Abstract:
INTRODUCTION:Recent evidence suggests a link between excess lipid peroxidation and specific organ failures in sepsis. No study has been performed in sepsis by multidrug-resistant (MDR) Gram-negative bacteria. METHODS:Lethal sepsis was induced in rats by the intraperitoneal injection of one MDR isolate of Pseudomonas aeruginosa. Produced malondialdehyde (MDA) was measured in tissues 5 hours after bacterial challenge with the thiobarbiturate assay followed by high-performance liquid chromatography (HPLC) analysis. Results were compared with those from a cohort of patients with ventilator-associated pneumonia (VAP) and sepsis by MDR Gram-negative bacteria. More precisely, serum MDA was measured on 7 consecutive days, and it was correlated with clinical characteristics. RESULTS:MDA of septic rats was greater in the liver, spleen, and aortic wall, and it was lower in the right kidney compared with sham operated-on animals. Findings were confirmed by the studied cohort. Circulating MDA was greater in patients with hepatic dysfunction and acute respiratory distress syndrome (ARDS) compared with patients without any organ failures. The opposite was found for patients with acute renal dysfunction. No differences were found between patients with ARDS without or with cardiovascular (CV) failure and patients without any organ failure. Serial measurements of MDA in serum of patients indicated that levels of MDA were greater in survivors of hepatic dysfunction and ARDS and lower in survivors of acute renal dysfunction. CONCLUSIONS:Animal findings and results of human sepsis are complementary, and they suggest a compartmentalization of lipid peroxidation in systemic infections by MDR gram-negative bacteria.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Toufekoula C,Papadakis V,Tsaganos T,Routsi C,Orfanos SE,Kotanidou A,Carrer DP,Raftogiannis M,Baziaka F,Giamarellos-Bourboulis EJdoi
10.1186/cc11930subject
Has Abstractpub_date
2013-01-16 00:00:00pages
R6issue
1eissn
1364-8535issn
1466-609Xpii
cc11930journal_volume
17pub_type
杂志文章,随机对照试验相关文献
CRITICAL CARE文献大全abstract:BACKGROUND:Renal perfusion status remains poorly studied at the bedside during septic shock. We sought to measure cortical renal perfusion in patients with septic shock during their first 3 days of care using renal contrast enhanced ultrasound (CEUS). METHODS:We prospectively included 20 ICU patients with septic shock...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-018-2067-0
更新日期:2018-06-15 00:00:00
abstract::Women are generally under-represented in many academic medical settings. Through a brief commentary on this issue, the present article discusses possible explanations for this under-representation as well as potential solutions. Issues examined include women in leadership positions, attrition out of academic medicine,...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc11915
更新日期:2013-01-29 00:00:00
abstract:IMPORTANCE:The optimal approach to airway management during in-hospital cardiac arrest is unknown. OBJECTIVE:To describe hospital-level variation in endotracheal intubation during cardiopulmonary resuscitation (CPR) for in-hospital cardiac arrest and the association between hospital use of endotracheal intubation and ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2426-5
更新日期:2019-05-06 00:00:00
abstract:INTRODUCTION:Mechanical ventilation with even moderate-sized tidal volumes synergistically increases lung injury in sepsis and has been associated with proinflammatory low-molecular-weight hyaluronan production. High-molecular-weight hyaluronan (HMW HA), in contrast, has been found to be anti-inflammatory. We hypothesi...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc6982
更新日期:2008-01-01 00:00:00
abstract::Severe sepsis is more and more frequent, especially because of an increased rate of immunocompromised patients. Despite the improvement in the overall prognosis of HIV/AIDS patients and the improvement of global ICU care, the prognosis of HIV/ADS patients hospitalized in ICU with severe sepsis remained poor. This situ...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc3923
更新日期:2005-01-01 00:00:00
abstract::Acute pancreatitis is an inflammatory disease process which may present with clinical manifestations ranging from benign self-limited disease to overwhelming sepsis. The ability to predict outcome would be helpful in developing treatment plans, and possibly in stratifying patients for clinical trials. ...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/s13054-014-0575-0
更新日期:2014-10-20 00:00:00
abstract::Two international multicentre randomised controlled trials of drotrecogin alfa (activated) (DrotAA), the Recombinant Human Activated Protein C Worldwide Evaluation of Severe Sepsis (PROWESS) and Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) trials, have produced inconsistent res...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc4947
