Abstract:
:Personalized nutrition has the potential to enhance individual health control. It could be seen as a means to strengthen people's autonomy as they learn more about their personal health risks, and receive dietary advice accordingly. We examine in what sense personalized nutrition strengthens or weakens individual autonomy. The impact of personalized nutrition on autonomy is analyzed in relation to responsibility and trustworthiness. On a societal level, individualization of health promotion may be accompanied by the attribution of extended individual responsibility for one's health. This constitutes a dilemma of individualization, caused by a conflict between the right to individual freedom and societal interests. The extent to which personalized nutrition strengthens autonomy is consequently influenced by how responsibility for health is allocated to individuals. Ethically adequate allocation of responsibility should focus on prospective responsibility and be differentiated with regard to individual differences concerning the capacity of adults to take responsibility. The impact of personalized nutrition on autonomy also depends on its methodological design. Owing to the complexity of information received, personalized nutrition through genetic testing (PNTGT) is open to misinterpretation and may not facilitate informed choices and autonomy. As new technologies, personalized nutrition and PNTGT are subject to issues of trust. To strengthen autonomy, trust should be approached in terms of trustworthiness. Trustworthiness implies that an organization that develops or introduces personalized nutrition can show that it is competent to deal with both the technical and moral dimensions at stake and that its decisions are motivated by the interests and expectations of the truster.
journal_name
Genes Nutrjournal_title
Genes & nutritionauthors
Nordström K,Juth N,Kjellström S,Meijboom FL,Görman U,Food4Me project.doi
10.1007/s12263-013-0337-7subject
Has Abstractpub_date
2013-07-01 00:00:00pages
365-72issue
4eissn
1555-8932issn
1865-3499journal_volume
8pub_type
杂志文章abstract::The nuclear factor (NF)-kappaB is a primary regulator of inflammatory responses and may be linked to pathology associated with obesity. We investigated the progression of NF-kappaB activity during a 12-week feeding period on a high-fat diet (HFD) or a low-fat diet (LFD) using NF-kappaB luciferase reporter mice. In viv...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-009-0133-6
更新日期:2009-09-01 00:00:00
abstract::There is a growing interest in assessing dietary intake more accurately across different population groups, and biomarkers have emerged as a complementary tool to replace traditional dietary assessment methods. The purpose of this study was to conduct a systematic review of the literature available and evaluate the ap...
journal_title:Genes & nutrition
pub_type: 杂志文章,评审
doi:10.1186/s12263-018-0614-6
更新日期:2018-09-10 00:00:00
abstract::The aim of this study was to examine the relationship between the L55M and Q192R paraoxonase (PON1) polymorphisms and obesity in a population of adult Mexican workers. The study population included 127 adult individuals from the Universidad Autónoma del Estado de Morelos, ranging in age from 20 to 56 years and represe...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-011-0215-0
更新日期:2011-11-01 00:00:00
abstract::While the effects of chronic ethanol consumption on liver have been well studied and documented, its effect on the cardiovascular system is bimodal. Thus, moderate drinking in many population studies is related to lower prevalence of coronary artery disease (CAD). In contrast, heavy drinking correlates with higher pre...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-009-0161-2
更新日期:2010-06-01 00:00:00
abstract::Fish aquaculture is considered to be one of the most sustainable sources of protein for humans. Many different species are cultured worldwide, but among them, marine flatfishes comprise a group of teleosts of high commercial interest because of their highly prized white flesh. However, the aquaculture of these fishes ...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-012-0312-8
更新日期:2013-01-01 00:00:00
