Dietary saturated and monounsaturated fats protect against acute acetaminophen hepatotoxicity by altering fatty acid composition of liver microsomal membrane in rats.

abstract：BACKGROUND:Buffalo milk is the second largest source of milk on the globe, it is highly suitable for the preparation of mozzarella cheese, however, it is not suitable for the preparation of cheddar cheese due to high buffering capacity, low acid development, excessive syneresis, lower lipolysis that lead to lower senso...

journal_title：Lipids in health and disease

authors： Batool M,Nadeem M,Imran M,Khan IT,Bhatti JA,Ayaz M

更新日期：2018-10-02 00:00:00

abstract：:Multiple Sclerosis (MS) patients present a decrease of antioxidants and neuroprotective and immunoregulatory vitamins and an increase of total homocysteine (tHcy), cholesterol (CHL), HDL-cholesterol, and of cellular stress markers, variably associated with the different phases of the disease. We compared the blood lev...

journal_title：Lipids in health and disease

authors： Salemi G,Gueli MC,Vitale F,Battaglieri F,Guglielmini E,Ragonese P,Trentacosti A,Massenti MF,Savettieri G,Bono A

更新日期：2010-02-18 00:00:00

abstract：BACKGROUND:Differential effects of individual saturated fatty acids (SFAs), particularly stearic acid (C18:0), relative to the shorter-chain SFAs have drawn interest for more accurate nutritional guidelines. However, specific biologic and pathologic functions that can be assigned to particular SFAs are very limited. Th...

journal_title：Lipids in health and disease

authors： Wang L,Xu F,Song Z,Han D,Zhang J,Chen L,Na L

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:Autism is a neurodevelopmental disorder that clinically presented as cognitive deficits, social impairments and sensory dysfunction. An increasing body of evidence has shown that oxidative stress and inflammation are involved in the pathophysiology of autism. Recording biomarkers as measure of the severity o...

journal_title：Lipids in health and disease

authors： Qasem H,Al-Ayadhi L,El-Ansary A

更新日期：2016-08-17 00:00:00

abstract：BACKGROUND:Heme oxygenase-1 (HO-1), an antioxidant defense enzyme, has been shown to protect against oxidant-induced liver injury. However, its role on liver fibrosis remains unclear. This study aims to elucidate the effect and the mechanism of HO-1 in nutritional fibrosing steatohepatitis in mice. METHODS:Male C57BL/...

journal_title：Lipids in health and disease

authors： Wang RQ,Nan YM,Wu WJ,Kong LB,Han F,Zhao SX,Kong L,Yu J

更新日期：2011-02-12 00:00:00

abstract：BACKGROUND:Mass spectrometry imaging (MSI) is a powerful tool for the study of intact tissue sections. Here, its application to the study of the distribution of lipids in sections of reconstructed living skin equivalents during their development and maturation is described. METHODS:Living skin equivalent (LSE) samples...

journal_title：Lipids in health and disease

authors： Mitchell CA,Long H,Donaldson M,Francese S,Clench MR

更新日期：2015-08-05 00:00:00

abstract：BACKGROUND:Adipocytes contribute to inflammation and the innate immune response through expression of inflammatory mediators. High levels of these mediators have been related to chronic inflammation state and insulin resistance, cardiovascular diseases and diabetes type 2, among other disorders. 3-octadecylglycerol (ba...

journal_title：Lipids in health and disease

authors： Ocaña A,Gómez-Asensio C,Arranz-Gutiérrez E,Torres C,Señoráns FJ,Reglero G

更新日期：2010-04-06 00:00:00

abstract：BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease in industrialized countries. The present study was undertaken to explore the preventive effect of dietary sea cucumber cerebroside (SCC) extracted from Acaudina molpadioides in fatty liver rats. METHODS:Male Wistar rats were rando...

journal_title：Lipids in health and disease

authors： Zhang B,Xue C,Hu X,Xu J,Li Z,Wang J,Yanagita T,Xue Y,Wang Y

更新日期：2012-05-08 00:00:00

abstract：BACKGROUND:The long-lasting and abundant blooming of Pelagia noctiluca in Tunisian coastal waters compromises both touristic and fishing activities and causes substantial economic losses. Determining their molecular mode of action is, important in order to limit or prevent the subsequent damages. Thus, the aim of the p...

journal_title：Lipids in health and disease

authors： Ayed Y,Boussabbeh M,Zakhama W,Bouaziz C,Abid S,Bacha H

更新日期：2011-12-09 00:00:00

abstract：BACKGROUND:Resynthesis of triglycerides in enterocytes of the small intestine plays a critical role in the absorption of dietary fat. Acyl-CoA:monoacylglycerol acyltransferase-2 (MGAT2) is highly expressed in the small intestine and catalyzes the synthesis of diacylglycerol from monoacylglycerol and acyl-CoA. To determ...

journal_title：Lipids in health and disease

authors： Tsuchida T,Fukuda S,Aoyama H,Taniuchi N,Ishihara T,Ohashi N,Sato H,Wakimoto K,Shiotani M,Oku A