更新日期:2006-01-01 00:00:00
abstract::Primary or secondary infection of necrotized areas by enteral bacteria is considered a primary cause of mortality in patients with severe acute pancreatitis (SAP). Indeed, 20-30% of patients die during the course of the disease from multiple organ dysfunction after infection. This is why strategies such as antibiotic ...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc3007
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:In ARDS patients, changes in respiratory mechanical properties and ventilatory settings can cause incomplete lung deflation at end-expiration. Both can promote dynamic hyperinflation and intrinsic positive end-expiratory pressure (PEEP). The aim of this study was to investigate, in a large population of ARDS...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2611-6
更新日期:2019-11-27 00:00:00
abstract::Facilitation of early spontaneous breathing activity is the most important measure to shorten weaning and avoid ventilator-induced lung injury and diaphragmatic injury in mechanically ventilated patients. However, the optimal degree of spontaneous muscle activity and ventilator support remains to be determined. Furthe...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc13120
更新日期:2013-11-19 00:00:00
abstract:BACKGROUND:Calcium release-activated calcium (CRAC) channel inhibitors stabilize the pulmonary endothelium and block proinflammatory cytokine release, potentially mitigating respiratory complications observed in patients with COVID-19. This study aimed to investigate the safety and efficacy of Auxora, a novel, intraven...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13054-020-03220-x
更新日期:2020-08-14 00:00:00
abstract:INTRODUCTION:Despite recent modifications, the clinical definition of the acute respiratory distress syndrome (ARDS) remains non-specific, leading to under-diagnosis and under-treatment. This study was designed to test the hypothesis that a biomarker panel would be useful for biologic confirmation of the clinical diagn...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13080
更新日期:2013-10-24 00:00:00
abstract:INTRODUCTION:The choice of invasive systemic haemodynamic monitoring in critically ill patients remains controversial as no multicentre comparative clinical data exist. Accordingly, we sought to study and compare the features and outcomes of patients who receive haemodynamic monitoring with either the pulmonary artery ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5126
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Recurrent delivery of tidal mechanical energy (ME) inflicts ventilator-induced lung injury (VILI) when stress and strain exceed the limits of tissue tolerance. Mechanical power (MP) is the mathematical description of the ME delivered to the respiratory system over time. It is unknown how ME relates to underl...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03313-7
更新日期:2020-10-07 00:00:00
abstract:BACKGROUND:Biomarkers can be of help to understand critical illness and to identify and stratify sepsis. Adrenomedullin is a vasoactive hormone, with reported prognostic and potentially therapeutic value in sepsis. The primary aim of this study was to investigate the association of circulating bioactive adrenomedullin ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03351-1
更新日期:2020-11-04 00:00:00
abstract::The use of controlled mechanical ventilation (CMV) in patients who experience weaning failure after a spontaneous breathing trial or after extubation is a strategy based on the premise that respiratory muscle fatigue (requiring rest to recover) is the cause of weaning failure. Recent evidence, however, does not suppor...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc3917
更新日期:2006-02-01 00:00:00
abstract::BACKGROUND: That thrombocytopenia results in increased mortality or transfusion requirements has not been confirmed by previous studies. We performed a case-control study in which 36 patients who developed severe thrombocytopenia of less than 50x109 platelets/l were carefully matched for the severity of underlying dis...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc369
更新日期:1999-01-01 00:00:00
abstract::During the past 50 years, caring for the critically ill has become increasingly complex and the need for an intensivist has become more evident. Management by intensivists has become a quality indicator for many ICUs. Numerous small studies have demonstrated the beneficial effect of intensivists on outcomes in the cri...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc13060
更新日期:2013-10-14 00:00:00