abstract::Moderate maternal calorie restriction during lactation protects rat offspring against obesity development in adulthood, due to an improved ability to handle and store excess dietary fuel. We used this model to identify early transcriptome-based biomarkers of metabolic health using peripheral blood mononuclear cells (P...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-013-0366-2
更新日期:2014-01-01 00:00:00
abstract:UNLABELLED:Intake of anthocyanin-rich foods has been associated with a reduced risk of cardiovascular diseases. Supplementation with anthocyanin-rich extracts from black rice or purple sweet potato was reported to attenuate atherosclerotic lesion development in apolipoprotein E-deficient (apo E(-/-)) mice. However, the...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-010-0171-0
更新日期:2010-12-01 00:00:00
abstract::Candidate gene association studies in cardiovascular diseases have provided evidence on the molecular basis of phenotypic differences between individuals. The comprehension of how inherited genetic variants are able to affect protein functions has increased the knowledge of how genes interact with environment in order...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-010-0193-7
更新日期:2011-02-01 00:00:00
abstract::A complex and heterogeneous microflora performs sugar and lactic acid fermentations in food products. Depending on the fermentable food matrix (dairy, meat, vegetable etc.) as well as on the species composition of the microbiota, specific combinations of molecules are produced that confer unique flavor, texture, and t...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-011-0226-x
更新日期:2011-08-01 00:00:00
abstract::Recent immunohistochemical characterization of the copper transport protein, Ctr1, reported enriched levels in mouse choroid plexus, and enhancement by copper deficiency. To extend and confirm this, experiments were conducted with Holtzman rats. Following perinatal copper deficiency there was an 80% reduction in brain...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/BF02829936
更新日期:2006-03-01 00:00:00
abstract::Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), riboflavin-dependent enzymes, participate in homocysteine metabolism. Reported effects of riboflavin status on the association between the MTHFR 677C>T polymorphism and homocysteine vary, and the effects of the MTRR 66A>G or MTRR 524...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-014-0435-1
更新日期:2014-11-01 00:00:00
abstract::Identification of new biomarkers of food and nutrient intake has developed fast over the past two decades and could potentially provide important new tools for compliance monitoring and dietary intake assessment in nutrition and health science. In recent years, metabolomics has played an important role in identifying ...
journal_title:Genes & nutrition
pub_type: 杂志文章,评审
doi:10.1186/s12263-018-0592-8
更新日期:2018-02-20 00:00:00
abstract:BACKGROUND:Inflammation plays a central role in chronic diseases occurring in the contemporary society. The health benefits of omega-3 (n-3) fatty acids (FAs), mostly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been reported. However, their mechanisms of action are poorly understood. We explored do...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-017-0554-6
更新日期:2017-02-21 00:00:00
abstract::Vitamin C is known to protect mucosal tissues from oxidative stress and inhibit nitrosamine formation in the stomach. High consumption of fruits, particularly citrus, and higher circulating vitamin C concentrations may be inversely associated with gastric cancer (GC) risk. We investigated 20 polymorphisms in vitamin C...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-013-0346-6
更新日期:2013-11-01 00:00:00
abstract::Functional polymorphisms in endogenous antioxidant defense genes including manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase (GPX-1) have been linked with risk of cancer at multiple sites. Although it is presumed that these germline variants impact disease risk by altering the host's a...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-011-0257-3
更新日期:2012-04-01 00:00:00
abstract::In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been the object of intensive research. miRNAs have emerged as key mediators of metabolic processes, playing crucial roles in maintaining/altering physiological processes, including energy balance and metabolic homeostasis. Altered miRNAs ...
