Genetic and early environmental components in sociodemographic influences on adult body fatness.

Abstract:

OBJECTIVE:To explore genetic and environmental contributions to the influence of parental social class and region of upbringing on adult human fatness. DESIGN:Survey of sample of adults who had been adopted in childhood to relate their body mass index to sociodemographic variables in a series of multiple linear regression analyses. SUBJECTS:4643 Subjects traced from a register of 5455 non-familial adoptees registered in 1924-47, of whom 3651 gave details of current height, weight, and occupation. The final sample totalled 2015 adoptees for whom there was also information on their region of upbringing and on the social class of their adoptive and biological fathers. MAIN OUTCOME MEASURES:Age, sex, body mass index, social class (of adoptee and adoptive and biological father), and geographical region. RESULTS:There was a significant inverse relation of adoptees' body mass index with their own social class and that of both their biological and adoptive fathers. Adoptees raised in provincial areas had a significantly greater body mass index than did those raised in Copenhagen. A multivariate regression model, including age, sex, and social class of the adoptee, confirmed the significant independent influence of the social class of both adoptive and biological fathers and of region of rearing on adoptees' body mass index. CONCLUSION:Both familial environmental and genetic factors contribute to the relation of parental social class to adult fatness, and they are partly independent of the effect of an individual's own social class. The influence of region of upbringing on adult fatness is of environmental origin and is independent of social class characteristics.

journal_name

BMJ

authors

Teasdale TW,Sørensen TI,Stunkard AJ

doi

10.1136/bmj.300.6740.1615

subject

Has Abstract

pub_date

1990-06-23 00:00:00

pages

1615-8

issue

6740

eissn

0959-8138

issn

1756-1833

journal_volume

300

pub_type

杂志文章
  • Single or multiple daily doses of aminoglycosides: a meta-analysis.

    abstract:OBJECTIVE:To assess relative efficacy and toxicity of aminoglycosides given by single daily dose compared with multiple daily doses. DESIGN:Meta-analysis of 21 randomised trials identified through MEDLARS (1966 to January 1995). Data were overviewed with fixed effects and random effects models and with meta-regression...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析

    doi:10.1136/bmj.312.7027.338

    authors: Barza M,Ioannidis JP,Cappelleri JC,Lau J

    更新日期:1996-02-10 00:00:00

  • Performance evaluation of a new rapid urine test for chlamydia in men: prospective cohort study.

    abstract:OBJECTIVE:To evaluate the performance of a rapid test for chlamydia with first void male urine samples as a potential tool for diagnosis and screening of chlamydial infection in men. DESIGN:Evaluation of test performance in prospective cohort study. Settings A young people's sexual health centre (site 1) and a genitou...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.b2655

    authors: Nadala EC,Goh BT,Magbanua JP,Barber P,Swain A,Alexander S,Laitila V,Michel CE,Mahilum-Tapay L,Ushiro-Lumb I,Ison C,Lee HH

    更新日期:2009-07-28 00:00:00

  • Influence of moving to the UK on maternal health behaviours: prospective cohort study.

    abstract:OBJECTIVE:To compare health behaviours during pregnancy (smoking and alcohol consumption) and after birth (initiation and duration of breast feeding) between British/Irish white mothers and mothers from ethnic minority groups; and, in mothers from ethnic minority groups, to examine whether indicators of acculturation (...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.39532.688877.25

    authors: Hawkins SS,Lamb K,Cole TJ,Law C,Millennium Cohort Study Child Health Group.

    更新日期:2008-05-10 00:00:00

  • Improving the preregistration experience: the New Zealand approach.

    abstract::There is currently much debate about how to improve undergraduate medical education, and in particular on how best to prepare students for clinical responsibility. For 20 years a period of trainee internship has formed part of New Zealand medical students' undergraduate training, and the model could have much to offer...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.308.6925.398

    authors: Allen PI,Colls BM

    更新日期:1994-02-05 00:00:00

  • Low dose aspirin and cognitive function in the women's health study cognitive cohort.

    abstract:OBJECTIVE:To determine whether low dose aspirin protects women aged 65 or more against cognitive decline. DESIGN:Cohort study within both arms of the women's health study, a randomised, double blind, placebo controlled trial of low dose aspirin for the primary prevention of cardiovascular disease and cancer, 1992-5. ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmj.39166.597836.BE

    authors: Kang JH,Cook N,Manson J,Buring JE,Grodstein F

    更新日期:2007-05-12 00:00:00

  • Cost effectiveness of COX 2 selective inhibitors and traditional NSAIDs alone or in combination with a proton pump inhibitor for people with osteoarthritis.

    abstract:OBJECTIVES:To investigate the cost effectiveness of cyclo-oxygenase-2 (COX 2) selective inhibitors and traditional non-steroidal anti-inflammatory drugs (NSAIDs), and the addition of proton pump inhibitors to these treatments, for people with osteoarthritis. DESIGN:An economic evaluation using a Markov model and data ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.b2538

    authors: Latimer N,Lord J,Grant RL,O'Mahony R,Dickson J,Conaghan PG,National Institute for Health and Clinical Excellence Osteoarthritis Guideline Development Group.

