Alginate dressings for healing diabetic foot ulcers.

Abstract:

BACKGROUND:Foot ulcers in people with diabetes mellitus are a common and serious global health issue. Dressings form a key part of ulcer treatment, with clinicians and patients having many different types to choose from including alginate dressings. A clear and current overview of current evidence is required to facilitate decision-making regarding dressing use. OBJECTIVES:To compare the effects of alginate wound dressings with no wound dressing or alternative dressings on the healing of foot ulcers in people with diabetes mellitus. SEARCH METHODS:We searched The Cochrane Wounds Group Specialised Register (searched 4 January 2012); The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 4); Ovid MEDLINE (1950 to December Week 3 2011); Ovid MEDLINE (In-Process & Other Non-Indexed Citations, January 03, 2012); Ovid EMBASE (1980 to 2011 Week 52); and EBSCO CINAHL (1982 to 30 December 2011). There were no restrictions based on language or date of publication. SELECTION CRITERIA:Published or unpublished randomised controlled trials (RCTs) that have compared the effects on ulcer healing of alginate dressings with alternative wound dressings or no dressing in the treatment of foot ulcers in people with diabetes. DATA COLLECTION AND ANALYSIS:Two review authors independently performed study selection, risk of bias assessment and data extraction. MAIN RESULTS:We included six studies (375 participants) in this review; these compared alginate dressings with basic wound contact dressings, foam dressings and a silver-containing, fibrous-hydrocolloid dressing. Meta analysis of two studies found no statistically significant difference between alginate dressings and basic wound contact dressings: risk ratio (RR) 1.09 (95% CI 0.66 to 1.80). Pooled data from two studies comparing alginate dressings with foam dressings found no statistically significant difference in ulcer healing (RR 0.67, 95% CI 0.41 to 1.08). There was no statistically significant difference in the number of diabetic foot ulcers healed when an anti-microbial (silver) hydrocolloid dressing was compared with a standard alginate dressing (RR 1.40, 95% CI 0.79 to 2.47). All studies had short follow-up times (six to 12 weeks), and small sample sizes. AUTHORS' CONCLUSIONS:Currently there is no research evidence to suggest that alginate wound dressings are more effective in healing foot ulcers in people with diabetes than other types of dressing however many trials in this field are very small. Decision makers may wish to consider aspects such as dressing cost and the wound management properties offered by each dressing type e.g. exudate management.

authors

Dumville JC,O'Meara S,Deshpande S,Speak K

doi

10.1002/14651858.CD009110.pub2

subject

Has Abstract

pub_date

2012-02-15 00:00:00

pages

CD009110

issue

2

issn

1469-493X

pub_type

杂志文章,meta分析,评审
  • Dressings and topical agents for preventing pressure ulcers.

    abstract:BACKGROUND:Pressure ulcers, localised injuries to the skin or underlying tissue, or both, occur when people cannot reposition themselves to relieve pressure on bony prominences. These wounds are difficult to heal, painful, expensive to manage and have a negative impact on quality of life. Prevention strategies include ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD009362.pub3

    authors: Moore ZE,Webster J

    更新日期:2018-12-06 00:00:00

  • Dietary salt reduction or exclusion for allergic asthma.

    abstract:BACKGROUND:There is a wide geographical variation in asthma prevalence and one explanation may be in dietary salt consumption. OBJECTIVES:To assess the effect of dietary sodium reduction in patients with asthma. SEARCH STRATEGY:A search was conducted using the Cochrane Airways Group asthma register. Bibliographies of...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000436

    authors: Ardern KD,Ram FS

    更新日期:2001-01-01 00:00:00

  • Fewer-than-four ports versus four ports for laparoscopic cholecystectomy.

    abstract:BACKGROUND:Traditionally, laparoscopic cholecystectomy is performed using two 10-mm ports and two 5-mm ports. Recently, a reduction in the number of ports has been suggested as a modification of the standard technique with a view to decreasing pain and improving cosmesis. The safety and effectiveness of using fewer-tha...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007109.pub2

    authors: Gurusamy KS,Vaughan J,Rossi M,Davidson BR

    更新日期:2014-02-20 00:00:00

  • Hospitalisation and bed rest for multiple pregnancy.

    abstract:BACKGROUND:Bed rest used to be widely advised for women with a multiple pregnancy. OBJECTIVES:The objective was to assess the effect of bed rest in hospital for women with a multiple pregnancy for prevention of preterm birth and other fetal, neonatal and maternal outcomes. SEARCH STRATEGY:We searched the Cochrane Pre...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000110.pub2

    authors: Crowther CA,Han S

    更新日期:2010-07-07 00:00:00

  • Propentofylline for dementia.

