Influenza A/H1N1 MF59 adjuvanted vaccine in pregnant women and adverse perinatal outcomes: multicentre study.

Abstract:

OBJECTIVE:To assess the risk of adverse perinatal events of vaccination of pregnant women with an MF59 adjuvanted vaccine. DESIGN:Cross sectional multicentre study. SETTING:49 public hospitals in major cities in Argentina, from September 2010 to May 2011. PARTICIPANTS:30,448 mothers (7293 vaccinated) and their 30,769 newborns. MAIN OUTCOME MEASURE:Primary composite outcome of low birth weight, preterm delivery, or fetal or early neonatal death up to seven days postpartum. RESULTS:Vaccinated women had a lower risk of the primary composite outcome (7.0% (n=513) v 9.3% (n=2160); adjusted odds ratio 0.80, 95% confidence interval 0.72 to 0.89). The propensity score analysis showed similar results. Adjusted odds ratios for vaccinated women were 0.74 (0.65 to 0.83) for low birth weight, 0.79 (0.69 to 0.90) for preterm delivery, and 0.68 (0.42 to 1.06) for perinatal mortality. These findings were consistent in further subgroup analysis. No significant differences in maternal outcomes were found. CONCLUSION:This large study using primary data collection found that MF59 adjuvanted A/H1N1 influenza vaccine did not result in an increased risk of adverse perinatal events and suggested a lower risk among vaccinated women. These findings should contribute to inform stakeholders and decision makers on the prescription of vaccination against influenza A/H1N1 in pregnant women.

journal_name

BMJ

authors

Rubinstein F,Micone P,Bonotti A,Wainer V,Schwarcz A,Augustovski F,Pichon Riviere A,Karolinski A,EVA Study Research Group Estudio Embarazo y Vacuna Antigripal.

doi

10.1136/bmj.f393

subject

Has Abstract

pub_date

2013-02-04 00:00:00

pages

f393

eissn

0959-8138

issn

1756-1833

journal_volume

346

pub_type

杂志文章,多中心研究
  • Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases.

    abstract:OBJECTIVE:To quantify an association between acute kidney injury and use of high potency statins versus low potency statins. DESIGN:Retrospective observational analysis of administrative databases, using nine population based cohort studies and meta-analysis. We performed as treated analyses in each database with a ne...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,多中心研究

    doi:10.1136/bmj.f880

    authors: Dormuth CR,Hemmelgarn BR,Paterson JM,James MT,Teare GF,Raymond CB,Lafrance JP,Levy A,Garg AX,Ernst P,Canadian Network for Observational Drug Effect Studies.

    更新日期:2013-03-18 00:00:00

  • Insulin pump therapy, multiple daily injections, and cardiovascular mortality in 18,168 people with type 1 diabetes: observational study.

    abstract:OBJECTIVE:To investigate the long term effects of continuous subcutaneous insulin infusion (insulin pump therapy) on cardiovascular diseases and mortality in people with type 1 diabetes. DESIGN:Observational study. SETTING:Swedish National Diabetes Register, Sweden 2005-12. PARTICIPANTS:18,168 people with type 1 dia...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.h3234

    authors: Steineck I,Cederholm J,Eliasson B,Rawshani A,Eeg-Olofsson K,Svensson AM,Zethelius B,Avdic T,Landin-Olsson M,Jendle J,Gudbjörnsdóttir S,Swedish National Diabetes Register.

    更新日期:2015-06-22 00:00:00

  • How well can radiographers triage x ray films in accident and emergency departments?

    abstract:OBJECTIVE:To assess the ability of radiographers to identify abnormal radiographs of patients attending accident and emergency departments. DESIGN:Prospective study over six weeks. SETTING:Teaching hospital casualty x ray department. PATIENTS:3394 consecutive patients referred for radiography. INTERVENTIONS:Radiogr...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章

    doi:10.1136/bmj.302.6776.568

    authors: Renwick IG,Butt WP,Steele B

    更新日期:1991-03-09 00:00:00

  • Estimates of burden and consequences of infants born small for gestational age in low and middle income countries with INTERGROWTH-21st standard: analysis of CHERG datasets.

    abstract::Objectives To estimate small for gestational age birth prevalence and attributable neonatal mortality in low and middle income countries with the INTERGROWTH-21st birth weight standard.Design Secondary analysis of data from the Child Health Epidemiology Reference Group (CHERG), including 14 birth cohorts with gestatio...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.j3677

    authors: Lee AC,Kozuki N,Cousens S,Stevens GA,Blencowe H,Silveira MF,Sania A,Rosen HE,Schmiegelow C,Adair LS,Baqui AH,Barros FC,Bhutta ZA,Caulfield LE,Christian P,Clarke SE,Fawzi W,Gonzalez R,Humphrey J,Huybregts L,Kariuki

