期：2018-05-30 00:00:00
abstract：:While the effects of chronic ethanol consumption on liver have been well studied and documented, its effect on the cardiovascular system is bimodal. Thus, moderate drinking in many population studies is related to lower prevalence of coronary artery disease (CAD). In contrast, heavy drinking correlates with higher pre...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-009-0161-2
更新日期：2010-06-01 00:00:00
abstract：:A large number of genome-wide association studies, transferability studies, and candidate gene studies performed in diverse populations around the world have identified gene variants that are associated with common human obesity. The mounting evidence suggests that these obesity gene variants interact with multiple en...
journal_title：Genes & nutrition
pub_type： 杂志文章,评审
doi：10.1186/s12263-017-0581-3
更新日期：2017-10-30 00:00:00
abstract：Background:Diminished brain levels of two neurohormones, 5-hydroxytryptamine (5-HT; serotonin) and 1,25-dihydroxyvitamin D3 (1,25D; active vitamin D metabolite), are proposed to play a role in the atypical social behaviors associated with psychological conditions including autism spectrum disorders and depression. We r...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-018-0605-7
更新日期：2018-07-11 00:00:00
abstract：Background:Evidence suggests that prenatal exposure to n-3 long-chain polyunsaturated fatty acids (LCPUFA) reduces the incidence of allergic disease in children. LCPUFAs are produced from dietary precursors catalyzed by desaturases and elongases encoded by the FADS1/2 and ELOVL5 genes. DNA methylation regulates gene ac...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-019-0644-8
更新日期：2019-06-18 00:00:00
abstract：:The nuclear factor (NF)-kappaB is a primary regulator of inflammatory responses and may be linked to pathology associated with obesity. We investigated the progression of NF-kappaB activity during a 12-week feeding period on a high-fat diet (HFD) or a low-fat diet (LFD) using NF-kappaB luciferase reporter mice. In viv...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-009-0133-6
更新日期：2009-09-01 00:00:00
abstract：:A methyl-deficient diet (MD) lacking folic acid and the associated methyl donors choline and methionine, fed to the laboratory rat during the periods of oocyte and embryo development, has been shown to programme glucose metabolism in the offspring. The hepatic proteome of the male offspring of female rats fed MD diets...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-012-0314-6
更新日期：2013-03-01 00:00:00
abstract：:Observational studies with healthy persons demonstrated an inverse association of vitamin E with the risk of coronary heart disease or cancer, the outcome of large-scale clinical trials conducted to prove a benefit of vitamin E in the recurrence and/or progression of such disease, however, was disappointing. Vitamin E...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-007-0055-0
更新日期：2007-12-01 00:00:00
abstract：Background:The neurodegenerative disorder Alzheimer's disease is caused by the accumulation of toxic aggregates of β-amyloid in the human brain. On the one hand, hyperhomocysteinemia has been shown to be a risk factor for cognitive decline in Alzheimer's disease. On the other hand, betaine has been demonstrated to atte...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-018-0611-9
更新日期：2018-07-27 00:00:00
abstract：:The traditional Mediterranean diet (MedDiet) has shown beneficial effects on cognitive decline. Nevertheless, diet-gene interactions have been poorly evaluated. We aimed to investigate diet-gene interaction in the PREDIMED-NAVARRA randomized trial. A total of 522 participants (67 ± 6 years at baseline) enrolled in the...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-014-0393-7
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:Mitochondria are of major importance in oocyte and early embryo, playing a key role in maintaining energy homeostasis. Epidemiological findings indicate that maternal undernutrition-induced mitochondrial dysfunction during pregnancy is associated with the development of metabolic disorders in offspring. Here...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-016-0535-1
更新日期：2016-06-23 00:00:00
abstract：:A long-term high-fat diet may result in a fatty liver. However, whether or not high-fat diets affect the hepatic circadian clock is controversial. The objective of this study is to investigate the effects of timed high-fat diet on the hepatic circadian clock and clock-controlled peroxisome proliferator-activated recep...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-013-0333-y
更新日期：2013-09-01 00:00:00
abstract：:The apolipoprotein E (APOE) genotype is an important risk factor for ageing and age-related diseases. The APOE4 genotype (in contrast to APOE3) has been shown to be associated with oxidative stress and chronic inflammation. Metallothioneins (MT) exhibit antioxidant and anti-inflammatory activity, and MT overexpression...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-012-0282-x
更新日期：2012-04-01 00:00:00
abstract：:Multiple factors have been implicated in the age-related declines in brain function. Thus, it is unlikely that modulating only a single factor will be effective at slowing this decline. A better approach is to identify small molecules that have multiple biological activities relevant to the maintenance of brain functi...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-009-0142-5
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Obesity is characterized by low-grade chronic inflammation and an excess of adipose tissue. The ASC gene encodes a protein that is part of the NLRP3 inflammasome, a cytosolic multiprotein complex that is associated with inflammation and metabolic alterations. To our knowledge, there is no evidence regarding ...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-020-00674-0
