Early detection of susceptibility to acute lung inflammation by molecular imaging in mice exposed to cigarette smoke.

abstract：:We investigated the capacity of normalized transillumination methods in imaging fluorescent proteins in visible light, in phantoms and in live mice. We demonstrate significant imaging improvements over epi-illumination imaging, as commonly applied today. Of particular importance is the significant betterment in contra...

journal_title：Molecular imaging

authors： Zacharakis G,Shih H,Ripoll J,Weissleder R,Ntziachristos V

更新日期：2006-07-01 00:00:00

abstract：:The lipid bilayer of a cell presents a significant barrier for the delivery of many molecular imaging reagents into cells at target sites in the body. Protein translocation domains (PTDs) are peptides that breach this barrier. Conjugation of PTDs to imaging agents can be utilized to facilitate the delivery of these ag...

journal_title：Molecular imaging

authors： Franc BL,Mandl SJ,Siprashvili Z,Wender P,Contag CH

更新日期：2003-10-01 00:00:00

abstract：:Cerenkov luminescence imaging is an emerging optical technique for imaging the distribution of radiopharmaceuticals in vivo. However, because of the light scattering effect, it cannot obtain optical information from deep internal organs. To overcome this challenge, we established a novel endoscopic Cerenkov luminescen...

journal_title：Molecular imaging

authors： Song T,Liu X,Qu Y,Liu H,Bao C,Leng C,Hu Z,Wang K,Tian J

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this study was to validate (99m)Tc-3P-RGD(2) single-photon emission computed tomography/computed tomography (SPECT/CT) as an imaging tool to monitor α(v)β(3) expression and tumor necrosis. The animal model was established by subcutaneous injection of 5 × 10(6) U87MG cells into the shoulder flank of each...

journal_title：Molecular imaging

authors： Shao G,Zhou Y,Wang F,Liu S

更新日期：2013-01-01 00:00:00

abstract：:β-Glucuronidase (β-GUS) plays an important role in inflammation and degenerative processes. The enzyme has also been investigated as a target in prodrug therapy for cancer. To investigate the role of β-GUS in pathologies and to optimize β-GUS-based prodrug therapies, we recently developed a positron emission tomograph...

journal_title：Molecular imaging

authors： Antunes IF,Haisma HJ,Elsinga PH,van Waarde A,Willemsen AT,Dierckx RA,de Vries EF

更新日期：2012-02-01 00:00:00

abstract：:Very early cancer detection is the key to improving cure. Our objective was to investigate manganese (Mn)-enhanced magnetic resonance imaging (MRI) for very early detection and characterization of breast cancers. Eighteen NOD scid gamma mice were inoculated with MCF7, MDA, and LM2 breast cancer cells and imaged period...

journal_title：Molecular imaging

authors： Alhamami M,Bayat Mokhtari R,Ganesh T,Tchouala Nofiele J,Yeger H,Margaret Cheng HL

更新日期：2014-01-01 00:00:00

abstract：:Mutated adenomatous polyposis coli (APC) genes predispose transformations to neoplasia, progressing to colorectal carcinoma. Early detection facilitates clinical management and therapy. Novel lectin-mediated polymerized targeted liposomes (Rh-I-UEA-1), with polyp specificity and incorporated imaging agents were fabric...

journal_title：Molecular imaging

authors： Roney CA,Xu B,Xie J,Yuan S,Wierwille J,Chen CW,Chen Y,Griffiths GL,Summers RM

更新日期：2011-08-01 00:00:00

abstract：:Macrophage infiltration is a prominent feature of abdominal aortic aneurysm (AAA) progression. We used a combined imaging approach with bioluminescence (BLI) and magnetic resonance imaging (MRI) to study macrophage homing and accumulation in experimental AAA disease. Murine AAAs were created via intra-aortic infusion ...

journal_title：Molecular imaging

authors： Miyama N,Dua MM,Schultz GM,Kosuge H,Terashima M,Pisani LJ,Dalman RL,McConnell MV

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:Melanoma is a lethal skin cancer with unmet clinical needs for targeted imaging and therapy. Nanoscale materials conjugated with targeting components have shown great potential to improve tumor delivery efficiency while minimizing undesirable side effects in vivo. Herein, we proposed to develop targeted nanopar...

journal_title：Molecular imaging

authors： Zhao Y,Pang B,Detering L,Luehmann H,Yang M,Black K,Sultan D,Xia Y,Liu Y

更新日期：2018-01-01 00:00:00

abstract：:We investigated the effect of diet on abdominal autofluorescence detected by in vivo fluorescence imaging (FLI) of living mice. Groups of mice were fed a regular, alfalfa-free, or purified diet, and whole-body FLI was performed without the administration of fluorescent probes. In addition, quantum dots were injected i...

