The spectrum of thyroid disease and risk of new onset atrial fibrillation: a large population cohort study.

Abstract:

OBJECTIVES:To examine the risk of atrial fibrillation in relation to the whole spectrum of thyroid function in a large cohort of patients. DESIGN:Population based cohort study of general practice patients identified by linkage of nationwide registries at the individual level. SETTING:Primary care patients in the city of Copenhagen. SUBJECTS:Registry data for 586,460 adults who had their thyroid function evaluated for the first time by their general practitioner during 2000-10 and who were without previously recorded thyroid disease or atrial fibrillation. MAIN OUTCOME MEASURE:Poisson regression models used to estimate risk of atrial fibrillation by thyroid function. RESULTS:Of the 586,460 individuals in the study population (mean (SD) age 50.2 (16.9) years, 39% men), 562,461 (96.0%) were euthyroid, 1670 (0.3%) had overt hypothyroidism, 12,087 (2.0%) had subclinical hypothyroidism, 3966 (0.7%) had overt hyperthyroidism, and 6276 (1.0%) had subclinical hyperthyroidism. Compared with the euthyroid individuals, the risk of atrial fibrillation increased with decreasing levels of thyroid stimulating hormone (TSH) from high normal euthyroidism (incidence rate ratio 1.12 (95% CI 1.03 to 1.21)) to subclinical hyperthyroidism with reduced TSH (1.16 (0.99 to 1.36)) and subclinical hyperthyroidism with supressed TSH (1.41 (1.25 to 1.59)). Both overt and subclinical hypothyroidism were associated with a lower risk of atrial fibrillation. CONCLUSION:The risk of atrial fibrillation was closely associated with thyroid activity, with a low risk in overt hypothyroidism, high risk in hyperthyroidism, and a TSH level dependent association with risk of atrial fibrillation across the spectrum of subclinical thyroid disease.

journal_name

BMJ

authors

Selmer C,Olesen JB,Hansen ML,Lindhardsen J,Olsen AM,Madsen JC,Faber J,Hansen PR,Pedersen OD,Torp-Pedersen C,Gislason GH

doi

10.1136/bmj.e7895

subject

Has Abstract

pub_date

2012-11-27 00:00:00

pages

e7895

eissn

0959-8138

issn

1756-1833

journal_volume

345

pub_type

杂志文章
  • Will new diagnostic criteria for diabetes mellitus change phenotype of patients with diabetes? Reanalysis of European epidemiological data. DECODE Study Group on behalf of the European Diabetes Epidemiology Study Group.

    abstract:OBJECTIVE:To evaluate the impact of the revised diagnostic criteria for diabetes mellitus adopted by the American Diabetes Association on prevalence of diabetes and on classification of patients. For epidemiological purposes the American criteria use a fasting plasma glucose concentration >=7.0 mmol/l in contrast with ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.317.7155.371

    authors:

    更新日期:1998-08-08 00:00:00

  • Factors associated with mortality in Scottish patients receiving methadone in primary care: retrospective cohort study.

    abstract:OBJECTIVE:To assess predictors of mortality in a population of people prescribed methadone. DESIGN:Retrospective cohort study. SETTING:Geographically defined population in Tayside, Scotland. PARTICIPANTS:2378 people prescribed and dispensed liquid methadone between January 1993 and February 2004. MAIN OUTCOME MEASU...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.b2225

    authors: McCowan C,Kidd B,Fahey T

    更新日期:2009-06-16 00:00:00

  • Is an information booklet for patients leaving hospital helpful and useful?

    abstract:OBJECTIVE:To determine whether a booklet given to patients being discharged from hospital giving details of their admission and treatment increased their knowledge and recall when reviewed in outpatient clinics. DESIGN:Patients alternately allocated to receive a booklet or to serve as controls. Assessment by a questio...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章

    doi:10.1136/bmj.298.6677.870

    authors: Sandler DA,Mitchell JR,Fellows A,Garner ST

    更新日期:1989-04-01 00:00:00

  • Tired, weak, or in need of rest: fatigue among general practice attenders.

    abstract:OBJECTIVES:To determine the prevalence and associations of symptoms of fatigue. DESIGN:Questionnaire survey. SETTING:London general practice. PARTICIPANTS:611 General practice attenders. MAIN OUTCOME MEASURES:Scores on a fatigue questionnaire and reasons given for fatigue. RESULTS:10.2% Of men (17/167) and 10.6% o...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.301.6762.1199

    authors: David A,Pelosi A,McDonald E,Stephens D,Ledger D,Rathbone R,Mann A

    更新日期:1990-11-24 00:00:00

  • Health information for the developing world.

