Chlamydia trachomatis genovar distribution in clinical urogenital specimens from Tunisian patients: high prevalence of C. trachomatis genovar E and mixed infections.

Abstract:

BACKGROUND:This epidemiological study was carried out in Sfax (south of Tunisia) and focused on genital Chlamydia trachomatis (C. trachomatis) genovar distribution. METHODS:One hundred and thirty seven genital samples from 4067 patients (4.2%) attending the Habib Bourguiba University hospital of Sfax over 12 years (from 2000 to 2011) were found to be C. trachomatis PCR positive by the Cobas Amplicor system. These samples were genotyped by an in house reverse hybridization method. RESULTS:One hundred and eight (78.8%) samples contained only one genovar and 29 (21.2%) samples contained two or three genovars. Genovar E was the most prevalent (70.8%) single genovar and it was detected in 90.6% of all the cases. Genovars J, C and L1-L3 were not detected in our samples whereas ocular genovars A and B were in 5 cases. All the five cases were mixed infections. Men had more mixed infections than women (p=0.02) and were more frequently infected by genovars F and K (p<0.05). No associations between current infection, infertility and the genovar distribution were observed. Patients coinfected with Neisseria gonorrhoeae were also significantly more frequently infected with mixed genovars (p=0.04). CONCLUSIONS:In conclusion, we have reported a high prevalence of genovar E and of mixed infections in our study population. Such data could have implications for the control and vaccine development of C. trachomatis in Tunisia.

journal_name

BMC Infect Dis

journal_title

BMC infectious diseases

authors

Gharsallah H,Frikha-Gargouri O,Sellami H,Besbes F,Znazen A,Hammami A

doi

10.1186/1471-2334-12-333

subject

Has Abstract

pub_date

2012-11-30 00:00:00

pages

333

issn

1471-2334

pii

1471-2334-12-333

journal_volume

12

pub_type

杂志文章
  • Endotoxin tolerance and cross-tolerance in mast cells involves TLR4, TLR2 and FcepsilonR1 interactions and SOCS expression: perspectives on immunomodulation in infectious and allergic diseases.

    abstract:BACKGROUND:The study of the endotoxin tolerance phenomenon in light of the recently defined roles of mast cells and toll-like receptors as essential components of the innate immune response and as orchestrators of acquired immunity may reveal potentially useful mechanisms of immunomodulation of infectious and allergic ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-10-240

    authors: Saturnino SF,Prado RO,Cunha-Melo JR,Andrade MV

    更新日期:2010-08-14 00:00:00

  • Necrotizing fasciitis in patients with diabetes mellitus: clinical characteristics and risk factors for mortality.

    abstract:BACKGROUND:Necrotizing fasciitis (NF) is a rapidly progressive and life-threatening infection. This study aimed to investigate the clinical characteristics and mortality- associated factors in diabetic patients. METHODS:Detailed clinical information of 165 NF cases was retrospectively collected and analyzed in Nationa...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-015-1144-0

    authors: Cheng NC,Tai HC,Chang SC,Chang CH,Lai HS

    更新日期:2015-10-13 00:00:00

  • Clinical and microbiological characteristics of bloodstream infections due to AmpC β-lactamase producing Enterobacteriaceae: an active surveillance cohort in a large centralized Canadian region.

    abstract:BACKGROUND:The objective of this study was to describe the clinical and microbiological characteristics of bloodstream infections (BSIs) due to AmpC producing Enterobacteriaceae (AE) in a large centralized Canadian region over a 9-year period. METHODS:An active surveillance cohort design in Calgary, Canada. RESULTS:A...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-014-0647-4

    authors: Chaubey VP,Pitout JD,Dalton B,Gregson DB,Ross T,Laupland KB

    更新日期:2014-12-14 00:00:00

  • Triple valve endocarditis by mycobacterium tuberculosis: a case report.

