Trends in biological joint resurfacing.

Abstract:

:The treatment of osteochondral lesions and osteoarthritis remains an ongoing clinical challenge in orthopaedics. This review examines the current research in the fields of cartilage regeneration, osteochondral defect treatment, and biological joint resurfacing, and reports on the results of clinical and pre-clinical studies. We also report on novel treatment strategies and discuss their potential promise or pitfalls. Current focus involves the use of a scaffold providing mechanical support with the addition of chondrocytes or mesenchymal stem cells (MSCs), or the use of cell homing to differentiate the organism's own endogenous cell sources into cartilage. This method is usually performed with scaffolds that have been coated with a chemotactic agent or with structures that support the sustained release of growth factors or other chondroinductive agents. We also discuss unique methods and designs for cell homing and scaffold production, and improvements in biological joint resurfacing. There have been a number of exciting new studies and techniques developed that aim to repair or restore osteochondral lesions and to treat larger defects or the entire articular surface. The concept of a biological total joint replacement appears to have much potential. Cite this article: Bone Joint Res 2013;2:193-9.

journal_name

Bone Joint Res

journal_title

Bone & joint research

authors

Myers KR,Sgaglione NA,Grande DA

doi

10.1302/2046-3758.29.2000189

subject

Has Abstract

pub_date

2013-09-16 00:00:00

pages

193-9

issue

9

issn

2046-3758

pii

2/9/193

journal_volume

2

pub_type

杂志文章
  • How 3D patient-specific instruments improve accuracy of pelvic bone tumour resection in a cadaveric study.

    abstract:OBJECTIVES:To assess the accuracy of patient-specific instruments (PSIs) versus standard manual technique and the precision of computer-assisted planning and PSI-guided osteotomies in pelvic tumour resection. METHODS:CT scans were obtained from five female cadaveric pelvises. Five osteotomies were designed using Mimic...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.610.BJR-2017-0094.R1

    authors: Sallent A,Vicente M,Reverté MM,Lopez A,Rodríguez-Baeza A,Pérez-Domínguez M,Velez R

    更新日期:2017-10-01 00:00:00

  • Is the synovial fluid cobalt-to-chromium ratio related to the serum partitioning of metal debris following metal-on-metal hip arthroplasty?

    abstract:Objectives:We investigated the reliability of the cobalt-chromium (CoCr) synovial joint fluid ratio (JFR) in identifying the presence of a severe aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL) response and/or suboptimal taper performance (SOTP) following metal-on-metal (MoM) hip arthroplasty. We then...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.83.BJR-2018-0049.R1

    authors: Langton DJ,Natu S,Harrington CF,Bowsher JG,Nargol AVF

    更新日期:2019-04-02 00:00:00

  • Induction heating for eradicating Staphylococcus epidermidis from biofilm.

    abstract:Aims:Induction heating is a noninvasive, nonantibiotic treatment modality that can potentially be used to cause thermal damage to the bacterial biofilm on the metal implant surface. The purpose of this study was to determine the effectiveness of induction heating on killing Staphylococcus epidermidis from biofilm and t...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.94.BJR-2019-0274.R1

    authors: Pijls BG,Sanders IMJG,Kujiper EJ,Nelissen RGHH

    更新日期:2020-05-16 00:00:00

  • The anterolateral ligament is a secondary stabilizer in the knee joint: A validated computational model of the biomechanical effects of a deficient anterior cruciate ligament and anterolateral ligament on knee joint kinematics.

    abstract:Objectives:The aim of this study was to investigate the biomechanical effect of the anterolateral ligament (ALL), anterior cruciate ligament (ACL), or both ALL and ACL on kinematics under dynamic loading conditions using dynamic simulation subject-specific knee models. Methods:Five subject-specific musculoskeletal mod...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.811.BJR-2019-0103.R1

    authors: Kang KT,Koh YG,Park KM,Choi CH,Jung M,Shin J,Kim SH

    更新日期:2019-12-03 00:00:00

  • The Warwick Hip Trauma Evaluation One -an abridged protocol for the WHiTE One Study: An embedded randomised trial comparing the X-bolt with slidinghip screw fixation in extracapsular hip fractures.

