Gene therapy for carcinoma of the breast: Therapeutic genetic correction strategies.

abstract：BACKGROUND:The PAM50-based (Prosigna) risk of recurrence (ROR) score and intrinsic subtypes are prognostic for women with high-risk breast cancer. We investigate the predictive ability of Prosigna regarding the effectiveness of cyclophosphamide-based adjuvant chemotherapy in premenopausal patients with high-risk breast...

journal_title：Breast cancer research : BCR

authors： Jensen MB,Lænkholm AV,Nielsen TO,Eriksen JO,Wehn P,Hood T,Ram N,Buckingham W,Ferree S,Ejlertsen B

更新日期：2018-07-27 00:00:00

abstract：INTRODUCTION:AIB1, located at 20q12, is a member of the steroid hormone coactivator family. It contains a glutamine repeat (CAG/CAA) polymorphism at its carboxyl-terminal region that may alter the transcriptional activation of the receptor and affect susceptibility to breast cancer through altered sensitivity to hormon...

journal_title：Breast cancer research : BCR

authors： Montgomery KG,Chang JH,Gertig DM,Dite GS,McCredie MR,Giles GG,Southey MC,Hopper JL,Campbell IG

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab) is a multidisciplinary, collaborative framework for the investigation of familial breast cancer. Based in Australia, the primary aim of kConFab is to facilitate high-quality research by amassing a large and comp...

journal_title：Breast cancer research : BCR

authors： Mann GJ,Thorne H,Balleine RL,Butow PN,Clarke CL,Edkins E,Evans GM,Fereday S,Haan E,Gattas M,Giles GG,Goldblatt J,Hopper JL,Kirk J,Leary JA,Lindeman G,Niedermayr E,Phillips KA,Picken S,Pupo GM,Saunders C,Scott CL

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Rapamycin, an inhibitor of the serine/threonine kinase target of rapamycin, induces G1 arrest and/or apoptosis. Although rapamycin and its analogues are attractive candidates for cancer therapy, their sensitivities with respect to growth inhibition differ markedly among various cancer cells. Using human br...

journal_title：Breast cancer research : BCR

authors： Kasukabe T,Okabe-Kado J,Kato N,Sassa T,Honma Y

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Vitamin D status measured during adulthood has been inversely associated with breast cancer risk in some, but not all, studies. Vitamin D has been hypothesized to prevent breast cancer through genomic and non-genomic actions in cell-cycle regulation. METHODS:A subset (n = 21,965) of female participants fr...

journal_title：Breast cancer research : BCR

authors： McCullough ML,Stevens VL,Patel R,Jacobs EJ,Bain EB,Horst RL,Gapstur SM,Thun MJ,Calle EE

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Breast ductal carcinoma in situ (DCIS) represent approximately 20% of screen-detected breast cancers. The overall risk for DCIS patients treated with breast-conserving surgery stems almost exclusively from local recurrence. Although a mastectomy or adjuvant radiation can reduce recurrence risk, there are sig...

journal_title：Breast cancer research : BCR

authors： Klimov S,Miligy IM,Gertych A,Jiang Y,Toss MS,Rida P,Ellis IO,Green A,Krishnamurti U,Rakha EA,Aneja R

更新日期：2019-07-29 00:00:00

abstract：:PIK3CA mutations represent one of the most common genetic aberrations in breast cancer. They have been reported to be present in over one-third of cases, with enrichment in the luminal and in human epidermal growth factor receptor 2-positive subtypes. Substantial preclinical data on the oncogenic properties of these m...

journal_title：Breast cancer research : BCR

authors： Zardavas D,Phillips WA,Loi S

更新日期：2014-01-23 00:00:00

abstract：INTRODUCTION:The aim of this study was to describe breast tumor subtypes by common breast cancer risk factors and to determine correlates of subtypes using baseline data from two pooled prospective breast cancer studies within a large health maintenance organization. METHODS:Tumor data on 2544 invasive breast cancer c...

journal_title：Breast cancer research : BCR

authors： Kwan ML,Kushi LH,Weltzien E,Maring B,Kutner SE,Fulton RS,Lee MM,Ambrosone CB,Caan BJ

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Full-term pregnancy (FTP) at an early age confers long-term protection against breast cancer. Previously, we reported that a FTP imprints a specific gene expression profile in the breast of postmenopausal women. Herein, we evaluated gene expression changes induced by parity in the breast of premenopausal wom...

journal_title：Breast cancer research : BCR

authors： Santucci-Pereira J,Zeleniuch-Jacquotte A,Afanasyeva Y,Zhong H,Slifker M,Peri S,Ross EA,López de Cicco R,Zhai Y,Nguyen T,Sheriff F,Russo IH,Su Y,Arslan AA,Bordas P,Lenner P,Åhman J,Landström Eriksson AS,Johansson R,H

更新日期：2019-03-28 00:00:00

abstract：INTRODUCTION:Activated leukocyte cell adhesion molecule (ALCAM) (CD166) is an immunoglobulin molecule that has been implicated in cell migration. The present study examined the expression of ALCAM in human breast cancer and assessed its prognostic value. METHODS:The immunohistochemical distribution and location of ALC...