    更新日期:2017-08-17 00:00:00

  • Dental disease and risk of coronary heart disease and mortality.

    abstract:OBJECTIVE:To investigate a reported association between dental disease and risk of coronary heart disease. SETTING:National sample of American adults who participated in a health examination survey in the early 1970s. DESIGN:Prospective cohort study in which participants underwent a standard dental examination at bas...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.306.6879.688

    authors: DeStefano F,Anda RF,Kahn HS,Williamson DF,Russell CM

    更新日期:1993-03-13 00:00:00

  • International variation in radiation dose for computed tomography examinations: prospective cohort study.

    abstract:OBJECTIVE:To determine patient, institution, and machine characteristics that contribute to variation in radiation doses used for computed tomography (CT). DESIGN:Prospective cohort study. SETTING:Data were assembled and analyzed from the University of California San Francisco CT International Dose Registry. PARTICI...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.k4931

    authors: Smith-Bindman R,Wang Y,Chu P,Chung R,Einstein AJ,Balcombe J,Cocker M,Das M,Delman BN,Flynn M,Gould R,Lee RK,Yellen-Nelson T,Schindera S,Seibert A,Starkey J,Suntharalingam S,Wetter A,Wildberger JE,Miglioretti DL

    更新日期:2019-01-02 00:00:00

  • Targets and self monitoring in hypertension: randomised controlled trial and cost effectiveness analysis.

    abstract:OBJECTIVES:To assess whether blood pressure control in primary care could be improved with the use of patient held targets and self monitoring in a practice setting, and to assess the impact of these on health behaviours, anxiety, prescribed antihypertensive drugs, patients' preferences, and costs. DESIGN:Randomised c...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmj.38558.393669.E0

    authors: McManus RJ,Mant J,Roalfe A,Oakes RA,Bryan S,Pattison HM,Hobbs FD

    更新日期:2005-09-03 00:00:00

  • Improving immunisation coverage in rural India: clustered randomised controlled evaluation of immunisation campaigns with and without incentives.

    abstract:OBJECTIVE:To assess the efficacy of modest non-financial incentives on immunisation rates in children aged 1-3 and to compare it with the effect of only improving the reliability of the supply of services. DESIGN:Clustered randomised controlled study. SETTING:Rural Rajasthan, India. PARTICIPANTS:1640 children aged 1...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmj.c2220

    authors: Banerjee AV,Duflo E,Glennerster R,Kothari D

    更新日期:2010-05-17 00:00:00

  • Diabetes registers: a grassroots approach.

    abstract:OBJECTIVES:To compile a register of diabetic patients within the catchment area of a district general hospital and evaluate the characteristics of the population using aggregated data from a general practice audit. DESIGN:Cross sectional study. Practices identified all known diabetics and completed a questionnaire fro...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.307.6911.1046

    authors: Howitt AJ,Cheales NA

    更新日期:1993-10-23 00:00:00

  • Reported social alcohol consumption during pregnancy and infants' development at 18 months.

    abstract:OBJECTIVE:To determine the relation between mothers' self reported drinking habits before, during, and after pregnancy and infants' mental and motor development at 18 months of age. DESIGN:Follow up study of all singleton live births born to primigravidas living in Dundee and booked into antenatal clinics from 1 May 1...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章

    doi:10.1136/bmj.303.6793.22

    authors: Forrest F,Florey CD,Taylor D,McPherson F,Young JA

    更新日期:1991-07-06 00:00:00

  • Effect of different forms of information produced for cancer patients on their use of the information, social support, and anxiety: randomised trial.

    abstract:OBJECTIVE:To explore the hypothesis that different methods of selecting and printing information for cancer patients could improve emotional support by affecting interaction with others, and so lead to improved psychological wellbeing. DESIGN:Randomised trial with eight groups (three factors, 2x2x2). Data collected at...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmj.38807.571042.68

    authors: Jones RB,Pearson J,Cawsey AJ,Bental D,Barrett A,White J,White CA,Gilmour WH

    更新日期:2006-04-22 00:00:00

  • Counselling needs and experience of junior hospital doctors.

    abstract::A sample of 106 senior house officers who had graduated from Nottingham University in 1987 was surveyed about their experience of and need for careers guidance, performance appraisal, and stress counselling. Of the 80 who replied, a quarter had received no careers guidance and a quarter no feedback about their work pe...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.300.6722.445

    authors: Garrud P

    更新日期:1990-02-17 00:00:00

  • Waiting list dynamics and the impact of earmarked funding.

    abstract:OBJECTIVE:To determine how changes in the number of admissions from waiting lists and changes in the number of additions to the lists are related to list size and waiting times, in the context of local waiting list initiatives. DESIGN:Review of national and Körner statistics. SETTING:England (1987-94) and districts o...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.311.7008.783

    authors: Newton JN,Henderson J,Goldacre MJ

    更新日期:1995-09-23 00:00:00

  • Effect of assertive outreach after suicide attempt in the AID (assertive intervention for deliberate self harm) trial: randomised controlled trial.

