Acatalasemic mice are mildly susceptible to adriamycin nephropathy and exhibit increased albuminuria and glomerulosclerosis.


BACKGROUND:Catalase is an important antioxidant enzyme that regulates the level of intracellular hydrogen peroxide and hydroxyl radicals. The effects of catalase deficiency on albuminuria and progressive glomerulosclerosis have not yet been fully elucidated. The adriamycin (ADR) nephropathy model is considered to be an experimental model of focal segmental glomerulosclerosis. A functional catalase deficiency was hypothesized to exacerbate albuminuria and the progression of glomerulosclerosis in this model. METHODS:ADR was intravenously administered to both homozygous acatalasemic mutant mice (C3H/AnLCs(b)Cs(b)) and control wild-type mice (C3H/AnLCs(a)Cs(a)). The functional and morphological alterations of the kidneys, including albuminuria, renal function, podocytic, glomerular and tubulointerstitial injuries, and the activities of catalase were then compared between the two groups up to 8 weeks after disease induction. Moreover, the presence of a mutation of the toll-like receptor 4 (tlr4) gene, which was previously reported in the C3H/HeJ strain, was investigated in both groups. RESULTS:The ADR-treated mice developed significant albuminuria and glomerulosclerosis, and the degree of these conditions in the ADR-treated acatalasemic mice was higher than that in the wild-type mice. ADR induced progressive renal fibrosis, renal atrophy and lipid peroxide accumulation only in the acatalasemic mice. In addition, the level of catalase activity was significantly lower in the kidneys of the acatalasemic mice than in the wild-type mice during the experimental period. The catalase activity increased after ADR injection in wild-type mice, but the acatalasemic mice did not have the ability to increase their catalase activity under oxidative stress. The C3H/AnL strain was found to be negative for the tlr4 gene mutation. CONCLUSIONS:These data indicate that catalase deficiency plays an important role in the progression of renal injury in the ADR nephropathy model.


BMC Nephrol


BMC nephrology


Takiue K,Sugiyama H,Inoue T,Morinaga H,Kikumoto Y,Kitagawa M,Kitamura S,Maeshima Y,Wang DH,Masuoka N,Ogino K,Makino H




Has Abstract


2012-03-25 00:00:00










  • Clinical features and CKD-related quality of life in patients with CKD G3a and CKD G3b in China: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE).

    abstract:BACKGROUND:This study aimed to compare clinical features and health-related quality of life (HRQoL) in the Chinese chronic kidney disease (CKD) 3 population and determined the necessity of the subdivision of CKD3 in Chinese patients with CKD. METHODS:Participants with stage 3 CKD (18-74 years of age) were recruited at...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Peng Z,Wang J,Yuan Q,Xiao X,Xu H,Xie Y,Wang W,Huang L,Zhong Y,Ao X,Zhang L,Zhao M,Tao L,Zhou Q,C-STRIDE study group.

    更新日期:2017-10-13 00:00:00

  • A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain.

    abstract:BACKGROUND:The end stage renal disease population has a 20 fold higher incidence of cardiovascular mortality compared to the overall population. The development of reno-cardiac syndrome in these patients will result in cardiovascular events to be the cause of 50% of fatalities. There is therefore a need to research imp...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Kieswich JE,Chen J,Alliouachene S,Caton PW,McCafferty K,Thiemermann C,Yaqoob MM

    更新日期:2018-12-04 00:00:00

  • Incidental findings on cardiac computed tomography in incident hemodialysis patients: the predictors of arrhythmic and cardiovascular events in end-stage renal disease (PACE) study.

    abstract:BACKGROUND:This is the first study that has examined non-cardiac incidental findings in research cardiac computed tomography (CT) of hemodialysis patients and their relationship with patient characteristics. METHODS:We performed a cross-sectional analysis in the Predictors of Arrhythmic and Cardiovascular Events in En...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Jaar BG,Zhang L,Chembrovich SV,Sozio SM,Shafi T,Scialla JJ,Tomaselli GF,Lima JA,Kao WH,Parekh RS,Meoni LA

    更新日期:2014-05-01 00:00:00

  • Relationship between early proteinuria and long term outcome of kidney transplanted patients from different decades of donor age.