更新日期：2012-06-14 00:00:00

abstract：OBJECTIVES:Variants of the secreted glycoprotein, proprotein convertase subtilisin/kexin 9 (PCSK9), associate with both hypo- and hyper-cholesterolemic phenotypes. Herein, we carried out full exonic sequencing of PCSK9 documenting the frequency of single and multiple PCSK9 variations and their effects on serum lipoprot...

journal_title：Lipids in health and disease

authors： Mayne J,Ooi TC,Raymond A,Cousins M,Bernier L,Dewpura T,Sirois F,Mbikay M,Davignon J,Chrétien M

更新日期：2013-05-10 00:00:00

abstract：BACKGROUND:Obesity increases the risk of developing diabetes mellitus. Clinical studies suggest that risk factors like palmitic acid (PA) and lipopolysaccharide (LPS) exist simultaneously in diabetes with obesity. Combination of PA and LPS even at low concentration can induce strong inflammatory reaction. Monocyte chem...

journal_title：Lipids in health and disease

authors： Wang X,Jiang X,Deng B,Xiao J,Jin J,Huang Z

更新日期：2019-03-25 00:00:00

abstract：:Elevated low-density lipoprotein (LDL)-cholesterol is associated with a significantly increased risk of coronary heart disease. Ezetimibe is the first member of a new class of selective cholesterol absorption inhibitors. It impairs the intestinal reabsorption of both dietary and hepatically excreted biliary cholestero...

journal_title：Lipids in health and disease

authors： Al-Shaer MH,Choueiri NE,Suleiman ES

更新日期：2004-10-07 00:00:00

abstract：BACKGROUND:α-linolenic acid (ALA) is an n-3 polyunsaturated fatty acid (PUFA) and the substrate for long-chain n-3 PUFAs. The beneficial effects of ALA on chronic diseases are still in dispute, unlike those of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). METHODS:The primary objective of this investigati...

journal_title：Lipids in health and disease

authors： Li J,Gu Z,Pan Y,Wang S,Chen H,Zhang H,Chen W,Chen YQ

更新日期：2017-07-11 00:00:00

abstract：BACKGROUND:Persons with spinal cord injury (SCI) often have low levels of physical activity, which predispose to increased adiposity and decreased high density lipoprotein cholesterol (HDL-C) concentrations, and, generally, normal low density lipoprotein cholesterol (LDL-C) concentrations. In spite of the mixed lipopro...

journal_title：Lipids in health and disease

authors： La Fountaine MF,Cirnigliaro CM,Emmons RR,Kirshblum SC,Galea M,Spungen AM,Bauman WA

更新日期：2015-07-28 00:00:00

abstract：BACKGROUND:Almonds have been shown to lower LDL cholesterol but there is limited information regarding their effects on the dyslipidemia characterized by increased levels of very low density lipoproteins (VLDL) and small, dense low-density lipoprotein (LDL) particles that is associated with abdominal adiposity and high...

journal_title：Lipids in health and disease

authors： Williams PT,Bergeron N,Chiu S,Krauss RM

更新日期：2019-04-03 00:00:00

abstract：BACKGROUND:Dyslipidemia is a key driver of coronary artery disease (CAD) development. This study aimed to determine whether the atherogenic index of plasma (AIP), a novel comprehensive lipid index, is an independent and reliable predictor of CAD risk in postmenopausal women. METHODS:A cohort of consecutive 4644 postme...

journal_title：Lipids in health and disease

authors： Guo Q,Zhou S,Feng X,Yang J,Qiao J,Zhao Y,Shi D,Zhou Y

更新日期：2020-02-24 00:00:00

abstract：BACKGROUND:One of the most important factors in the initiation and progression of atherosclerosis is the default in macrophage cholesterol homeostasis. Many genes and transcription factors such as peroxisome proliferators activated receptors (PPARs) and acyl coenzyme A: cholesterol acyltransferase1 (ACAT1) are involved...

journal_title：Lipids in health and disease

authors： Reza JZ,Doosti M,Salehipour M,Packnejad M,Mojarrad M,Heidari M

更新日期：2009-09-02 00:00:00

abstract：BACKGROUND:Atherosclerosis is a chronic inflammatory disease that is promoted, among others, by pro-inflammatory cytokines such as IL-1β and IL-18 produced by NLRP 3 inflammasome. Development of atherosclerotic lesions is also affected by leptin. Furthermore, inflammasome's action is interfered with other inflammatory ...

journal_title：Lipids in health and disease

authors： Kaminiotis VV,Agrogiannis G,Konstantopoulos P,Androutsopoulou V,Korou LM,Vlachos IS,Dontas IA,Perrea D,Iliopoulos DC

更新日期：2017-09-26 00:00:00

abstract：BACKGROUND:Fragarianilgerrensis Schlecht. medicine compound (FN-MC) is a kind of Chinese herbs' compound consisted of Fragarianilgerrensis Schlecht. and Centella asiatica (L.) Urban. The study was to investigate the hypolipidemia effect of FN-MC in a hypolipidemic rat model. METHODS:Male SD rats were randomly divided ...