journal_title：Molecular imaging

authors： Inoue Y,Izawa K,Kiryu S,Tojo A,Ohtomo K

更新日期：2008-01-01 00:00:00

abstract：:The use of micro-CT in small animals has increased in recent years. Although the radiation levels used for micro-CT are generally not lethal to the animal, they are high enough where changes in the immune response and other biological pathways may alter the experimental outcomes. Therefore, it is important to understa...

journal_title：Molecular imaging

authors： Boone JM,Velazquez O,Cherry SR

更新日期：2004-07-01 00:00:00

abstract：:Quantifying the bone erosion in preclinical models of rheumatoid arthritis is valuable for the evaluation of drug treatments. This study introduces a three-dimensional method for bone surface roughness measurement from micro-computed tomographic data obtained from rats subjected to collagen-induced arthritis (CIA), in...

journal_title：Molecular imaging

authors： Silva MD,Ruan J,Siebert E,Savinainen A,Jaffee B,Schopf L,Chandra S

更新日期：2006-10-01 00:00:00

abstract：:Molecular imaging with magnetic resonance imaging (MRI) may benefit from the ferrimagnetic properties of magnetosomes, membrane-enclosed iron biominerals whose formation in magnetotactic bacteria is encoded by multiple genes. One such gene is MagA, a putative iron transporter. We have examined expression of MagA in mo...

journal_title：Molecular imaging

authors： Goldhawk DE,Lemaire C,McCreary CR,McGirr R,Dhanvantari S,Thompson RT,Figueredo R,Koropatnick J,Foster P,Prato FS

更新日期：2009-05-01 00:00:00

abstract：:Imaging of glutamate carboxypeptidase II (GCP II), also known as N-acetylated alpha-linked L-amino dipeptidase (NAALADase), may enable study of glutamatergic transmission, prostate cancer, and tumor neovasculature in vivo. Our goal was to develop a probe for GCP II for use with positron emission tomography (PET). Radi...

journal_title：Molecular imaging

authors： Pomper MG,Musachio JL,Zhang J,Scheffel U,Zhou Y,Hilton J,Maini A,Dannals RF,Wong DF,Kozikowski AP

更新日期：2002-04-01 00:00:00

abstract：:Brain anatomy variability is a major problem in quantifying functional images in nuclear medicine, in particular relative to aging and neurodegenerative diseases. The aim of this study was to compare affine and elastic model-based methods for magnetic resonance imaging (MRI) to brain atlas registration and to assess t...

journal_title：Molecular imaging

authors： Lamare F,Mazere J,Attila M,Mayo W,De Clermont-Gallerande H,Meissner W,Fernandez P,Allard M

更新日期：2013-07-01 00:00:00

abstract：:Solid tumors containing more hypoxic regions show a more malignant phenotype by increasing the expression of genes encoding angiogenic and metastatic factors. Hypoxia-inducible factor-1 (HIF-1) is a master transcriptional activator of such genes, and thus, imaging and targeting hypoxic tumor cells where HIF-1 is activ...

journal_title：Molecular imaging

authors： Harada H,Kizaka-Kondoh S,Hiraoka M

更新日期：2005-07-01 00:00:00

abstract：:We delivered adenovirus vector (Ad) via intravitreous injection and monitored transgene (luciferase) expression in living mice (BALB/c) at multiple time points. In vivo live imaging technology was able to assess dynamically intraocular luciferase expression in a single animal population throughout the entire experimen...

journal_title：Molecular imaging

authors： Gehlbach PL,Chuck RS,Park CG,Park CY

更新日期：2012-09-01 00:00:00

abstract：:This article presents and validates a newly developed GATE model of the Siemens Inveon trimodal imaging platform. Fully incorporating the positron emission tomography (PET), single-photon emission computed tomography (SPECT), and computed tomography (CT) data acquisition subsystems, this model enables feasibility stud...

journal_title：Molecular imaging

authors： Lee S,Gregor J,Osborne D

更新日期：2013-10-01 00:00:00

abstract：:The pharmacokinetic properties of radiotracers are crucial for successful in vivo single-photon emission computed tomographic (SPECT) imaging. Our goal was to determine if MDR1A-deficient animals could allow better SPECT imaging outcomes than wild-type (WT) animals for a selection of serotoninergic radioligands. Thus,...

journal_title：Molecular imaging

authors： Dumas N,Moulin-Sallanon M,Ginovart N,Tournier BB,Suzanne P,Cailly T,Fabis F,Rault S,Charnay Y,Millet P

更新日期：2014-01-01 00:00:00

abstract：:Surgical biopsy of potential tumor recurrence is a common challenge facing oncologists, surgeons, and cancer patients. Imaging modalities have limited ability to accurately detect recurrent cancer in fields affected by previous surgery, chemotherapy, or radiation. However, definitive tissue diagnosis is often needed t...

journal_title：Molecular imaging

authors： Okusanya OT,Deshpande C,Barbosa EM Jr,Aggarwal C,Simone CB 2nd,Jiang J,Judy R,DeJesus E,Albelda S,Nie S,Low PS,Singhal S