    abstract:BACKGROUND:Proteinuria after kidney transplantation portends a worse graft survival. However the magnitude of proteinuria related to patient and graft survival and its correlation with donor and recipient characteristics are poorly explored. METHODS:This study investigated the impact of post transplant proteinuria in ...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Diena D,Messina M,De Biase C,Fop F,Scardino E,Rossetti MM,Barreca A,Verri A,Biancone L

    更新日期:2019-12-02 00:00:00

  • How do parents deal with their children's chronic kidney disease? A qualitative study for identifying factors related to parent's adaptation.

    abstract:BACKGROUND:Parents' adaptation affects the health outcomes of children with chronic kidney diseases (CKD). Identifying factors that affect parents' adaptation is necessary to understand their adaptation status. This study aims to explore factors related to the adaptation of parents who have children with CKD. METHODS:...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Khorsandi F,Parizad N,Feizi A,Hemmati MaslakPak M

    更新日期:2020-11-25 00:00:00

  • Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis.

    abstract:BACKGROUND:Accurately determining renal function is essential for clinical management of HIV patients. Classically, it has been evaluated by estimating glomerular filtration rate (eGFR) with the MDRD-equation, but today there is evidence that the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation ...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Cristelli MP,Cofán F,Rico N,Trullàs JC,Manzardo C,Agüero F,Bedini JL,Moreno A,Oppenheimer F,Miro JM,CKD-H. Clinic Investigators.

    更新日期:2017-02-10 00:00:00

  • Effects of uremic solutes on reactive oxygen species in vitro model systems as a possibility of support the renal function management.

    abstract:BACKGROUND:In view of the prevalence of oxidative stress in chronic kidney disease (CKD) patients, the loss of low-molecular-weight biomolecules by hemodialysis and the antioxidant potential of some uremic solutes that accumulate in CKD, we used in vitro model systems to test the antioxidant potential of the following ...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Assis RP,Castro JF,Gutierres VO,Arcaro CA,Brotto RS,Oliveira OM,Baviera AM,Brunetti IL

    更新日期:2015-04-11 00:00:00

  • ANCA vasculitis in a patient with Alport syndrome: a difficult diagnosis but a treatable disease!

    abstract:BACKGROUND:Alport syndrome and ANCA-associated vasculitis are both rare diseases. The co-existence of these two conditions has never been reported. There is no obvious pathogenic link between these two glomerular diseases. The management of this case highlights the importance of a systematic approach when investigating...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Gillion V,Jadoul M,Aydin S,Godefroid N

    更新日期:2017-03-29 00:00:00

  • Process evaluation of the RaDIANT community study: a dialysis facility-level intervention to increase referral for kidney transplantation.

    abstract:BACKGROUND:The Reducing Disparities in Access to kidNey Transplantation Community Study (RaDIANT) was an End-Stage Renal Disease (ESRD) Network 6-developed, dialysis facility-level randomized trial testing the effectiveness of a 1-year multicomponent education and quality improvement intervention in increasing referral...

    journal_title:BMC nephrology

    pub_type: 杂志文章,随机对照试验


    authors: Hamoda RE,Gander JC,McPherson LJ,Arriola KJ,Cobb L,Pastan SO,Plantinga L,Browne T,Hartmann E,Mulloy L,Zayas C,Krisher J,Patzer RE

    更新日期:2018-01-15 00:00:00

  • Treatment of hemolytic uremic syndrome related to Bordetella pertussis infection -is plasma exchange or eculizumab use necessary?

    abstract:BACKGROUND:Bordetella pertussis infection is a known trigger of atypical hemolytic uremic syndrome (HUS). For patients suspected of having atypical HUS, prompt plasma exchange/infusion (PE/PI) or eculizumab (ECZ) treatment is recommended. CASE PRESENTATION:We report a 1-month-old female infant who was admitted with a ...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Saida K,Ogura M,Kano Y,Ishimori S,Yoshikawa T,Nagata H,Sato M,Kamei K,Ishikura K

    更新日期:2018-12-17 00:00:00

  • Blood oxygen level dependent magnetic resonance imaging for detecting pathological patterns in lupus nephritis patients: a preliminary study using a decision tree model.

