Lymphocytic hypophysitis: report of an unusual case of a rare disorder.

Abstract:

:A 36-year-old non-pregnant woman presented with a four-month history of progressive visual deterioration and amenorrhea. The latest gestation was 6 years earlier. Hormonal study revealed central diabetes insipidus, hypopituitarism, and slightly increased prolactin level. Ophthalmologic examination showed bilateral hemianopsia. In the magnetic resonance imaging an intrasellar mass with supra and retrosellar extension was found. The mass showed a polylobular aspect with heterogeneous signal within the tissue. The normal neurohypophysis could not be identified. Pterional craniotomy was performed. The pathological examinations revealed fibrous tissue with heavy inflammatory infiltrate composed of lymphocytes and plasma cells, islands of eosinophilic epithelial cells stained positively for chromogranin, GH, ACTH, and PRL and negatively for antibodies directed against HLA-II antigens. This case of lymphocytic hypophysitis was not related to pregnancy and involved the neurohypophysis. We discuss the features that can help to make a preoperative differential diagnosis.

journal_name

J Endocrinol Invest

authors

Durán Martínez M,Santonja C,Pavón de Paz I,Monereo Megías S

doi

10.1007/BF03343842

keywords:

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

190-3

issue

3

eissn

0391-4097

issn

1720-8386

journal_volume

24

pub_type

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