Compartmentalization of lipid peroxidation in sepsis by multidrug-resistant gram-negative bacteria: experimental and clinical evidence.

Abstract:

INTRODUCTION:Recent evidence suggests a link between excess lipid peroxidation and specific organ failures in sepsis. No study has been performed in sepsis by multidrug-resistant (MDR) Gram-negative bacteria. METHODS:Lethal sepsis was induced in rats by the intraperitoneal injection of one MDR isolate of Pseudomonas aeruginosa. Produced malondialdehyde (MDA) was measured in tissues 5 hours after bacterial challenge with the thiobarbiturate assay followed by high-performance liquid chromatography (HPLC) analysis. Results were compared with those from a cohort of patients with ventilator-associated pneumonia (VAP) and sepsis by MDR Gram-negative bacteria. More precisely, serum MDA was measured on 7 consecutive days, and it was correlated with clinical characteristics. RESULTS:MDA of septic rats was greater in the liver, spleen, and aortic wall, and it was lower in the right kidney compared with sham operated-on animals. Findings were confirmed by the studied cohort. Circulating MDA was greater in patients with hepatic dysfunction and acute respiratory distress syndrome (ARDS) compared with patients without any organ failures. The opposite was found for patients with acute renal dysfunction. No differences were found between patients with ARDS without or with cardiovascular (CV) failure and patients without any organ failure. Serial measurements of MDA in serum of patients indicated that levels of MDA were greater in survivors of hepatic dysfunction and ARDS and lower in survivors of acute renal dysfunction. CONCLUSIONS:Animal findings and results of human sepsis are complementary, and they suggest a compartmentalization of lipid peroxidation in systemic infections by MDR gram-negative bacteria.

journal_name

Crit Care

authors

Toufekoula C,Papadakis V,Tsaganos T,Routsi C,Orfanos SE,Kotanidou A,Carrer DP,Raftogiannis M,Baziaka F,Giamarellos-Bourboulis EJ

doi

10.1186/cc11930

subject

Has Abstract

pub_date

2013-01-16 00:00:00

pages

R6

issue

1

eissn

1364-8535

issn

1466-609X

pii

cc11930

journal_volume

17

pub_type

杂志文章,随机对照试验
  • Acute kidney injury is associated with a decrease in cortical renal perfusion during septic shock.

    abstract:BACKGROUND:Renal perfusion status remains poorly studied at the bedside during septic shock. We sought to measure cortical renal perfusion in patients with septic shock during their first 3 days of care using renal contrast enhanced ultrasound (CEUS). METHODS:We prospectively included 20 ICU patients with septic shock...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/s13054-018-2067-0

    authors: Harrois A,Grillot N,Figueiredo S,Duranteau J

    更新日期:2018-06-15 00:00:00

  • Still a man's world, but why?

    abstract::Women are generally under-represented in many academic medical settings. Through a brief commentary on this issue, the present article discusses possible explanations for this under-representation as well as potential solutions. Issues examined include women in leadership positions, attrition out of academic medicine,...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章

    doi:10.1186/cc11915

    authors: Weinacker A,Stapleton RD

    更新日期:2013-01-29 00:00:00

  • Retrospective cohort study of hospital variation in airway management during in-hospital cardiac arrest and the association with patient survival: insights from Get With The Guidelines-Resuscitation.

    abstract:IMPORTANCE:The optimal approach to airway management during in-hospital cardiac arrest is unknown. OBJECTIVE:To describe hospital-level variation in endotracheal intubation during cardiopulmonary resuscitation (CPR) for in-hospital cardiac arrest and the association between hospital use of endotracheal intubation and ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/s13054-019-2426-5

    authors: Bradley SM,Zhou Y,Ramachandran SK,Engoren M,Donnino M,Girotra S

    更新日期:2019-05-06 00:00:00

  • High-molecular-weight hyaluronan--a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated rats.

    abstract:INTRODUCTION:Mechanical ventilation with even moderate-sized tidal volumes synergistically increases lung injury in sepsis and has been associated with proinflammatory low-molecular-weight hyaluronan production. High-molecular-weight hyaluronan (HMW HA), in contrast, has been found to be anti-inflammatory. We hypothesi...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc6982

    authors: Liu YY,Lee CH,Dedaj R,Zhao H,Mrabat H,Sheidlin A,Syrkina O,Huang PM,Garg HG,Hales CA,Quinn DA

    更新日期:2008-01-01 00:00:00

  • Open the intensive care unit doors to HIV-infected patients with sepsis.

