Botulinum toxin for myofascial pain syndromes in adults.

Abstract:

BACKGROUND:Myofascial pain syndrome (MPS) is a regional muscular pain syndrome characterised by the presence of trigger points, which are painful points in one or more muscles. The pain can be felt at the site where the trigger point is located or it can be felt away from that place when the muscle is pressed (referred pain). Botulinum toxin is a protein produced by the bacterium Clostridium botulinum and is a potent neurotoxin that eventually inhibits muscle contractions. It is capable of selectively weakening painful muscles and interrupting the pain cycle. OBJECTIVES:To assess the effectiveness and safety of botulinum toxin in treating MPS, excluding MPS in neck and head muscles. SEARCH METHODS:The search strategy was composed of terms for myofascial pain and botulinum toxin. We searched the Cochrane Pain, Palliative and Supportive Care (PaPaS) Review Group's Specialised Register until December 2011, CENTRAL (Cochrane Database of Systematic Reviews 2011, Issue 4), PUBMED (from 1966 to 2011), EMBASE (from 1980 to 2011) and LILACS (from 1982 to 2011). There was no language restriction. SELECTION CRITERIA:We included randomised controlled trials (RCTs) involving botulinum toxin for treating participants with MPS. We excluded studies with MPS of the neck and head from this review, as they have already been assessed in existing systematic reviews. We considered a diagnosis of MPS to be based on the identification of trigger points in the taut band through palpation of sensitive nodules, local twitch response and specific patterns of referred pain associated with each trigger point. DATA COLLECTION AND ANALYSIS:Two review authors independently screened identified studies, extracted data, assessed trial quality and analysed results using the Cochrane PaPaS Review Group criteria. MAIN RESULTS:Four studies with a total of 233 participants, comparing botulinum toxin A (BTXA) with placebo, met the inclusion criteria. In one study with 145 participants, a significant improvement rate of pain intensity scores, as shown by the mean difference (MD) of -0.23 (95% confidence interval (CI) -0.26 to -0.20; P value < 0.00001) and duration of daily pain (MD -1.11; 95% CI -1.37 to -0.85; P value < 0.00001), was demonstrated when comparing BTXA with placebo. The three other studies showed that there was no statistically significant difference between BTXA and placebo in pain intensity. AUTHORS' CONCLUSIONS:There is inconclusive evidence to support the use of botulinum toxin in the treatment of MPS based on data from four studies with a total of 233 participants, which we considered adequate to be included in this review. Meta-analyses were not possible due to the heterogeneity between studies. We suggest that in future studies the same methodology to assess pain, a standardised dose of treatment, follow-up of at least four months (to observe the maximum/minimum curve of the drug effect) and appropriate data presentation should be used. More high-quality RCTs of botulinum toxin for treating MPS need to be conducted before firm conclusions on its effectiveness and safety can be drawn.

authors

Soares A,Andriolo RB,Atallah AN,da Silva EM

doi

10.1002/14651858.CD007533.pub2

subject

Has Abstract

pub_date

2012-04-18 00:00:00

pages

CD007533

issue

4

issn

1469-493X

pub_type

杂志文章,评审
  • Prophylactic syntometrine versus oxytocin for delivery of the placenta.

    abstract:BACKGROUND:The routine prophylactic administration of an oxytocic agent is an integral part of active management of the third stage of labour. These agents help prevent postpartum haemorrhage. OBJECTIVES:The objective of this review was to assess the effects of ergometrine-oxytocin (syntometrine) with oxytocin alone i...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000201

    authors: McDonald S,Prendiville WJ,Elbourne D

    更新日期:2000-01-01 00:00:00

  • Different intensities of glycaemic control for pregnant women with pre-existing diabetes.

    abstract:BACKGROUND:The optimal glycaemic control target in pregnant women with pre-existing diabetes is unclear, although there is a clear link between high glucose concentrations and adverse birth outcomes. OBJECTIVES:To assess the effects of different intensities of glycaemic control in pregnant women with pre-existing type...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD008540.pub2

    authors: Middleton P,Crowther CA,Simmonds L,Muller P

    更新日期:2010-09-08 00:00:00

  • Paracetamol (acetaminophen) for prevention or treatment of pain in newborns.

    abstract:BACKGROUND:Newborn infants have the ability to experience pain. Hospitalised infants are exposed to numerous painful procedures. Healthy newborns are exposed to pain if the birth process consists of assisted vaginal birth by vacuum extraction or by forceps and during blood sampling for newborn screening tests. OBJECTI...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD011219.pub4

    authors: Ohlsson A,Shah PS

    更新日期:2020-01-27 00:00:00

  • Elective delivery of women with a twin pregnancy from 37 weeks' gestation.