abstract:INTRODUCTION:Management of daily activities in ICUs is challenging. ICU shift leaders, charge nurses and intensivists have to make several immediate ad hoc decisions to enable the fluent flow of ICU activities. Even though the management of ICU activities is quite well delineated by international consensus guidelines, ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10341
更新日期:2011-08-08 00:00:00
abstract::The first part of this review addresses the diagnosis and differential diagnosis of the primary vasculitides Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and polyarteritis nodosa. Prompt diagnosis and treatment of these conditions ensures an optimal prognosis. The development of assays fo...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc2936
更新日期:2005-02-01 00:00:00
abstract:INTRODUCTION:The main objective was to determine risk factors for presence of multidrug resistant bacteria (MDR) in postoperative peritonitis (PP) and optimal empirical antibiotic therapy (EA) among options proposed by Infectious Disease Society of America and the Surgical Infection Society guidelines. METHODS:One hun...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc8877
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to determine whether using pharmacodynamic-based dosing of antimicrobials, such as extended/continuous infusions, in critically ill patients is associated with improved outcomes as compared with traditional dosing methods. METHODS:We searched Medline, HealthStar, EMBASE, Cochrane...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析,评审
doi:10.1186/cc13134
更新日期:2013-11-29 00:00:00
abstract:INTRODUCTION:In critically ill patients, delirium is a serious and frequent disorder that is associated with a prolonged intensive care and hospital stay and an increased morbidity and mortality. Without the use of a delirium screening instrument, delirium is often missed by ICU nurses and physicians. The effects of im...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7991
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Kidney congestion is a common pathophysiologic pathway of acute kidney injury (AKI) in sepsis and heart failure. There is no noninvasive tool to measure kidney intracapsular pressure (KIP) directly. METHODS:We evaluated the correlation of KIP with kidney elasticity measured by ultrasound surface wave elasto...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-017-1847-2
更新日期:2017-10-19 00:00:00
abstract:INTRODUCTION:There is limited information on whether the incidence of acute kidney injury (AKI) in critically ill patients has changed over time and there is controversy on whether its outcome has improved. METHODS:We interrogated the Australian New Zealand Intensive Care Society Adult Patient Database to obtain data ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5949
更新日期:2007-01-01 00:00:00
abstract::Organ failure in the heart or kidney can initiate various complex metabolic, cell-mediated and humoral pathways affecting distant organs, contributing to the high therapeutic costs and significantly higher morbidity and mortality. The universal outreach of cells in an injured state has myriad consequences to distant o...
journal_title:Critical care (London, England)
pub_type: 信件,评审
doi:10.1186/cc13177
更新日期:2014-01-06 00:00:00
abstract:INTRODUCTION:To determine whether single nucleotide polymorphisms (SNPs) in FAS and related genes are associated with acute kidney injury (AKI) in patients with acute respiratory distress syndrome (ARDS). METHODS:We studied 401 (Caucasian N = 310 and African-American N = 91) patients aged ≥ 13 years with ALI who enrol...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-1084-5
更新日期:2015-10-19 00:00:00
abstract:BACKGROUND:Prior retrospective cross-sectional work has associated antimicrobials with a non-specific phrase: encephalopathy without seizures. The purpose of this study is to determine whether different classes of antimicrobials have differential associations with the daily risk of delirium after critical illness is ad...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-018-2262-z
更新日期:2018-12-12 00:00:00
abstract::The present review introduces the notion of statistical power and the hazard of under-powered studies. The problem of how to calculate an ideal sample size is also discussed within the context of factors that affect power, and specific methods for the calculation of sample size are presented for two common scenarios, ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc1521
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND:Atherosclerotic intracranial arterial stenosis is an important cause of stroke that is increasingly being treated with percutaneous transluminal angioplasty and stenting (PTAS) to prevent recurrent stroke. However, PTAS has not been compared with medical management in a randomized trial. METHODS:Objective: ...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc11326
更新日期:2012-05-09 00:00:00