Purpura and dermal thinning associated with high dose inhaled corticosteroids.

Abstract:

OBJECTIVE:To assess the effect of high dose inhaled corticosteroids on skin. DESIGN:Cross sectional study of patients receiving treatment for chest diseases. SETTING:Outpatient chest clinic in a teaching hospital. PATIENTS:68 Patients divided into four groups of similar age--namely, 15 receiving long term oral prednisolone, 21 receiving high dose inhaled corticosteroids, 15 receiving low dose inhaled corticosteroids, and 17 controls. MAIN OUTCOME MEASURES:Skin thickness at three sites measured by A scan ultrasound and clinical assessment of purpura. RESULTS:Compared with controls patients in both the oral prednisolone treated group and the high dose inhaled corticosteroid treated group had significantly thinner skin at all three sites (group median thicknesses: prednisolone treated group 28-33% less than controls; high dose inhaled corticosteroid treated group 15-19% less than controls). Differences in skin thicknesses between the low dose inhaled corticosteroid treated group and the controls were trivial. The prevalence of purpura was significantly greater in patients receiving oral prednisolone (12/15 patients) and high dose inhaled corticosteroids (10/21) than in controls (2/17). CONCLUSION:Skin thinning and purpura represent further evidence of systemic effects of high dose inhaled corticosteroids.

journal_name

BMJ

authors

Capewell S,Reynolds S,Shuttleworth D,Edwards C,Finlay AY

doi

10.1136/bmj.300.6739.1548

subject

Has Abstract

pub_date

1990-06-16 00:00:00

pages

1548-51

issue

6739

eissn

0959-8138

issn

1756-1833

journal_volume

300

pub_type

杂志文章
  • Increased risk of atherosclerosis in women after the menopause.

    abstract::An increase in the incidence of cardiovascular disease has generally been observed in postmenopausal women, but there have been few studies of the association between menopausal state and atherosclerosis. In this study 294 premenopausal and 319 postmenopausal women aged 45 to 55 were examined radiographically for calc...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.298.6674.642

    authors: Witteman JC,Grobbee DE,Kok FJ,Hofman A,Valkenburg HA

    更新日期:1989-03-11 00:00:00

  • Waiting times for carotid endarterectomy in UK: observational study.

    abstract:OBJECTIVES:To assess timeliness of carotid endarterectomy services in the United Kingdom. DESIGN:Observational study with follow-up to March 2008. SETTING:UK hospitals performing carotid endarterectomy. PARTICIPANTS:UK surgeons undertaking carotid endarterectomy from December 2005 to December 2007. MAIN OUTCOME MEA...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.b1847

    authors: Halliday AW,Lees T,Kamugasha D,Grant R,Hoffman A,Rothwell PM,Potter JF,Horrocks M,Naylor R,Rudd AG,Carotid Endarterectomy Steering Group.,Clinical Effectiveness and Evaluation Unit, Royal College of Physicians.,Vascular Society o

    更新日期:2009-06-04 00:00:00

  • Efficacy of PD-1 or PD-L1 inhibitors and PD-L1 expression status in cancer: meta-analysis.

    abstract:OBJECTIVE:To evaluate the relative efficacy of programmed cell death 1 (PD-1) or programmed cell death ligand 1 (PD-L1) inhibitors versus conventional drugs in patients with cancer that were PD-L1 positive and PD-L1 negative. DESIGN:Meta-analysis of randomised controlled trials. DATA SOURCES:PubMed, Embase, Cochrane ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析

    doi:10.1136/bmj.k3529

    authors: Shen X,Zhao B

    更新日期:2018-09-10 00:00:00

  • How well can radiographers triage x ray films in accident and emergency departments?

    abstract:OBJECTIVE:To assess the ability of radiographers to identify abnormal radiographs of patients attending accident and emergency departments. DESIGN:Prospective study over six weeks. SETTING:Teaching hospital casualty x ray department. PATIENTS:3394 consecutive patients referred for radiography. INTERVENTIONS:Radiogr...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章

    doi:10.1136/bmj.302.6776.568

    authors: Renwick IG,Butt WP,Steele B

    更新日期:1991-03-09 00:00:00

  • Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis.

    abstract:OBJECTIVES:To compare the efficacy and tolerability of butterbur (Petasites hybridus) with cetirizine in patients with seasonal allergic rhinitis (hay fever). DESIGN:Randomised, double blind, parallel group comparison. SETTING:Four outpatient general medicine and allergy clinics in Switzerland and Germany. PARTICIPA...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.324.7330.144

    authors: Schapowal A,Petasites Study Group.