    abstract:BACKGROUND:The optimal timing of birth for women with an otherwise uncomplicated twin pregnancy at term is uncertain, with clinical support for both elective delivery at 37 weeks, as well as expectant management (awaiting the spontaneous onset of labour). OBJECTIVES:To assess a policy of elective delivery from 37 week...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003582

    authors: Dodd JM,Crowther CA

    更新日期:2003-01-01 00:00:00

  • Antibiotics for the common cold.

    abstract:BACKGROUND:The common cold is considered to be caused by viruses and it has long been believed that antibiotics have no role in treating this condition. In many countries doctors will often prescribe antibiotics for the common cold in the belief that they may prevent secondary bacterial infection and in some cases to r...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000247

    authors: Arroll B,Kenealy T

    更新日期:2002-01-01 00:00:00

  • Laparoscopic colposuspension for urinary incontinence in women.

    abstract:BACKGROUND:Laparoscopic colposuspension was one of the first minimal access operations for treating stress urinary incontinence in women, with the presumed advantages of shorter hospital stays and quicker return to normal activities. This Cochrane Review was last updated in 2010. OBJECTIVES:To assess the effects of la...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD002239.pub4

    authors: Freites J,Stewart F,Omar MI,Mashayekhi A,Agur WI

    更新日期:2019-12-10 00:00:00

  • Family and carer smoking control programmes for reducing children's exposure to environmental tobacco smoke.

    abstract:BACKGROUND:Children's exposure to other people's tobacco smoke (environmental tobacco smoke, or ETS) is associated with a range of adverse health outcomes for children. Parental smoking is a common source of children's exposure to ETS. Older children in child care or educational settings are also at risk of exposure to...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD001746.pub4

    authors: Behbod B,Sharma M,Baxi R,Roseby R,Webster P

    更新日期:2018-01-31 00:00:00

  • Pulmonary artery flow catheters for directing management in pre-eclampsia.

    abstract:BACKGROUND:Gestational hypertension and pre-eclampsia can cause fluid shifts. Pulmonary oedema and renal failure can result from these shifts. Fluid management is crucial in managing pre-eclampsia, especially in the context of pulmonary oedema and renal failure. Pulmonary artery catheterisation may be a method of effec...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD008882.pub2

    authors: Li YH,Novikova N

    更新日期:2012-06-13 00:00:00

  • Interventions for patients and caregivers to improve knowledge of sickle cell disease and recognition of its related complications.

    abstract:BACKGROUND:Sickle cell disease is a group of genetic diseases which is especially prevalent in tropical and subtropical regions; however, forced migration and ongoing population movement have spread it throughout the world, with estimated birth rates reaching 0.49 per 1000 in the Americas, 0.07 per 1000 in Europe, 0.68...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD011175.pub2

    authors: Asnani MR,Quimby KR,Bennett NR,Francis DK

    更新日期:2016-10-06 00:00:00

  • Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases.

    abstract:BACKGROUND:Our systematic review has demonstrated that antioxidant supplements may increase mortality. We have now updated this review. OBJECTIVES:To assess the beneficial and harmful effects of antioxidant supplements for prevention of mortality in adults. SEARCH METHODS:We searched The Cochrane Library, MEDLINE, EM...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD007176.pub2

    authors: Bjelakovic G,Nikolova D,Gluud LL,Simonetti RG,Gluud C

    更新日期:2012-03-14 00:00:00

  • Horse chestnut seed extract for chronic venous insufficiency.

    abstract:BACKGROUND:Conservative therapy of chronic venous insufficiency (CVI) consists largely of compression treatment. However, this often causes discomfort and has been associated with poor compliance. Therefore, oral drug treatment is an attractive option. OBJECTIVES:To review the efficacy and safety of oral horse chestnu...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003230.pub3

    authors: Pittler MH,Ernst E

    更新日期:2006-01-25 00:00:00

  • Opioid antagonists with minimal sedation for opioid withdrawal.

    abstract:BACKGROUND:Managed withdrawal is a necessary step prior to drug-free treatment or as the end point of long-term substitution treatment. OBJECTIVES:To assess the effectiveness of opioid antagonists in combination with minimal sedation to manage opioid withdrawal. SEARCH STRATEGY:We searched the Cochrane Central Regist...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD002021.pub3

    authors: Gowing L,Ali R,White JM

    更新日期:2009-10-07 00:00:00

  • Corticosteroids for treating optic neuritis.