    abstract::Severe sepsis is more and more frequent, especially because of an increased rate of immunocompromised patients. Despite the improvement in the overall prognosis of HIV/AIDS patients and the improvement of global ICU care, the prognosis of HIV/ADS patients hospitalized in ICU with severe sepsis remained poor. This situ...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章

    doi:10.1186/cc3923

    authors: Timsit JF

    更新日期:2005-01-01 00:00:00

  • Circulating cytokines in predicting development of severe acute pancreatitis.

    abstract::Acute pancreatitis is an inflammatory disease process which may present with clinical manifestations ranging from benign self-limited disease to overwhelming sepsis. The ability to predict outcome would be helpful in developing treatment plans, and possibly in stratifying patients for clinical trials. ...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章

    doi:10.1186/s13054-014-0575-0

    authors: Rotstein OD

    更新日期:2014-10-20 00:00:00

  • Drotrecogin alfa (activated): does current evidence support treatment for any patients with severe sepsis?

    abstract::Two international multicentre randomised controlled trials of drotrecogin alfa (activated) (DrotAA), the Recombinant Human Activated Protein C Worldwide Evaluation of Severe Sepsis (PROWESS) and Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) trials, have produced inconsistent res...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/cc4947

    authors: Friedrich JO,Adhikari NK,Meade MO

    更新日期:2006-01-01 00:00:00

  • Risk management in patients with severe acute pancreatitis.

    abstract::Primary or secondary infection of necrotized areas by enteral bacteria is considered a primary cause of mortality in patients with severe acute pancreatitis (SAP). Indeed, 20-30% of patients die during the course of the disease from multiple organ dysfunction after infection. This is why strategies such as antibiotic ...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章

    doi:10.1186/cc3007

    authors: Gerlach H

    更新日期:2004-12-01 00:00:00

  • Dynamic hyperinflation and intrinsic positive end-expiratory pressure in ARDS patients.

    abstract:BACKGROUND:In ARDS patients, changes in respiratory mechanical properties and ventilatory settings can cause incomplete lung deflation at end-expiration. Both can promote dynamic hyperinflation and intrinsic positive end-expiratory pressure (PEEP). The aim of this study was to investigate, in a large population of ARDS...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/s13054-019-2611-6

    authors: Coppola S,Caccioppola A,Froio S,Ferrari E,Gotti M,Formenti P,Chiumello D

    更新日期:2019-11-27 00:00:00

  • Preserving spontaneous breathing during mechanical ventilatory support: an old yet fascinating story.

    abstract::Facilitation of early spontaneous breathing activity is the most important measure to shorten weaning and avoid ventilator-induced lung injury and diaphragmatic injury in mechanically ventilated patients. However, the optimal degree of spontaneous muscle activity and ventilator support remains to be determined. Furthe...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章

    doi:10.1186/cc13120

    authors: Calzia E,Dembinski R

    更新日期:2013-11-19 00:00:00

  • Auxora versus standard of care for the treatment of severe or critical COVID-19 pneumonia: results from a randomized controlled trial.

    abstract:BACKGROUND:Calcium release-activated calcium (CRAC) channel inhibitors stabilize the pulmonary endothelium and block proinflammatory cytokine release, potentially mitigating respiratory complications observed in patients with COVID-19. This study aimed to investigate the safety and efficacy of Auxora, a novel, intraven...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s13054-020-03220-x

    authors: Miller J,Bruen C,Schnaus M,Zhang J,Ali S,Lind A,Stoecker Z,Stauderman K,Hebbar S

    更新日期:2020-08-14 00:00:00

  • Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome.

    abstract:INTRODUCTION:Despite recent modifications, the clinical definition of the acute respiratory distress syndrome (ARDS) remains non-specific, leading to under-diagnosis and under-treatment. This study was designed to test the hypothesis that a biomarker panel would be useful for biologic confirmation of the clinical diagn...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc13080

    authors: Ware LB,Koyama T,Zhao Z,Janz DR,Wickersham N,Bernard GR,May AK,Calfee CS,Matthay MA

    更新日期:2013-10-24 00:00:00

  • Pulmonary artery catheter versus pulse contour analysis: a prospective epidemiological study.

    abstract:INTRODUCTION:The choice of invasive systemic haemodynamic monitoring in critically ill patients remains controversial as no multicentre comparative clinical data exist. Accordingly, we sought to study and compare the features and outcomes of patients who receive haemodynamic monitoring with either the pulmonary artery ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc5126

    authors: Uchino S,Bellomo R,Morimatsu H,Sugihara M,French C,Stephens D,Wendon J,Honore P,Mulder J,Turner A,PAC\/PiCCO Use and Likelihood of Success Evaluation PULSE Study Group.