    abstract:BACKGROUND:Granulomas caused by Mycobacterium Tuberculosis have been observed at autopsy in the heart, pre-dominantly in the myocardium and endocardium, but rarely involving the coronary vessels and valvular structures. Mycobacterium tuberculosis valvular endocarditis is extremely rare, with most reports coming from au...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-12-231

    authors: Shaikh Q,Mahmood F

    更新日期:2012-09-27 00:00:00

  • Study and interest of cellular load in respiratory samples for the optimization of molecular virological diagnosis in clinical practice.

    abstract:BACKGROUND:Respiratory viral diagnosis of upper respiratory tract infections has largely developed through multiplex molecular techniques. Although the sensitivity of different types of upper respiratory tract samples seems to be correlated to the number of sampled cells, this link remains largely unexplored. METHODS:...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-1730-9

    authors: Bonnin P,Miszczak F,Kin N,Resa C,Dina J,Gouarin S,Viron F,Morello R,Vabret A

    更新日期:2016-08-09 00:00:00

  • Identification of pathogens for differential diagnosis of fever with jaundice in the Central African Republic: a retrospective assessment, 2008-2010.

    abstract:BACKGROUND:Febrile jaundice results clinically in generalized yellow coloration of the teguments and mucous membranes due to excess plasma bilirubin, accompanied by fever. Two types are found: conjugated and unconjugated bilirubin jaundice. Jaundice is a sign in several diseases due to viruses (viral hepatitis and arbo...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2840-8

    authors: Gadia CLB,Manirakiza A,Tekpa G,Konamna X,Vickos U,Nakoune E

    更新日期:2017-11-29 00:00:00

  • High prevalence of CXCR4 usage among treatment-naive CRF01_AE and CRF51_01B-infected HIV-1 subjects in Singapore.

    abstract:BACKGROUND:Recent studies suggest HIV-1 inter-subtype differences in co-receptor usage. We examined the correlation between HIV-1 subtype and co-receptor usage among treatment-naïve HIV-1 subjects in Singapore. Additionally, we investigated whether the subtype co-receptor association was influenced by stage of infectio...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-90

    authors: Ng KY,Chew KK,Kaur P,Kwan JY,Khong WX,Lin L,Chua A,Tan MT,Quinn TC,Laeyendecker O,Leo YS,Ng OT

    更新日期:2013-02-19 00:00:00

  • Multiple subcutaneous tuberculous abscesses in a dermatomyositis patient without pulmonary tuberculosis: a case report and literature review.

    abstract:BACKGROUND:Even though remarkable progress for diagnostics of pulmonary TB has been made, it is still a challenge to establish a definitive diagnosis for extrapulmonary TB (EPTB) in clinical practice. Among all the presentations of EPTB, cold abscesses are unusual and deceptive, which are often reported in the chest wa...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1186/s12879-020-05137-w

    authors: Gao W,Zeng Y,Chen W

    更新日期:2020-06-12 00:00:00

  • Factors affecting immunogenicity of BCG in infants, a study in Malawi, The Gambia and the UK.

    abstract:BACKGROUND:BCG immunogenicity in infants differs between populations and these differences have been attributed to various factors. In this study, the influence of geographical location, season of birth, timing of vaccination, micronutrient status (zinc) and inflammatory status (C-reactive protein, CRP) were assessed. ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-184

    authors: Hur YG,Gorak-Stolinska P,Lalor MK,Mvula H,Floyd S,Raynes J,Ben-Smith A,Fitchett JR,Flanagan KL,Burl S,Ota MO,Crampin AC,Smith SG,Dockrell HM

    更新日期:2014-04-05 00:00:00

  • The burden of varicella from a parent's perspective and its societal impact in The Netherlands: an Internet survey.

    abstract:BACKGROUND:Varicella is a common childhood disease. Only 5% of first varicella-zoster-virus infections occur asymptomatically. Most data on the burden of varicella stem from health service databases. This study aims to provide insight in the burden of varicella from a parent's perspective including cases outside the he...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-11-320

    authors: Wolleswinkel-van den Bosch JH,Speets AM,Rümke HC,Gumbs PD,Fortanier SC

    更新日期:2011-11-17 00:00:00

  • Factors associated with stigma attitude towards people living with HIV among general individuals in Heilongjiang, Northeast China.

