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Pituitary granuloma and pyoderma gangrenosum.

Abstract：

:Pyoderma gangrenosum is a rare chronic and recurrent skin disease characterized by progressing lesions from papulopustules to large necrotic sterile ulcers. Its definite etiology remains unknown. In a 40-year-old woman with typical pyoderma gangrenosum an intrasellar mass with suprasellar extension was diagnosed and removed by transsphenoidal surgery. Histopathological features of the lesion were those of a nonspecific granulomatous hypophysitis. Five months postoperatively the patient experienced visual defects and hypopituitarism demonstrated by endocrine evaluation. Computerized tomography showed the recurrence of the intrasellar expanding mass. Extensive and repeated evaluation failed to find any evidence of sarcoidosis, tuberculosis or histiocytosis. Corticosteroid therapy was preferred to surgery and 80 mg daily prednisone produced a dramatic shrinkage of the pituitary pseudotumor. Long-term follow-up studies did not disclose any recurrence of the pituitary granulomatous process nor objective evidence of underlying disease even after steroid dosage has been tapered. The hypothesis of a pituitary localization of pyoderma gangrenosum is suggested by the similarity between the histopathologic findings of the two conditions and the excellent response to steroid therapy.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Chanson P,Timsit J,Kujas M,Violante A,Guillausseau PJ,Derome PJ,Warnet A,Lubetzki J

doi

10.1007/BF03349595

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

677-81

issue

8

eissn

0391-4097

issn

1720-8386

journal_volume

13

pub_type

杂志文章

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