Abstract:
OBJECTIVES:To investigate psychosocial and biomedical outcomes following total hip replacement (THR) and to identify predictors of recovery from THR. METHODS:Patients with osteoarthritis (OA) on the waiting list for primary THR in North West England were assessed pre-operatively and at six and 12 months post-operatively to investigate psychosocial and biomedical outcomes. Psychosocial outcomes were anxiety and depression, social support and health-related quality of life (HRQoL). Biomedical outcomes were pain, physical function and stiffness. The primary outcome was the Short-Form 36 (SF-36) Health Survey Total Physical Function. Potential predictors of outcome were age, sex, body mass index, previous joint replacement, involvement in the decision for THR, any comorbidities, any complications, type of medication, and pre-operative ENRICHD Social Support Instrument score, Hospital Anxiety and Depression scores and Western Ontario and McMaster Universities osteoarthritis index score. RESULTS:The study included 206 patients undergoing THR. There were 88 men and 118 women with a mean age of 66.3 years (sd 10.4;36 to 89). Pain, stiffness and physical function, severity of OA, HRQoL, anxiety and depression all improved significantly from pre-operative to 12-month assessment (all p < 0.001), with the greatest improvement occurring in the first six months (all p < 0.001). The predictors that were found to influence recovery six months after THR were: pain (p < 0.001), anxiety (p = 0.034), depression (p = 0.001), previous joint replacement (p = 0.006) and anti-inflammatory drugs (p = 0.012). CONCLUSIONS:The study identified the key psychosocial and biomedical predictors of recovery following THR. By identifying these predictors, we are able to identify and provide more support for patients at risk of poor recovery following THR. Cite this article: Bone Joint Res 2013;2:248-54.
journal_name
Bone Joint Resjournal_title
Bone & joint researchauthors
McHugh GA,Campbell M,Luker KAdoi
10.1302/2046-3758.211.2000206subject
Has Abstractpub_date
2013-11-27 00:00:00pages
248-54issue
11issn
2046-3758pii
2/11/248journal_volume
2pub_type
杂志文章abstract:OBJECTIVES:We aimed to examine the characteristics of deep venous flow in the leg in a cast and the effects of a wearable neuromuscular stimulator (geko; FirstKind Ltd) and also to explore the participants' tolerance of the stimulator. METHODS:This is an open-label physiological study on ten healthy volunteers. Duplex...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.29.2000176
更新日期:2013-09-02 00:00:00
abstract::In vivo animal experimentation has been one of the cornerstones of biological and biomedical research, particularly in the field of clinical medicine and pharmaceuticals. The conventional in vivo model system is invariably associated with high production costs and strict ethical considerations. These limitations led t...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.512.BJR-2016-0102.R2
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVES:To assess the structure and extracellular matrix molecule expression of osteogenic cell sheets created via culture in medium with both dexamethasone (Dex) and ascorbic acid phosphate (AscP) compared either Dex or AscP alone. METHODS:Osteogenic cell sheets were prepared by culturing rat bone marrow stromal c...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.511.BJR-2016-0013.R1
更新日期:2016-11-01 00:00:00
abstract:Objectives:The aim of this study was to investigate the biomechanical effect of the anterolateral ligament (ALL), anterior cruciate ligament (ACL), or both ALL and ACL on kinematics under dynamic loading conditions using dynamic simulation subject-specific knee models. Methods:Five subject-specific musculoskeletal mod...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.811.BJR-2019-0103.R1
更新日期:2019-12-03 00:00:00
abstract:AIMS:The study aimed to determine whether the microRNA miR21-5p (MiR21) mediates temporomandibular joint osteoarthritis (TMJ-OA) by targeting growth differentiation factor 5 (Gdf5). METHODS:TMJ-OA was induced in MiR21 knockout (KO) mice and wild-type (WT) mice by a unilateral anterior crossbite (UAC) procedure. Mouse ...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.910.BJR-2020-0140.R1
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:To investigate the differences of open reduction and internal fixation (ORIF) of complex AO Type C distal radius fractures between two different models of a single implant type. METHODS:A total of 136 patients who received either a 2.4 mm (n = 61) or 3.5 mm (n = 75) distal radius locking compression plate (...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.16.2000008
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVES:Pedicle-lengthening osteotomy is a novel surgery for lumbar spinal stenosis (LSS), which achieves substantial enlargement of the spinal canal by expansion of the bilateral pedicle osteotomy sites. Few studies have evaluated the impact of this new surgery on spinal canal volume (SCV) and neural foramen dimens...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.56.2000469
