Effects of apolipoprotein A gene polymorphisms on lipoprotein (a) concentrations in Japanese.


:1. Elevated plasma lipoprotein (a) (Lp(a)) concentrations have been correlated with an increased risk of premature cardiovascular disease. The plasma Lp(a) concentration is quantitatively heritable and the apolipoprotein (Apo) A gene is known as a major locus-determining Lp(a) concentration. 2. The aim of the present study was to evaluate the genetic effect of polymorphisms in the 5'-untranslated region (UTR) of the ApoA gene on plasma concentrations of Lp(a). 3. We analysed two sequence variations in the 5'-UTR, a pentanucleotide repeat (PNR) polymorphism and haplotypes composed of three single base substitutions, in 325 Japanese subjects. The ApoA size polymorphism was also analysed by western blotting. 4. The plasma Lp(a) concentration was inversely correlated with the size of the ApoA molecule. Both PNR and the haplotype polymorphisms had significant effects on serum Lp(a) concentrations (P = 0.001 and 0.004, respectively) when the effects were evaluated by ANCOVA using the ApoA size polymorphism as a covariate. 5. When a stratified subpopulation with a larger ApoA size was analysed, both variations influenced or tended to influence the serum Lp(a) concentration, confirming the results of the ANCOVA. 6. Pentanucleotide repeat showed a tight linkage disequilibrium with the haplotypes. This disequilibrium may account for the apparent effects of PNR on Lp(a) concentrations.


Park HY,Nabika T,Notsu Y,Kobayashi S,Masuda J





Has Abstract


1999-04-01 00:00:00












  • Taurine prevents high-fat diet-induced-hepatic steatosis in rats by direct inhibition of hepatic sterol regulatory element-binding proteins and activation of AMPK.

    abstract::This study investigated if the protective effect of taurine against high fat diet-induced hepatic steatosis involves modulating the hepatic activity of 5' AMP-activated protein kinase (AMPK) and levels/activity of the sterol regulatory element-binding proteins-1/2 (SREBP1/2). Rats were divided into four groups (n = 12...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Morsy MD,Aboonq MS,ALsleem MA,Abusham AA

    更新日期:2020-07-21 00:00:00

  • Dual nitric oxide mechanisms of cholestasis-induced bradycardia in the rat.

    abstract::1. Cholestatic liver disease is associated with nitric oxide (NO) overproduction and bradycardia. Nitric oxide has a dual effect on sinoatrial node and its effects depend on its concentration. Nitric oxide can increase heart rate by activating hyperpolarization-activated pacemaker current (If) but, at high concentrati...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Mani AR,Nahavandi A,Moosavi M,Safarinejad R,Dehpour AR

    更新日期:2002-10-01 00:00:00

  • Is Fleming's lysozyme an analgesic agent? Experiments on mice.

    abstract::1. Antinociceptive activity of hen egg white lysozyme (Fleming's lysozyme) was determined against abdominal contractions provoked by irritants injected intraperitoneally into mice. Carrageenan (2 mg) (CA) injected with arachidonic acid (15 micrograms) (AA) or prostaglandins PGE1 or PGF2 alpha (0.04 ng), brewer's yeast...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Bianchi C

    更新日期:1983-01-01 00:00:00

  • Salt- and angiotensin II-dependent variations in amiloride-sensitive rectal potential difference in mice.

    abstract::1. In the rectum and distal nephron, sodium reabsorption is mediated by the amiloride-sensitive epithelial sodium channel (ENaC). The ENaC-mediated sodium transport is electrogenic and creates an amiloride-sensitive transepithelial potential difference (PD). 2. We have evaluated the salt- and angiotensin (Ang)II-depen...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Wang Q,Horisberger JD,Maillard M,Brunner HR,Rossier BC,Burnier M

    更新日期:2000-01-01 00:00:00

  • Cimetidine and ranitidine: a study of competitive and ion-channel blockade in the toad isolated rectus abdominis muscle.

    abstract::Responses of the toad isolated rectus abdominis muscle to cumulative doses of carbachol were recorded in the absence or presence of varying concentrations of cimetidine or ranitidine. The corresponding cumulative log concentration-response curves for carbachol were then plotted for each antagonist studied. Cimetidine ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Gwee MC,Cheah LS,Shoon ML