    abstract::Fractures of the proximal femur are one of the greatest challenges facing the medical community, constituting a heavy socioeconomic burden worldwide. Controversy exists regarding the optimal treatment for patients with unstable trochanteric proximal femoral fractures. The recognised treatment alternatives are extramed...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.210.2000183

    authors: Griffin XL,McArthur J,Achten J,Parsons N,Costa ML

    更新日期:2013-10-02 00:00:00

  • Characteristics of two different locking compression plates in the volar fixation of complex articular distal radius fractures.

    abstract:OBJECTIVES:To investigate the differences of open reduction and internal fixation (ORIF) of complex AO Type C distal radius fractures between two different models of a single implant type. METHODS:A total of 136 patients who received either a 2.4 mm (n = 61) or 3.5 mm (n = 75) distal radius locking compression plate (...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.16.2000008

    authors: von Recum J,Matschke S,Jupiter JB,Ring D,Souer JS,Huber M,Audigé L

    更新日期:2012-06-01 00:00:00

  • Barriers and facilitators experienced in collaborative prospective research in orthopaedic oncology: A qualitative study.

    abstract:OBJECTIVES:As tumours of bone and soft tissue are rare, multicentre prospective collaboration is essential for meaningful research and evidence-based advances in patient care. The aim of this study was to identify barriers and facilitators encountered in large-scale collaborative research by orthopaedic oncological sur...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.65.BJR-2016-0192.R1

    authors: Rendon JS,Swinton M,Bernthal N,Boffano M,Damron T,Evaniew N,Ferguson P,Galli Serra M,Hettwer W,McKay P,Miller B,Nystrom L,Parizzia W,Schneider P,Spiguel A,Vélez R,Weiss K,Zumárraga JP,Ghert M

    更新日期:2017-05-01 00:00:00

  • Comparison of Baumgaertner and Chang reduction quality criteria for the assessment of trochanteric fractures.

    abstract:Objectives:Different criteria for assessing the reduction quality of trochanteric fractures have been reported. The Baumgaertner reduction quality criteria (BRQC) are relatively common and the Chang reduction quality criteria (CRQC) are relatively new. The objectives of the current study were to compare the reliability...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.810.BJR-2019-0032.R1

    authors: Mao W,Ni H,Li L,He Y,Chen X,Tang H,Dong Y

    更新日期:2019-11-02 00:00:00

  • The histological and elemental characterisation of corrosion particles from taper junctions.

    abstract:OBJECTIVES:This study aimed to characterise and qualitatively grade the severity of the corrosion particles released into the hip joint following taper corrosion. METHODS:The 26 cases examined were CoC/ABG Modular (n = 13) and ASR/SROM (n = 13). Blood serum metal ion levels were collected before and after revision sur...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.59.2000507

    authors: Munir S,Oliver RA,Zicat B,Walter WL,Walter WK,Walsh WR

    更新日期:2016-09-01 00:00:00

  • Culturing bone marrow cells with dexamethasone and ascorbic acid improves osteogenic cell sheet structure.

    abstract:OBJECTIVES:To assess the structure and extracellular matrix molecule expression of osteogenic cell sheets created via culture in medium with both dexamethasone (Dex) and ascorbic acid phosphate (AscP) compared either Dex or AscP alone. METHODS:Osteogenic cell sheets were prepared by culturing rat bone marrow stromal c...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.511.BJR-2016-0013.R1

    authors: Akahane M,Shimizu T,Kira T,Onishi T,Uchihara Y,Imamura T,Tanaka Y

    更新日期:2016-11-01 00:00:00

  • Optimal interference of the tibial component of the cementless Oxford Unicompartmental Knee Replacement.