    更新日期:2006-01-01 00:00:00

  • Energy transmission in mechanically ventilated children: a translational study.

    abstract:BACKGROUND:Recurrent delivery of tidal mechanical energy (ME) inflicts ventilator-induced lung injury (VILI) when stress and strain exceed the limits of tissue tolerance. Mechanical power (MP) is the mathematical description of the ME delivered to the respiratory system over time. It is unknown how ME relates to underl...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/s13054-020-03313-7

    authors: Kneyber MCJ,Ilia S,Koopman AA,van Schelven P,van Dijk J,Burgerhof JGM,Markhorst DG,Blokpoel RGT

    更新日期:2020-10-07 00:00:00

  • Circulating bioactive adrenomedullin as a marker of sepsis, septic shock and critical illness.

    abstract:BACKGROUND:Biomarkers can be of help to understand critical illness and to identify and stratify sepsis. Adrenomedullin is a vasoactive hormone, with reported prognostic and potentially therapeutic value in sepsis. The primary aim of this study was to investigate the association of circulating bioactive adrenomedullin ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/s13054-020-03351-1

    authors: Lundberg OHM,Lengquist M,Spångfors M,Annborn M,Bergmann D,Schulte J,Levin H,Melander O,Frigyesi A,Friberg H

    更新日期:2020-11-04 00:00:00

  • Bench-to-bedside review: weaning failure--should we rest the respiratory muscles with controlled mechanical ventilation?

    abstract::The use of controlled mechanical ventilation (CMV) in patients who experience weaning failure after a spontaneous breathing trial or after extubation is a strategy based on the premise that respiratory muscle fatigue (requiring rest to recover) is the cause of weaning failure. Recent evidence, however, does not suppor...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/cc3917

    authors: Vassilakopoulos T,Zakynthinos S,Roussos C

    更新日期:2006-02-01 00:00:00

  • Thrombocytopenia in critically ill surgical patients: a case-control study evaluating attributable mortality and transfusion requirements.

    abstract::BACKGROUND: That thrombocytopenia results in increased mortality or transfusion requirements has not been confirmed by previous studies. We performed a case-control study in which 36 patients who developed severe thrombocytopenia of less than 50x109 platelets/l were carefully matched for the severity of underlying dis...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc369

    authors: Stephan F,Montblanc Jd,Cheffi A,Bonnet F

    更新日期:1999-01-01 00:00:00

  • Intensivists at night: putting resources in the right place.

    abstract::During the past 50 years, caring for the critically ill has become increasingly complex and the need for an intensivist has become more evident. Management by intensivists has become a quality indicator for many ICUs. Numerous small studies have demonstrated the beneficial effect of intensivists on outcomes in the cri...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/cc13060

    authors: Levy MM

    更新日期:2013-10-14 00:00:00

  • Managing daily intensive care activities: an observational study concerning ad hoc decision making of charge nurses and intensivists.

    abstract:INTRODUCTION:Management of daily activities in ICUs is challenging. ICU shift leaders, charge nurses and intensivists have to make several immediate ad hoc decisions to enable the fluent flow of ICU activities. Even though the management of ICU activities is quite well delineated by international consensus guidelines, ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc10341

    authors: Lundgrén-Laine H,Kontio E,Perttilä J,Korvenranta H,Forsström J,Salanterä S

    更新日期:2011-08-08 00:00:00

  • Clinical review: Vasculitis on the intensive care unit--part 1: diagnosis.

    abstract::The first part of this review addresses the diagnosis and differential diagnosis of the primary vasculitides Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and polyarteritis nodosa. Prompt diagnosis and treatment of these conditions ensures an optimal prognosis. The development of assays fo...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/cc2936

    authors: Semple D,Keogh J,Forni L,Venn R

    更新日期:2005-02-01 00:00:00

  • Risk factors for multidrug resistant bacteria and optimization of empirical antibiotic therapy in postoperative peritonitis.

    abstract:INTRODUCTION:The main objective was to determine risk factors for presence of multidrug resistant bacteria (MDR) in postoperative peritonitis (PP) and optimal empirical antibiotic therapy (EA) among options proposed by Infectious Disease Society of America and the Surgical Infection Society guidelines. METHODS:One hun...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc8877

    authors: Augustin P,Kermarrec N,Muller-Serieys C,Lasocki S,Chosidow D,Marmuse JP,Valin N,Desmonts JM,Montravers P

    更新日期:2010-01-01 00:00:00

  • Optimal dosing of antibiotics in critically ill patients by using continuous/extended infusions: a systematic review and meta-analysis.