    更新日期:1986-08-01 00:00:00

  • Effects of losartan on the cardiovascular system, renal haemodynamics and function and lung liquid flow in fetal sheep.

    abstract::1. The angiotensin type 1 (AT1) receptor antagonist, losartan (10 mg/kg) was infused intravenously into nine chronically catheterized fetal sheep (125-132 days gestation). Losartan reduced the fetal systolic (P <0.01) and diastolic (P <0.01) pressor response to 5 microg angiotensin II (AngII) i.v. from 27.4 +/- 1.5 to...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Stevenson KM,Gibson KJ,Lumbers ER

    更新日期:1996-02-01 00:00:00

  • P2X7 receptor in cardiovascular disease: The heart side.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Guerra Martinez C

    更新日期:2019-06-01 00:00:00

  • Long-term deficiency of essential fatty acids in rats and its effect on brain recovery.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Odutuga AA

    更新日期:1979-07-01 00:00:00

  • NBPA: a cerebral ischaemic protective agent.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Zhang J,Peng X,Wei G,Su D

    更新日期:1999-10-01 00:00:00

  • Phytosterol additives increase blood pressure and promote stroke onset in salt-loaded stroke-prone spontaneously hypertensive rats.

    abstract::1. To assess the effect of dietary phytosterol on stroke and the lifespan of salt-loaded stroke-prone spontaneously hypertensive rats (SHRSP), we investigated the effects of the addition of phytosterol to soybean oil (phytosterol content: 0.3%) on stroke onset, lifespan following onset of stroke and overall lifespan c...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ogawa H,Yamamoto K,Kamisako T,Meguro T

    更新日期:2003-12-01 00:00:00

  • Visfatin is associated with lipid metabolic abnormalities in Lyon hypertensive rats.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Wang P,Bai C,Xu QY,Xu TY,Su DF,Sassard J,Miao CY

    更新日期:2010-09-01 00:00:00

  • Cardiac-specific overexpression of catalase prolongs lifespan and attenuates ageing-induced cardiomyocyte contractile dysfunction and protein damage.

    abstract::1. Oxidative stress plays a role in senescence-associated organ deterioration. This is supported by the beneficial effects of anti-oxidants against ageing-related organ damage, although their role in cardiac ageing has not been elucidated. 2. The aim of the present study was to examine the impact of cardiac-specific o...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Wu S,Li Q,Du M,Li SY,Ren J

    更新日期:2007-01-01 00:00:00

  • Strategies of treating cancer by cytokine regulation of chromosome end remodelling.

    abstract::1. Telomeres (ends of chromosomes) undergo constant remodelling during cell development, proliferation and differentiation, as well as in neoplastic cell immortalization and transformation. How the cellular microenvironment influences telomere remodelling (lengthening or shortening) remains largely unknown. 2. Recentl...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Liu JP,Nicholls C,Chen SM,Li H,Tao ZZ

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  • Sensitivity changes in guinea-pig atria and ileum following subacute administration of dyflos.

    abstract::1. Subacute administration of dyflos to guinea-pigs (1.2 mg/kg, s.c., daily for 10 days) led to the development of subsensitivity to carbachol in the ileum but not in the electrically stimulated left atrium. 2. Atria from dyflos-pretreated animals became supersensitive to acetylcholine but the ileum became subsensitiv...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Mitchelson F,O'Shea RA

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  • Original and generic latanoprost for the treatment of glaucoma and ocular hypertension: are they really the same?

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,随机对照试验


    authors: Golan S,Rosenfeld E,Shemesh G,Kurtz S

    更新日期:2015-02-01 00:00:00

  • Effect of ethamsylate on carrageenan-induced rat paw oedema: a comparison with indomethacin.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Gard PR,Trigger DJ

    更新日期:1990-12-01 00:00:00

  • Failure of neomycin to modify ACTH induced hypertension in sheep.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Tresham J,Coghlan JP,Denton DA,Scoggins BA,Whitworth JA

    更新日期:1984-11-01 00:00:00

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kohzuki H,Misawa H,Kishi T,Ohga Y,Sakata S,Takaki M

    更新日期:1999-08-01 00:00:00

  • Relationship between serum osteocalcin and glycaemic variability in Type 2 diabetes.