journal_title:Genes & nutrition
pub_type: 杂志文章,评审
doi:10.1186/s12263-017-0577-z
更新日期:2017-09-25 00:00:00
abstract::Current evidence indicates that genetic testing for obesity risk has limited affective or behavioral impact, but few studies have explored the effects among individuals who self-identify as having weight problems. Here, we report findings from in-depth telephone interviews with seven overweight or obese volunteers who...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-013-0374-2
更新日期:2014-01-01 00:00:00
abstract::The nutraceutical benefits of β-sitosterol (SIT) are well documented. The present study investigated the in vitro effects of SIT on adipogenesis, glucose transport, and lipid mobilization in rat adipocytes. Primary cultures of rat preadipocytes and differentiated adipocytes were used in this study. Glucose uptake was ...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-010-0196-4
更新日期:2011-05-01 00:00:00
abstract::Transmembrane protease, serine 6 (TMPRSS6), is likely to be involved in iron metabolism through its pleiotropic effect on hepcidin concentrations. Recently, genome-wide association studies have identified common variants in the TMPRSS6 gene to be linked to anaemia and low iron status. To get a more precise evaluation ...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-014-0442-2
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Obesity is characterized by low-grade chronic inflammation and an excess of adipose tissue. The ASC gene encodes a protein that is part of the NLRP3 inflammasome, a cytosolic multiprotein complex that is associated with inflammation and metabolic alterations. To our knowledge, there is no evidence regarding ...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-020-00674-0
更新日期:2020-08-27 00:00:00
abstract:Background:Diminished brain levels of two neurohormones, 5-hydroxytryptamine (5-HT; serotonin) and 1,25-dihydroxyvitamin D3 (1,25D; active vitamin D metabolite), are proposed to play a role in the atypical social behaviors associated with psychological conditions including autism spectrum disorders and depression. We r...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-018-0605-7
更新日期:2018-07-11 00:00:00
abstract::Multiple factors have been implicated in the age-related declines in brain function. Thus, it is unlikely that modulating only a single factor will be effective at slowing this decline. A better approach is to identify small molecules that have multiple biological activities relevant to the maintenance of brain functi...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-009-0142-5
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are small non-coding RNAs involved in the modulation of gene expression and in the control of numerous cell functions. Alterations of miRNA patterns frequently occur in cancer and metabolic disorders, including obesity. Recent studies showed remarkable stability of miRNAs in both plasma an...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-016-0525-3
更新日期:2016-03-21 00:00:00
abstract::The demand for diet products is continuously increasing, together with that for natural food ingredients. Stevioside and other steviol glycosides extracted from the leaves of the plant Stevia rebaudiana Bertoni are the first natural high-potency sweeteners to be approved for consumption in the United States and the Eu...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-014-0401-y
更新日期:2014-05-01 00:00:00
abstract::Biomarkers of food intake (BFIs) are a promising tool for limiting misclassification in nutrition research where more subjective dietary assessment instruments are used. They may also be used to assess compliance to dietary guidelines or to a dietary intervention. Biomarkers therefore hold promise for direct and objec...
journal_title:Genes & nutrition
pub_type: 杂志文章,评审
doi:10.1186/s12263-018-0603-9
更新日期:2018-05-30 00:00:00
abstract::The suitability of C. elegans as a model for the question of nutritional science is a controversial topic. The discussion makes clear that C. elegans is its own best model for revealing, via genetic approaches, biological principles of nutritional behavior, and the biochemical function of vitamins. In this case, the m...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-018-0625-3
更新日期:2019-01-09 00:00:00
abstract:Background:We investigated whether the long-term consumption of a symbiotic formulation with Lactobacillus fermentum (probiotic) and β-glucan from cauliflower mushroom (prebiotic) would delay the progression of post-menopausal symptoms in ovariectomized (OVX) rats and explored their mechanisms of action, including chan...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-017-0585-z
更新日期:2017-11-09 00:00:00
abstract::Breast cancer is the second most frequent cancer affecting women worldwide after lung cancer. The toxicity factor associated with synthetic drugs has turned the attention toward natural compounds as the primary focus of interest as anticancer agents. Vitamin E derivatives consisting of the well-established tocopherols...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-011-0224-z
更新日期:2012-01-01 00:00:00
abstract:UNLABELLED:A single high-fat challenge induces plasmatic pro-inflammatory and pro-oxidative responses in the postprandial state, even in healthy men. This period is also associated with vascular endothelial dysfunction, which is an early event in the development of cardiovascular diseases. However, knowledge about the ...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-010-0166-x
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:The ability to digest lactose after weaning, namely, lactase persistence (LP), is encoded by polymorphisms in the MCM6 gene and varies widely in frequency among different human populations. Although, evolution of LP-related genetic variants was investigated in many groups of Sub-Saharan African, Middle Easte...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-017-0573-3
更新日期:2017-08-24 00:00:00