    更新日期:2002-01-19 00:00:00

  • Fifteen year quality of life outcomes in men with localised prostate cancer: population based Australian prospective study.

    abstract:OBJECTIVE:To assess treatment related changes in quality of life up to 15 years after diagnosis of localised prostate cancer. DESIGN:Population based, prospective cohort study with follow-up over 15 years. SETTING:New South Wales, Australia. PARTICIPANTS:1642 men with localised prostate cancer, aged less than 70, an...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.m3503

    authors: Mazariego CG,Egger S,King MT,Juraskova I,Woo H,Berry M,Armstrong BK,Smith DP

    更新日期:2020-10-07 00:00:00

  • Impact of rice based oral rehydration solution on stool output and duration of diarrhoea: meta-analysis of 13 clinical trials.

    abstract:OBJECTIVE:To define the benefit of rice oral rehydration salts solution in relation to the glucose based World Health Organisation oral rehydration salts solution for treating and preventing dehydration in patients with severe dehydrating diarrhoea. DESIGN:Meta-analysis using data from 13 available randomised trials t...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析

    doi:10.1136/bmj.304.6822.287

    authors: Gore SM,Fontaine O,Pierce NF

    更新日期:1992-02-01 00:00:00

  • Use of vitamin B-12 in Leicestershire practices: a single topic audit led by a medical audit advisory group.

    abstract:OBJECTIVE:To encourage active participation of Leicestershire general practitioners and their staff in audit; to examine the use of vitamin B-12 injections and to achieve a more appropriate use. DESIGN:Implementation of an agreed audit protocol, with central analysis and feedback of anonymous and aggregated data by a ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.311.6996.28

    authors: Fraser RC,Farooqi A,Sorrie R

    更新日期:1995-07-01 00:00:00

  • Effects of obesity and weight loss on left ventricular mass and relative wall thickness: survey and intervention study.

    abstract:OBJECTIVES:To investigate the consequences of longstanding obesity on left ventricular mass and structure and to examine the effects of weight loss on these variables. DESIGN:Cross sectional survey and controlled intervention study. SETTING:City of Gothenburg and surrounding areas. Sweden. SUBJECTS:41 obese patients...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.315.7113.912

    authors: Karason K,Wallentin I,Larsson B,Sjöström L

    更新日期:1997-10-11 00:00:00

  • Immune response to a new hepatitis B vaccine in healthcare workers who had not responded to standard vaccine: randomised double blind dose-response study.

    abstract:OBJECTIVE:To evaluate the immunogenicity and reactogenicity of a new triple S recombinant hepatitis B vaccine in a cohort of healthy people in whom currently licensed hepatitis B vaccines had persistently not induced an immune response. DESIGN:Single centre, randomised, double blind, dose-response study. SETTING:Rese...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.314.7077.329

    authors: Zuckerman JN,Sabin C,Craig FM,Williams A,Zuckerman AJ

    更新日期:1997-02-01 00:00:00

  • Altered calcitonin gene in a young patient with osteoporosis.

    abstract::To assess whether calcitonin is important in maintaining the integrity of bone the calcitonin gene of a young male patient with osteoporosis and no detectable plasma concentrations of calcitonin was studied. Genomic Southern blots with various restriction enzymes showed no large abnormalities in his calcitonin gene. G...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,收录出版

    doi:10.1136/bmj.298.6682.1215

    authors: Alevizaki M,Stevenson JC,Girgis SI,MacIntyre I,Legon S

    更新日期:1989-05-06 00:00:00

  • Case-control study of self reported genitourinary infections and risk of gastroschisis: findings from the national birth defects prevention study, 1997-2003.

    abstract:OBJECTIVE:To assess the association between genitourinary infections in the month before conception to the end of the first trimesterand gastroschisis. DESIGN:Case-control study with self reported infections from a computer assisted telephone interview. SETTING:National birth defects prevention study, a multisite, po...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.39567.509074.25

    authors: Feldkamp ML,Reefhuis J,Kucik J,Krikov S,Wilson A,Moore CA,Carey JC,Botto LD

    更新日期:2008-06-21 00:00:00

  • Protective efficacy of standard Edmonston-Zagreb measles vaccination in infants aged 4.5 months: interim analysis of a randomised clinical trial.

    abstract:OBJECTIVE:To examine the protective efficacy of measles vaccination in infants in a low income country before 9 months of age. DESIGN:Randomised clinical trial. PARTICIPANTS:1333 infants aged 4.5 months: 441 in treatment group and 892 in control group. SETTING:Urban area in Guinea-Bissau. INTERVENTION:Measles vacci...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmj.a661

    authors: Martins CL,Garly ML,Balé C,Rodrigues A,Ravn H,Whittle HC,Lisse IM,Aaby P

    更新日期:2008-07-24 00:00:00

  • Radiography of the lumbar spine in primary care patients with low back pain: randomised controlled trial.