    更新日期:2009-07-14 00:00:00

  • Residence near high voltage facilities and risk of cancer in children.

    abstract:OBJECTIVE:To investigate whether residence before and after birth near 50 Hz high voltage installations increases a child's risk of cancer and whether risk correlates with the strength of the magnetic field. DESIGN:A population based case-control study. SETTING:Denmark. SUBJECTS:1707 children under the age of 15 wit...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.307.6909.891

    authors: Olsen JH,Nielsen A,Schulgen G

    更新日期:1993-10-09 00:00:00

  • Cancer prevention in primary care. Current trends and some prospects for the future--1.

    abstract::Cancer control encompasses the whole spectrum from prevention and early diagnosis to treatment and palliation. The key to the future of cancer control will be to establish multidisciplinary approaches to each type of cancer across this spectrum. For primary prevention this requires some understanding of the causes of ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.309.6952.449

    authors: Austoker J

    更新日期:1994-08-13 00:00:00

  • Community care in London: the prospects.

    abstract::Elderly and disabled people have been led to expect great improvements in the quality of community care after April 1993. The choice to live safely at home is to be offered as an alternative to residential care. The financial and organisational relationships are all intended to support this in practice. The Tomlinson ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.305.6866.1418

    authors: Jowell T

    更新日期:1992-12-05 00:00:00

  • Trial of support treatment with human chorionic gonadotrophin in the luteal phase after treatment with buserelin and human menopausal gonadotrophin in women taking part in an in vitro fertilisation programme.

    abstract:OBJECTIVE:To evaluate the effect of support with human chorionic gonadotrophin in the luteal phase in women taking part in an in vitro fertilisation programme after buserelin and human menopausal gonadotrophin were used to hyperstimulate their ovaries. DESIGN:Controlled group comparison. SETTING:Outpatient department...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章

    doi:10.1136/bmj.298.6686.1483

    authors: Smith EM,Anthony FW,Gadd SC,Masson GM

    更新日期:1989-06-03 00:00:00

  • The impact on general practitioners of the changing balance of care for elderly people living in institutions.

    abstract:OBJECTIVES:To describe utilisation of general practitioners by elderly people resident in communal establishments; to examine variations in general practitioner utilisation and estimate the likely impact of the "downsizing" of long stay provision in NHS hospitals. DESIGN:Secondary analyses of the survey of disability ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.317.7154.322

    authors: Kavanagh S,Knapp M

    更新日期:1998-08-01 00:00:00

  • Female streetworking prostitution and HIV infection in Glasgow.

    abstract:OBJECTIVES:To identify the extent of HIV infection and injecting drug use among female streetworking prostitutes in Glasgow; to estimate the size of the female streetworking prostitute population in the city; and to estimate the number of HIV positive women working as prostitutes on the streets in Glasgow. DESIGN:Obse...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.305.6857.801

    authors: McKeganey N,Barnard M,Leyland A,Coote I,Follet E

    更新日期:1992-10-03 00:00:00

  • Education, income inequality, and mortality: a multiple regression analysis.

    abstract:OBJECTIVE:To test whether the relation between income inequality and mortality found in US states is because of different levels of formal education. DESIGN:Cross sectional, multiple regression analysis. SETTING:All US states and the District of Columbia (n=51). DATA SOURCES:US census statistics and vital statistics...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.324.7328.23

    authors: Muller A

    更新日期:2002-01-05 00:00:00

  • Familial risks of squamous cell carcinoma of the head and neck: retrospective case-control study.

    abstract:OBJECTIVE:To determine the contribution of inheritance to the incidence of squamous cell carcinoma of the head and neck. DESIGN:Historical cohort study. First degree relatives of cases with squamous cell carcinoma of the head and neck made up the exposed cohort and first degree relatives of spouses of cases made up th...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.313.7059.716

    authors: Foulkes WD,Brunet JS,Sieh W,Black MJ,Shenouda G,Narod SA

    更新日期:1996-09-21 00:00:00

  • Effectiveness of teaching general practitioners skills in brief cognitive behaviour therapy to treat patients with depression: randomised controlled trial.

