Optimal dosing of antibiotics in critically ill patients by using continuous/extended infusions: a systematic review and meta-analysis.

abstract：INTRODUCTION:This study pools data from the UK Intensive Care National Audit and Research Center (ICNARC) Case Mix Programme (CMP) to evaluate the case mix, outcome and activity for 17,326 patients with severe acute kidney injury (AKI) occurring during the first 24 hours of admission to intensive care units (ICU). MET...

journal_title：Critical care (London, England)

authors： Kolhe NV,Stevens PE,Crowe AV,Lipkin GW,Harrison DA

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:The choice of invasive systemic haemodynamic monitoring in critically ill patients remains controversial as no multicentre comparative clinical data exist. Accordingly, we sought to study and compare the features and outcomes of patients who receive haemodynamic monitoring with either the pulmonary artery ...

journal_title：Critical care (London, England)

authors： Uchino S,Bellomo R,Morimatsu H,Sugihara M,French C,Stephens D,Wendon J,Honore P,Mulder J,Turner A,PAC\/PiCCO Use and Likelihood of Success Evaluation PULSE Study Group.

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:There is a complex interplay between changes in acid-base components and inflammation. This manuscript aims to explore associations between plasma cytokines and chemokines and acid-base status on admission to intensive care. METHODS:We conducted a prospective cohort study in a 13-bed ICU in a tertiary-car...

journal_title：Critical care (London, England)

authors： Zampieri FG,Kellum JA,Park M,Ranzani OT,Barbeiro HV,de Souza HP,da Cruz Neto LM,da Silva FP

更新日期：2014-07-17 00:00:00

abstract：:This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2017. Other selected articles can be found online at http://ccforum.com/series/annualupdate2017 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www...

journal_title：Critical care (London, England)

authors： Tagami T,Yasunaga H,Yokota H

更新日期：2017-03-21 00:00:00

abstract：:Antithrombotic prophylaxis in critically ill patients frequently fails. Venous thromboembolism is associated with adverse clinical outcomes, including a prolonged intensive care unit stay and death. A potential mechanism by which critically ill patients may be predisposed to antithrombotic failure is the inability to ...

journal_title：Critical care (London, England)

authors： Crowther M,Lim W

更新日期：2006-01-01 00:00:00

abstract：:Experiencing treatment on a modern intensive care unit (ICU) is a potentially traumatic event. People who experience traumatic events have an increased risk of depression, anxiety disorders and post-traumatic stress disorder (PTSD). Extended follow-up has confirmed that many patients suffer physical and psychological ...

journal_title：Critical care (London, England)

authors： Hatch R,McKechnie S,Griffiths J

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Following trauma, patients may suffer an overwhelming pro-inflammatory response and immune paralysis resulting in infection and multiple organ failure (MOF). Various potentially immunomodulative interventions have been tested. The objective of this study is to systematically review the randomized controlle...

journal_title：Critical care (London, England)

authors： Spruijt NE,Visser T,Leenen LP

更新日期：2010-01-01 00:00:00

abstract：:The recognition of colonization pressure as an important risk factor for acquisition of antibiotic-resistant bacteria in the ICU, including Acinetobacter species, has major consequences for our understanding of risk factor analyses. Moreover, the importance of colonization pressure underpins the role of cross-transmis...

journal_title：Critical care (London, England)

authors： Bonten MJ

更新日期：2012-07-31 00:00:00

abstract：INTRODUCTION:Delivery of bronchodilators with a metered-dose inhaler (MDI) and a spacer device in mechanically ventilated patients has become a widespread practice. However, except for the short-acting beta2-agonist salbutamol, the duration of action of other bronchodilators, including long-acting beta2-agonists, deliv...

journal_title：Critical care (London, England)

authors： Malliotakis P,Linardakis M,Gavriilidis G,Georgopoulos D

更新日期：2008-01-01 00:00:00

abstract：:Fluid resuscitation is a cornerstone of intensive care unit patient care, but prediction of the cardiovascular response remains difficult, despite many efforts in clinical research. The concept of responders and nonresponders illustrates such a difficulty. Many techniques have been tested, from strictly non-invasive t...

journal_title：Critical care (London, England)

authors： Payen D

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Control of blood glucose (BG) in critically ill patients is considered important, but is difficult to achieve, and often associated with increased risk of hypoglycemia. We examined the use of a computerized insulin dosing algorithm to manage hyperglycemia with particular attention to frequency and conditio...

journal_title：Critical care (London, England)

authors： Juneja R,Roudebush CP,Nasraway SA,Golas AA,Jacobi J,Carroll J,Nelson D,Abad VJ,Flanders SJ

