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Activating mutations and senescence secretome: new insights into HER2 activation, drug sensitivity and metastatic progression.

Abstract：

:HER2 amplification and overexpression is observed in approximately 20% of breast cancers and is strongly associated with poor prognosis and therapeutic responsiveness to HER2 targeted agents. A recent study by Bose and colleagues suggests that another subset of breast cancer patients without HER2 amplification but with activating HER2 mutation might also benefit from existing HER2-targeted agents and the authors functionally characterize these somatic mutations in experimental models. In a second study on HER2-driven breast cancer, Angelini and colleagues investigate how the constitutively active, truncated carboxy-terminal fragment of HER2, p95HER2, promotes metastatic progression through non-cellautonomous secretion of factors from senescent cells. These new findings advance our understanding of HER2 biology in the context of HER2 activation as well as offer new insights into our understanding of drug sensitivity and metastatic progression.

journal_name

Breast Cancer Res

journal_title

Breast cancer research : BCR

authors

Acharyya S

doi

10.1186/bcr3406

subject

Has Abstract

pub_date

2013-04-23 00:00:00

pages

309

issue

2

eissn

1465-5411

issn

1465-542X

pii

bcr3406

journal_volume

15

pub_type

杂志文章

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