Speech and language therapy versus placebo or no intervention for speech problems in Parkinson's disease.

Abstract:

BACKGROUND:Parkinson's disease patients commonly suffer from speech and vocal problems including dysarthric speech, reduced loudness and loss of articulation. These symptoms increase in frequency and intensity with progression of the disease). Speech and language therapy (SLT) aims to improve the intelligibility of speech with behavioural treatment techniques or instrumental aids. OBJECTIVES:To compare the efficacy of speech and language therapy versus placebo or no intervention for speech and voice problems in patients with Parkinson's disease. SEARCH METHODS:Relevant trials were identified by electronic searches of numerous literature databases including MEDLINE, EMBASE, and CINAHL, as well as handsearching of relevant conference abstracts and examination of reference lists in identified studies and other reviews. The literature search included trials published prior to 11(th) April 2011. SELECTION CRITERIA:Only randomised controlled trials (RCT) of speech and language therapy versus placebo or no intervention were included. DATA COLLECTION AND ANALYSIS:Data were abstracted independently by CH and CT and differences settled by discussion. MAIN RESULTS:Three randomised controlled trials with a total of 63 participants were found comparing SLT with placebo for speech disorders in Parkinson's disease. Data were available from 41 participants in two trials. Vocal loudness for reading a passage increased by 6.3 dB (P = 0.0007) in one trial, and 11.0 dB (P = 0.0002) in another trial. An increase was also seen in both of these trials for monologue speaking of 5.4 dB (P = 0.002) and 11.0 dB (P = 0.0002), respectively. It is likely that these are clinically significant improvements. After six months, patients from the first trial were still showing a statistically significant increase of 4.5 dB (P = 0.0007) for reading and 3.5 dB for monologue speaking. Some measures of speech monotoni city and articulation were investigated; however, all these results were non-significant. AUTHORS' CONCLUSIONS:Although improvements in speech impairments were noted in these studies, due to the small number of patients examined, methodological flaws, and the possibility of publication bias, there is insufficient evidence to conclusively support or refute the efficacy of SLT for speech problems in Parkinson's disease. A large well designed placebo-controlled RCT is needed to demonstrate SLT's effectiveness in Parkinson's disease. The trial should conform to CONSORT guidelines. Outcome measures with particular relevance to patients with Parkinson's disease should be chosen and patients followed for at least six months to determine the duration of any improvement.

authors

Herd CP,Tomlinson CL,Deane KH,Brady MC,Smith CH,Sackley CM,Clarke CE

doi

10.1002/14651858.CD002812.pub2

subject

Has Abstract

pub_date

2012-08-15 00:00:00

pages

CD002812

issue

8

issn

1469-493X

pub_type

杂志文章,meta分析,评审
  • Local corticosteroid injection for carpal tunnel syndrome.

    abstract:BACKGROUND:Carpal tunnel syndrome is a clinical syndrome manifested by signs and symptoms of irritation of the median nerve at the level of the carpal tunnel in the wrist. Local corticosteroid injection for carpal tunnel syndrome has been studied but its effectiveness and duration of benefit of local corticosteroid inj...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD001554

    authors: Marshall S,Tardif G,Ashworth N

    更新日期:2002-01-01 00:00:00

  • Long-acting beta2-agonists versus placebo in addition to inhaled corticosteroids in children and adults with chronic asthma.

    abstract:BACKGROUND:Long-acting inhaled beta2-adrenergic agonists are recommended as 'add-on' medication to inhaled corticosteroids in the maintenance therapy of asthmatic adults and children aged two years and above. OBJECTIVES:To quantify in asthmatic patients the safety and efficacy of the addition of long-acting beta2-agon...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005535

    authors: Ni Chroinin M,Greenstone IR,Danish A,Magdolinos H,Masse V,Zhang X,Ducharme FM

    更新日期:2005-10-19 00:00:00

  • Trihexyphenidyl for dystonia in cerebral palsy.

    abstract:BACKGROUND:Cerebral palsy occurs in up to 2.1 of every 1000 live births and encompasses a range of motor problems and movement disorders. One commonly occurring movement disorder amongst those with cerebral palsy is dystonia: sustained or intermittent involuntary muscle spasms and contractions that cause twisting, repe...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD012430.pub2

    authors: Harvey AR,Baker LB,Reddihough DS,Scheinberg A,Williams K

    更新日期:2018-05-15 00:00:00

  • Frequency of endotracheal suctioning for the prevention of respiratory morbidity in ventilated newborns.