    abstract:BACKGROUND:Propentofylline is a novel therapeutic agent for dementia that readily crosses the blood-brain barrier and acts by blocking the uptake of adenosine and inhibiting the enzyme phosphodiesterase. In vitro and in vivo its mechanism of action appears to be twofold; it inhibits the production of free radicals and ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD002853

    authors: Frampton M,Harvey RJ,Kirchner V

    更新日期:2003-01-01 00:00:00

  • Opioid antagonists for smoking cessation.

    abstract:BACKGROUND:The reinforcing properties of nicotine may be mediated through release of various neurotransmitters both centrally and systemically. Smokers report positive effects such as pleasure, arousal, and relaxation as well as relief of negative affect, tension, and anxiety. Opioid (narcotic) antagonists are of parti...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003086.pub2

    authors: David S,Lancaster T,Stead LF,Evins AE

    更新日期:2006-10-18 00:00:00

  • Recombinant human activated protein C for severe sepsis in neonates.

    abstract:BACKGROUND:Sepsis is a common problem in preterm and term infants. The incidence of neonatal sepsis has declined, but mortality remains high. Recombinant human activated protein C (rhAPC) possess a broad spectrum of activity modulating coagulation and inflammation. In septic adults it may reduce mortality, but no signi...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD005385.pub3

    authors: Kylat RI,Ohlsson A

    更新日期:2012-04-18 00:00:00

  • Oestrogens alone or with amniotomy for cervical ripening or induction of labour.

    abstract:BACKGROUND:Studies in sheep showed that there is a pre-labour rise in oestrogen and a decrease in progesterone, both of these changes stimulate prostaglandin production and may help initiate labour. Though oestrogen has been suggested as an effective cervical ripening or induction agent, research in humans have failed ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003393

    authors: Thomas J,Kelly AJ,Kavanagh J

    更新日期:2001-01-01 00:00:00

  • Surgery or embolisation for varicoceles in subfertile men.

    abstract:BACKGROUND:A varicoceles is a meshwork of distended blood vessels in the scrotum, usually left-sided, due to dilatation of the spermatic vein. Although the concept that varicoceles causes, and varicocelectomy cures, male subfertility has been around for almost fifty years, the mechanisms by which varicoceles would affe...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000479.pub4

    authors: Evers JH,Collins J,Clarke J

    更新日期:2009-01-21 00:00:00

  • Glutamine supplementation to prevent morbidity and mortality in preterm infants.

    abstract:BACKGROUND:Glutamine is a conditionally essential amino acid. Endogenous biosynthesis may be insufficient for tissue needs in states of metabolic stress. Evidence exists that glutamine supplementation improves clinical outcomes in critically ill adults. It has been suggested that glutamine supplementation may also bene...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD001457.pub5

    authors: Moe-Byrne T,Brown JV,McGuire W

    更新日期:2016-01-12 00:00:00

  • Prolonged antibiotics for non-cystic fibrosis bronchiectasis in children and adults.

    abstract:BACKGROUND:The vicious cycle hypothesis for bronchiectasis predicts that bacterial colonisation of the respiratory tract perpetuates inflammatory change. This damages the mucociliary escalator, preventing bacterial clearance and allowing persistence of pro-inflammatory mediators. Conventional treatment with physiothera...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD001392.pub3

    authors: Hnin K,Nguyen C,Carson KV,Evans DJ,Greenstone M,Smith BJ

    更新日期:2015-08-13 00:00:00

  • Hypnotherapy for treatment of irritable bowel syndrome.

    abstract:BACKGROUND:Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder of unknown aetiology. Current pharmacological treatments have limited value. Hypnotherapy has been reported to have beneficial effects for IBS symptoms. OBJECTIVES:To evaluate the efficacy of hypnotherapy for the treatment of ir...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD005110.pub2

    authors: Webb AN,Kukuruzovic RH,Catto-Smith AG,Sawyer SM

    更新日期:2007-10-17 00:00:00

  • Glucocorticoid with cyclophosphamide for paraquat-induced lung fibrosis.