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:Pseudotumours (abnormal peri-prosthetic soft-tissue reactions) following metal-on-metal hip resurfacing arthroplasty (MoMHRA) have been associated with elevated metal ion levels, suggesting that excessive wear may occur due to edge-loading of these MoM implants. This study aimed to quantify in vivo edge-load...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.14.2000019
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVES:To study the measurement properties of a joint specific patient reported outcome measure, a measure of capability and a general health-related quality of life (HRQOL) tool in a large cohort of patients with a hip fracture. METHODS:Responsiveness and associations between the Oxford Hip Score (a hip specific ...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.33.2000250
更新日期:2014-03-19 00:00:00
abstract:Objectives:We investigated the reliability of the cobalt-chromium (CoCr) synovial joint fluid ratio (JFR) in identifying the presence of a severe aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL) response and/or suboptimal taper performance (SOTP) following metal-on-metal (MoM) hip arthroplasty. We then...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.83.BJR-2018-0049.R1
更新日期:2019-04-02 00:00:00
abstract::Fractures of the proximal femur are one of the greatest challenges facing the medical community, constituting a heavy socioeconomic burden worldwide. Controversy exists regarding the optimal treatment for patients with unstable trochanteric proximal femoral fractures. The recognised treatment alternatives are extramed...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.210.2000183
更新日期:2013-10-02 00:00:00
abstract:OBJECTIVES:We aimed to determine the effect of surgical approach on the histology of the femoral head following resurfacing of the hip. METHODS:We performed a histological assessment of the bone under the femoral component taken from retrieval specimens of patients having revision surgery following resurfacing of the ...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.29.2000179
更新日期:2013-09-18 00:00:00
abstract:Objectives:We studied subchondral intraosseous pressure (IOP) in an animal model during loading, and with vascular occlusion. We explored bone compartmentalization by saline injection. Materials and Methods:Needles were placed in the femoral condyle and proximal tibia of five anaesthetized rabbits and connected to pre...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.78.BJR-2017-0343.R2
更新日期:2018-09-15 00:00:00
abstract:OBJECTIVES:The radiographic union score for tibial (RUST) fractures was developed by Whelan et al to assess the healing of tibial fractures following intramedullary nailing. In the current study, the repeatability and reliability of the RUST score was evaluated in an independent centre (a) using the original descriptio...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.54.2000628
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:This study aimed to characterise and qualitatively grade the severity of the corrosion particles released into the hip joint following taper corrosion. METHODS:The 26 cases examined were CoC/ABG Modular (n = 13) and ASR/SROM (n = 13). Blood serum metal ion levels were collected before and after revision sur...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.59.2000507
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:Osteophytes are products of active endochondral and intramembranous ossification, and therefore could theoretically provide significant efficacy as bone grafts. In this study, we compared the bone mineralisation effectiveness of osteophytes and cancellous bone, including their effects on secretion of growth ...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.62.BJR-2016-0199.R1
更新日期:2017-02-01 00:00:00
abstract:AIMS:Treatment of chronic osteomyelitis (COM) for young patients remains a challenge. Large bone deficiencies secondary to COM can be treated using induced membrane technique (IMT). However, it is unclear which type of bone graft is optimal. The goal of the study was to determine the clinical effectiveness of bone marr...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.101.BJR-2020-0229.R1
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVES:Local corticosteroid infiltration is a common practice of treatment for lateral epicondylitis. In recent studies no statistically significant or clinically relevant results in favour of corticosteroid injections were found. The injection of autologous blood has been reported to be effective for both intermed...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.18.2000095