    abstract:BACKGROUND:Endotracheal suctioning consists of the mechanical aspiration of pulmonary secretions from the endotracheal tube (ETT) to prevent obstruction. The optimal frequency of ETT suctioning has not been defined. OBJECTIVES:To determine the effect of specific ordered frequency of ETT suctioning ('as scheduled') ver...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD011493.pub2

    authors: Bruschettini M,Zappettini S,Moja L,Calevo MG

    更新日期:2016-03-07 00:00:00

  • Blue-light filtering intraocular lenses (IOLs) for protecting macular health.

    abstract:BACKGROUND:An intraocular lens (IOL) is a synthetic lens that is surgically implanted within the eye following removal of the crystalline lens, during cataract surgery. While all modern IOLs attenuate the transmission of ultra-violet (UV) light, some IOLs, called blue-blocking or blue-light filtering IOLs, also reduce ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD011977.pub2

    authors: Downie LE,Busija L,Keller PR

    更新日期:2018-05-22 00:00:00

  • Aerobic physical exercise for adult patients with haematological malignancies.

    abstract:BACKGROUND:Although people with haematological malignancies have to endure long phases of therapy and immobility, which is known to diminish their physical performance level, the advice to rest and avoid intensive exercises is still common practice. This recommendation is partly due to the severe anaemia and thrombocyt...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD009075.pub3

    authors: Knips L,Bergenthal N,Streckmann F,Monsef I,Elter T,Skoetz N

    更新日期:2019-01-31 00:00:00

  • Bisphosphonates for breast cancer.

    abstract:BACKGROUND:Bone is the most common site of metastatic disease associated with breast cancer affecting more than half of women during the course of their disease. Bone metastases are a significant cause of morbidity due to pain, pathological fractures, hypercalcaemia and spinal cord compression, and contribute to mortal...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003474.pub2

    authors: Pavlakis N,Schmidt R,Stockler M

    更新日期:2005-07-20 00:00:00

  • Laetrile treatment for cancer.

    abstract:BACKGROUND:Laetrile is the name for a semi-synthetic compound which is chemically related to amygdalin, a cyanogenic glycoside from the kernels of apricots and various other species of the genus Prunus. Laetrile and amygdalin are promoted under various names for the treatment of cancer although there is no evidence for...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD005476.pub4

    authors: Milazzo S,Horneber M

    更新日期:2015-04-28 00:00:00

  • Cervical assessment by ultrasound for preventing preterm delivery.

    abstract:BACKGROUND:Measurement of cervical length by ultrasound is predictive of preterm birth (PTB). There are three methods of ultrasound cervical assessment: transvaginal (TVU), transabdominal (TAU), and transperineal (TPU, also called translabial). Cervical length measured by TVU is a relatively new screening test, and has...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD007235.pub4

    authors: Berghella V,Saccone G

    更新日期:2019-09-25 00:00:00

  • Hormone replacement therapy for women with type 1 diabetes mellitus.

    abstract:BACKGROUND:There is conflicting information about the impact of the menopause on glycaemic control amongst women with type 1 diabetes. Some menopausal women with type 1 diabetes are treated with hormone replacement therapy (HRT) but the effects of this treatment have, to date, not been established. OBJECTIVES:To asses...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD008613.pub2

    authors: Mackay L,Kilbride L,Adamson KA,Chisholm J

    更新日期:2013-06-06 00:00:00

  • Lisuride versus bromocriptine for levodopa-induced complications in Parkinson's disease.

    abstract:OBJECTIVES:To compare the efficacy and safety of adjunct lisuride therapy versus bromocriptine in patients with Parkinson's disease, already established on levodopa and suffering the long-term complications of therapy. SEARCH STRATEGY:Electronic searches of MEDLINE, EMBASE and the Cochrane Controlled Trials Register. ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001514

    authors: Clarke CE,Speller JM

    更新日期:2000-01-01 00:00:00

  • Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases.

    abstract:BACKGROUND:Historically, whole brain radiation therapy (WBRT) has been the main treatment for brain metastases. Stereotactic radiosurgery (SRS) delivers high-dose focused radiation and is being increasingly utilized to treat brain metastases. The benefit of adding SRS to WBRT is unclear. This is an updated version of t...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006121.pub4

    authors: Patil CG,Pricola K,Sarmiento JM,Garg SK,Bryant A,Black KL

    更新日期:2017-09-25 00:00:00

  • Single dose oral indometacin for the treatment of acute postoperative pain.