    abstract:OBJECTIVE:To assess whether an assertive outreach intervention after suicide attempt could reduce the frequency of subsequent suicidal acts, compared with standard treatment. DESIGN:Randomised, parallel group, superiority trial with blinded outcome assessment. SETTING:Outpatient intervention at one location at Copenh...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmj.e4972

    authors: Morthorst B,Krogh J,Erlangsen A,Alberdi F,Nordentoft M

    更新日期:2012-08-22 00:00:00

  • Effect of combinations of drugs on all cause mortality in patients with ischaemic heart disease: nested case-control analysis.

    abstract:OBJECTIVE:To determine the effect of combinations of statins, aspirin, beta blockers, and angiotensin converting enzyme inhibitors in the secondary prevention of all cause mortality in patients with ischaemic heart disease. DESIGN:Open prospective cohort study with nested case-control analysis. SETTING:1.18 million p...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.330.7499.1059

    authors: Hippisley-Cox J,Coupland C

    更新日期:2005-05-07 00:00:00

  • Impact of misclassification of in vitro fertilisation in studies of folic acid and twinning: modelling using population based Swedish vital records.

    abstract:OBJECTIVE:To determine whether failure to adequately adjust for a reported 40% misclassification of use of in vitro fertilisation (IVF) as reported in a Swedish study could have led to a false finding that folic acid increases dizygotic twinning. DESIGN:Modelling with population based data. SETTING:Swedish vital reco...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.38369.437789.82

    authors: Berry RJ,Kihlberg R,Devine O

    更新日期:2005-04-09 00:00:00

  • Effectiveness of early switch from intravenous to oral antibiotics in severe community acquired pneumonia: multicentre randomised trial.

    abstract:OBJECTIVES:To compare the effectiveness of an early switch to oral antibiotics with the standard 7 day course of intravenous antibiotics in severe community acquired pneumonia. DESIGN:Multicentre randomised controlled trial. SETTING:Five teaching hospitals and 2 university medical centres in the Netherlands. PARTICI...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmj.38993.560984.BE

    authors: Oosterheert JJ,Bonten MJ,Schneider MM,Buskens E,Lammers JW,Hustinx WM,Kramer MH,Prins JM,Slee PH,Kaasjager K,Hoepelman AI

    更新日期:2006-12-09 00:00:00

  • Effectiveness of health checks conducted by nurses in primary care: results of the OXCHECK study after one year. Imperial Cancer Research Fund OXCHECK Study Group.

    abstract:OBJECTIVE:To assess the effectiveness of health checks by nurses in reducing risk factors for cardiovascular disease in patients from general practice. DESIGN:Randomised controlled trial. SETTING:Five urban general practices in Bedfordshire. SUBJECTS:2136 patients receiving an initial health check in 1989-91 and sch...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors:

    更新日期:1994-01-29 00:00:00

  • Rates for obstetric intervention among private and public patients in Australia: population based descriptive study.

    abstract:OBJECTIVE:To compare the risk profile of women receiving public and private obstetric care and to compare the rates of obstetric intervention among women at low risk in these groups. DESIGN:Population based descriptive study. SETTING:New South Wales, Australia. SUBJECTS:All 171,157 women having a live baby during 19...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.321.7254.137

    authors: Roberts CL,Tracy S,Peat B

    更新日期:2000-07-15 00:00:00

  • India bans female feticide.

    abstract::About 70% of all abortions performed in Delhi, India, are terminations due to the fetus being female. Private clinics make a profit out of offering sex determination tests. The new bill (the Prenatal Diagnostic Techniques Bill) introduced in Lok Sabha by Deputy Health Minister Pawan Singh Ghatowatr would stop "sex d...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 新闻

    doi:10.1136/bmj.309.6952.428

    authors: Imam Z

    更新日期:1994-08-13 00:00:00

  • Heterosexually acquired HIV infection.

    abstract::The import of the HIV or AIDS epidemic for heterosexuals in Britain is difficult to evaluate at this stage. By June 1988, only 60 cases of heterosexually acquired AIDS are known, out of 1598 reported AIDS cases. Of these, only 6 women and 4 men presumably were infected in Britain, the rest abroad. But, judging from...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 社论

    doi:10.1136/bmj.298.6671.401

    authors: Skegg DC

    更新日期:1989-02-18 00:00:00

  • Tired, weak, or in need of rest: fatigue among general practice attenders.

