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Glucose-stimulated insulin secretion: Effects of high-fat diet and acute stress.

Abstract：

BACKGROUND:One of the major topics in modern societies is the study of relationships between diet, stress and incidence of metabolic disorders. AIM:This study aimed to investigate possible impairment in glucose-stimulated insulin secretion induced by a high-fat (cow intra-abdominal fat) diet in response to acute stress. MATERIALS AND METHODS:Male Wistar rats were divided into high-fat and normal diet groups and each group was further divided into stress and control subgroups. Stress was induced by a communication box. Plasma levels of glucose, insulin and corticosterone were measured in both diet groups. Glucose tolerance, homeostasis model assessment of insulin resistance (HOMA-IR) index, glucose-stimulated insulin secretion from isolated islets, food and energy intake as well as body weight were also evaluated. RESULTS:In the normal diet group, physical stress increased plasma glucose concentrations. In both diet groups, plasma corticosterone levels increased after stress. HOMA-IR index decreased in high-fat fed rats. Food intake decreased while energy intake increased in the high-fat diet rats. Body weight in both diet groups increased in a similar manner. The high-fat diet did not affect insulin secretion; however, stress decreased insulin secretion from isolated islets of both diet groups. Only in the high fat diet group did physical stress increase insulin secretion at 16.7 mM glucose. CONCLUSIONS:The cow intra-abdominal fat, did not affect either plasma glucose and insulin concentrations or glucose-induced insulin secretion. Interestingly, it seems that the high-fat diet enabled the islets of the physically stressed rats to secrete more insulin in response to high glucose concentrations.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Ghalami J,Zardooz H,Rostamkhani F,Farrokhi B,Hedayati M

doi

10.3275/8959

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

835-42

issue

10

eissn

0391-4097

issn

1720-8386

pii

8959

journal_volume

36

pub_type

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