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Resveratrol is a polyphenolic compound commonly found in the skins of red grapes. Sirtuin 1 (SIRT1) is a human gene that is activated by resveratrol and has been shown to promote longevity and boost mitochondrial metabolism. We examined the effect of resveratrol on normal and osteoarthritic (OA) human chondr...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.33.2000226
更新日期:2014-03-10 00:00:00
abstract:OBJECTIVES:Lengthening osteotomies of the calcaneus in children are in general grafted with bone from the iliac crest. Artificial bone grafts have been introduced, however, their structural and clinical durability has not been documented. Radiostereometric analysis (RSA) is a very accurate and precise method for measur...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.45.2000292
更新日期:2015-05-01 00:00:00
abstract:Objectives:Different criteria for assessing the reduction quality of trochanteric fractures have been reported. The Baumgaertner reduction quality criteria (BRQC) are relatively common and the Chang reduction quality criteria (CRQC) are relatively new. The objectives of the current study were to compare the reliability...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.810.BJR-2019-0032.R1
更新日期:2019-11-02 00:00:00
abstract:Objectives:Recently, the field of tissue engineering has made numerous advances towards achieving artificial tendon substitutes with excellent mechanical and histological properties, and has had some promising experimental results. The purpose of this systematic review is to assess the efficacy of tissue engineering in...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.74.BJR-2017-0326
更新日期:2018-05-05 00:00:00
abstract:OBJECTIVES:To assess the accuracy of patient-specific instruments (PSIs) versus standard manual technique and the precision of computer-assisted planning and PSI-guided osteotomies in pelvic tumour resection. METHODS:CT scans were obtained from five female cadaveric pelvises. Five osteotomies were designed using Mimic...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.610.BJR-2017-0094.R1
更新日期:2017-10-01 00:00:00
abstract::Cartilage repair in terms of replacement, or regeneration of damaged or diseased articular cartilage with functional tissue, is the 'holy grail' of joint surgery. A wide spectrum of strategies for cartilage repair currently exists and several of these techniques have been reported to be associated with successful clin...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.34.2000238
更新日期:2014-04-02 00:00:00
abstract:OBJECTIVES:The goals of this study were: 1) to determine if high-fat diet (HFD) feeding in female mice would negatively impact biomechanical and histologic consequences on the Achilles tendon and quadriceps muscle; and 2) to investigate whether exercise and branched-chain amino acid (BCAA) supplementation would affect ...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.29.2000196
更新日期:2013-09-10 00:00:00
abstract::Chondrocyte hypertrophy represents a crucial turning point during endochondral bone development. This process is tightly regulated by various factors, constituting a regulatory network that maintains normal bone development. Histone deacetylase 4 (HDAC4) is the most well-characterized member of the HDAC class IIa fami...
journal_title:Bone & joint research
pub_type: 杂志文章,评审
doi:10.1302/2046-3758.92.BJR-2019-0172.R1
更新日期:2020-05-16 00:00:00
abstract:AIMS:This study aimed to investigate the effect of solute carrier family 20 member 2 (SLC20A2) gene mutation (identified from a hereditary multiple exostoses family) on chondrocyte proliferation and differentiation. METHODS:ATDC5 chondrocytes were cultured in insulin-transferrin-selenium medium to induce differentiati...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.911.BJR-2020-0112.R1
更新日期:2020-11-01 00:00:00
abstract:Aims:Induction heating is a noninvasive, nonantibiotic treatment modality that can potentially be used to cause thermal damage to the bacterial biofilm on the metal implant surface. The purpose of this study was to determine the effectiveness of induction heating on killing Staphylococcus epidermidis from biofilm and t...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.94.BJR-2019-0274.R1
更新日期:2020-05-16 00:00:00
abstract:Objectives:The paradoxical migration of the femoral neck element (FNE) superomedially against gravity, with respect to the intramedullary component of the cephalomedullary device, is a poorly understood phenomenon increasingly seen in the management of pertrochanteric hip fractures with the intramedullary nail. The aim...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.87.BJR-2018-0271.R1
更新日期:2019-08-02 00:00:00
abstract:Aims:Commonly performed unicompartmental knee arthroplasty (UKA) is not designed for the lateral compartment. Additionally, the anatomical medial and lateral tibial plateaus have asymmetrical geometries, with a slightly dished medial plateau and a convex lateral plateau. Therefore, this study aims to investigate the na...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.812.BJR-2019-0114.R1
更新日期:2020-01-08 00:00:00