    abstract:OBJECTIVE:To assess the effectiveness of teaching general practitioners skills in brief cognitive behaviour therapy. DESIGN:Parallel group, cluster randomised, controlled trial of an educational package on cognitive behaviour therapy. SETTING:General practices in north London. PARTICIPANTS:84 general practitioner pr...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.324.7343.947

    authors: King M,Davidson O,Taylor F,Haines A,Sharp D,Turner R

    更新日期:2002-04-20 00:00:00

  • Classroom based cognitive behavioural therapy in reducing symptoms of depression in high risk adolescents: pragmatic cluster randomised controlled trial.

    abstract:OBJECTIVE:To compare the effectiveness of classroom based cognitive behavioural therapy with attention control and usual school provision for adolescents at high risk of depression. DESIGN:Three arm parallel cluster randomised controlled trial. SETTING:Eight UK secondary schools. PARTICIPANTS:Adolescents (n=5030) ag...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmj.e6058

    authors: Stallard P,Sayal K,Phillips R,Taylor JA,Spears M,Anderson R,Araya R,Lewis G,Millings A,Montgomery AA

    更新日期:2012-10-05 00:00:00

  • Diet and cancer.

    abstract::Accumulating data indicate that modifications in diet may reduce the risk of cancer by as much as one third and possibly by as much as two thirds. On the basis of the existing evidence, however, it is not possible to be certain which cancers are causally related to diet and what proportion of them are due to specific ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.308.6944.1610

    authors: Austoker J

    更新日期:1994-06-18 00:00:00

  • Bone density and risk of hip fracture in men and women: cross sectional analysis.

    abstract:OBJECTIVE:To determine the relative contribution of decline in bone density to the increase in risk of hip fracture with age in men and women. DESIGN:Incidence data of hip fracture from the general population were combined with the bone density distribution in a sample from the same population and with a risk estimate...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.315.7102.221

    authors: De Laet CE,van Hout BA,Burger H,Hofman A,Pols HA

    更新日期:1997-07-26 00:00:00

  • Sleep related vehicle accidents.

    abstract:OBJECTIVES:To assess the incidence, time of day, and driver morbidity associated with vehicle accidents where the most likely cause was the driver falling asleep at the wheel. DESIGN:Two surveys were undertaken, in southwest England and the midlands, by using police databases or on the spot interviews. SUBJECTS:Drive...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.310.6979.565

    authors: Horne JA,Reyner LA

    更新日期:1995-03-04 00:00:00

  • Informed choice for users of health services: views on ultrasonography leaflets of women in early pregnancy, midwives, and ultrasonographers.

    abstract::With the aim of promoting the informed choice of pregnant women, staff and pregnant women at two urban hospitals were offered leaflets summarising the best available evidence about the effectiveness of routine ultrasonography in early pregnancy. Ultrasonographers doubted the credibility of the evidence and were concer...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.313.7067.1251a

    authors: Oliver S,Rajan L,Turner H,Oakley A,Entwistle V,Watt I,Sheldon TA,Rosser J

    更新日期:1996-11-16 00:00:00

  • Attendance at cultural events, reading books or periodicals, and making music or singing in a choir as determinants for survival: Swedish interview survey of living conditions.

    abstract:OBJECTIVES:To investigate the possible influence of attendance at cultural events, reading books or periodicals, making music or singing in a choir as determinants for survival. DESIGN:A simple random sample was drawn of 15,198 individuals aged 16-74 years. Of these, 85% (12,982) were interviewed by trained non-medica...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.313.7072.1577

    authors: Bygren LO,Konlaan BB,Johansson SE

    更新日期:1996-12-21 00:00:00

  • Nutritional status and mortality of refugee and resident children in a non-camp setting during conflict: follow up study in Guinea-Bissau.

    abstract:OBJECTIVE:To study the effects on children of humanitarian aid agencies restricting help to refugee families (internally displaced people). DESIGN:Follow up study of 3 months. SETTING:Prabis peninsular outside Bissau, the capital of Guinea-Bissau, which has functioned as a refugee area for internally displaced people...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.319.7214.878

    authors: Aaby P,Gomes J,Fernandes M,Djana Q,Lisse I,Jensen H

    更新日期:1999-10-02 00:00:00

  • Association between body mass index and cardiovascular disease mortality in east Asians and south Asians: pooled analysis of prospective data from the Asia Cohort Consortium.