    abstract:OBJECTIVE:To test the hypothesis that radiography of the lumbar spine in patients with low back pain is not associated with improved clinical outcomes or satisfaction with care. DESIGN:Randomised unblinded controlled trial. SETTING:73 general practices in Nottingham, north Nottinghamshire, southern Derbyshire, north ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmj.322.7283.400

    authors: Kendrick D,Fielding K,Bentley E,Kerslake R,Miller P,Pringle M

    更新日期:2001-02-17 00:00:00

  • Heat and risk of myocardial infarction: hourly level case-crossover analysis of MINAP database.

    abstract:OBJECTIVE:To quantify the association between exposure to higher temperatures and the risk of myocardial infarction at an hourly temporal resolution. DESIGN:Case-crossover study. SETTING:England and Wales Myocardial Ischaemia National Audit Project (MINAP) database. PARTICIPANTS:24,861 hospital admissions for myocar...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.e8050

    authors: Bhaskaran K,Armstrong B,Hajat S,Haines A,Wilkinson P,Smeeth L

    更新日期:2012-12-13 00:00:00

  • Subacromial decompression surgery for adults with shoulder pain: a clinical practice guideline.

    abstract:CLINICAL QUESTION:Do adults with atraumatic shoulder pain for more than 3 months diagnosed as subacromial pain syndrome (SAPS), also labelled as rotator cuff disease, benefit from subacromial decompression surgery? This guideline builds on to two recent high quality trials of shoulder surgery. CURRENT PRACTICE:SAPS is...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.l294

    authors: Vandvik PO,Lähdeoja T,Ardern C,Buchbinder R,Moro J,Brox JI,Burgers J,Hao Q,Karjalainen T,van den Bekerom M,Noorduyn J,Lytvyn L,Siemieniuk RAC,Albin A,Shunjie SC,Fisch F,Proulx L,Guyatt G,Agoritsas T,Poolman RW

    更新日期:2019-02-06 00:00:00

  • Use of inhaled corticosteroids during pregnancy and risk of pregnancy induced hypertension: nested case-control study.

    abstract:OBJECTIVE:To determine whether the use of inhaled corticosteroids during pregnancy increases the risk of pregnancy induced hypertension and pre-eclampsia among asthmatic women. DESIGN:Nested case-control study. SETTING:Three administrative health databases from Quebec: RAMQ, MED-ECHO, and Fichier des evenements demog...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.38313.624352.8F

    authors: Martel MJ,Rey E,Beauchesne MF,Perreault S,Lefebvre G,Forget A,Blais L

    更新日期:2005-01-29 00:00:00

  • The World Health Organisation needs to reconsider its definition of health.

    abstract::The World Health Organization's (WHO) definition of health as "a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity" had the merit of widening concepts of health to include psychological and social aspects, but is of no practical use. In fact, this statement m...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.314.7091.1409

    authors: Saracci R

    更新日期:1997-05-10 00:00:00

  • Abortion laws cause problems in Poland.

    abstract::A doctor who performed an abortion in Poland faces two years in prison and the loss of his medical license for up to 10 years if he is found guilty of violating the new abortion laws introduced in 1993 after a lengthy campaign by the Catholic church and the Christian Democratic Union party. The new laws permit aborti...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 新闻

    doi:10.1136/bmj.310.6994.1556a

    authors: Gajewski M

    更新日期:1995-06-17 00:00:00

  • Use of magnetic resonance angiography to select candidates with recently symptomatic carotid stenosis for surgery: systematic review.

    abstract:OBJECTIVE:To determine if sufficient evidence exists to support the use of magnetic resonance angiography as a means of selecting patients with recently symptomatic high grade carotid stenosis for surgery. DESIGN:Systematic review of published research on the diagnostic performance of magnetic resonance angiography, 1...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.324.7331.198

    authors: Westwood ME,Kelly S,Berry E,Bamford JM,Gough MJ,Airey CM,Meaney JF,Davies LM,Cullingworth J,Smith MA

    更新日期:2002-01-26 00:00:00

  • Diet and cancer.

    abstract::Accumulating data indicate that modifications in diet may reduce the risk of cancer by as much as one third and possibly by as much as two thirds. On the basis of the existing evidence, however, it is not possible to be certain which cancers are causally related to diet and what proportion of them are due to specific ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.308.6944.1610

    authors: Austoker J

    更新日期:1994-06-18 00:00:00

  • Randomised trial of personalised computer based information for cancer patients.

    abstract:OBJECTIVE:To compare the use and effect of a computer based information system for cancer patients that is personalised using each patient's medical record with a system providing only general information and with information provided in booklets. DESIGN:Randomised trial with three groups. Data collected at start of r...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.319.7219.1241

    authors: Jones R,Pearson J,McGregor S,Cawsey AJ,Barrett A,Craig N,Atkinson JM,Gilmour WH,McEwen J

    更新日期:1999-11-06 00:00:00

  • Evaluation of a call programme for cervical cytology screening in women aged 50-60.