    abstract:Objectives:The primary stability of the cementless Oxford Unicompartmental Knee Replacement (OUKR) relies on interference fit (or press fit). Insufficient interference may cause implant loosening, whilst excessive interference could cause bone damage and fracture.The aim of this study was to identify the optimal interf...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.73.BJR-2017-0193.R1

    authors: Campi S,Mellon SJ,Ridley D,Foulke B,Dodd CAF,Pandit HG,Murray DW

    更新日期:2018-05-05 00:00:00

  • Characterisation of osteophytes as an autologous bone graft source: An experimental study in vivo and in vitro.

    abstract:OBJECTIVES:Osteophytes are products of active endochondral and intramembranous ossification, and therefore could theoretically provide significant efficacy as bone grafts. In this study, we compared the bone mineralisation effectiveness of osteophytes and cancellous bone, including their effects on secretion of growth ...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.62.BJR-2016-0199.R1

    authors: Ishihara K,Okazaki K,Akiyama T,Akasaki Y,Nakashima Y

    更新日期:2017-02-01 00:00:00

  • The role of histone deacetylase 4 during chondrocyte hypertrophy and endochondral bone development.

    abstract::Chondrocyte hypertrophy represents a crucial turning point during endochondral bone development. This process is tightly regulated by various factors, constituting a regulatory network that maintains normal bone development. Histone deacetylase 4 (HDAC4) is the most well-characterized member of the HDAC class IIa fami...

    journal_title:Bone & joint research

    pub_type: 杂志文章,评审

    doi:10.1302/2046-3758.92.BJR-2019-0172.R1

    authors: Chen Z,Zhang Z,Guo L,Wei X,Zhang Y,Wang X,Wei L

    更新日期:2020-05-16 00:00:00

  • Predictors of outcomes of recovery following total hip replacement surgery: A prospective study.

    abstract:OBJECTIVES:To investigate psychosocial and biomedical outcomes following total hip replacement (THR) and to identify predictors of recovery from THR. METHODS:Patients with osteoarthritis (OA) on the waiting list for primary THR in North West England were assessed pre-operatively and at six and 12 months post-operative...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.211.2000206

    authors: McHugh GA,Campbell M,Luker KA

    更新日期:2013-11-27 00:00:00

  • The effect of surgical approach on the histologyof the femoral head following resurfacing of the hip: Analysis of retrieval specimens.

    abstract:OBJECTIVES:We aimed to determine the effect of surgical approach on the histology of the femoral head following resurfacing of the hip. METHODS:We performed a histological assessment of the bone under the femoral component taken from retrieval specimens of patients having revision surgery following resurfacing of the ...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.29.2000179

    authors: Amarasekera HW,Campbell PC,Parsons N,Achten J,Masters J,Griffin DR,Costa ML

    更新日期:2013-09-18 00:00:00

  • Impact of pedicle-lengthening osteotomy on spinal canal volume and neural foramen size in three types of lumbar spinal stenosis.

    abstract:OBJECTIVES:Pedicle-lengthening osteotomy is a novel surgery for lumbar spinal stenosis (LSS), which achieves substantial enlargement of the spinal canal by expansion of the bilateral pedicle osteotomy sites. Few studies have evaluated the impact of this new surgery on spinal canal volume (SCV) and neural foramen dimens...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.56.2000469

    authors: Li P,Qian L,Wu WD,Wu CF,Ouyang J

    更新日期:2016-06-01 00:00:00

  • The feasibility of performing a randomised controlled trial for femoroacetabular impingement surgery.

    abstract:OBJECTIVES:The number of surgical procedures performed each year to treat femoroacetabular impingement (FAI) continues to rise. Although there is evidence that surgery can improve symptoms in the short-term, there is no evidence that it slows the development of osteoarthritis (OA). We performed a feasibility study to d...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.22.2000137

    authors: Palmer AJ,Thomas GE,Pollard TC,Rombach I,Taylor A,Arden N,Beard DJ,Andrade AJ,Carr AJ,Glyn-Jones S