    abstract:BACKGROUND:Indometacin is a non-steroidal anti-inflammatory drug (NSAID) used most commonly for the treatment of inflammation and pain resulting from rheumatic disease (arthritis), and less commonly in postoperative pain management. When taken for chronic pain conditions, indometacin has been associated with a high inc...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD004308.pub2

    authors: Mason L,Edwards J,Moore RA,McQuay HJ

    更新日期:2004-10-18 00:00:00

  • Antithrombotic drugs for carotid artery dissection.

    abstract:BACKGROUND:Extracranial internal carotid artery dissection can lead to occlusion of the artery and hence cause an ischemic stroke. It is the underlying stroke mechanism in approximately 2.5% of all strokes, and the second leading cause of stroke in patients younger than 45 years of age. Antithrombotic agents (heparin, ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000255

    authors: Lyrer P,Engelter S

    更新日期:2000-01-01 00:00:00

  • WITHDRAWN: Ribavirin with or without alpha interferon for chronic hepatitis C.

    abstract:BACKGROUND:Hepatitis C is a major cause of liver-related morbidity and mortality. Ribavirin plus interferon combination therapy is presently considered the optimal treatment of interferon naive patients with chronic hepatitis C, but its role in relapsers and non-responders to previous interferon therapy is not establis...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD002234.pub2

    authors: Gluud LL,Krogsgaard K,Gluud C

    更新日期:2007-07-18 00:00:00

  • Iron therapy in anaemic adults without chronic kidney disease.

    abstract:BACKGROUND:Anaemia affects about a quarter of the world's population. An estimated 50% of anaemic people have anaemia due to iron deficiency. OBJECTIVES:To assess the safety and efficacy of iron therapies for the treatment of adults with anaemia who are not pregnant or lactating and do not have chronic kidney disease....

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD010640.pub2

    authors: Gurusamy KS,Nagendran M,Broadhurst JF,Anker SD,Richards T

    更新日期:2014-12-31 00:00:00

  • Multifocal versus monofocal intraocular lenses after cataract extraction.

    abstract:BACKGROUND:Good unaided distance visual acuity (VA) is now a realistic expectation following cataract surgery and intraocular lens (IOL) implantation. Near vision, however, still requires additional refractive power, usually in the form of reading glasses. Multiple optic (multifocal) IOLs are available which claim to a...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003169.pub4

    authors: de Silva SR,Evans JR,Kirthi V,Ziaei M,Leyland M

    更新日期:2016-12-12 00:00:00

  • Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation.

    abstract:BACKGROUND:Atrial fibrillation is the most frequent sustained arrhythmia. Atrial fibrillation often recurs after restoration of normal sinus rhythm. Antiarrhythmic drugs have been widely used to prevent recurrence. This is an update of a review previously published in 2006, 2012 and 2015. OBJECTIVES:To determine the e...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD005049.pub5

    authors: Valembois L,Audureau E,Takeda A,Jarzebowski W,Belmin J,Lafuente-Lafuente C

    更新日期:2019-09-04 00:00:00

  • Interleukin-1 inhibitors for acute gout.

    abstract:BACKGROUND:Acute gout flares cause significant pain and disability and it is important to provide quick and effective pain relief. Traditional options for managing acute flares include colchicine, non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids. OBJECTIVES:To assess the benefits and harms of interle...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD009993.pub2

    authors: Sivera F,Wechalekar MD,Andrés M,Buchbinder R,Carmona L

    更新日期:2014-09-01 00:00:00

  • Intravascular brachytherapy for peripheral vascular disease.

    abstract:BACKGROUND:International treatment of atherosclerotic narrowed and blocked arteries involves either bypassing the blockage using a graft, widening it from the inside with a balloon, a procedure known as percutaneous transluminal angioplasty (PTA), or providing a strut to hold the vessel open, known as a stent. All of t...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003504

    authors: Hansrani M,Overbeck K,Smout J,Stansby G

    更新日期:2002-01-01 00:00:00

  • Antimicrobial drugs for treating cholera.

    abstract:BACKGROUND:Cholera is an acute watery diarrhoea caused by infection with the bacterium Vibrio cholerae, which if severe can cause rapid dehydration and death. Effective management requires early diagnosis and rehydration using oral rehydration salts or intravenous fluids. In this review, we evaluate the additional bene...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD008625.pub2

    authors: Leibovici-Weissman Y,Neuberger A,Bitterman R,Sinclair D,Salam MA,Paul M

    更新日期:2014-06-19 00:00:00

  • Antibiotics for treating scrub typhus.