    abstract::For many years Tayside has benefited from a successful opportunistic cytology screening programme. In recent years, however, the decrease in mortality due to cervical cancer has levelled off, with most cases of severe disease arising in women who have not been screened. In view of this the health board developed a new...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.299.6692.163

    authors: Robertson AJ,Reid GS,Stoker CA,Bissett C,Waugh N,Fenton I,Rowan J,Halkerston R

    更新日期:1989-07-15 00:00:00

  • Efficacy of lipid lowering drug treatment for diabetic and non-diabetic patients: meta-analysis of randomised controlled trials.

    abstract:OBJECTIVE:To evaluate the clinical benefit of lipid lowering drug treatment in patients with and without diabetes mellitus, for primary and secondary prevention. DESIGN:Systematic review and meta-analysis. DATA SOURCES:Cochrane, Medline, Embase, and reference lists up to April 2004. STUDY SELECTION:Randomised, place...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/bmj.38793.468449.AE

    authors: Costa J,Borges M,David C,Vaz Carneiro A

    更新日期:2006-05-13 00:00:00

  • Accuracy of the "traffic light" clinical decision rule for serious bacterial infections in young children with fever: a retrospective cohort study.

    abstract:OBJECTIVES:To determine the accuracy of a clinical decision rule (the traffic light system developed by the National Institute for Health and Clinical Excellence (NICE)) for detecting three common serious bacterial infections (urinary tract infection, pneumonia, and bacteraemia) in young febrile children. DESIGN:Retro...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.f866

    authors: De S,Williams GJ,Hayen A,Macaskill P,McCaskill M,Isaacs D,Craig JC

    更新日期:2013-02-13 00:00:00

  • Non-specific immunological effects of selected routine childhood immunisations: systematic review.

    abstract:OBJECTIVE: To identify and characterise non-specific immunological effects after routine childhood vaccines against BCG, measles, diphtheria, pertussis, and tetanus. DESIGN: Systematic review of randomised controlled trials, cohort studies, and case-control studies. DATA SOURCES: Embase, PubMed, Cochrane library, and...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.i5225

    authors: Kandasamy R,Voysey M,McQuaid F,de Nie K,Ryan R,Orr O,Uhlig U,Sande C,O'Connor D,Pollard AJ

    更新日期:2016-10-13 00:00:00

  • Secondary prevention of coronary heart disease in older patients after the national service framework: population based study.

    abstract:OBJECTIVE:To examine the extent of uptake of medication for secondary prevention of coronary heart disease in older British men and women before (1998-2001) and after (2003) the implementation of the national service framework. DESIGN:Two population based, longitudinal studies of men and women aged 60-79 in 1998-2001,...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.38704.770127.BE

    authors: Ramsay SE,Whincup PH,Lawlor DA,Papacosta O,Lennon LT,Thomas MC,Ebrahim S,Morris RW

    更新日期:2006-01-21 00:00:00

  • Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE-RAD-RISK).

    abstract:OBJECTIVE:To estimate the risk of breast cancer associated with diagnostic radiation in carriers of BRCA1/2 mutations. DESIGN:Retrospective cohort study (GENE-RAD-RISK). SETTING:Three nationwide studies (GENEPSO, EMBRACE, HEBON) in France, United Kingdom, and the Netherlands, PARTICIPANTS:1993 female carriers of BRC...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.e5660

    authors: Pijpe A,Andrieu N,Easton DF,Kesminiene A,Cardis E,Noguès C,Gauthier-Villars M,Lasset C,Fricker JP,Peock S,Frost D,Evans DG,Eeles RA,Paterson J,Manders P,van Asperen CJ,Ausems MG,Meijers-Heijboer H,Thierry-Chef I,Hau

    更新日期:2012-09-06 00:00:00

  • Randomised trial of heroin maintenance programme for addicts who fail in conventional drug treatments.

    abstract:OBJECTIVE:To evaluate an experimental heroin maintenance programme. DESIGN:Randomised trial. SETTING:Outpatient clinic in Geneva, Switzerland. SUBJECTS:Heroin addicts recruited from the community who were socially marginalised and in poor health and had failed in at least two previous drug treatments. INTERVENTION:...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.317.7150.13

    authors: Perneger TV,Giner F,del Rio M,Mino A

    更新日期:1998-07-04 00:00:00

  • Substance use in remand prisoners: a consecutive case study.

    abstract:OBJECTIVES:To determine the prevalence of drug and alcohol use among newly remanded prisoners, assess the effectiveness of prison reception screening, and examine the clinical management of substance misusers among remand prisoners. DESIGN:A consecutive case study of remand prisoners screened at reception for substanc...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.315.7099.18

    authors: Mason D,Birmingham L,Grubin D

    更新日期:1997-07-05 00:00:00