    abstract:BACKGROUND:Optic neuritis is an inflammatory disease of the optic nerve. It occurs more commonly in women than in men. Usually presenting with an abrupt loss of vision, recovery of vision is almost never complete. Closely linked in pathogenesis to multiple sclerosis, it may be the initial manifestation for this conditi...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD001430.pub3

    authors: Gal RL,Vedula SS,Beck R

    更新日期:2012-04-18 00:00:00

  • Carbamazepine for schizophrenia.

    abstract:BACKGROUND:Many people with schizophrenia do not achieve a satisfactory treatment response with just antipsychotic drug treatment and various adjunct medications are used to promote additional response. The antiepileptic carbamazepine is one such drug. OBJECTIVES:To evaluate the effects of carbamazepine and its deriva...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001258.pub2

    authors: Leucht S,Kissling W,McGrath J,White P

    更新日期:2007-07-18 00:00:00

  • Vitamin C for preventing and treating tetanus.

    abstract:BACKGROUND:Tetanus is a severe infection that can be prevented by vaccination. In developing countries vaccination coverage is not always high and in developed countries cases may still occur, particularly in elderly people owing to their reduced immunoprotection. It has been estimated that there are about one million ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD006665.pub2

    authors: Hemilä H,Koivula TT

    更新日期:2008-04-16 00:00:00

  • Chinese medicinal herbs to treat the side-effects of chemotherapy in breast cancer patients.

    abstract:BACKGROUND:Short term side-effects of chemotherapy include fatigue, nausea, vomiting, mucositis and myelosuppression or neutropenia. These occur during the course of treatment and generally resolve within months of completion of chemotherapy. A variety of Chinese medicinal herbs have been used for managing these side e...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004921.pub2

    authors: Zhang M,Liu X,Li J,He L,Tripathy D

    更新日期:2007-04-18 00:00:00

  • Percutaneous transluminal angioplasty for treatment of chronic cerebrospinal venous insufficiency (CCSVI) in people with multiple sclerosis.

    abstract:BACKGROUND:Multiple sclerosis (MS) is a leading cause of neurological disability in young adults. The most widely accepted hypothesis regarding its pathogenesis is that it is an immune-mediated disease. It has been hypothesised that intraluminal defects, compression, or hypoplasia in the internal jugular or azygos vein...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD009903.pub3

    authors: Jagannath VA,Pucci E,Asokan GV,Robak EW

    更新日期:2019-05-31 00:00:00

  • Cerebrospinal fluid drainage for thoracic and thoracoabdominal aortic aneurysm surgery.

    abstract:BACKGROUND:During aortic aneurysm surgery, cross-clamping can lead to inadequate blood supply to the spinal cord resulting in neurological deficit. Cerebrospinal fluid drainage (CSFD) may increase the perfusion pressure to the spinal cord and hence reduce the risk of ischaemic spinal cord injury. OBJECTIVES:To determi...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003635.pub3

    authors: Khan SN,Stansby G

    更新日期:2012-10-17 00:00:00

  • Endometriosis: an overview of Cochrane Reviews.

    abstract:BACKGROUND:This overview reports on interventions for pain relief and for subfertility in pre-menopausal women with clinically diagnosed endometriosis. OBJECTIVES:The objective of this overview was to summarise the evidence from Cochrane systematic reviews on treatment options for women with pain or subfertility assoc...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD009590.pub2

    authors: Brown J,Farquhar C

    更新日期:2014-03-10 00:00:00

  • Pelvic floor muscle training for prevention and treatment of urinary and faecal incontinence in antenatal and postnatal women.

    abstract:BACKGROUND:About a third of women have urinary incontinence and up to a tenth have faecal incontinence after childbirth. Pelvic floor muscle training is commonly recommended during pregnancy and after birth both for prevention and treatment of incontinence. OBJECTIVES:To determine the effect of pelvic floor muscle tra...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD007471

    authors: Hay-Smith J,Mørkved S,Fairbrother KA,Herbison GP

    更新日期:2008-10-08 00:00:00

  • Psychosocial interventions for recurrent abdominal pain in childhood.

    abstract:BACKGROUND:This review supersedes the original Cochrane review first published in 2008 (Huertas-Ceballos 2008).Between 4% and 25% of school-aged children complain of recurrent abdominal pain (RAP) severe enough to interfere with their daily activities. No organic cause for this pain can be found on physical examination...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD010971.pub2

    authors: Abbott RA,Martin AE,Newlove-Delgado TV,Bethel A,Thompson-Coon J,Whear R,Logan S

    更新日期:2017-01-10 00:00:00

  • Trifluoperazine for schizophrenia.