    abstract:BACKGROUND:Scrub typhus is a cause of fever in regions of Asia and the Pacific. Recently, resistance to antibiotics has been reported. OBJECTIVES:To assess treatment regimens for scrub typhus through time to fever resolution and incidence of relapse. SEARCH STRATEGY:Cochrane Controlled Trials Register, MEDLINE, EMBAS...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD002150

    authors: Panpanich R,Garner P

    更新日期:2000-01-01 00:00:00

  • Calcitonin for metastatic bone pain.

    abstract:BACKGROUND:Pain is the most frequent symptom experienced by cancer patients, its intensity dependent on the site of the tumour. Tumours that compromise bone or nervous structures due to the bone destruction process are the most painful. There are several treatments to deal with pain (and other symptoms) caused by bone ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003223.pub2

    authors: Martinez-Zapata MJ,Roqué M,Alonso-Coello P,Català E

    更新日期:2006-07-19 00:00:00

  • Anabolic-androgenic steroids for alcoholic liver disease.

    abstract:BACKGROUND:Alcohol is one of the most common causes of liver disease in the Western World today. Randomised clinical trials have examined the effects of anabolic-androgenic steroids for alcoholic liver disease. OBJECTIVES:The objectives were to assess the beneficial and harmful effects of anabolic-androgenic steroids ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003045

    authors: Rambaldi A,Iaquinto G,Gluud C

    更新日期:2003-01-01 00:00:00

  • Interventions for treating oral mucositis for patients with cancer receiving treatment.

    abstract:BACKGROUND:Treatment of cancer is increasingly effective but associated with short and long term side effects. Oral side effects, including oral mucositis (mouth ulceration), remain a major source of illness despite the use of a variety of agents to treat them. OBJECTIVES:To assess the effectiveness of interventions f...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD001973.pub4

    authors: Clarkson JE,Worthington HV,Furness S,McCabe M,Khalid T,Meyer S

    更新日期:2010-08-04 00:00:00

  • Supplemental oxygen for the treatment of prethreshold retinopathy of prematurity.

    abstract:BACKGROUND:Oxygen has long been implicated in the pathogenesis of retinopathy of prematurity (ROP) and is rigorously monitored in today's neonatal intensive care units. Recent research using a feline model has shown an improvement in ROP outcome of kittens treated with supplemental oxygen. Current treatment for ROP by ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003482

    authors: Lloyd J,Askie L,Smith J,Tarnow-Mordi W

    更新日期:2003-01-01 00:00:00

  • Physician advice for smoking cessation.

    abstract:BACKGROUND:Healthcare professionals frequently advise patients to improve their health by stopping smoking. Such advice may be brief, or part of more intensive interventions. OBJECTIVES:The aims of this review were to assess the effectiveness of advice from physicians in promoting smoking cessation; to compare minimal...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000165.pub3

    authors: Stead LF,Bergson G,Lancaster T

    更新日期:2008-04-16 00:00:00

  • Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults.

    abstract:BACKGROUND:Acetylcholinesterase inhibitors, such as neostigmine, have traditionally been used for reversal of non-depolarizing neuromuscular blocking agents. However, these drugs have significant limitations, such as indirect mechanisms of reversal, limited and unpredictable efficacy, and undesirable autonomic response...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD012763

    authors: Hristovska AM,Duch P,Allingstrup M,Afshari A

    更新日期:2017-08-14 00:00:00

  • Linezolid versus vancomycin for skin and soft tissue infections.

    abstract:BACKGROUND:The morbidity and treatment costs associated with skin and soft tissue infections (SSTIs) are high. Linezolid and vancomycin are antibiotics that are commonly used in treating skin and soft-tissue infections, specifically those infections due to methicillin-resistant Staphylococcus aureus (MRSA). OBJECTIVES...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD008056.pub2

    authors: Yue J,Dong BR,Yang M,Chen X,Wu T,Liu GJ

    更新日期:2013-07-12 00:00:00

  • Quetiapine versus other atypical antipsychotics for schizophrenia.

    abstract:BACKGROUND:In many countries of the industrialised world second generation ('atypical') antipsychotic drugs have become the first line drug treatment for people with schizophrenia. It is not clear how the effects of the various second generation antipsychotic drugs differ. OBJECTIVES:To evaluate the effects of quetiap...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006625.pub2

    authors: Komossa K,Rummel-Kluge C,Schmid F,Hunger H,Schwarz S,Srisurapanont M,Kissling W,Leucht S

    更新日期:2010-01-20 00:00:00