    abstract::1. Recent reports have described the role of osteocalcin in glucose metabolism and glycaemic variability has been proven to be associated with an increased risk of diabetes complications. However, the relationship between osteocalcin and glycaemic variability remains unclear. The aim of the present study was to examin...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章


    authors: Bao YQ,Zhou M,Zhou J,Lu W,Gao YC,Pan XP,Tang JL,Lu HJ,Jia WP

    更新日期:2011-01-01 00:00:00

  • Enhancement by endothelin-1 of the release of catecholamines from the canine adrenal gland in response to splanchnic nerve stimulation.

    abstract::1. The effect of endothelin-1 on the release of adrenal catecholamines was examined in anaesthetized dogs. 2. Splanchnic nerve stimulation (SNS) at 1 and 3 Hz was applied before and after the intravenous injection of endothelin-1. 3. Endothelin-1 (0.1 and 0.3 micrograms/kg) significantly enhanced the release of adrena...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Takeuchi A,Kimura T,Satoh S

    更新日期:1992-09-01 00:00:00

  • Similar renoprotection after renin-angiotensin-dependent and -independent antihypertensive therapy in 5/6-nephrectomized Ren-2 transgenic rats: are there blood pressure-independent effects?

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kujal P,Chábová VČ,Vernerová Z,Walkowska A,Kompanowska-Jezierska E,Sadowski J,Vaňourková Z,Husková Z,Opočenský M,Skaroupková P,Schejbalová S,Kramer HJ,Rakušan D,Malý J,Netuka I,Vaněčková I,Kopkan L,Cervenka L

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  • Streptokinase alters myocardial creatine kinase depletion after ischaemia and reperfusion in rabbits.

    abstract::The efficacy of streptokinase as an intracoronary thrombolytic agent is well-recognized. The effect of streptokinase, distinct from its thrombolytic action, on ischaemic myocardium distal to an area of coronary artery occlusion when reperfusion occurs has not been well-defined. In order to do this, myocardial creatine...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Mickelson JK,Carlson CJ,Margaretten W,Rapaport E

    更新日期:1986-09-01 00:00:00

  • Endoplasmic reticulum stress involved in heart and liver injury in iron-loaded rats.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Lou LX,Geng B,Chen Y,Yu F,Zhao J,Tang CS

    更新日期:2009-07-01 00:00:00

  • Time course of changes in baroreceptor reflex control of heart rate in conscious SHR and WKY: contribution of the cardiac vagus and sympathetic nerves.

    abstract::1. The aim of this study was to assess the vagal and sympathetic nerve contribution to the relationship between mean arterial pressure (MAP) and heart rate (HR) at 6, 9, 14 and 20 weeks of age in conscious Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) with methoxamine- and nitroprusside-induced steady-s...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Head GA,Adams MA

    更新日期:1988-04-01 00:00:00

  • Possible participation of NMDA and glycine receptors but not GABAA receptors in enflurane-induced opisthotonus in mice.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Komatsu H,Nogaya J,Ueki M,Yokono S,Ogli K

    更新日期:1994-06-01 00:00:00

  • Sequential activation of the reactive oxygen species/angiotensinogen/renin-angiotensin system axis in renal injury of type 2 diabetic rats.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Miyata K,Ohashi N,Suzaki Y,Katsurada A,Kobori H

    更新日期:2008-08-01 00:00:00

  • The effect of spontaneous diabetes mellitus on fatty acid oxidation, beta-hydroxybutyrate dehydrogenase activity and respiratory coupling of hepatic mitochondria in the guinea-pig (Cavia porcellus).

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Nevalainen TO,White WJ,Lang CM,Munger BL

    更新日期:1978-05-01 00:00:00

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Li Y,Cheng KC,Asakawa A,Amitani H,Takimoto Y,Runtuwene J,Inui A

    更新日期:2015-09-01 00:00:00

  • Childhood obesity, hypertension, the metabolic syndrome and adult cardiovascular disease.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Beilin L,Huang RC

    更新日期:2008-04-01 00:00:00

  • Cholinergic prejunctional inhibition of nitrergic neurotransmission in the guinea-pig isolated basilar artery.

    abstract::1. The effects of endogenous and exogenous acetylcholine (ACh) on nitrergic relaxations elicited by electrical field stimulation (EFS) were studied in guinea-pig endothelium-denuded basilar artery preparations precontracted with 1 mumol/L prostaglandin F2 alpha and a possible role of K+ channels in mediating the effec...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Jiang F,Li CG,Rand MJ

    更新日期:1999-04-01 00:00:00