Lobeline for smoking cessation.

Abstract:

BACKGROUND:Lobeline is a partial nicotine agonist, which has been used in a variety of commercially available preparations to help stop smoking. OBJECTIVES:The objective of this review was to assess the effects of lobeline on long term smoking cessation. SEARCH METHODS:We searched the Cochrane Tobacco Addiction Group trials register (most recent search December 2011). SELECTION CRITERIA:Randomized trials comparing lobeline to placebo or an alternative therapeutic control, which reported smoking cessation with at least six months follow-up. DATA COLLECTION AND ANALYSIS:We extracted data in duplicate on the type of subjects, the dose and form of lobeline, the outcome measures, method of randomisation, and completeness of follow-up. MAIN RESULTS:We identified no trials meeting the full inclusion criteria including long term follow-up. One large trial failed to detect any effect on short-term abstinence. AUTHORS' CONCLUSIONS:There is no evidence available from long term trials that lobeline can aid smoking cessation, and the short-term evidence suggests there is no benefit.

authors

Stead LF,Hughes JR

doi

10.1002/14651858.CD000124.pub2

subject

Has Abstract

pub_date

2012-02-15 00:00:00

pages

CD000124

issue

2

issn

1469-493X

pub_type

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