更新日期：2020-08-27 00:00:00
abstract：:The long latency and high incidence of prostate carcinogenesis provides the opportunity to intervene with chemoprevention in order to prevent or eradicate prostate malignancies. We present here an overview of the chemopreventive potential of curcumin (diferuloylmethane), a well-known natural compound that exhibits the...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-009-0152-3
更新日期：2010-03-01 00:00:00
abstract：:Transmembrane protease, serine 6 (TMPRSS6), is likely to be involved in iron metabolism through its pleiotropic effect on hepcidin concentrations. Recently, genome-wide association studies have identified common variants in the TMPRSS6 gene to be linked to anaemia and low iron status. To get a more precise evaluation ...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-014-0442-2
更新日期：2015-01-01 00:00:00
abstract：:Two cases of zinc deficiency in breastfed neonates were investigated where zinc levels in the mothers' milk were reduced by more than 75 % compared to normal. The objective of this study was to find the molecular basis of the maternal zinc deficiency condition. Significant reductions in mRNA expression and protein lev...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-015-0487-x
更新日期：2015-09-01 00:00:00
abstract：:Low plasma levels of high-density lipoprotein cholesterol (HDL-C) are identified as a risk factor for cardiovascular disease (CVD). Sexual dimorphism, however, is widely reported in both HDL-C and CVD, with the underlying explanations of these sexual differences not fully understood. HDL-C is a complex trait influence...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-008-0075-4
更新日期：2008-07-01 00:00:00
abstract：:Genetic variation in bitter taste receptors, such as hTAS2R38, may affect food preferences and intake. The aim of the present study was to investigate the association between bitter taste receptor haplotypes and the consumption of vegetables, fruits, berries and sweet foods among an adult Finnish population. A cross-s...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-014-0433-3
更新日期：2014-11-01 00:00:00
abstract：:Moderate maternal calorie restriction during lactation protects rat offspring against obesity development in adulthood, due to an improved ability to handle and store excess dietary fuel. We used this model to identify early transcriptome-based biomarkers of metabolic health using peripheral blood mononuclear cells (P...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-013-0366-2
更新日期：2014-01-01 00:00:00
abstract：UNLABELLED:A single high-fat challenge induces plasmatic pro-inflammatory and pro-oxidative responses in the postprandial state, even in healthy men. This period is also associated with vascular endothelial dysfunction, which is an early event in the development of cardiovascular diseases. However, knowledge about the ...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-010-0166-x
更新日期：2010-09-01 00:00:00
abstract：:It is widely accepted that metabolic disorders, such as obesity, are closely linked to lifestyle and diet. Recently, the central role played by the intestinal microbiota in human metabolism and in progression of metabolic disorders has become evident. In this context, animal studies and human trials have demonstrated ...
journal_title：Genes & nutrition
pub_type： 杂志文章,评审
doi：10.1186/s12263-017-0566-2
更新日期：2017-06-15 00:00:00
abstract：:The aim of the present study was to investigate the anti-obesity effect of a mixture composed of Garcinia cambogia extract, soypeptide, and L: -carnitine (1.2:0.3:0.02, w/w/w) in rats rendered obese by a high-fat diet (HFD). Sprague-Dawley rats were fed either the high-fat control diet (CD) or the 0.38% mixture-supple...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-007-0070-1
更新日期：2008-02-01 00:00:00
abstract：:Fish aquaculture is considered to be one of the most sustainable sources of protein for humans. Many different species are cultured worldwide, but among them, marine flatfishes comprise a group of teleosts of high commercial interest because of their highly prized white flesh. However, the aquaculture of these fishes ...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-012-0312-8
更新日期：2013-01-01 00:00:00
abstract：:Anthocyanins (AC) are water-soluble natural pigments found in various parts of higher plants. Despite their limited oral bioavailability and very low post-absorption plasma concentrations, the dietary consumption of these pigments has been proposed to be associated with a significant protection against several human p...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-014-0404-8
更新日期：2014-07-01 00:00:00
abstract：:Phytoestrogens are naturally occurring plantderived polyphenols with estrogenic potency. They are ubiquitous in diet and therefore, generally consumed. Among Europeans, the diet is rich in multiple putative phytoestrogens including flavonoids, tannins, stilbenoids, and lignans. These compounds have been suggested to p...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/BF02829964
更新日期：2006-09-01 00:00:00
abstract：:Functional polymorphisms in endogenous antioxidant defense genes including manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase (GPX-1) have been linked with risk of cancer at multiple sites. Although it is presumed that these germline variants impact disease risk by altering the host's a...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-011-0257-3
更新日期：2012-04-01 00:00:00
abstract：:The aim of this study was to examine the relationship between the L55M and Q192R paraoxonase (PON1) polymorphisms and obesity in a population of adult Mexican workers. The study population included 127 adult individuals from the Universidad Autónoma del Estado de Morelos, ranging in age from 20 to 56 years and represe...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-011-0215-0
更新日期：2011-11-01 00:00:00