    abstract:BACKGROUND:Paraquat is an effective and widely used herbicide but is also a lethal poison. In many developing countries paraquat is widely available and inexpensive, making poisoning prevention difficult. However most of the people who become poisoned from paraquat have taken it as a means of suicide.Standard treatment...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD008084.pub2

    authors: Li LR,Sydenham E,Chaudhary B,You C

    更新日期:2010-06-16 00:00:00

  • Palliative interventions for controlling vaginal bleeding in advanced cervical cancer.

    abstract:BACKGROUND:This is an updated version of the original Cochrane review published in Issue 5, 2015.Cervical cancer is the fourth most common cancer among women worldwide, with estimated 569,847 new diagnoses and 311,365 deaths per year. However, incidence and stage at diagnosis vary greatly between geographic areas and a...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD011000.pub3

    authors: Eleje GU,Eke AC,Igberase GO,Igwegbe AO,Eleje LI

    更新日期:2019-03-19 00:00:00

  • Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases.

    abstract:BACKGROUND:Our systematic review has demonstrated that antioxidant supplements may increase mortality. We have now updated this review. OBJECTIVES:To assess the beneficial and harmful effects of antioxidant supplements for prevention of mortality in adults. SEARCH METHODS:We searched The Cochrane Library, MEDLINE, EM...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD007176.pub2

    authors: Bjelakovic G,Nikolova D,Gluud LL,Simonetti RG,Gluud C

    更新日期:2012-03-14 00:00:00

  • Combined inhaled anticholinergic agents and beta-2-agonists for initial treatment of acute asthma in children.

    abstract:BACKGROUND:Anti-cholinergic agents and beta2-agonist drugs are both bronchodilators used to reverse acute bronchospasm in children with asthma. These drugs have different modes of action, so may have complementary or additive effects. OBJECTIVES:The objective of this review was to assess the effects of adding inhaled ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000060

    authors: Plotnick LH,Ducharme FM

    更新日期:2000-01-01 00:00:00

  • Caffeine versus theophylline for apnea in preterm infants.

    abstract:BACKGROUND:Recurrent apnea is common in preterm infants, particularly at very early gestational ages. These episodes of loss of effective breathing can lead to hypoxemia and bradycardia which may be severe enough to require resuscitation including use of positive pressure ventilation. Two forms of methylxanthine (caffe...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000273

    authors: Steer PA,Henderson-Smart DJ

    更新日期:2000-01-01 00:00:00

  • Glutamine supplementation for young infants with severe gastrointestinal disease.

    abstract:BACKGROUND:Endogenous glutamine biosynthesis may be insufficient to meet the needs of infants with severe gastrointestinal disease. Studies using animal models of gastrointestinal disease and controlled trials in adult patients have suggested that glutamine supplementation improves clinical outcomes. OBJECTIVES:To ass...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005947.pub2

    authors: Grover Z,Tubman R,McGuire W

    更新日期:2007-01-24 00:00:00

  • Support surfaces for treating pressure ulcers.

    abstract:BACKGROUND:Pressure ulcers are treated by reducing pressure on the areas of damaged skin. Special support surfaces (including beds, mattresses and cushions) designed to redistribute pressure, are widely used as treatments. The relative effects of different support surfaces are unclear. OBJECTIVES:To assess the effects...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD009490

    authors: McInnes E,Dumville JC,Jammali-Blasi A,Bell-Syer SE

    更新日期:2011-12-07 00:00:00

  • WITHDRAWN. Universal neonatal hearing screening versus selective screening as part of the management of childhood deafness.

    abstract:BACKGROUND:The principal factors that decide how deafness affects a child's development are the degree of hearing impairment and the age at which it is diagnosed. A number of factors are thought to increase the risk of hearing impairment: low birth weight, prematurity, perinatal hypoxia and jaundice, among others. The ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003731.pub3

    authors: Puig Reixach MT,Municio A,Medà MC

    更新日期:2010-01-20 00:00:00

  • Scalpel versus no-scalpel incision for vasectomy.

    abstract:BACKGROUND:Currently, the two most common surgical techniques for approaching the vas during vasectomy are the incisional method and the no-scalpel technique. Whereas the conventional incisional technique involves the use of a scalpel to make one or two incisions, the no-scalpel technique uses a sharp-pointed, forceps-...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD004112.pub3

    authors: Cook LA,Pun A,van Vliet H,Gallo MF,Lopez LM

    更新日期:2007-04-18 00:00:00

  • Antibiotics for acute maxillary sinusitis in adults.