    abstract:BACKGROUND:HIV-related stigma always is major obstacles to an effective HIV response worldwide. The effect of HIV-related stigma on HIV prevention and treatment is particularly serious in China. This study was to examine stigma attitude towards people living with HIV/AIDS (PLWHA) among general individuals in Heilongjia...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2216-0

    authors: Li X,Yuan L,Li X,Shi J,Jiang L,Zhang C,Yang X,Zhang Y,Zhao D,Zhao Y

    更新日期:2017-02-17 00:00:00

  • Successful treatment with baloxavir marboxil of a patient with peramivir-resistant influenza A/H3N2 with a dual E119D/R292K substitution after allogeneic hematopoietic cell transplantation: a case report.

    abstract:BACKGROUND:Extended use of oseltamivir in an immunocompromised host could reportedly induce neuraminidase gene mutation possibly leading to oseltamivir-resistant influenza A/H3N2 virus. To our knowledge, no report is available on the clinical course of a severely immunocompromised patient with a dual E119D/R292K neuram...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05205-1

    authors: Harada N,Shibata W,Koh H,Takashita E,Fujisaki S,Okamura H,Nanno S,Yamada K,Nakamae H,Hino M,Kakeya H

    更新日期:2020-07-06 00:00:00

  • Transmissibility and temporal changes of 2009 pH1N1 pandemic during summer and fall/winter waves.

    abstract:BACKGROUND:In order to compare the transmissibility of the 2009 pH1N1 pandemic during successive waves of infections in summer and fall/winter in the Northern Hemisphere, and to assess the temporal changes during the course of the outbreak in relation to the intervention measures implemented, we analyze the epidemiolog...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-11-332

    authors: Hsieh YH,Cheng KF,Wu TN,Li TC,Chen CY,Chen JH,Lin MH,Center for Infectious Education and Research Team.

    更新日期:2011-12-02 00:00:00

  • Deep sequencing of hepatitis C virus hypervariable region 1 reveals no correlation between genetic heterogeneity and antiviral treatment outcome.

    abstract:BACKGROUND:Hypervariable region 1 (HVR1) contained within envelope protein 2 (E2) gene is the most variable part of HCV genome and its translation product is a major target for the host immune response. Variability within HVR1 may facilitate evasion of the immune response and could affect treatment outcome. The aim of ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-389

    authors: Cortés KC,Zagordi O,Perlejewski K,Laskus T,Maroszek K,Bukowska-Ośko I,Pawełczyk A,Płoski R,Berak H,Horban A,Radkowski M

    更新日期:2014-07-13 00:00:00

  • Oxidative stress markers in saliva and periodontal disease status: modulation during pregnancy and postpartum.

    abstract:BACKGROUND:Periodontal diseases may affect local and systemic inflammation, and reactive oxygen species (ROS) levels. This systemic health burden could compromise the outcome of pregnancy in expectant mothers. The aim of the present study was to evaluate oxidative stress markers, including glutathione peroxidase (GPx),...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-015-1003-z

    authors: Gümüş P,Emingil G,Öztürk VÖ,Belibasakis GN,Bostanci N

    更新日期:2015-07-08 00:00:00

  • Prenatal testing and prevalence of HIV infection during pregnancy: data from the "Birth in Brazil" study, a national hospital-based study.

    abstract:BACKGROUND:The rate of vertical HIV transmission has decreased in Brazil, but regional inequalities suggest problems in implementing control measures during pregnancy and delivery. The aims of this study were to ascertain the coverage of HIV testing during prenatal care and estimate the prevalence of HIV infection duri...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-015-0837-8

    authors: Domingues RM,Szwarcwald CL,Souza PR Jr,Leal Mdo C

    更新日期:2015-02-26 00:00:00

  • Group B streptococcus serotype prevalence in reproductive-age women at a tertiary care military medical center relative to global serotype distribution.