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:The goal of personalised medicine in the intensive care unit (ICU) is to predict which diagnostic tests, monitoring interventions and treatments translate to improved outcomes given the variation between patients. Unfortunately, processes such as gene transcription and drug metabolism are dynamic in the cr...

journal_title：Critical care (London, England)

authors： Celi LA,Hinske LC,Alterovitz G,Szolovits P

更新日期：2008-01-01 00:00:00

abstract：:Disagreements between the perceptions of nurses and physicians regarding end-of-life (EOL) decisions are frequent. In a survey carried out in 13 Brazilian ICUs, Fumis and Deheinzelin reported that the majority of nurses, physicians and family members are in favor of limiting life-sustaining therapies in terminally ill...

journal_title：Critical care (London, England)

authors： Soares M

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:The accurate assessment of intravascular volume status for the therapy of severe hypovolemia and shock is difficult and critical to critically ill patients. Non-invasive evaluation of fluid responsiveness by the rapid infusion of a very limited amount of volume is an important clinical goal. This study aim...

journal_title：Critical care (London, England)

authors： Wu Y,Zhou S,Zhou Z,Liu B

更新日期：2014-05-27 00:00:00

abstract：:The early detection and treatment of sepsis are the most important factors in improving the outcome of patients with this condition. However, many patients admitted to hospital experience a long delay in the diagnosis of sepsis. Furthermore, it is not uncommon for febrile patients to be sent home from the Emergency De...

journal_title：Critical care (London, England)

authors： Marik PE

更新日期：2014-09-27 00:00:00

abstract：BACKGROUND:The lack of a patent source of infection after 24 hours of management of shock considered septic is a common and disturbing scenario. We aimed to determine the prevalence and the causes of shock with no diagnosis 24 hours after its onset, and to compare the outcomes of patients with early-confirmed septic sh...

journal_title：Critical care (London, England)

authors： Contou D,Roux D,Jochmans S,Coudroy R,Guérot E,Grimaldi D,Ricome S,Maury E,Plantefève G,Mayaux J,Mekontso Dessap A,Brun-Buisson C,de Prost N

更新日期：2016-11-06 00:00:00

abstract：INTRODUCTION:Dynamic predictors of fluid responsiveness, namely systolic pressure variation, pulse pressure variation, stroke volume variation and pleth variability index have been shown to be useful to identify in advance patients who will respond to a fluid load by a significant increase in stroke volume and cardiac ...

journal_title：Critical care (London, England)

authors： Benes J,Giglio M,Brienza N,Michard F

更新日期：2014-10-28 00:00:00

abstract：BACKGROUND:Patients with infective endocarditis (IE) have an elevated risk of renal dysfunction because of extensive systemic inflammation and use of nephrotoxic antibiotics. In this randomized, placebo-controlled trial, we investigated whether perioperative sodium bicarbonate administration could attenuate postoperati...

journal_title：Critical care (London, England)

authors： Cho JS,Soh S,Shim JK,Kang S,Choi H,Kwak YL

更新日期：2017-01-05 00:00:00

abstract：INTRODUCTION:The respiratory variation in pulse pressure (PP) has been established as a dynamic variable of cardiac preload which indicates fluid responsiveness in mechanically ventilated patients. The impact of acute changes in cardiac performance on respiratory fluctuations in PP has not been evaluated until now. We ...

journal_title：Critical care (London, England)

authors： Keyl C,Stockinger J,Laule S,Staier K,Schiebeling-Römer J,Wiesenack C

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Prevalence of iron deficiency (ID) at intensive care (ICU) admission is around 25 to 40%. Blood losses are important during ICU stay, leading to iron losses, but prevalence of ID at ICU discharge is unknown. ID has been associated with fatigue and muscular weakness, and may thus impair post-ICU rehabilitat...

journal_title：Critical care (London, England)

authors： Lasocki S,Chudeau N,Papet T,Tartiere D,Roquilly A,Carlier L,Mimoz O,Seguin P,Malledant Y,Asehnoune K,Hamel JF,AtlanREA group.