    abstract:BACKGROUND:Precise renal histopathological diagnosis will guide therapy strategy in patients with lupus nephritis. Blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) has been applicable noninvasive technique in renal disease. This current study was performed to explore whether BOLD MRI could contribut...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Shi H,Jia J,Li D,Wei L,Shang W,Zheng Z

    更新日期:2018-02-09 00:00:00

  • Reno-protective effects of oral alkalizing agents in chronic kidney disease with aciduria: protocol for a randomized cohort study.

    abstract:BACKGROUND:Aciduria caused by urinary excretion of acidic metabolic wastes produced in daily life is known to be augmented in patients with chronic kidney disease (CKD). To evaluate the reno-protective effect of oral alkalizing agents for the improvement of metabolic acidosis and neutralization of intratubular pH in th...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Abe M,Akaishi T,Shoji M,Yamaguchi T,Miki T,Satoh F,Takayama S,Yamasaki S,Kawaguchi K,Sato H,Ishii T,Ito S,CKOALA study group.

    更新日期:2020-04-22 00:00:00

  • Vitamin D receptor gene polymorphisms and susceptibility to urolithiasis: a meta-regression and meta-analysis.

    abstract:BACKGROUND:The currently available data with respect to the association between vitamin D receptor (VDR) gene polymorphism and risk to urolithiasis are inconclusive and inconsistent. Hence, an exhaustive meta-analysis can solve the discrepancies and provide a hint for upcoming investigations. Herein, a meta-analysis wa...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Imani D,Razi B,Khosrojerdi A,Lorian K,Motallebnezhad M,Rezaei R,Aslani S

    更新日期:2020-07-10 00:00:00

  • Trends in anemia care in non-dialysis-dependent chronic kidney disease (CKD) patients in the United States (2006-2015).

    abstract:BACKGROUND:The objective of the study was to examine overall anemia management trends in non-dialysis patients with chronic kidney disease (CKD) from 2006 to 2015, and to evaluate the impact of Trial to Reduced Cardiovascular Events with Ananesp Therapy (TREAT)'s study results (October 2009) and the US Food and Drug Ad...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Park H,Liu X,Henry L,Harman J,Ross EA

    更新日期:2018-11-09 00:00:00

  • Association of anaemia in primary care patients with chronic kidney disease: cross sectional study of quality improvement in chronic kidney disease (QICKD) trial data.

    abstract:BACKGROUND:Anaemia is a known risk factor for cardiovascular disease and treating anaemia in chronic kidney disease (CKD) may improve outcomes. However, little is known about the scope to improve primary care management of anaemia in CKD. METHODS:An observational study (N = 1,099,292) with a nationally representative ...

    journal_title:BMC nephrology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Dmitrieva O,de Lusignan S,Macdougall IC,Gallagher H,Tomson C,Harris K,Desombre T,Goldsmith D

    更新日期:2013-01-25 00:00:00

  • Angiotensin converting enzyme inhibition increases ADMA concentration in patients on maintenance hemodialysis--a randomized cross-over study.

    abstract:BACKGROUND:Endothelial dysfunction occurs in patients with end-stage renal disease (ESRD) and is associated with increased cardiovascular morbidity and mortality. Asymmetric dimethylarginine (ADMA) contributes to endothelial dysfunction in ESRD. In the general population, angiotensin-converting enzyme (ACE) inhibitors ...

    journal_title:BMC nephrology

    pub_type: 杂志文章,随机对照试验


    authors: Gamboa JL,Pretorius M,Sprinkel KC,Brown NJ,Ikizler TA

    更新日期:2015-10-22 00:00:00

  • Patient discourse on chronic kidney disease monitoring: a qualitative study at a Veterans Affairs Renal Clinic.

    abstract:BACKGROUND:Knowing how chronic kidney disease (CKD) patients talk about their encounters with providers (i.e., their discourse) can inform the important clinical goal of engaging patients in their chronic disease self-management. The aim of this study was to analyze patient discourse on ongoing CKD monitoring encounter...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Vandenberg AE,Echt KV,Johnson TM 2nd,Bowling CB

    更新日期:2018-07-19 00:00:00

  • Traditional medicine practices among community members with chronic kidney disease in northern Tanzania: an ethnomedical survey.

