Abstract：
:Background : Acetaminophen is a widely used analgesic and antipyretic agent in the pediatric population. While the hepatotoxic effects of the drug have been well recognized in cases of acute overdose and chronic supratherapeutic doses, the toxic effects of acetaminophen are rarely documented in cases where therapeutic guidelines are followed. Case : An 8-month-old boy underwent cleft palate repair and placement of bilateral myringotomy tubes. His anesthetic course was uneventful, consisting of maintenance with desflurane and fentanyl. He received acetaminophen for routine postoperative pain management and was tolerating liquids and discharged home on postoperative day 1. On day 3, the child was profoundly lethargic with multiple episodes of emesis and was taken to the emergency department. He suffered a 45-second tonic-clonic seizure in transport to the regional children's medical center, and initial laboratory results demonstrated acute hepatitis with AST 24,424 U/L, ALT 12,885 U/L, total bilirubin 3.1 mg/dL, and a serum acetaminophen level of 83 μg/mL. Aggressive supportive measures including blood products and periprocedural fresh frozen plasma, piperacillin/tazobactam, and intravenous infusions of N-acetylcysteine, sodium phenylacetate and sodium benzoate, carnitine, and citrulline were administered. His metabolic acidosis and acute hepatitis began to correct by day 4, and he was discharged home without further surgical intervention on day 15. Conclusion : Although acetaminophen is an effective and commonly used analgesic in pediatric practice, hepatotoxicity is a potentially devastating complication. This report challenges the appropriateness of existing guidelines for acetaminophen administration and emphasizes the importance of close follow-up and hydration after even relatively minor surgery.
journal_name
Cleft Palate Craniofac Jjournal_title
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Associationauthors
Iorio ML,Cheerharan M,Kaufman SS,Reece-Stremtan S,Boyajian Mdoi
10.1597/12-109subject
Has Abstractpub_date
2013-11-01 00:00:00pages
747-50issue
6eissn
1055-6656issn
1545-1569journal_volume
50pub_type
杂志文章abstract：:The development of the dental arch is well designed for adaptive and compensatory growth. In this study, the relationship between the sleep position and dental arch development was investigated. A group of 42 infants with unilateral complete cleft lip and palate with either prone (16) or supine (26) sleep position wer...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/1545-1569_1994_031_0179_mdaabd_2.3.co_2
更新日期：1994-05-01 00:00:00
abstract：:A review of the studies of the caries prevalence and periodontal health of patients with cleft lip and palate (CLP) revealed that only five investigations of caries prevalence in CLP patients included children. One reported that CLP children did not have a higher caries prevalence in the permanent dentition, whereas m...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章,评审
doi：10.1597/1545-1569_1998_035_0248_tohocw_2.3.co_2
更新日期：1998-05-01 00:00:00
abstract：OBJECTIVE:To determine the percentage of patients with complete unilateral cleft lip and palate and complete bilateral cleft lip and palate treated at SickKids since birth who would benefit from orthognathic surgery. DESIGN:Retrospective cohort study. SUBJECTS:The review comprised records of 258 patients with complet...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/08-176.1
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to examine the relationship between dental maturation and somatic development and to discover their possible deviations in children with shunt-treated hydrocephalus. DESIGN:Radiographs (orthopantomogram and hand-wrist radiograph) from children with shunt-treated hydrocephalus were a...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/03-018.1
更新日期：2004-11-01 00:00:00
abstract：OBJECTIVE:The focus of this study was to determine whether there were any significant differences in academic achievement between students with a cleft and the general population of Swedish students at the typical time of graduation from compulsory school (usually 16 years of age). DESIGN:A retrospective population-ba...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/09-047
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVE:Children with cleft lip and palate are reported to be commonly associated with higher prevalence of dental anomalies such as hypodontia, supernumeraries, and abnormalities in tooth size, shape, and position. This study investigated the prevalence of dental anomalies in a longitudinal cohort of children with u...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1177/1055665617750489
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:The current study was designed to evaluate the neurobiology of reading in a group of men with nonsyndromic clefts of the lip or palate (NSCLP) compared with healthy controls by positron emission tomography. DESIGN:SUBJECTS included eight men with NSCLP compared with six healthy control men. By using radioact...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/05-043