journal_title：Lipids in health and disease

authors： Gao L,Lin Z,Liu Y,Wang X,Wan L,Zhang L,Liu X

更新日期：2018-09-19 00:00:00

abstract：BACKGROUND:Previously, we found a significant relationship in a rat study between energy intake and bile acid (BA) metabolism especially 12α-hydroxylated (12αOH) BAs. The present study was designed to reveal relationships among BA metabolism, glucose tolerance, and cecal organic acids in rats fed a high-fat and high-su...

journal_title：Lipids in health and disease

authors： Yoshitsugu R,Kikuchi K,Hori S,Iwaya H,Hagio M,Shimizu H,Hira T,Ishizuka S

更新日期：2020-01-15 00:00:00

abstract：BACKGROUND:The pharmacological inhibitor of phosphodiesterase 5 (PDE5), sildenafil, is a promising candidate for antioxidant therapy that can result in cardiovascular protection. In addition to its known effects on the cardiovascular system, hypercholesterolemia leads to increased oxidative stress and DNA damage in the...

journal_title：Lipids in health and disease

authors： Bernardes FP,Batista AT,Porto ML,Vasquez EC,Campagnaro BP,Meyrelles SS

更新日期：2016-05-27 00:00:00

abstract：BACKGROUND:Cholesterol oxidation products (COPs) are produced during thermal processing of animal origin foods and are considered to have negative health impacts. The model systems are helpful to understand the impact of various factors on oxidation changes in foods during cooking process. METHODS:The study presented ...

journal_title：Lipids in health and disease

authors： Min JS,Lee SO,Khan MI,Yim DG,Seol KH,Lee M,Jo C

更新日期：2015-07-23 00:00:00

abstract：BACKGROUND:The role of pro-inflammatory lipids in systemic immune activation in HIV infection remains largely unknown. We hypothesized that HIV-1-infected persons on antiretroviral therapy would have pro-inflammatory high density lipoprotein (HDL), and that an apoA-1 mimetic peptide might reverse the inflammatory prope...

journal_title：Lipids in health and disease

authors： Kelesidis T,Yang OO,Currier JS,Navab K,Fogelman AM,Navab M

更新日期：2011-02-23 00:00:00

abstract：BACKGROUND:Rho kinase over-activation is associated with nitric oxide (NO) reduction and atherosclerosis. Metformin is favorable for endothelial function improvement and cardiovascular outcomes. Whether cardio-protective effect of metformin is associated with Rho kinase activity is unknown. METHODS:Hyperlipidemia mode...

journal_title：Lipids in health and disease

authors： Liu Y,Huang C,Ceng C,Zhan H,Zheng D,Han W

更新日期：2014-07-15 00:00:00

abstract：BACKGROUND:The body mass index (BMI) is the most commonly used marker for evaluating obesity related risks, however, central obesity measures have been proposed to be more informative. Lipid accumulation product (LAP) is an alternative continuous index of lipid accumulation, which is computed from waist circumference (...

journal_title：Lipids in health and disease

authors： Bozorgmanesh M,Hadaegh F,Azizi F

更新日期：2010-05-10 00:00:00

abstract：BACKGROUND:Lipoprotein Lipase (LPL), a key enzyme in lipid metabolism, catalyzes the hydrolysis of triglycerides (TG) from TG-rich lipoproteins, and serves a bridging function that enhances the cellular uptake of lipoproteins. Abnormalities in LPL function are associated with pathophysiological conditions, including fa...

journal_title：Lipids in health and disease

authors： Wung SF,Kulkarni MV,Pullinger CR,Malloy MJ,Kane JP,Aouizerat BE

更新日期：2006-07-05 00:00:00

abstract：BACKGROUND:The purpose of the study was to evaluate the effects of high dietary cholesterol in ovariectomized (Ovx) rats on several key markers of hepatic cholesterol and bile acid metabolism. METHOD:Ovx and sham operated (Sham) rats were given either a standard diet (SD), a SD diet supplemented with 0.25% cholesterol...

journal_title：Lipids in health and disease

authors： Farahnak Z,Côté I,Ngo Sock ET,Lavoie JM

更新日期：2015-10-09 00:00:00

abstract：BACKGROUND:Many disorders with plasmalogen deficiency have been reported. Replenishment or replacement of tissue plasmalogens of these disorders would be beneficial to the patients with these disorders, but effects of dietary plasmalogen on mammals have not been reported. METHODS:Plasmalogens were purified from chicke...

journal_title：Lipids in health and disease

authors： Mawatari S,Katafuchi T,Miake K,Fujino T

更新日期：2012-11-21 00:00:00

abstract：BACKGROUND:Physical activity has long been associated with reduced risk of coronary heart disease (CHD). In this work we evaluated the effect of physical activity on lipid levels, in a sample of cardiovascular disease free people. METHODS:The ATTICA study is a population-based cohort that has randomly enrolled 2772 in...

journal_title：Lipids in health and disease

authors： Skoumas J,Pitsavos C,Panagiotakos DB,Chrysohoou C,Zeimbekis A,Papaioannou I,Toutouza M,Toutouzas P,Stefanadis C

更新日期：2003-06-12 00:00:00