    abstract:OBJECTIVES:To determine the prevalence and associations of symptoms of fatigue. DESIGN:Questionnaire survey. SETTING:London general practice. PARTICIPANTS:611 General practice attenders. MAIN OUTCOME MEASURES:Scores on a fatigue questionnaire and reasons given for fatigue. RESULTS:10.2% Of men (17/167) and 10.6% o...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.301.6762.1199

    authors: David A,Pelosi A,McDonald E,Stephens D,Ledger D,Rathbone R,Mann A

    更新日期:1990-11-24 00:00:00

  • Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts.

    abstract:OBJECTIVES:To assess the associations between both uric acid levels and hyperuricaemia, with ischaemic heart disease and blood pressure, and to explore the potentially confounding role of body mass index. DESIGN:Mendelian randomisation analysis, using variation at specific genes (SLC2A9 (rs7442295) as an instrument fo...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.f4262

    authors: Palmer TM,Nordestgaard BG,Benn M,Tybjærg-Hansen A,Davey Smith G,Lawlor DA,Timpson NJ

    更新日期:2013-07-18 00:00:00

  • Primary care--opportunities and threats. The changing meaning of the GP contract.

    abstract::The meaning of the GP contract has changed since the last major upheaval in the mid-1960s. The government has always dealt with general practitioners as independent contractors, but the way in which it treated them in 1990 was entirely different from the way in which they were treated in 1966. In 1966, the profession'...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.314.7084.895

    authors: Lewis J

    更新日期:1997-03-22 00:00:00

  • Congenital anomaly surveillance in England--ascertainment deficiencies in the national system.

    abstract:OBJECTIVE:Firstly, to assess the completeness of ascertainment in the National Congenital Anomaly System (NCAS), the basis for congenital anomaly surveillance in England and Wales, and its variation by defect, geographical area, and socioeconomic deprivation. Secondly, to assess the impact of the lack of data on pregna...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.38300.665301.3A

    authors: Boyd PA,Armstrong B,Dolk H,Botting B,Pattenden S,Abramsky L,Rankin J,Vrijheid M,Wellesley D

    更新日期:2005-01-01 00:00:00

  • Prevalence of HIV among childbearing women and women having termination of pregnancy: multidisciplinary steering group study.

    abstract:OBJECTIVE:To determine the prevalence of HIV among pregnant women, in particular those whose behaviour or that of their partners put them at "low risk" of infection. DESIGN:Voluntary named or anonymous HIV testing of pregnant women during 21 months (November 1988 to July 1990). SUBJECTS AND SETTING:All women who plan...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.304.6834.1082

    authors: Goldberg DJ,MacKinnon H,Smith R,Patel NB,Scrimgeour JB,Inglis JM,Peutherer JF,Urquhart GE,Emslie JA,Covell RG

    更新日期:1992-04-25 00:00:00

  • Randomised controlled trial comparing effectiveness and acceptability of an early discharge, hospital at home scheme with acute hospital care.

    abstract:OBJECTIVE:To compare effectiveness and acceptability of early discharge to a hospital at home scheme with that of routine discharge from acute hospital. DESIGN:Pragmatic randomised controlled trial. SETTING:Acute hospital wards and community in north of Bristol, with a catchment population of about 224 000 people. S...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.316.7147.1796

    authors: Richards SH,Coast J,Gunnell DJ,Peters TJ,Pounsford J,Darlow MA

    更新日期:1998-06-13 00:00:00

  • Transcutaneous electrical nerve stimulation as adjunct to primary care management for tennis elbow: pragmatic randomised controlled trial (TATE trial).

    abstract:OBJECTIVE:To investigate the effectiveness of supplementing information and advice on analgesia and exercise from a general practitioner with transcutaneous electrical nerve stimulation (TENS) as a non-drug form of analgesia to reduce pain intensity in patients with tennis elbow. DESIGN:Pragmatic randomised controlled...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmj.f5160

    authors: Chesterton LS,Lewis AM,Sim J,Mallen CD,Mason EE,Hay EM,van der Windt DA

    更新日期:2013-09-02 00:00:00

  • Where have all the pennies gone? The work of Manchester Medical Audit Advisory Group.

    abstract::Medical audit has its critics, who point to the large sums of NHS cash that seem to be disappearing down a medical plughole. These criticisms are recognised by medical audit advisory groups but there are many reasons why the work of these groups has not yet resulted in many publications in journals or bumped up health...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.309.6947.98

    authors: Johnson R

    更新日期:1994-07-09 00:00:00

  • Coffee consumption and death from coronary heart disease in middle aged Norwegian men and women.

    abstract:OBJECTIVE:To study the association between number of cups of coffee consumed per day and coronary death when taking other major coronary risk factors into account. DESIGN:Men and women attending screening and followed up for a mean of 6.4 years. SETTING:Cardiovascular survey performed by ambulatory teams from the Nat...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.300.6724.566

    authors: Tverdal A,Stensvold I,Solvoll K,Foss OP,Lund-Larsen P,Bjartveit K

    更新日期:1990-03-03 00:00:00