    abstract::Doctors and other health professionals in developing countries are missing out on relevant information about health. A lot of the information they need is available in the developed countries, and those who have it are happy to share it with them. But transporting information, like food or medicines, from one part of ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.309.6959.939

    authors: Kale R

    更新日期:1994-10-08 00:00:00

  • Frankincense: systematic review.

    abstract:OBJECTIVE:To assess evidence from randomised clinical trials about the effectiveness of extracts of Boswellia serrata (frankincense). DESIGN:Systematic review. DATA SOURCES:Electronic searches on Medline, Embase, Cinahl, Amed, and Cochrane Library. Hand searches of conference proceedings, bibliographies, and departme...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.a2813

    authors: Ernst E

    更新日期:2008-12-17 00:00:00

  • Risk of suicide after suicide attempt according to coexisting psychiatric disorder: Swedish cohort study with long term follow-up.

    abstract:OBJECTIVE:To investigate the impact of coexistent psychiatric morbidity on risk of suicide after a suicide attempt. DESIGN:Cohort study with follow-up for 21-31 years. SETTING:Swedish national register based study. PARTICIPANTS:39 685 people (53% women) admitted to hospital for attempted suicide during 1973-82. MAI...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.a2205

    authors: Tidemalm D,Långström N,Lichtenstein P,Runeson B

    更新日期:2008-11-18 00:00:00

  • Period trends in rate of suicide in first 28 days after discharge from psychiatric hospital in Scotland, 1968-92.

    abstract:OBJECTIVE:To examine period trends in the rate of suicide in the first 28 days after discharge from psychiatric hospital. DESIGN:Cohort study of patients discharged from psychiatric hospital. SETTING:Scotland. SUBJECTS:All patients aged 15-84 who were discharged from Scottish psychiatric hospitals during 1968 to 199...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.311.7001.357

    authors: Geddes JR,Juszczak E

    更新日期:1995-08-05 00:00:00

  • Prescribing injectable and oral methadone to opiate addicts: results from the 1995 national postal survey of community pharmacies in England and Wales.

    abstract:OBJECTIVE:To establish the extent of prescribing injectable and oral methadone to opiate addicts and the practice characteristics and dispensing arrangements attached to these prescriptions. DESIGN:National survey of 25% random sample of community (high street) pharmacies through postal questionnaire, with four mailin...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.313.7052.270

    authors: Strang J,Sheridan J,Barber N

    更新日期:1996-08-03 00:00:00

  • Serum screening for Down's syndrome: experiences of obstetricians in England and Wales.

    abstract:OBJECTIVES:To assess the experiences of obstetricians in England and Wales of serum screening for Down's syndrome. DESIGN:Postal questionnaire survey. SUBJECTS:Questionnaires were sent to all practising obstetricians in England and Wales with nonacademic appointments who had not participated in an earlier (randomly s...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.309.6957.769

    authors: Green JM

    更新日期:1994-09-24 00:00:00

  • Presentation of continuous outcomes in randomised trials: an observational study.

    abstract:OBJECTIVE:To characterise the percentage of available outcome data being presented in reports of randomised clinical trials with continuous outcome measures, thereby determining the potential for incomplete reporting bias. DESIGN:Descriptive cross sectional study. DATA SOURCES:A random sample of 200 randomised trials...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.e8486

    authors: Schriger DL,Savage DF,Altman DG

    更新日期:2012-12-18 00:00:00

  • Randomised controlled trial of integrated care to reduce disability from chronic low back pain in working and private life.

    abstract:OBJECTIVE:To evaluate the effectiveness of an integrated care programme, combining a patient directed and a workplace directed intervention, for patients with chronic low back pain. DESIGN:Population based randomised controlled trial. SETTING:Primary care (10 physiotherapy practices, one occupational health service, ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmj.c1035

    authors: Lambeek LC,van Mechelen W,Knol DL,Loisel P,Anema JR

    更新日期:2010-03-16 00:00:00

  • Hormone replacement therapy and risk of venous thromboembolism: population based case-control study.

    abstract:OBJECTIVE:To evaluate the association between use of hormone replacement therapy and the risk of idiopathic venous thromboembolism. DESIGN:Population based case-control study. SETTING:Population enrolled in the General Practice Research Database, United Kingdom. SUBJECTS:A cohort of 347,253 women aged 50 to 79 witho...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.314.7083.796

    authors: Pérez Gutthann S,García Rodríguez LA,Castellsague J,Duque Oliart A

    更新日期:1997-03-15 00:00:00

  • Prevalence of antibodies to hepatitis B, hepatitis C, and HIV and risk factors in entrants to Irish prisons: a national cross sectional survey.

