Drug interaction: omeprazole and phenprocoumon.


BACKGROUND:Oral anticoagulants like the coumarin derivatives are characterised by a particularly narrow therapeutic range. Any interfering co-medication can pose a challenge to establishing a stable anticoagulant dosage regimen and thus present a serious risk for the patient. Here we describe two cases of patients on anticoagulant therapy that suggest possible drug interactions between phenprocoumon and the proton pump inhibitor omeprazole. RESULTS:In both patients, the International Normalised Ratio (INR) increased beyond the therapeutic range after they were given omeprazole for the treatment of gastrointestinal symptoms. The INR returned to therapeutic levels after the phenprocoumon dose was reduced (Case 1) and omeprazole discontinued (Case 2). CONCLUSIONS:The increased anticoagulant activity of phenprocoumon observed in the two described cases and the known interaction potential of omeprazole suggest that the clearance of phenprocoumon may have been reduced due to competitive inhibition of its degradation by omeprazole. Drug interactions may be one of the reasons for the difficulties encountered with some patients in establishing a stable anticoagulant therapy. Physicians should carefully review any concurrently used medication and if possible opt for drugs with a low interaction potential.


BMC Gastroenterol


BMC gastroenterology


Enderle C,Müller W,Grass U





Has Abstract


2001-01-01 00:00:00








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    abstract:BACKGROUND:The combination of boceprevir or telaprevir with peginterferon-alfa and ribavirin for the treatment of patients infected with HCV genotype 1 has led to significantly increased rates of sustained virological response (SVR) in phase III trials. There is only limited data regarding the safety and efficacy in a ...

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    authors: Wehmeyer MH,Eißing F,Jordan S,Röder C,Hennigs A,Degen O,Hüfner A,Hertling S,Schmiedel S,Sterneck M,van Lunzen J,Lohse AW,Schulze zur Wiesch J,Lüth S

    更新日期:2014-05-05 00:00:00

  • Human cystic echinococcosis in Heilongjiang Province, China: a retrospective study.

    abstract:BACKGROUND:Cystic echinococcosis (CE) is one of emerging zoonotic parasitic diseases throughout the world, having significant medical and economic importance in developing countries. The western and northwestern China is considered as CE endemic areas. In northeastern China's Heilongjiang Province, the increasing numbe...

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    authors: Zhang T,Zhao W,Yang D,Piao D,Huang S,Mi Y,Zhao X,Cao J,Shen Y,Zhang W,Liu A

    更新日期:2015-03-10 00:00:00

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    abstract:BACKGROUND:The assessment of Health Related Quality of Life (HRQOL) has been applied as a significant outcome indicator for patients with chronic diseases. No HRQOL study, however, has looked at HRQOL in patients with chronic gastritis and peptic ulcers. This paper focuses on comparing HRQOL in patients with chronic ga...

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    更新日期:2014-08-20 00:00:00

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    abstract:BACKGROUND:Hepatitis C virus (HCV) infection is commonly associated with a disturbance of glucose metabolism. However, there have been conflicting reports on whether the clearance of the HCV may be followed by changes of serum blood glucose and insulin resistance. The aim of the present study was to evaluate the impact...

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    更新日期:2019-06-13 00:00:00

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    authors: Kandilis AN,Koskinas J,Vlachos I,Skaltsas S,Karandrea D,Karakitsos P,Pantopoulou A,Palaiologou M,Nikiteas N,Tiniakos DG,Perrea DN

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    authors: Ritze Y,Böhle M,Haub S,Hubert A,Enck P,Zipfel S,Bischoff SC

    更新日期:2013-12-09 00:00:00

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    更新日期:2010-01-27 00:00:00

  • Transplantation of human fetal biliary tree stem/progenitor cells into two patients with advanced liver cirrhosis.

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    更新日期:2014-12-04 00:00:00

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    pub_type: 杂志文章,多中心研究,随机对照试验


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    authors: Pan A,Doyle T,Schlup M,Lubcke R,Schultz M

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    authors: Purchiaroni F,Nakajima T,Sakamoto T,Abe S,Saito Y

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    更新日期:2019-05-02 00:00:00

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    journal_title:BMC gastroenterology

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    authors: Park B,Jun JK,Kim BC,Choi KS,Suh M,Expert Advisory Committee.,Monitoring Committee.,Center for Korean Colonoscopy Screening Pilot Study.,Research Team on the Protocol Development of Pilot study.

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    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Yang R,Chen Y,Chen X

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    pub_type: 杂志文章


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    journal_title:BMC gastroenterology

    pub_type: 杂志文章,meta分析


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    更新日期:2015-07-16 00:00:00

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    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Tian Y,Zheng Y,Teng G,Li J,Wang H

    更新日期:2019-07-01 00:00:00

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    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Itagaki H,Hagino T

    更新日期:2019-04-18 00:00:00

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    abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is mutually and bidirectionally linked with metabolic syndrome (MetS) of which it is both the cause and the consequences. Worldwide, 6.3 to 33% of the general populations are estimated to suffer from the disease with even higher prevalence in the group sharing metabo...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Pardhe BD,Shakya S,Bhetwal A,Mathias J,Khanal PR,Pandit R,Shakya J,Joshi HO,Marahatta SB

    更新日期:2018-07-06 00:00:00