journal_title：Breast cancer research : BCR

authors： King JA,Ofori-Acquah SF,Stevens T,Al-Mehdi AB,Fodstad O,Jiang WG

更新日期：2004-01-01 00:00:00

abstract：:The Developmental Origins of Health and Disease (DOHaD) theory focuses on the consequences of periconceptional and in utero exposures. A wide range of environmental conditions during early development are now being investigated as a driving force for epigenetic disruptions that enhance disease risk in later life, incl...

journal_title：Breast cancer research : BCR

authors： Romanus S,Neven P,Soubry A

更新日期：2016-10-12 00:00:00

abstract：:Genome-wide expression microarray studies have revealed that the biological and clinical heterogeneity of breast cancer can be partly explained by information embedded within a complex but ordered transcriptional architecture. Comprising this architecture are gene expression networks, or signatures, reflecting biochem...

journal_title：Breast cancer research : BCR

authors： Miller LD,Liu ET

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase that is highly expressed in Human Epidermal Growth Factor 2(+) (Her2(+)) breast cancers. Overexpression of PTK6 enhances anchorage-independent survival, proliferation, and migration of breast cancer cells. We hypothesized that PTK6 inhibiti...

journal_title：Breast cancer research : BCR

authors： Park SH,Ito K,Olcott W,Katsyv I,Halstead-Nussloch G,Irie HY

更新日期：2015-06-19 00:00:00

abstract：INTRODUCTION:Global gene expression analysis of tumor samples has been a valuable tool to subgroup tumors and has the potential to be of prognostic and predictive value. However, tumors are heterogeneous, and homogenates will consist of several different cell types. This study was designed to obtain more refined expres...

journal_title：Breast cancer research : BCR

authors： Winslow S,Leandersson K,Edsjö A,Larsson C

更新日期：2015-02-21 00:00:00

abstract：INTRODUCTION:Natural herbal compounds with novel actions different from existing breast cancer (BCa) treatment modalities are attractive for improving therapeutic efficacy and safety. We have recently shown that penta-1,2,3,4,6-O-galloyl-β-D-glucose (PGG) induced S-phase arrest in prostate cancer (PCa) cells through in...

journal_title：Breast cancer research : BCR

authors： Chai Y,Lee HJ,Shaik AA,Nkhata K,Xing C,Zhang J,Jeong SJ,Kim SH,Lu J

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Radiation exposure at a young age is one of the strongest risk factors for breast cancer. Germline mutations in genes involved in the DNA-damage repair pathway (DDRP) may render women more susceptible to radiation-induced breast cancer. METHODS:We evaluated the contribution of germline mutations in the DD...

journal_title：Breast cancer research : BCR

authors： Broeks A,Braaf LM,Huseinovic A,Nooijen A,Urbanus J,Hogervorst FB,Schmidt MK,Klijn JG,Russell NS,Van Leeuwen FE,Van 't Veer LJ

更新日期：2007-01-01 00:00:00

abstract：:Women's perceptions of breast cancer risk are largely inaccurate and are often associated with high levels of anxiety about cancer. There are interesting cultural differences that are not well researched. Genetic risk counselling significantly improves accuracy of women's perceptions of risk, but not necessarily to th...

journal_title：Breast cancer research : BCR

authors： Hopwood P

更新日期：2000-01-01 00:00:00

abstract：:Currently, there is limited data regarding the effectiveness of standard subsequent line therapies such as endocrine therapy, chemotherapy, or targeted agents after progression on CDK4/6 inhibitor-based regimens. This paper describes time-to-treatment failure beyond progression on palbociclib or palbociclib+endocrine ...

journal_title：Breast cancer research : BCR

authors： Rossi L,Biagioni C,McCartney A,Migliaccio I,Curigliano G,Sanna G,Moretti E,Minisini AM,Cinieri S,Tondini C,Arpino G,Bernardo A,Martignetti A,Risi E,Pestrin M,Boni L,Benelli M,Biganzoli L,Di Leo A,Malorni L

更新日期：2019-05-29 00:00:00

abstract：INTRODUCTION:There is an unmet clinical need for biomarkers to identify breast cancer patients at an increased risk of developing brain metastases. The objective is to identify gene signatures and biological pathways associated with human epidermal growth factor receptor 2-positive (HER2+) brain metastasis. METHODS:We...

journal_title：Breast cancer research : BCR

authors： McMullin RP,Wittner BS,Yang C,Denton-Schneider BR,Hicks D,Singavarapu R,Moulis S,Lee J,Akbari MR,Narod SA,Aldape KD,Steeg PS,Ramaswamy S,Sgroi DC

更新日期：2014-03-14 00:00:00

abstract：BACKGROUND:The contribution of BRCA1 and BRCA2 to the incidence of male breast cancer (MBC) in the United Kingdom is not known, and the importance of these genes in the increased risk of female breast cancer associated with a family history of breast cancer in a male first-degree relative is unclear. METHODS:We have c...