    abstract:OBJECTIVES:To determine the prevalence of antibodies to hepatitis B core antigen, hepatitis C virus, and HIV in entrants to Irish prisons and to examine risk factors for infection. DESIGN:Cross sectional, anonymous survey, with self completed risk factor questionnaire and oral fluid specimen for antibody testing. SET...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.323.7323.1209

    authors: Long J,Allwright S,Barry J,Reynolds SR,Thornton L,Bradley F,Parry JV

    更新日期:2001-11-24 00:00:00

  • Effect of a national primary care pay for performance scheme on emergency hospital admissions for ambulatory care sensitive conditions: controlled longitudinal study.

    abstract:OBJECTIVE:To estimate the impact of a national primary care pay for performance scheme, the Quality and Outcomes Framework in England, on emergency hospital admissions for ambulatory care sensitive conditions (ACSCs). DESIGN:Controlled longitudinal study. SETTING:English National Health Service between 1998/99 and 20...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.g6423

    authors: Harrison MJ,Dusheiko M,Sutton M,Gravelle H,Doran T,Roland M

    更新日期:2014-11-11 00:00:00

  • Defibrillation time intervals and outcomes of cardiac arrest in hospital: retrospective cohort study from Get With The Guidelines-Resuscitation registry.

    abstract:OBJECTIVE:To describe temporal trends in the time interval between first and second attempts at defibrillation and the association between this time interval and outcomes in patients with persistent ventricular tachycardia or ventricular fibrillation (VT/VF) arrest in hospital. DESIGN:Retrospective cohort study SETTI...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.i1653

    authors: Bradley SM,Liu W,Chan PS,Nallamothu BK,Grunwald GK,Self A,Sasson C,Varosy PD,Anderson ML,Schneider PM,Ho PM,American Heart Association’s Get With The Guidelines-Resuscitation Investigators.

    更新日期:2016-04-06 00:00:00

  • The New Zealand cervical cancer study: could it happen again?

    abstract::The author is one of the medical advisers to the judge who led a government inquiry into allegations that an experimental research program at the National Women's Hospital in Auckland, New Zealand, to study the natural course of cervical carcinoma in situ had withheld conventional treatment from some patients. She ar...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.297.6647.533

    authors: Paul C

    更新日期:1988-08-20 00:00:00

  • Lichen planus and liver diseases: a multicentre case-control study. Gruppo Italiano Studi Epidemiologici in Dermatologia (GISED).

    abstract:OBJECTIVE:To assess the association of lichen planus with liver complaints and with known aetiological factors of liver diseases. DESIGN:Multicentre case-control study. Interviews were conducted by trained medical investigators on the basis of a structured questionnaire. At the interview patients and controls were ask...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1136/bmj.300.6719.227

    authors:

    更新日期:1990-01-27 00:00:00

  • Influence of data display formats on physician investigators' decisions to stop clinical trials: prospective trial with repeated measures.

    abstract:OBJECTIVE:To examine the effect of the method of data display on physician investigators' decisions to stop hypothetical clinical trials for an unplanned statistical analysis. DESIGN:Prospective, mixed model design with variables between subjects and within subjects (repeated measures). SETTING:Comprehensive cancer c...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.318.7197.1527

    authors: Elting LS,Martin CG,Cantor SB,Rubenstein EB

    更新日期:1999-06-05 00:00:00

  • Effects of obesity and weight loss on left ventricular mass and relative wall thickness: survey and intervention study.

    abstract:OBJECTIVES:To investigate the consequences of longstanding obesity on left ventricular mass and structure and to examine the effects of weight loss on these variables. DESIGN:Cross sectional survey and controlled intervention study. SETTING:City of Gothenburg and surrounding areas. Sweden. SUBJECTS:41 obese patients...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.315.7113.912

    authors: Karason K,Wallentin I,Larsson B,Sjöström L

    更新日期:1997-10-11 00:00:00

  • Risk factors and 25 year risk of coronary heart disease in a male population with a high incidence of the disease: the Finnish cohorts of the seven countries study.

    abstract:OBJECTIVE:To assess the efficacy of high serum cholesterol concentration, raised blood pressure, and smoking as predictors of coronary heart disease. DESIGN:Prospective cohort study of middle aged men conducted over 25 years. SETTING:Finish components of an ongoing international study (seven countries study). PARTIC...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.299.6691.81

    authors: Pekkanen J,Nissinen A,Puska P,Punsar S,Karvonen MJ

    更新日期:1989-07-08 00:00:00

  • BMI and all cause mortality: systematic review and non-linear dose-response meta-analysis of 230 cohort studies with 3.74 million deaths among 30.3 million participants.

    abstract:OBJECTIVE:To conduct a systematic review and meta-analysis of cohort studies of body mass index (BMI) and the risk of all cause mortality, and to clarify the shape and the nadir of the dose-response curve, and the influence on the results of confounding from smoking, weight loss associated with disease, and preclinical...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 评论,杂志文章

    doi:10.1136/bmj.i2156

    authors: Aune D,Sen A,Prasad M,Norat T,Janszky I,Tonstad S,Romundstad P,Vatten LJ