更新日期：2014-01-01 00:00:00

abstract：:The ability of tumor cells to adhere to, migrate on, and remodel extracellular matrices is mediated by cell surface receptors such as beta1-integrins. Here we conducted functional live-cell imaging in real time to investigate the effects of modulating beta1-integrin expression and function on proteolytic remodeling of...

journal_title：Molecular imaging

authors： Sameni M,Dosescu J,Yamada KM,Sloane BF,Cavallo-Medved D

更新日期：2008-09-01 00:00:00

abstract：:High spectral and spatial resolution (HiSS) data, acquired with echo-planar spectroscopic imaging (EPSI), can be used to acquire water spectra from each small image voxel. These images are sensitive to changes in local susceptibility caused by superparamagnetic iron oxide particles (SPIO); therefore, we hypothesized t...

journal_title：Molecular imaging

authors： Haney CR,Pelizzari CA,Foxley S,Zamora MA,Mustafi D,Tretiakova M,Li S,Fan X,Karczmar GS

更新日期：2011-06-01 00:00:00

abstract：:The lung remains one of the most challenging organs to image using magnetic resonance imaging (MRI) due to intrinsic rapid signal decay. However, unlike conventional modalities such as computed tomography, MRI does not involve radiation and can provide functional and morphologic information on a regional basis. Here w...

journal_title：Molecular imaging

authors： Tchouala Nofiele J,Cheng W,Haedicke IE,Ganesh T,Zhang XA,Cheng HL

更新日期：2014-01-01 00:00:00

abstract：:18F positron emission tomography (PET) has a number of attributes that make it clinically attractive, including nearly 100% positron efficiency, very high specific radioactivity, and a short half-life of ≈ 110 minutes. However, the short half-life of 18F and the poor nucleophilicity of fluoride introduce challenges fo...

journal_title：Molecular imaging

authors： Liu S,Hassink M,Selvaraj R,Yap LP,Park R,Wang H,Chen X,Fox JM,Li Z,Conti PS

更新日期：2013-03-01 00:00:00

abstract：:Breast cancer continues to be the most lethal cancer type in women and one of the most diagnosed. Understanding Breast cancer receptor status is one of the most vital processes for determining treatment options. One type of breast cancer, human epidermal growth factor receptor 2 (HER2) positive, has approved receptor-...

journal_title：Molecular imaging

authors： Ducharme M,Lapi SE

更新日期：2020-01-01 00:00:00

abstract：:Bioluminescence imaging (BLI) of luciferase reporters provides a cost-effective and sensitive means to image biological processes. However, transport of luciferase substrates across the cell membrane does affect BLI readout intensity from intact living cells. To investigate the effect of ATP-binding cassette (ABC) tra...

journal_title：Molecular imaging

authors： Huang R,Vider J,Serganova I,Blasberg RG

更新日期：2011-06-01 00:00:00

abstract：:We introduce and demonstrate the utility of coded aperture (CA) nuclear scintigraphy for imaging small animals. CA imaging uses multiple pinholes in a carefully designed mask pattern, mounted on a conventional gamma camera. System performance was assessed using point sources and phantoms, while several animal experime...

journal_title：Molecular imaging

authors： Schellingerhout D,Accorsi R,Mahmood U,Idoine J,Lanza RC,Weissleder R

更新日期：2002-10-01 00:00:00

abstract：:Development of an α-synuclein (α-Syn) positron emission tomography agent for the diagnosis and evaluation of Parkinson disease therapy is a key goal of neurodegenerative disease research. BF-227 has been described as an α-Syn binder and hence was employed as a lead to generate a library of α-Syn-binding compounds. [3H...

journal_title：Molecular imaging

authors： Josephson L,Stratman N,Liu Y,Qian F,Liang SH,Vasdev N,Patel S

更新日期：2018-01-01 00:00:00

abstract：:For clinical application of stem cell-based therapies, noninvasive detection of applied stem cells is of high importance. We report on the feasibility of detecting implanted neural progenitor cells (NPCs) noninvasively and follow their fate and functional status by sequential multimodal molecular imaging and reporter ...

journal_title：Molecular imaging

authors： Waerzeggers Y,Klein M,Miletic H,Himmelreich U,Li H,Monfared P,Herrlinger U,Hoehn M,Coenen HH,Weller M,Winkeler A,Jacobs AH

更新日期：2008-03-01 00:00:00

abstract：:Bacterial genes involved in the biomineralization of magnetic nanoparticles in magnetotactic bacteria have recently been proposed as reporters for magnetic resonance imaging (MRI). In such systems, the expression of the bacterial genes in mammalian cells purportedly leads to greater concentrations of intracellular iro...

journal_title：Molecular imaging

authors： Pereira SM,Williams SR,Murray P,Taylor A

更新日期：2016-04-26 00:00:00