更新日期：2006-11-01 00:00:00
abstract：OBJECTIVE:This histomorphometric study compared the open and prematurely fused side of the coronal suture in subjects with unilateral coronal synostosis (UCS). METHODS:Sutures and parasutural bone were obtained from seven subjects with nonsyndromic UCS during operative correction at 3 to 24 months of age. Histological...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/03-012.1
更新日期：2004-07-01 00:00:00
abstract：:Objective : Palatal fistulas are not uncommon after palatoplasty. Although there are currently many techniques that can be used to close large palatal fistulae, most of these procedures are usually cumbersome and mostly unreliable with high recurrence rates. The facial artery musculomucosal (FAMM) flap was described t...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/12-115
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to determine whether the reading problems of children with cleft fit models of developmental dyslexia. DESIGN:The study compared children with nonsyndromic cleft lip and palate who had reading disability (n = 46) with those who did not have reading disability (n = 46). The child...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/1545-1569_2003_040_0154_dtrdoc_2.0.co_2
更新日期：2003-03-01 00:00:00
abstract：OBJECTIVE:A meta-analysis was performed to estimate the association between maternal cigarette smoking and the risk of having a child with a nonsyndromic oral cleft (NSOC). DESIGN:Studies published from 1966 through 1996 were retrieved using MEDLINE, Current Contents, bibliographies, and other sources. MEDLINE and Cur...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章,meta分析
doi：10.1597/1545-1569_1997_034_0206_mcsaoc_2.3.co_2
更新日期：1997-05-01 00:00:00
abstract：OBJECTIVE:To present a historical appraisal of the use of anthropological and cephalometrical facial soft tissue measurements in cleft patients. DESIGN:The McDowell Indexes and a Medline search were used to trace references up to 1999. Also, references listed with chapters and articles on facial clefts were searched f...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 历史文章,杂志文章
doi：10.1597/1545-1569_2001_038_0577_faicpa_2.0.co_2
更新日期：2001-11-01 00:00:00
abstract：OBJECTIVE:To present orthodontic treatment combined with dual segmental distraction osteogenesis in a patient with Apert syndrome. PATIENT:A 15-year-old boy exhibited severe midfacial hypoplasia with retruded and hypoplastic maxilla and anterior open bite. The patient was treated with a rigid external distraction II s...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/04-151.1
更新日期：2006-07-01 00:00:00
abstract：OBJECTIVE:Premaxillary distraction osteogenesis was introduced using intraoral devices to correct maxillary hypoplasia and lengthen the alveolar bone horizontally in a patient with unilateral cleft lip and palate. METHODS:For premaxillary distraction osteogenesis, Le Fort I osteotomy was performed. Vertical osteotomy ...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/14-105
更新日期：2015-07-01 00:00:00
abstract：OBJECTIVE:To evaluate speech in adults treated for unilateral cleft lip and palate with one-stage or two-stage palate closure and compare the speech of the patients with that of a noncleft control group. DESIGN:Cross-sectional study with long-term follow-up. PARTICIPANTS/SETTING:All unilateral cleft lip and palate pa...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/15-037
更新日期：2017-11-01 00:00:00
abstract：OBJECTIVE:Comparison of the effects of vomerine flap (VF) closure of the hard palate at the time of lip repair with non-closure of the hard palate in subjects with unilateral cleft lip and palate (UCLP). DESIGN:Retrospective, single-blinded, cohort study. SETTING:Study model sets of 40 consecutive, non-syndromic, inf...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/11-297
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:To outline three main categories of nasoalveolar molding complications, describe their etiologies and manifestations, and prescribe preventive and palliative therapy for their proper management. Estimates of the incidence of each complication also are provided. MATERIALS AND METHODS:Data were collected retro...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/07-236.1
更新日期：2009-09-01 00:00:00
abstract：:Primary cheiloplasty in adult patients with unrepaired complete bilateral cleft lip and palate is quite challenging due to severe premaxillary anterior projection. To get the best repair results, the author carried out repositioning of the premaxilla and repair of the lip deformity in a single stage. Positive results ...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/09-225
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVE:This research studied the relationship between associated congenital malformations and the mental and psychomotor development of children with clefts. DESIGN:The study was cross-sectional. SETTING:The study was conducted in a university hospital for children. PARTICIPANTS:The sample consisted of 148 childr...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/1545-1569_2003_040_0297_aiotrb_2.0.co_2