    abstract:INTRODUCTION:The aim of this study was to determine whether using pharmacodynamic-based dosing of antimicrobials, such as extended/continuous infusions, in critically ill patients is associated with improved outcomes as compared with traditional dosing methods. METHODS:We searched Medline, HealthStar, EMBASE, Cochrane...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/cc13134

    authors: Chant C,Leung A,Friedrich JO

    更新日期:2013-11-29 00:00:00

  • Implementation of a delirium assessment tool in the ICU can influence haloperidol use.

    abstract:INTRODUCTION:In critically ill patients, delirium is a serious and frequent disorder that is associated with a prolonged intensive care and hospital stay and an increased morbidity and mortality. Without the use of a delirium screening instrument, delirium is often missed by ICU nurses and physicians. The effects of im...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc7991

    authors: van den Boogaard M,Pickkers P,van der Hoeven H,Roodbol G,van Achterberg T,Schoonhoven L

    更新日期:2009-01-01 00:00:00

  • Association between kidney intracapsular pressure and ultrasound elastography.

    abstract:BACKGROUND:Kidney congestion is a common pathophysiologic pathway of acute kidney injury (AKI) in sepsis and heart failure. There is no noninvasive tool to measure kidney intracapsular pressure (KIP) directly. METHODS:We evaluated the correlation of KIP with kidney elasticity measured by ultrasound surface wave elasto...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/s13054-017-1847-2

    authors: Kashani KB,Mao SA,Safadi S,Amiot BP,Glorioso JM,Lieske JC,Nyberg SL,Zhang X

    更新日期:2017-10-19 00:00:00

  • Changes in the incidence and outcome for early acute kidney injury in a cohort of Australian intensive care units.

    abstract:INTRODUCTION:There is limited information on whether the incidence of acute kidney injury (AKI) in critically ill patients has changed over time and there is controversy on whether its outcome has improved. METHODS:We interrogated the Australian New Zealand Intensive Care Society Adult Patient Database to obtain data ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc5949

    authors: Bagshaw SM,George C,Bellomo R,ANZICS Database Management Committee.

    更新日期:2007-01-01 00:00:00

  • Heart-kidney crosstalk and role of humoral signaling in critical illness.

    abstract::Organ failure in the heart or kidney can initiate various complex metabolic, cell-mediated and humoral pathways affecting distant organs, contributing to the high therapeutic costs and significantly higher morbidity and mortality. The universal outreach of cells in an injured state has myriad consequences to distant o...

    journal_title:Critical care (London, England)

    pub_type: 信件,评审

    doi:10.1186/cc13177

    authors: Virzì G,Day S,de Cal M,Vescovo G,Ronco C

    更新日期:2014-01-06 00:00:00

  • Associations between single nucleotide polymorphisms in the FAS pathway and acute kidney injury.

    abstract:INTRODUCTION:To determine whether single nucleotide polymorphisms (SNPs) in FAS and related genes are associated with acute kidney injury (AKI) in patients with acute respiratory distress syndrome (ARDS). METHODS:We studied 401 (Caucasian N = 310 and African-American N = 91) patients aged ≥ 13 years with ALI who enrol...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/s13054-015-1084-5

    authors: Bhatraju P,Hsu C,Mukherjee P,Glavan BJ,Burt A,Mikacenic C,Himmelfarb J,Wurfel M

    更新日期:2015-10-19 00:00:00

  • Antimicrobial exposure and the risk of delirium in critically ill patients.

    abstract:BACKGROUND:Prior retrospective cross-sectional work has associated antimicrobials with a non-specific phrase: encephalopathy without seizures. The purpose of this study is to determine whether different classes of antimicrobials have differential associations with the daily risk of delirium after critical illness is ad...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/s13054-018-2262-z

    authors: Grahl JJ,Stollings JL,Rakhit S,Person AK,Wang L,Thompson JL,Pandharipande PP,Ely EW,Patel MB

    更新日期:2018-12-12 00:00:00

  • Statistics review 4: sample size calculations.

    abstract::The present review introduces the notion of statistical power and the hazard of under-powered studies. The problem of how to calculate an ideal sample size is also discussed within the context of factors that affect power, and specific methods for the calculation of sample size are presented for two common scenarios, ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/cc1521

    authors: Whitley E,Ball J

    更新日期:2002-08-01 00:00:00

  • Stenting versus aggressive medical therapy for intracranial arterial stenosis: more harm than good.

    abstract:BACKGROUND:Atherosclerotic intracranial arterial stenosis is an important cause of stroke that is increasingly being treated with percutaneous transluminal angioplasty and stenting (PTAS) to prevent recurrent stroke. However, PTAS has not been compared with medical management in a randomized trial. METHODS:Objective: ...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章

    doi:10.1186/cc11326

    authors: Al Hasan M,Murugan R

    更新日期:2012-05-09 00:00:00