    更新日期:2016-05-04 00:00:00

  • Referrals from general practice to hospital outpatient departments: a strategy for improvement.

    abstract:OBJECTIVE:To determine the appropriateness of referrals from general practice to hospital outpatient departments. DESIGN:Prospective audit of referrals from a group practice over one year. SETTING:Six handed practice in a southern coastal town. SUBJECTS:All patients referred during the study period for whom a copy o...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.299.6701.722

    authors: Emmanuel J,Walter N

    更新日期:1989-09-16 00:00:00

  • Use of thermometers in general practice.

    abstract:OBJECTIVE:To identify the attitudes of general practitioners towards the use of thermometers in general practice. DESIGN:Postal questionnaire survey. SETTING:All general practitioners in the catchment area of Frimley Park Hospital, Surrey. SUBJECTS:145 general practitioners. MAIN OUTCOME MEASURES:Answers to questio...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.304.6832.961

    authors: Clarke S

    更新日期:1992-04-11 00:00:00

  • Heat related mortality in warm and cold regions of Europe: observational study.

    abstract:OBJECTIVES:To assess heat related mortalities in relation to climate within Europe. DESIGN:Observational population study. SETTING:North Finland, south Finland, Baden-Württemberg, Netherlands, London, north Italy, and Athens. SUBJECTS:People aged 65-74. MAIN OUTCOME MEASURES:Mortalities at temperatures above, below...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.321.7262.670

    authors: Keatinge WR,Donaldson GC,Cordioli E,Martinelli M,Kunst AE,Mackenbach JP,Nayha S,Vuori I

    更新日期:2000-09-16 00:00:00

  • Change in cough reflex after treatment with enalapril and ramipril.

    abstract:OBJECTIVE:To find out whether enalapril or ramipril causes the sensitivity of the cough reflex to change or symptomatic cough to develop in patients with hypertension. DESIGN:Prospective, placebo controlled, double blind, randomised crossover study. SETTING:Academic units of clinical pharmacology and medicine. PATIE...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.299.6690.13

    authors: McEwan JR,Choudry N,Street R,Fuller RW

    更新日期:1989-07-01 00:00:00

  • Social deprivation and prognostic benefits of cardiac surgery: observational study of 44 902 patients from five hospitals over 10 years.

    abstract:OBJECTIVE:To assess the effects of social deprivation on survival after cardiac surgery and to examine the influence of potentially modifiable risk factors. DESIGN:Analysis of prospectively collected data. Prognostic models used to examine the additional effect of social deprivation on the end points. SETTING:Birming...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.b902

    authors: Pagano D,Freemantle N,Bridgewater B,Howell N,Ray D,Jackson M,Fabri BM,Au J,Keenan D,Kirkup B,Keogh BE,Quality and Outcomes Research Unit (QuORU) UHB Birmingham.,North West Quality Improvement Programme in Cardiac Interventions (U

    更新日期:2009-04-02 00:00:00

  • Computerisation of primary care in Wales.

    abstract:OBJECTIVE:To obtain information about the computerisation of general practice in Wales, and to enable more effective planning of educational provision for doctors and other primary health care workers. DESIGN:Postal questionnaire sent to all general practices in Wales. SUBJECTS:553 general practices, of which 401 (73...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.303.6794.93

    authors: Goves JR,Davies T,Reilly T

    更新日期:1991-07-13 00:00:00

  • Postal survey of approaches to learning among Ontario physicians: implications for continuing medical education.

    abstract:OBJECTIVES:To understand the approaches to learning of practising physicians in their workplace and to assess the relation of these approaches to their motivation for, preferred methods of, and perceived barriers to continuing medical education. DESIGN:Postal survey of 800 Ontario physicians. PARTICIPANTS:373 physici...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.325.7374.1218

    authors: Delva MD,Kirby JR,Knapper CK,Birtwhistle RV

    更新日期:2002-11-23 00:00:00

  • Risk factors for HIV infection in people attending clinics for sexually transmitted diseases in India.

    abstract:OBJECTIVE:To investigate the risk factors for HIV infection in patients attending clinics for sexually transmitted diseases in India. DESIGN:Descriptive study of HIV serology, risk behaviour, and findings on physical examination. SUBJECTS:2800 patients presenting to outpatient clinics between 13 May 1993 and 15 July ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.311.7000.283

    authors: Rodrigues JJ,Mehendale SM,Shepherd ME,Divekar AD,Gangakhedkar RR,Quinn TC,Paranjape RS,Risbud AR,Brookmeyer RS,Gadkari DA

    更新日期:1995-07-29 00:00:00