更新日期：2003-05-01 00:00:00
abstract：:Our recent experience with cleft palate closure in the neonatal period (within 28 days of birth) is reviewed in this study. The research involved a series of 21 neonates who presented with untreated cleft palates and underwent a modified Veau-Wardill-Kilner palate closure by a single surgeon between 1991 and 1994. The...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/1545-1569_1996_033_0057_cpcitn_2.3.co_2
更新日期：1996-01-01 00:00:00
abstract：OBJECTIVE:Microform cleft lip (MCL), also known as congenital healed cleft lip, is a rare anomaly that is thought to be a spontaneously healed variant of the more common clefting of lip and palate. Although conventional clefting is known to be associated with congenital heart disease (CHD), MCL has not been similarly a...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/1545-1569_2000_037_0596_chdiap_2.0.co_2
更新日期：2000-11-01 00:00:00
abstract：:Cleft of the palate and congenital anomaly of the tongue is a rare occurrence. A child with the tongue in three segments is being presented for the first time in the literature. This child also had partial cleft palate. The cleft palate was repaired at 7 months of age, and the tongue was reconstructed at 15 months. Th...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/13-117
更新日期：2014-11-01 00:00:00
abstract：:Assessment of the role of gravitational forces in the motor control of the velopharyngeal mechanism was the focus of this study. Specifically, the effect of gravity on activation levels of the levator veli palatini and palatoglossus muscles was assessed. Nineteen volunteers repeated a CV syllable in upright and supine...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/1545-1569_1995_032_0371_eogovm_2.3.co_2
更新日期：1995-09-01 00:00:00
abstract：:Cleft lip and/or cleft palate defects often result in a functional deficiency in the patient's chewing, speech ability, and aesthetic appearance, usually demanding multidisciplinary effort for addressing the aesthetic and functional patient's requirements. This clinical report describes the planned oral rehabilitation...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1177/1055665620946560
更新日期：2020-08-07 00:00:00
abstract：:Objective : To investigate the change in occlusal evaluations from the 5-year-olds' index to the Goslon Yardstick and to compare the relationship between the evaluations and maxillofacial growth in patients with complete unilateral cleft lip and palate (UCLP). Design : A prospective longitudinal study. Subjects : The ...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/12-103
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:To investigate anatomical variations and abnormalities of cervical spine morphology in unoperated infants with cleft lip and palate. DESIGN:Retrospective cross-sectional investigation of infants born with nonsyndromic cleft lip and palate using computed tomography scans acquired for investigation of a spectr...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/05-023
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVE:Virtual surgery and virtual patients necessitate quantitative data on the area of interest. The study was conducted to exactly describe the embryonic and fetal uvular muscle (MU), relevant for clinical as well as virtual surgery and virtual patient generation. METHOD:Serially sectioned viscerocrania of 10 ab...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/08-181
更新日期：2011-11-01 00:00:00
abstract：:Objective : This study compared measures of nasalance obtained using the Nasometer 6200 versus the Nasometer II 6400 in typically speaking young adult males and females for the nonnasal Zoo Passage, the phonetically balanced Rainbow Passage, and the Nasal Sentences. Design : Participants read passages at a comfortab...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/11-219
更新日期：2013-05-01 00:00:00
abstract：:This paper discusses the social and psychological experiences of patients with the most severe forms of craniofacial deformity. The paper concludes that individuals with the most severe forms of craniofacial deformities are at risk for experiencing social and psychological stress and for having their quality of life n...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章,评审
doi：10.1597/1545-1569_1992_029_0578_sapeom_2.3.co_2
更新日期：1992-11-01 00:00:00
abstract：OBJECTIVE:This objective of this study was to determine the effect of presurgical nasoalveolar molding on long-term nasal shape in complete unilateral clefts. DESIGN:The study was retrospective, and the subjects were chosen at random. Nasal casts of the subjects were scanned in three dimensions. Each nose was best fit...
journal_title：The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
pub_type： 杂志文章
doi：10.1597/1545-1569_1999_036_0391_lteonm_2.3.co_2
更新日期：1999-09-01 00:00:00
