Abstract:
BACKGROUND:Many people with atopic eczema are reluctant to use the most commonly recommended treatments because they fear the long-term health effects. As a result, many turn to dietary supplements as a possible treatment approach, often with the belief that some essential ingredient is 'missing' in their diet. Various supplements have been proposed, but it is unclear whether any of these interventions are effective. OBJECTIVES:To evaluate dietary supplements for treating established atopic eczema/dermatitis.Evening primrose oil, borage oil, and probiotics are covered in other Cochrane reviews. SEARCH METHODS:We searched the following databases up to July 2010: the Cochrane Skin Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, MEDLINE (from 2005), EMBASE (from 2007), PsycINFO (from 1806), AMED (from 1985), LILACS (from 1982), ISI Web of Science, GREAT (Global Resource of EczemA Trials) database, and reference lists of articles. We searched ongoing trials registers up to April 2011. SELECTION CRITERIA:Randomised controlled trials (RCTs) of dietary supplements for the treatment of those with established atopic eczema/dermatitis. DATA COLLECTION AND ANALYSIS:Two authors independently screened the titles and abstracts, read the full text of the publications, extracted data, and assessed the risk of bias. MAIN RESULTS:We included 11 studies with a total of 596 participants. Two studies assessed fish oil versus olive oil or corn oil placebo. The following were all looked at in single studies: oral zinc sulphate compared to placebo, selenium versus selenium plus vitamin E versus placebo, vitamin D versus placebo, vitamin D versus vitamin E versus vitamins D plus vitamin E together versus placebo, pyridoxine versus placebo, sea buckthorn seed oil versus sea buckthorn pulp oil versus placebo, hempseed oil versus placebo, sunflower oil (linoleic acid) versus fish oil versus placebo, and DHA versus control (saturated fatty acids of the same energy value). Two small studies on fish oil suggest a possible modest benefit, but many outcomes were explored. A convincingly positive result from a much larger study with a publicly-registered protocol is needed before clinical practice can be influenced. AUTHORS' CONCLUSIONS:There is no convincing evidence of the benefit of dietary supplements in eczema, and they cannot be recommended for the public or for clinical practice at present. Whilst some may argue that at least supplements do not do any harm, high doses of vitamin D may give rise to serious medical problems, and the cost of long-term supplements may also mount up.
journal_name
Cochrane Database Syst Revjournal_title
The Cochrane database of systematic reviewsauthors
Bath-Hextall FJ,Jenkinson C,Humphreys R,Williams HCdoi
10.1002/14651858.CD005205.pub3subject
Has Abstractpub_date
2012-02-15 00:00:00pages
CD005205issue
2issn
1469-493Xpub_type
杂志文章,meta分析,评审abstract:BACKGROUND:Use of smokeless tobacco (ST) can lead to tobacco dependence and long-term use can lead to health problems including periodontal disease, cancer, and cerebrovascular and cardiovascular disease. OBJECTIVES:To assess the effects of behavioural and pharmacologic interventions for the treatment of ST use. SEAR...
journal_title:The Cochrane database of systematic reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1002/14651858.CD004306.pub5
更新日期:2015-10-26 00:00:00
abstract:BACKGROUND:Yoga is an ancient spiritual practice that originated in India and is currently accepted in the Western world as a form of relaxation and exercise. It has been of interest for people with schizophrenia to determine its efficacy as an adjunct to standard-care treatment. OBJECTIVES:To examine the effects of y...
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doi:10.1002/14651858.CD010554.pub2
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abstract:BACKGROUND:Cervical dystonia is the most common form of focal dystonia. It is characterized by involuntary posturing of the head and frequently is associated with neck pain. Disability and social withdrawal are common. Most cases are idiopathic, and generally it is a life-long disorder. In recent years, botulinum toxin...
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doi:10.1002/14651858.CD004314.pub2
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doi:10.1002/14651858.CD003109
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doi:10.1002/14651858.CD000166
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doi:10.1002/14651858.CD002239.pub4
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doi:10.1002/14651858.CD012506.pub2
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doi:10.1002/14651858.CD012494.pub2
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doi:10.1002/14651858.CD006340.pub3
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pub_type: 杂志文章,meta分析,评审
doi:10.1002/14651858.CD012331.pub2
更新日期:2017-04-19 00:00:00
abstract:OBJECTIVES:To compare the efficacy and safety of adjuvant pramipexole therapy versus inactive placebo in patients with Parkinson's disease, already established on levodopa. SEARCH STRATEGY:Electronic searches of MEDLINE, EMBASE and the Cochrane Controlled Trials Register. Handsearching of the neurology literature as p...
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doi:10.1002/14651858.CD002261
更新日期:2000-01-01 00:00:00
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doi:10.1002/14651858.CD006379.pub2
更新日期:2009-01-21 00:00:00
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journal_title:The Cochrane database of systematic reviews
pub_type: 杂志文章,评审
doi:10.1002/14651858.CD003472
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Scabies is a common public health problem with an estimated global prevalence of 300 million. Infestation can cause considerable discomfort and intense itching. Severe adverse effects have been reported for some drugs used to treat scabies. OBJECTIVES:The objective of this review is to assess the effects an...
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doi:10.1002/14651858.CD000320
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:The risk of maternal mortality and morbidity (particularly postoperative infection) is higher for caesarean section (CS) than for vaginal birth. With the increasing rate of CS, it is important to minimise the risks to the mother as much as possible. This review focused on different forms and methods of preop...
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doi:10.1002/14651858.CD007462.pub4
更新日期:2018-10-22 00:00:00
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doi:10.1002/14651858.CD007398.pub2
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doi:10.1002/14651858.CD000480.pub2
更新日期:2008-01-23 00:00:00
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journal_title:The Cochrane database of systematic reviews
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