    abstract:BACKGROUND:In sub-Saharan Africa, chronic kidney disease (CKD) is being recognized as a non-communicable disease (NCD) with high morbidity and mortality. In countries like Tanzania, people access many sources, including traditional medicines, to meet their healthcare needs for NCDs, but little is known about traditiona...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Stanifer JW,Lunyera J,Boyd D,Karia F,Maro V,Omolo J,Patel UD

    更新日期:2015-10-23 00:00:00

  • The association of dialysis adequacy, body mass index, and mortality among hemodialysis patients.

    abstract:BACKGROUND:Although hemodialysis (HD) adequacy, single-pool Kt/Vurea (spKt/V), is inversely correlated with body size, each is known to affect patient survival in the same direction. Therefore, we sought to examine the relationship between HD adequacy and mortality according to body mass index (BMI) in HD patients and ...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Hong WP,Lee YJ

    更新日期:2019-10-22 00:00:00

  • Indoleamine 2, 3-dioxygenase (IDO) increases during renal fibrogenesis and its inhibition potentiates TGF-β 1-induced epithelial to mesenchymal transition.

    abstract:BACKGROUND:Indoleamine 2, 3-dioxygenase (IDO) is an immunomodulatory molecule that has been implicated in several biological processes. Although IDO has been linked with some renal diseases, its role in renal fibrosis is still unclear. Because IDO may be modulated by TGF-β1, a potent fibrogenic molecule, we hypothesize...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Matheus LHG,Simão GM,Amaral TA,Brito RBO,Malta CS,Matos YST,Santana AC,Rodrigues GGC,Albejante MC,Bach EE,Dalboni MA,Camacho CP,Dellê H

    更新日期:2017-09-06 00:00:00

  • Early detection and intervention using neutrophil gelatinase-associated lipocalin (NGAL) may improve renal outcome of acute contrast media induced nephropathy: a randomized controlled trial in patients undergoing intra-arterial angiography (ANTI-CIN Study

    abstract:BACKGROUND:Patients with pre-existing impaired renal function are prone to develop acute contrast media induced nephropathy (CIN). Neutrophil gelatinase-associated lipocalin (NGAL), a new biomarker predictive for acute kidney injury (AKI), has been shown to be useful for earlier diagnosis of CIN; however, urinary NGAL ...

    journal_title:BMC nephrology

    pub_type: 杂志文章,随机对照试验


    authors: Schilcher G,Ribitsch W,Otto R,Portugaller RH,Quehenberger F,Truschnig-Wilders M,Zweiker R,Stiegler P,Brodmann M,Weinhandl K,Horina JH

    更新日期:2011-08-17 00:00:00

  • Evaluation of High Resolution Melting analysis as an alternate tool to screen for risk alleles associated with small kidneys in Indian newborns.

    abstract:BACKGROUND:Single nucleotide polymorphisms (SNPs) are the most common forms of sequence variations in the human genome. They contribute to the human phenotypic spectrum and are associated with variations in response to pathogens, drugs and vaccines. Recently, SNPs in three human genes involved in kidney development (RE...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Raghavendra A,Siji A,Sridhar TS,Phadke K,Vasudevan A

    更新日期:2011-10-28 00:00:00

  • Beyond dialysis decisions: a qualitative exploration of decision-making among culturally and linguistically diverse adults with chronic kidney disease on haemodialysis.

    abstract:BACKGROUND:To date, limited research has been dedicated to exploring the experience of decision-making for chronic kidney disease (CKD) patients who have initiated dialysis and have to make decisions in the context of managing multiple illnesses. Evidence about the experience of decision-making for minority or disadvan...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究


    authors: Muscat DM,Kanagaratnam R,Shepherd HL,Sud K,McCaffery K,Webster A

    更新日期:2018-11-27 00:00:00

  • IgM monoclonal gammopathy with heavy-and-light-chain amyloidosis resembling fibrillary glomerulonephritis determined by tandem mass spectrometry: a case report.