    abstract:BACKGROUND:Sinusitis is one of the most common diagnoses among adults in ambulatory care, accounting for 15% to 21% of all adult outpatient antibiotic prescriptions. However, the role of antibiotics for sinusitis is controversial. OBJECTIVES:To assess the effects of antibiotics in adults with acute maxillary sinusitis...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000243.pub3

    authors: Ahovuo-Saloranta A,Rautakorpi UM,Borisenko OV,Liira H,Williams JW Jr,Mäkelä M

    更新日期:2014-02-11 00:00:00

  • Face-to-face interventions for informing or educating parents about early childhood vaccination.

    abstract:BACKGROUND:Early childhood vaccination is an essential global public health practice that saves two to three million lives each year, but many children do not receive all the recommended vaccines. To achieve and maintain appropriate coverage rates, vaccination programmes rely on people having sufficient awareness and a...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD010038.pub3

    authors: Kaufman J,Ryan R,Walsh L,Horey D,Leask J,Robinson P,Hill S

    更新日期:2018-05-08 00:00:00

  • Trimetazidine for stable angina.

    abstract:BACKGROUND:Patients with stable angina not controlled by monotherapy with nitrates, beta blockers, or calcium channel blockers are often treated with combinations of these drugs. There may be adverse effects from, or contraindications to, the use of combinations. In low risk groups, medical treatment appears to be as g...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003614.pub2

    authors: Ciapponi A,Pizarro R,Harrison J

    更新日期:2005-10-19 00:00:00

  • Treatment for methaqualone dependence in adults.

    abstract:BACKGROUND:Methaqualone is a potent quinazoline, a class of sedative-hypnotics, that has a high potential for abuse. While the oral use of methaqualone (Quaalude, Mandrax) has waned in western countries since the mid-late 1980's, the practice of smoking methaqualone is a serious public health problem in South Africa, o...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD004146.pub2

    authors: McCarthy G,Myers B,Siegfried N

    更新日期:2005-04-18 00:00:00

  • Pre-admission antibiotics for suspected cases of meningococcal disease.

    abstract:BACKGROUND:Meningococcal disease begins suddenly and death can follow within hours. Pre-admission antibiotic therapy aims to prevent delay in starting therapy that occurs if bacterial confirmation is sought before instituting therapy. OBJECTIVES:To study the effectiveness and safety of pre-admission antibiotics versus...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD005437.pub2

    authors: Sudarsanam T,Rupali P,Tharyan P,Abraham OC,Thomas K

    更新日期:2008-01-23 00:00:00

  • Combination contraceptives: effects on weight.

    abstract:BACKGROUND:Weight gain is often considered a side effect of combination hormonal contraceptives, and many women and clinicians believe that an association exists. Concern about weight gain can limit the use of this highly effective method of contraception by deterring the initiation of its use and causing early discont...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003987.pub2

    authors: Gallo MF,Lopez LM,Grimes DA,Schulz KF,Helmerhorst FM

    更新日期:2006-01-25 00:00:00

  • Motor control exercise for acute non-specific low back pain.

    abstract:BACKGROUND:Motor control exercise (MCE) is used by healthcare professionals worldwide as a common treatment for low back pain (LBP). However, the effectiveness of this intervention for acute LBP remains unclear. OBJECTIVES:To evaluate the effectiveness of MCE for patients with acute non-specific LBP. SEARCH METHODS:W...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD012085

    authors: Macedo LG,Saragiotto BT,Yamato TP,Costa LO,Menezes Costa LC,Ostelo RW,Maher CG

    更新日期:2016-02-10 00:00:00

  • Early erythropoiesis-stimulating agents in preterm or low birth weight infants.

    abstract:BACKGROUND:Preterm infants have low plasma levels of erythropoietin (EPO), providing a rationale for the use of erythropoiesis-stimulating agents (ESAs) to prevent or treat anaemia and to provide neuro protection and protection against necrotising enterocolitis (NEC). Darbepoetin (Darbe) and EPO are currently available...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD004863.pub6

    authors: Ohlsson A,Aher SM

    更新日期:2020-02-11 00:00:00

  • Vitamin A supplementation for postpartum women.

    abstract:BACKGROUND:In areas where vitamin A deficiency (VAD) is a public health concern, the maternal dietary intake of vitamin A may be not sufficient to meet either the maternal nutritional requirements, or those of the breastfed infant, due the low retinol concentrations in breast milk. OBJECTIVES:To evaluate the effects o...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005944.pub3

    authors: Oliveira JM,Allert R,East CE

    更新日期:2016-03-25 00:00:00