更新日期：2014-09-30 00:00:00

abstract：OBJECTIVES:To evaluate the resuscitative effects of mechanical and manual chest compression in patients with out-of-hospital cardiac arrest (OHCA). METHODS:All randomized controlled and cohort studies comparing the effects of mechanical compression and manual compression on cardiopulmonary resuscitation in OHCA patien...

journal_title：Critical care (London, England)

authors： Zhu N,Chen Q,Jiang Z,Liao F,Kou B,Tang H,Zhou M

更新日期：2019-03-27 00:00:00

abstract：INTRODUCTION:Elevated serum levels of S100beta, an astrocyte-derived protein, correlate with unfavourable neurological outcomes following cardiac surgery, neurotrauma, and resuscitation. This study evaluated whether pre-/postoperative serum S100beta levels correlate with unfavourable clinical and radiological findings ...

journal_title：Critical care (London, England)

authors： Einav S,Shoshan Y,Ovadia H,Matot I,Hersch M,Itshayek E

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The safety of perioperative hyperoxia is currently unclear. Previous studies in patients undergoing coronary artery bypass surgery suggest reduced myocardial damage when avoiding extreme perioperative hyperoxia (>400 mmHg). In this study we investigated whether an oxygenation strategy from moderate hyperoxia...

journal_title：Critical care (London, England)

authors： Smit B,Smulders YM,de Waard MC,Boer C,Vonk AB,Veerhoek D,Kamminga S,de Grooth HJ,García-Vallejo JJ,Musters RJ,Girbes AR,Oudemans-van Straaten HM,Spoelstra-de Man AM

更新日期：2016-03-10 00:00:00

abstract：BACKGROUND:Coronavirus disease 2019 (COVID-19) has become a public health emergency of global concern. We aimed to explore the risk factors of 14-day and 28-day mortality and develop a model for predicting 14-day and 28-day survival probability among adult hospitalized patients with COVID-19. METHODS:In this multicent...

journal_title：Critical care (London, England)

authors： Zhang S,Guo M,Duan L,Wu F,Hu G,Wang Z,Huang Q,Liao T,Xu J,Ma Y,Lv Z,Xiao W,Zhao Z,Tan X,Meng D,Zhang S,Zhou E,Yin Z,Geng W,Wang X,Zhang J,Chen J,Zhang Y,Jin Y

更新日期：2020-07-16 00:00:00

abstract：:An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global pandemic. Both SARS-CoV-2 and SARS-CoV enter host cells via the angiotensin-converting enzyme 2 (ACE2) receptor, which is expressed in various human organ...

journal_title：Critical care (London, England)

authors： Ni W,Yang X,Yang D,Bao J,Li R,Xiao Y,Hou C,Wang H,Liu J,Yang D,Xu Y,Cao Z,Gao Z

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:The present study was designed to (1) establish current sedation practice in UK critical care to inform evidence synthesis and potential future primary research and (2) to compare practice reported via a survey with actual practice assessed in a point prevalence study (PPS). METHODS:UK adult general critica...

journal_title：Critical care (London, England)

authors： Richards-Belle A,Canter RR,Power GS,Robinson EJ,Reschreiter H,Wunsch H,Harvey SE

更新日期：2016-10-27 00:00:00

abstract：INTRODUCTION:Sepsis is characterized by systemic microvascular dysfunction. Endothelial progenitor cells (EPCs) are critically involved in maintaining vascular homeostasis under both physiological and pathological conditions. The aim of the present study was to analyze the endothelial progenitor cell system in patients...

journal_title：Critical care (London, England)

authors： Patschan SA,Patschan D,Temme J,Korsten P,Wessels JT,Koziolek M,Henze E,Müller GA

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:In ARDS patients, changes in respiratory mechanical properties and ventilatory settings can cause incomplete lung deflation at end-expiration. Both can promote dynamic hyperinflation and intrinsic positive end-expiratory pressure (PEEP). The aim of this study was to investigate, in a large population of ARDS...

journal_title：Critical care (London, England)

authors： Coppola S,Caccioppola A,Froio S,Ferrari E,Gotti M,Formenti P,Chiumello D

更新日期：2019-11-27 00:00:00

abstract：INTRODUCTION:Between 1 and 31% of patients suffering out-of-hospital cardiac arrest (OHCA) survive to discharge from hospital. International studies have shown that the level of care provided by the admitting hospital determines survival for patients suffering from OHCA. These data may only be partially transferable to...

journal_title：Critical care (London, England)

authors： Wnent J,Seewald S,Heringlake M,Lemke H,Brauer K,Lefering R,Fischer M,Jantzen T,Bein B,Messelken M,Gräsner JT

更新日期：2012-09-12 00:00:00

abstract：:Chloride is the principal anion in the extracellular fluid and is the second main contributor to plasma tonicity. Its concentration is frequently abnormal in intensive care unit patients, often as a consequence of fluid therapy. Yet chloride has received less attention than any other ion in the critical care literatur...

journal_title：Critical care (London, England)

authors： Yunos NM,Bellomo R,Story D,Kellum J

更新日期：2010-01-01 00:00:00