    abstract:BACKGROUND:Group B Streptococcus (GBS) serotype (Ia, Ib, II-IX) correlates with pathogen virulence and clinical prognosis. Epidemiological studies of seroprevalence are an important metric for determining the proportion of serotypes in a given population. The purpose of this study was to evaluate the prevalence of indi...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-10-336

    authors: Ippolito DL,James WA,Tinnemore D,Huang RR,Dehart MJ,Williams J,Wingerd MA,Demons ST

    更新日期:2010-11-24 00:00:00

  • Performance comparison of CareStart™ HRP2/pLDH combo rapid malaria test with light microscopy in north-western Tigray, Ethiopia: a cross-sectional study.

    abstract:BACKGROUND:Rapid diagnostic tests (RDTs) are alternative methods for microscopy in the diagnosis of malaria in resource limited settings. Among commercially available RDTs, CareStart™ Malaria test was found to show reliable results. This study evaluated the performance of CareStart™ Malaria Combo test kit in Northweste...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2503-9

    authors: Feleke DG,Tarko S,Hadush H

    更新日期:2017-06-06 00:00:00

  • Lateral gene transfer (LGT) between Archaea and Escherichia coli is a contributor to the emergence of novel infectious disease.

    abstract:BACKGROUND:Lateral gene transfer is the major mechanism for acquisition of new virulence genes in pathogens. Recent whole genome analyses have suggested massive gene transfer between widely divergent organisms. PRESENTATION OF THE HYPOTHESIS:Archeal-like genes acting as virulence genes are present in several pathogens...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-3-13

    authors: Faguy DM

    更新日期:2003-06-19 00:00:00

  • The coronavirus diseases 2019 (COVID-19) pneumonia with spontaneous pneumothorax: a case report.

    abstract:BACKGROUND:The outbreak of the novel coronavirus (COVID-19) that was firstly reported in Wuhan, China, with cases now confirmed in more than 100 countries. However, COVID-19 pneumonia with spontaneous pneumothorax is unknown. CASE PRESENTATION:We reported a case of 66-year-old man infected with COVID-19, presenting wi...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05384-x

    authors: Chen X,Zhang G,Tang Y,Peng Z,Pan H

    更新日期:2020-09-09 00:00:00

  • Infection with high proportion of multidrug-resistant bacteria in conflict-related injuries is associated with poor outcomes and excess resource consumption: a cohort study of Syrian patients treated in Jordan.

    abstract:BACKGROUND:Armed conflicts are a major contributor to injury and death globally. Conflict-related injuries are associated with a high risk of wound infection, but it is unknown to what extent infection directly relates to sustainment of life and restoration of function. The aim of this study was to investigate the outc...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3149-y

    authors: Älgå A,Wong S,Shoaib M,Lundgren K,Giske CG,von Schreeb J,Malmstedt J

    更新日期:2018-05-22 00:00:00

  • Rubella seroprevalence among pregnant women in Beijing, China.

    abstract:BACKGROUND:Rubella infection in pregnant women can result in serious effects, such as miscarriages, stillbirths, and congenital rubella syndrome (CRS). However, very little is known about the rubella seroprevalence among pregnant women in China. METHODS:This is a cross-sectional and hospital-based study. From June 201...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3032-x

    authors: Meng Q,Luo J,Li L,Shi W,Yu J,Shen Y,Li L,Wang Y,Yao K

    更新日期:2018-03-15 00:00:00

  • The prognostic value of the suPARnostic ELISA in HIV-1 infected individuals is not affected by uPAR promoter polymorphisms.

    abstract:BACKGROUND:High blood levels of soluble urokinase Plasminogen Activator Receptor (suPAR) are associated with poor outcomes in human immunodeficiency-1 (HIV-1) infected individuals. Research on the clinical value of suPAR in HIV-1 infection led to the development of the suPARnostic(R) assay for commercial use in 2006. T...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-7-134

    authors: Schneider UV,Nielsen RL,Pedersen C,Eugen-Olsen J

    更新日期:2007-11-16 00:00:00

  • Anopheles coluzzii larval habitat and insecticide resistance in the island area of Manoka, Cameroon.

