Abstract:
OBJECTIVE:To assess the risk of adverse perinatal events of vaccination of pregnant women with an MF59 adjuvanted vaccine. DESIGN:Cross sectional multicentre study. SETTING:49 public hospitals in major cities in Argentina, from September 2010 to May 2011. PARTICIPANTS:30,448 mothers (7293 vaccinated) and their 30,769 newborns. MAIN OUTCOME MEASURE:Primary composite outcome of low birth weight, preterm delivery, or fetal or early neonatal death up to seven days postpartum. RESULTS:Vaccinated women had a lower risk of the primary composite outcome (7.0% (n=513) v 9.3% (n=2160); adjusted odds ratio 0.80, 95% confidence interval 0.72 to 0.89). The propensity score analysis showed similar results. Adjusted odds ratios for vaccinated women were 0.74 (0.65 to 0.83) for low birth weight, 0.79 (0.69 to 0.90) for preterm delivery, and 0.68 (0.42 to 1.06) for perinatal mortality. These findings were consistent in further subgroup analysis. No significant differences in maternal outcomes were found. CONCLUSION:This large study using primary data collection found that MF59 adjuvanted A/H1N1 influenza vaccine did not result in an increased risk of adverse perinatal events and suggested a lower risk among vaccinated women. These findings should contribute to inform stakeholders and decision makers on the prescription of vaccination against influenza A/H1N1 in pregnant women.
journal_name
BMJjournal_title
BMJ (Clinical research ed.)authors
Rubinstein F,Micone P,Bonotti A,Wainer V,Schwarcz A,Augustovski F,Pichon Riviere A,Karolinski A,EVA Study Research Group Estudio Embarazo y Vacuna Antigripal.doi
10.1136/bmj.f393subject
Has Abstractpub_date
2013-02-04 00:00:00pages
f393eissn
0959-8138issn
1756-1833journal_volume
346pub_type
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