journal_title：Breast cancer research : BCR

authors： Basham VM,Lipscombe JM,Ward JM,Gayther SA,Ponder BA,Easton DF,Pharoah PD

更新日期：2002-01-01 00:00:00

abstract：INTRODUCTION:Inhibition of phosphatidylinositol-3-kinase (PI3K) induces apoptosis when combined with estrogen deprivation in estrogen receptor (ER)-positive breast cancer. The aims of the present study were to identify effective PI3K pathway inhibitor and endocrine therapy combinations, to evaluate the effect of PI3K p...

journal_title：Breast cancer research : BCR

authors： Sanchez CG,Ma CX,Crowder RJ,Guintoli T,Phommaly C,Gao F,Lin L,Ellis MJ

更新日期：2011-03-01 00:00:00

abstract：INTRODUCTION:Estrogens play a pivotal role in the initiation and progression of breast cancer. The genes that mediate these processes are not fully defined, but potentially include the known mammary oncogene MYC. Characterization of estrogen-target genes may help to elucidate further the mechanisms of estrogen-induced ...

journal_title：Breast cancer research : BCR

authors： Butt AJ,Sergio CM,Inman CK,Anderson LR,McNeil CM,Russell AJ,Nousch M,Preiss T,Biankin AV,Sutherland RL,Musgrove EA

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Reliable predictive and prognostic markers for routine diagnostic purposes are needed for breast cancer patients treated with neoadjuvant chemotherapy. We evaluated protein biomarkers in a cohort of 116 participants of the GeparDuo study on anthracycline/taxane-based neoadjuvant chemotherapy for operable b...

journal_title：Breast cancer research : BCR

authors： Darb-Esfahani S,Loibl S,Müller BM,Roller M,Denkert C,Komor M,Schlüns K,Blohmer JU,Budczies J,Gerber B,Noske A,du Bois A,Weichert W,Jackisch C,Dietel M,Richter K,Kaufmann M,von Minckwitz G

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Bone is one of the most frequent metastatic sites of advanced breast cancer. Current therapeutic agents aim to inhibit osteoclast-mediated bone resorption but only have palliative effects. During normal bone remodeling, the balance between bone resorption and osteoblast-mediated bone formation is essential f...

journal_title：Breast cancer research : BCR

authors： Liu X,Cao M,Palomares M,Wu X,Li A,Yan W,Fong MY,Chan WC,Wang SE

更新日期：2018-10-22 00:00:00

abstract：:The key to optimising our approach in early breast cancer is to individualise care. Each patient has a tumour with innate features that dictate their chance of relapse and their responsiveness to treatment. Often patients with similar clinical and pathological tumours will have markedly different outcomes and response...

journal_title：Breast cancer research : BCR

authors： Oakman C,Bessi S,Zafarana E,Galardi F,Biganzoli L,Di Leo A

更新日期：2009-01-01 00:00:00

abstract：:Many women newly diagnosed with breast cancer and with a strong family history of breast cancer are referred to a family cancer service for genetic counselling and for consideration of genetic testing for germline mutations in cancer predisposition genes following completion of their cancer treatment. However, there i...

journal_title：Breast cancer research : BCR

authors： Meiser B,Tucker K,Friedlander M,Barlow-Stewart K,Lobb E,Saunders C,Mitchell G

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Breast cancers can be classified using whole genome expression into distinct subtypes that show differences in prognosis. One of these groups, the basal-like subtype, is poorly differentiated, highly metastatic, genomically unstable, and contains specific genetic alterations such as the loss of tumour prot...

journal_title：Breast cancer research : BCR

authors： Herschkowitz JI,He X,Fan C,Perou CM

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Bisphosphonates are inhibitors of osteoclast-mediated tumor-stimulated osteolysis, and they have become standard therapy for the management of bone metastases from breast cancer. These drugs can also directly induce growth inhibition and apoptosis of osteotropic cancer cells, including estrogen receptor-po...

journal_title：Breast cancer research : BCR

authors： Journe F,Chaboteaux C,Magne N,Duvillier H,Laurent G,Body JJ

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:With the improvement of therapeutic options for the treatment of breast cancer, the development of brain metastases has become a major limitation to life expectancy in many patients. Therefore, our aim was to identify molecular markers associated with the development of brain metastases in breast cancer. ...

journal_title：Breast cancer research : BCR

authors： Wikman H,Lamszus K,Detels N,Uslar L,Wrage M,Benner C,Hohensee I,Ylstra B,Eylmann K,Zapatka M,Sauter G,Kemming D,Glatzel M,Müller V,Westphal M,Pantel K

更新日期：2012-03-19 00:00:00

abstract：:The potential for a reduction in dietary fat or for an increase in dietary fiber to reduce breast cancer risk has been debated for some years. It is argued here that available research data, even though extensive, leave open hypotheses ranging from little or no potential to major public health potential for breast can...

journal_title：Breast cancer research : BCR

authors： Prentice RL

更新日期：2000-01-01 00:00:00