    abstract:OBJECTIVE:To evaluate the association between body mass index and mortality from overall cardiovascular disease and specific subtypes of cardiovascular disease in east and south Asians. DESIGN:Pooled analyses of 20 prospective cohorts in Asia, including data from 835,082 east Asians and 289,815 south Asians. Cohorts w...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/bmj.f5446

    authors: Chen Y,Copeland WK,Vedanthan R,Grant E,Lee JE,Gu D,Gupta PC,Ramadas K,Inoue M,Tsugane S,Tamakoshi A,Gao YT,Yuan JM,Shu XO,Ozasa K,Tsuji I,Kakizaki M,Tanaka H,Nishino Y,Chen CJ,Wang R,Yoo KY,Ahn YO,Ahsan H,

    更新日期:2013-10-01 00:00:00

  • Cardiovascular safety of central nervous system stimulants in children and adolescents: population based cohort study.

    abstract:OBJECTIVES:To evaluate the cardiac safety of central nervous system stimulants in children and adolescents. DESIGN:Population based retrospective cohort study. SETTING:Automated healthcare claims data from 1,219,847 children and young people eligible for 28 state Medicaid programmes from 1999 to 2006 linked to the So...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.e4627

    authors: Winterstein AG,Gerhard T,Kubilis P,Saidi A,Linden S,Crystal S,Zito J,Shuster JJ,Olfson M

    更新日期:2012-07-18 00:00:00

  • Beta lactam monotherapy versus beta lactam-aminoglycoside combination therapy for fever with neutropenia: systematic review and meta-analysis.

    abstract:OBJECTIVE:To compare the effectiveness of beta lactam monotherapy versus beta lactam-aminoglycoside combination therapy in the treatment of patients with fever and neutropenia. DATA SOURCES:Medline, Embase, Lilacs, the Cochrane Library, and conference proceedings to 2002. References of included studies and contact wit...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/bmj.326.7399.1111

    authors: Paul M,Soares-Weiser K,Leibovici L

    更新日期:2003-05-24 00:00:00

  • Risk of heart failure after community acquired pneumonia: prospective controlled study with 10 years of follow-up.

    abstract::Objective To determine the attributable risk of community acquired pneumonia on incidence of heart failure throughout the age range of affected patients and severity of the infection.Design Cohort study.Setting Six hospitals and seven emergency departments in Edmonton, Alberta, Canada, 2000-02.Participants 4988 adults...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.j413

    authors: Eurich DT,Marrie TJ,Minhas-Sandhu JK,Majumdar SR

    更新日期:2017-02-13 00:00:00

  • Adverse drug reactions to tocolytic treatment for preterm labour: prospective cohort study.

    abstract:OBJECTIVE:To evaluate the incidence of serious maternal complications after the use of various tocolytic drugs for the treatment of preterm labour in routine clinical situations. DESIGN:Prospective cohort study. SETTING:28 hospitals in the Netherlands and Belgium. PARTICIPANTS:1920 consecutive women treated with toc...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.b744

    authors: de Heus R,Mol BW,Erwich JJ,van Geijn HP,Gyselaers WJ,Hanssens M,Härmark L,van Holsbeke CD,Duvekot JJ,Schobben FF,Wolf H,Visser GH

    更新日期:2009-03-05 00:00:00

  • How good is general practice developmental screening?

    abstract::All developmental screening in Somerset is performed by general practitioners and health visitors. A retrospective review of a cohort of 1504 7 year old children living in semirural Somerset found that the development assessment by a health visitor at age 3 1/2 years had a sensitivity of 45% for identifying the 103 ch...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.300.6733.1177

    authors: Dearlove J,Kearney D

    更新日期:1990-05-05 00:00:00

  • Injuries from antipersonnel mines: the experience of the International Committee of the Red Cross.

    abstract:OBJECTIVE:To describe and quantify patterns of injury from antipersonnel mines in terms of distribution of injury, drain on surgical resources, and residual disability. DESIGN:Retrospective analysis. SETTING:Two hospitals for patients injured in war. SUBJECTS:757 patients with injuries from antipersonnel mines. MAI...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.303.6816.1509

    authors: Coupland RM,Korver A

    更新日期:1991-12-14 00:00:00

  • Implications of childhood obesity for adult health: findings from thousand families cohort study.

    abstract:OBJECTIVE:To determine whether being overweight in childhood increases adult obesity and risk of disease. DESIGN:Prospective cohort study. SETTING:City of Newcastle upon Tyne. PARTICIPANTS:932 members of thousand families 1947 birth cohort, of whom 412 attended for clinical examination age 50. MAIN OUTCOME MEASURES...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.323.7324.1280

    authors: Wright CM,Parker L,Lamont D,Craft AW

    更新日期:2001-12-01 00:00:00