    abstract:BACKGROUND:Trifluoperazine is an inexpensive accessible 'high potency' antipsychotic drug, widely used to treat schizophrenia or related psychoses. OBJECTIVES:To estimate the effects of trifluoperazine compared with placebo and other drugs. SEARCH STRATEGY:Searches of the Cochrane Schizophrenia Group's register of tr...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003545.pub2

    authors: Marques LO,Lima MS,Soares BG

    更新日期:2004-01-01 00:00:00

  • Skin preparation for preventing infection following caesarean section.

    abstract:BACKGROUND:The risk of maternal mortality and morbidity (particularly postoperative infection) is higher for caesarean section (CS) than for vaginal birth. With the increasing rate of CS, it is important to minimise the risks to the mother as much as possible. This review focused on different forms and methods of preop...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD007462.pub4

    authors: Hadiati DR,Hakimi M,Nurdiati DS,da Silva Lopes K,Ota E

    更新日期:2018-10-22 00:00:00

  • Haloperidol versus placebo for schizophrenia.

    abstract:BACKGROUND:Haloperidol was developed in the late 1950s for use in the field of anaesthesia. Research subsequently demonstrated effects on hallucinations, delusions, aggressiveness, impulsiveness and states of excitement and led to the introduction of haloperidol as an antipsychotic. OBJECTIVES:To evaluate the clinical...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003082.pub3

    authors: Adams CE,Bergman H,Irving CB,Lawrie S

    更新日期:2013-11-15 00:00:00

  • Prophylactic drug management for febrile seizures in children.

    abstract:BACKGROUND:Febrile seizures occurring in a child older than one month during an episode of fever affect 2% to 4% of children in Great Britain and the United States and recur in 30%. Rapid-acting antiepileptics and antipyretics given during subsequent fever episodes have been used to avoid the adverse effects of continu...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003031.pub3

    authors: Offringa M,Newton R,Cozijnsen MA,Nevitt SJ

    更新日期:2017-02-22 00:00:00

  • Strategies for managing sexual dysfunction induced by antidepressant medication.

    abstract:BACKGROUND:Sexual dysfunction (including altered desire, orgasmic dysfunction, erectile and ejaculatory problems) is a relatively common side effect of antidepressant medication. These sexual side effects may compromise a person's lifestyle and result in a lack of compliance with the prescribed antidepressant to the de...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003382.pub2

    authors: Rudkin L,Taylor MJ,Hawton K

    更新日期:2004-10-18 00:00:00

  • Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding.

    abstract:BACKGROUND:There is conflicting evidence regarding the clinical efficacy of proton pump inhibitors (PPI) initiated before endoscopy for upper gastrointestinal bleeding. OBJECTIVES:To systematically review evidence from randomised controlled trials (RCTs) of PPI treatment initiated before endoscopy for upper gastrointe...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005415.pub3

    authors: Sreedharan A,Martin J,Leontiadis GI,Dorward S,Howden CW,Forman D,Moayyedi P

    更新日期:2010-07-07 00:00:00

  • Nicotine replacement therapy for smoking cessation.

    abstract:BACKGROUND:The aim of nicotine replacement therapy (NRT) is temporarily to replace much of the nicotine from cigarettes to reduce motivation to smoke and nicotine withdrawal symptoms, thus easing the transition from cigarette smoking to complete abstinence. OBJECTIVES:The aims of this review were:To determine the effe...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000146.pub3

    authors: Stead LF,Perera R,Bullen C,Mant D,Lancaster T

    更新日期:2008-01-23 00:00:00

  • Imaging modalities for characterising focal pancreatic lesions.

    abstract:BACKGROUND:Increasing numbers of incidental pancreatic lesions are being detected each year. Accurate characterisation of pancreatic lesions into benign, precancerous, and cancer masses is crucial in deciding whether to use treatment or surveillance. Distinguishing benign lesions from precancerous and cancerous lesions...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD010213.pub2

    authors: Best LM,Rawji V,Pereira SP,Davidson BR,Gurusamy KS

    更新日期:2017-04-17 00:00:00

  • Breastfeeding or nipple stimulation for reducing postpartum haemorrhage in the third stage of labour.

    abstract:BACKGROUND:Oxytocin and prostaglandin are hormones responsible for uterine contraction during the third stage of labour. Receptors in the uterine muscles are stimulated by exogenous or endogenous oxytocin leading to uterine contractions. Nipple stimulation or breastfeeding are stimuli that can lead to the secretion of ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD010845.pub2

    authors: Abedi P,Jahanfar S,Namvar F,Lee J

    更新日期:2016-01-27 00:00:00