    更新日期:2013-02-01 00:00:00

  • Neuromuscular electrostimulation viathe common peroneal nerve promotes lower limb blood flow in a below-kneecast: A potential for thromboprophylaxis.

    abstract:OBJECTIVES:We aimed to examine the characteristics of deep venous flow in the leg in a cast and the effects of a wearable neuromuscular stimulator (geko; FirstKind Ltd) and also to explore the participants' tolerance of the stimulator. METHODS:This is an open-label physiological study on ten healthy volunteers. Duplex...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.29.2000176

    authors: Warwick DJ,Shaikh A,Gadola S,Stokes M,Worsley P,Bain D,Tucker AT,Gadola SD

    更新日期:2013-09-02 00:00:00

  • Patients' decision making in total knee arthroplasty: a systematic review of qualitative research.

    abstract:OBJECTIVES:A patient-centred approach, usually achieved through shared decision making, has the potential to help improve decision making around knee arthroplasty surgery. However, such an approach requires an understanding of the factors involved in patient decision making. This review's objective is to systematically...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.410.2000420

    authors: Barlow T,Griffin D,Barlow D,Realpe A

    更新日期:2015-10-01 00:00:00

  • Vancomycin elution from a biphasic ceramic bone substitute.

    abstract:Objectives:The aim of this study was to analyze drain fluid, blood, and urine simultaneously to follow the long-term release of vancomycin from a biphasic ceramic carrier in major hip surgery. Our hypothesis was that there would be high local vancomycin concentrations during the first week with safe low systemic trough...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.82.BJR-2018-0174.R2

    authors: Stravinskas M,Nilsson M,Vitkauskiene A,Tarasevicius S,Lidgren L

    更新日期:2019-03-02 00:00:00

  • Knockout of miR-21-5p alleviates cartilage matrix degradation by targeting Gdf5 in temporomandibular joint osteoarthritis.

    abstract:AIMS:The study aimed to determine whether the microRNA miR21-5p (MiR21) mediates temporomandibular joint osteoarthritis (TMJ-OA) by targeting growth differentiation factor 5 (Gdf5). METHODS:TMJ-OA was induced in MiR21 knockout (KO) mice and wild-type (WT) mice by a unilateral anterior crossbite (UAC) procedure. Mouse ...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.910.BJR-2020-0140.R1

    authors: Zhang A,Ma S,Yuan L,Wu S,Liu S,Wei X,Chen L,Ma C,Zhao H

    更新日期:2020-10-01 00:00:00

  • Intraosseous pressure during loading and with vascular occlusion in an animal model.

    abstract:Objectives:We studied subchondral intraosseous pressure (IOP) in an animal model during loading, and with vascular occlusion. We explored bone compartmentalization by saline injection. Materials and Methods:Needles were placed in the femoral condyle and proximal tibia of five anaesthetized rabbits and connected to pre...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.78.BJR-2017-0343.R2

    authors: Beverly M,Mellon S,Kennedy JA,Murray DW

    更新日期:2018-09-15 00:00:00

  • In vivo evaluation of edge-loading in metal-on-metal hip resurfacing patients with pseudotumours.

    abstract:OBJECTIVES:Pseudotumours (abnormal peri-prosthetic soft-tissue reactions) following metal-on-metal hip resurfacing arthroplasty (MoMHRA) have been associated with elevated metal ion levels, suggesting that excessive wear may occur due to edge-loading of these MoM implants. This study aimed to quantify in vivo edge-load...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.14.2000019

    authors: Kwon YM,Mellon SJ,Monk P,Murray DW,Gill HS

    更新日期:2012-04-01 00:00:00

  • Gut microbiome and osteoporosis: a review.

    abstract::Osteoporosis (OP) is a chronic metabolic bone disease characterized by the decrease of bone tissue per unit volume under the combined action of genetic and environmental factors, which leads to the decrease of bone strength, makes the bone brittle, and raises the possibility of bone fracture. However, the exact mechan...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.98.BJR-2020-0089.R1

    authors: Li S,Mao Y,Zhou F,Yang H,Shi Q,Meng B

    更新日期:2020-08-02 00:00:00

  • Can pain and function be distinguished in the Oxford Hip Score in a meaningful way? : an exploratory and confirmatory factor analysis.