    abstract:BACKGROUND:The effectiveness of Long-Lasting Insecticidal Nets and Indoor Residual Spraying in malaria vector control is threatened by vector resistance to insecticides. Knowledge of mosquito habitats and patterns of insecticide resistance would facilitate the development of appropriate vector control strategies. There...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-1542-y

    authors: Etang J,Mbida Mbida A,Ntonga Akono P,Binyang J,Eboumbou Moukoko CE,Lehman LG,Awono-Ambene P,Talipouo A,Ekoko Eyisab W,Tagne D,Tchoffo R,Manga L,Mimpfoundi R

    更新日期:2016-05-20 00:00:00

  • Comparative efficacies of different antibiotic treatments to eradicate nontypeable Haemophilus influenzae infection.

    abstract:BACKGROUND:Nonencapsulated and nontypeable Haemophilus influenzae (NTHi) is a major cause of human respiratory tract infections. Some strains of NTHi can cause invasive diseases such as septicemia and meningitis, even if H. influenzae is not generally considered to be an intracellular pathogen. There have been very few...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-8-15

    authors: Sekiya Y,Eguchi M,Nakamura M,Ubukata K,Omura S,Matsui H

    更新日期:2008-02-07 00:00:00

  • Low and declining attack rates of imported typhoid fever in the Netherlands 1997-2014, in spite of a restricted vaccination policy.

    abstract:BACKGROUND:Typhoid fever mainly occurs in (sub) tropical regions where sanitary conditions remain poor. In other regions it occurs mainly among returning travelers or their direct contacts. The aim of this study was to evaluate the current Dutch guidelines for typhoid vaccination. METHOD:Crude annual attack rates (AR)...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-2059-0

    authors: Suryapranata FS,Prins M,Sonder GJ

    更新日期:2016-12-01 00:00:00

  • Serum 25-Hydroxyvitamin D and the risk of mortality in adult patients with Sepsis: a meta-analysis.

    abstract:BACKGROUND:Vitamin D deficiency has been related to the risk of sepsis. However, previous studies showed inconsistent results regarding the association between serum 25-hydroxyvitamin D (25 (OH) D) and mortality risk in septic patients. We aimed to evaluate the relationship between serum 25 (OH) D at admission and mort...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12879-020-4879-1

    authors: Li Y,Ding S

    更新日期:2020-03-04 00:00:00

  • Assessing the impact of multidrug-resistant tuberculosis in children: an exploratory qualitative study.

    abstract:BACKGROUND:While the prevalence of multidrug-resistant (MDR) tuberculosis (TB) is high among children in the Western Cape of South Africa, the psychosocial implications of treatment for children with MDR-TB remain poorly understood. We sought to explore how MDR-TB and its treatment impact children on an individual, fam...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-426

    authors: Franck C,Seddon JA,Hesseling AC,Schaaf HS,Skinner D,Reynolds L

    更新日期:2014-08-01 00:00:00

  • Prevalence, intensity and factors associated with soil-transmitted helminths infections among preschool-age children in Hoima district, rural western Uganda.

    abstract:BACKGROUND:Over 80% of morbidity due to soil-transmitted helminthiasis (STH) occurs in low-income countries. Children under 5 account for 20-30% of the burden in endemic areas. This study assessed the prevalence, intensity and factors associated with STH infections among preschool-age children (PSAC) in Hoima district,...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3289-0

    authors: Ojja S,Kisaka S,Ediau M,Tuhebwe D,Kisakye AN,Halage AA,Mugambe RK,Mutyoba JN

    更新日期:2018-08-17 00:00:00

  • Severe falciparum malaria complicated by prolonged haemolysis and rhinomaxillary mucormycosis after parasite clearance: a case report.

    abstract:BACKGROUND:Severe falciparum malaria may be complicated by prolonged haemolysis and recurrent fever after parasite clearance. However, their respective etiologies are unclear and challenging to diagnose. We report the first case of severe falciparum malaria followed by prolonged haemolytic anaemia and rhinomaxillary mu...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-015-1285-1

    authors: Plewes K,Maude RJ,Ghose A,Dondorp AM

    更新日期:2015-12-03 00:00:00