    abstract:BACKGROUND:Fibrillary glomerulonephritis (FGN) is distinguished from amyloidosis by thicker fibrils and the lack of staining with histochemical dyes typically reactive with amyloid. However, congophilic FGN has been proposed recently and adding laser microdissection followed by mass spectrometry (LMD/MS) to conventiona...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Adachi M,Kitamura M,Muta K,Maekawa A,Uramatsu T,Tadokoro M,Funakoshi S,Hisano S,Kuwahara N,Shimizu A,Mukae H,Nishino T

    更新日期:2020-05-24 00:00:00

  • Duration of temporary catheter use for hemodialysis: an observational, prospective evaluation of renal units in Brazil.

    abstract:BACKGROUND:For chronic hemodialysis, the ideal permanent vascular access is the arteriovenous fistula (AVF). Temporary catheters should be reserved for acute dialysis needs. The AVF is associated with lower infection rates, better clinical results, and a higher quality of life and survival when compared to temporary ca...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Bonfante GM,Gomes IC,Andrade EI,Lima EM,Acurcio FA,Cherchiglia ML

    更新日期:2011-11-17 00:00:00

  • RhoA deficiency disrupts podocyte cytoskeleton and induces podocyte apoptosis by inhibiting YAP/dendrin signal.

    abstract:BACKGROUND:Podocyte apoptosis is a major mechanism that leads to proteinuria in many kidney diseases. However, the concert mechanisms that cause podocyte apoptosis in these kidney diseases are not fully understood. RhoA is one of Rho GTPases that has been well studied and plays a key role in regulating cytoskeletal arc...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Huang Z,Zhang L,Chen Y,Zhang H,Yu C,Zhou F,Zhang Z,Jiang L,Li R,Ma J,Li Z,Lai Y,Lin T,Zhao X,Zhang Q,Zhang B,Ye Z,Liu S,Wang W,Liang X,Liao R,Shi W

    更新日期:2016-07-07 00:00:00

  • Sedentary behaviour, physical activity, and renal function in older adults: isotemporal substitution modelling.

    abstract:BACKGROUND:Physical inactivity and sedentary behaviour (too much sitting) can contribute to renal dysfunction. However, the potential benefits of behavioural change (e.g. replacing sedentary behaviour with physical activity) on renal function are not well understood. We used isotemporal substitution to model potential ...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Kosaki K,Tanahashi K,Matsui M,Akazawa N,Osuka Y,Tanaka K,Dunstan DW,Owen N,Shibata A,Oka K,Maeda S

    更新日期:2020-06-03 00:00:00

  • Treatment with cinacalcet increases plasma sclerostin concentration in hemodialysis patients with secondary hyperparathyroidism.

    abstract:BACKGROUND:Sclerostin is a paracrine acting factor, which is expressed in the osteocytes and articular chondrocytes. Sclerostin decreases the osteoblast-related bone formation through the inhibition of the Wnt/β-catenin pathway. Osteocytes also express the Calcium sensing receptor which is a target for cinacalcet. The ...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Kuczera P,Adamczak M,Więcek A

    更新日期:2016-11-15 00:00:00

  • Red urine, updated for the nephrologist: a case report.

    abstract:BACKGROUND:Sickle cell trait is not completely benign, and some renal complications can occur. The baseline rate of admission for gross hematuria in normal males carrying the sickle cell trait is 2%. CASE PRESENTATION:A 35-year-old non-smoking African man experienced a 2-week history of painless, profuse and persisten...

    journal_title:BMC nephrology

    pub_type: 杂志文章


    authors: Le Joncour A,Mesnard L,Hertig A,Robert T

    更新日期:2018-06-08 00:00:00

  • Impact of mannose-binding lectin deficiency on radiocontrast-induced renal dysfunction: a post-hoc analysis of a multicenter randomized controlled trial.

    abstract:BACKGROUND:Local renal ischemia is regarded as an important factor in the development of contrast-induced nephropathy (CIN). Mannose-binding lectin (MBL) is involved in the tissue damage during experimental ischemia/reperfusion injury of the kidneys. The aim of the present study was to investigate the association of MB...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Osthoff M,Piezzi V,Klima T,Christ A,Marana I,Hartwiger S,Breidthardt T,Marenzi G,Trendelenburg M,Mueller C

    更新日期:2012-09-03 00:00:00