    abstract:OBJECTIVE:The objective of this study was to explore dimensionality of the Oxford Hip Score (OHS) and examine whether self-reported pain and functioning can be distinguished in the form of subscales. METHODS:This was a secondary data analysis of the UK NHS hospital episode statistics/patient-reported outcome measures ...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.311.2000313

    authors: Harris KK,Price AJ,Beard DJ,Fitzpatrick R,Jenkinson C,Dawson J

    更新日期:2014-11-01 00:00:00

  • The effect of resveratrol on normal and osteoarthritic chondrocyte metabolism.

    abstract:BACKGROUND:Resveratrol is a polyphenolic compound commonly found in the skins of red grapes. Sirtuin 1 (SIRT1) is a human gene that is activated by resveratrol and has been shown to promote longevity and boost mitochondrial metabolism. We examined the effect of resveratrol on normal and osteoarthritic (OA) human chondr...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.33.2000226

    authors: Kim HJ,Braun HJ,Dragoo JL

    更新日期:2014-03-10 00:00:00

  • A mutation in SLC20A2 (c.C1849T) promotes proliferation while inhibiting hypertrophic differentiation in ATDC5 chondrocytes.

    abstract:AIMS:This study aimed to investigate the effect of solute carrier family 20 member 2 (SLC20A2) gene mutation (identified from a hereditary multiple exostoses family) on chondrocyte proliferation and differentiation. METHODS:ATDC5 chondrocytes were cultured in insulin-transferrin-selenium medium to induce differentiati...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.911.BJR-2020-0112.R1

    authors: Li Y,Lin X,Zhu M,Xun F,Li J,Yuan Z,Liu Y,Xu H

    更新日期:2020-11-01 00:00:00

  • Medial migration in cephalomedullary nail fixation of pertrochanteric hip fractures: A biomechanical analysis using a novel bidirectional cyclic loading model.

    abstract:Objectives:The paradoxical migration of the femoral neck element (FNE) superomedially against gravity, with respect to the intramedullary component of the cephalomedullary device, is a poorly understood phenomenon increasingly seen in the management of pertrochanteric hip fractures with the intramedullary nail. The aim...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.87.BJR-2018-0271.R1

    authors: Law GW,Wong YR,Yew AK,Choh ACT,Koh JSB,Howe TS

    更新日期:2019-08-02 00:00:00

  • Biodistribution of locally or systemically transplantedosteoblast-like cells.

    abstract:OBJECTIVES:In order to ensure safety of the cell-based therapy for bone regeneration, we examined in vivo biodistribution of locally or systemically transplanted osteoblast-like cells generated from bone marrow (BM) derived mononuclear cells. METHODS:BM cells obtained from a total of 13 Sprague-Dawley (SD) green fluor...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.33.2000257

    authors: Okabe YT,Kondo T,Mishima K,Hayase Y,Kato K,Mizuno M,Ishiguro N,Kitoh H

    更新日期:2014-03-20 00:00:00

  • Three dimensional measurement of minimum joint space width in the knee from stereo radiographs using statistical shape models.

    abstract:OBJECTIVES:An important measure for the diagnosis and monitoring of knee osteoarthritis is the minimum joint space width (mJSW). This requires accurate alignment of the x-ray beam with the tibial plateau, which may not be accomplished in practice. We investigate the feasibility of a new mJSW measurement method from ste...

    journal_title:Bone & joint research

    pub_type: 杂志文章

    doi:10.1302/2046-3758.58.2000626

    authors: van IJsseldijk EA,Valstar ER,Stoel BC,Nelissen RG,Baka N,Van't Klooster R,Kaptein BL

    更新日期:2016-08-01 00:00:00