The pathology of familial breast cancer: Morphological aspects.


:A small proportion of breast cancers are due to a heritable predisposition. Recently, two predisposition genes, BRCA1 and BRCA2, have been identified and cloned. The morphological features of tumours from patients harbouring mutations in the BRCA1 and BRCA2 genes differ from each other and from sporadic breast cancers. Both are of higher grade than are sporadic cases. An excess of medullary/atypical medullary carcinoma has been reported in patients with BRCA1 mutations. Multifactorial analysis, however, shows that the only features independently associated with BRCA1 mutations are a high mitotic count, pushing tumour margins and a lymphocytic infiltrate. For BRCA2 mutation, an association with tubular/lobular carcinoma has been suggested, but not substantiated in a larger Breast Cancer Linkage Consortium study. In multifactorial analysis, the independent features were a lack of tubule formation and pushing tumour margins only. The morphological analysis has implications for clinical management of patients.


Breast Cancer Res


Lakhani SR





Has Abstract


1999-01-01 00:00:00












  • Tricho-rhino-phalangeal syndrome 1 protein functions as a scaffold required for ubiquitin-specific protease 4-directed histone deacetylase 2 de-ubiquitination and tumor growth.

    abstract:BACKGROUND:Although numerous studies have reported that tricho-rhino-phalangeal syndrome type I (TRPS1) protein, the only reported atypical GATA transcription factor, is overexpressed in various carcinomas, the underlying mechanism(s) by which it contributes to cancer remain unknown. METHODS:Both overexpression and kn...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Wang Y,Zhang J,Wu L,Liu W,Wei G,Gong X,Liu Y,Ma Z,Ma F,Thiery JP,Chen L

    更新日期:2018-08-02 00:00:00

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    abstract:INTRODUCTION:Endocrine therapies target oestrogenic stimulation of breast cancer (BC) growth, but resistance remains problematic. Our aims in this study were (1) to identify genes most strongly associated with resistance to endocrine therapy by intersecting global gene transcription data from patients treated presurgic...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Ribas R,Ghazoui Z,Gao Q,Pancholi S,Rani A,Dunbier A,Dowsett M,Martin LA

    更新日期:2014-10-31 00:00:00

  • Expression genomics in breast cancer research: microarrays at the crossroads of biology and medicine.

    abstract::Genome-wide expression microarray studies have revealed that the biological and clinical heterogeneity of breast cancer can be partly explained by information embedded within a complex but ordered transcriptional architecture. Comprising this architecture are gene expression networks, or signatures, reflecting biochem...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,评审


    authors: Miller LD,Liu ET

    更新日期:2007-01-01 00:00:00

  • Breast cancer incidence and case fatality among 4.7 million women in relation to social and ethnic background: a population-based cohort study.

    abstract:INTRODUCTION:Incidence of breast cancer is increasing around the world and it is still the leading cause of cancer mortality in low- and middle-income countries. We utilized Swedish nationwide registers to study breast cancer incidence and case fatality to disentangle the effect of socioeconomic position (SEP) and immi...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Beiki O,Hall P,Ekbom A,Moradi T

    更新日期:2012-01-06 00:00:00

  • CRIPTO antagonist ALK4L75A-Fc inhibits breast cancer cell plasticity and adaptation to stress.

    abstract:BACKGROUND:CRIPTO is a multi-functional signaling protein that promotes stemness and oncogenesis. We previously developed a CRIPTO antagonist, ALK4L75A-Fc, and showed that it causes loss of the stem cell phenotype in normal mammary epithelia suggesting it may similarly inhibit CRIPTO-dependent plasticity in breast canc...

    journal_title:Breast cancer research : BCR

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    authors: Balcioglu O,Heinz RE,Freeman DW,Gates BL,Hagos BM,Booker E,Mirzaei Mehrabad E,Diesen HT,Bhakta K,Ranganathan S,Kachi M,Leblanc M,Gray PC,Spike BT

    更新日期:2020-11-13 00:00:00

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    journal_title:Breast cancer research : BCR

    pub_type: 评论,杂志文章


    authors: Holler E

    更新日期:2005-01-01 00:00:00

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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,评审


    authors: Azim HA Jr,Partridge AH

    更新日期:2014-08-27 00:00:00

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    journal_title:Breast cancer research : BCR

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    更新日期:2010-01-01 00:00:00

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    journal_title:Breast cancer research : BCR

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    authors: Pardo I,Lillemoe HA,Blosser RJ,Choi M,Sauder CA,Doxey DK,Mathieson T,Hancock BA,Baptiste D,Atale R,Hickenbotham M,Zhu J,Glasscock J,Storniolo AM,Zheng F,Doerge RW,Liu Y,Badve S,Radovich M,Clare SE,Susan G. Komen f

    更新日期:2014-03-17 00:00:00

  • New highlights on stroma-epithelial interactions in breast cancer.

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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,评审


    authors: Barcellos-Hoff MH,Medina D

    更新日期:2005-01-01 00:00:00

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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Roussos ET,Wang Y,Wyckoff JB,Sellers RS,Wang W,Li J,Pollard JW,Gertler FB,Condeelis JS

    更新日期:2010-01-01 00:00:00

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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Melchor L,Saucedo-Cuevas LP,Muñoz-Repeto I,Rodríguez-Pinilla SM,Honrado E,Campoverde A,Palacios J,Nathanson KL,García MJ,Benítez J

    更新日期:2009-01-01 00:00:00

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    abstract:BACKGROUND:The tamoxifen metabolite, Z-endoxifen, demonstrated promising antitumor activity in endocrine-resistant estrogen receptor-positive (ER+) breast cancer. We compared the antitumor activity of Z-endoxifen with tamoxifen and letrozole in the letrozole-sensitive MCF7 aromatase expressing model (MCF7AC1), as well ...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


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    更新日期:2020-05-19 00:00:00

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    更新日期:2018-11-06 00:00:00

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    更新日期:2016-03-09 00:00:00

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    pub_type: 杂志文章


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    更新日期:2017-03-16 00:00:00

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    pub_type: 临床试验,杂志文章,多中心研究


    authors: López-Knowles E,Segal CV,Gao Q,Garcia-Murillas I,Turner NC,Smith I,Martin LA,Dowsett M

    更新日期:2014-06-30 00:00:00

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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,评审


    authors: Mayer A,Earl H

    更新日期:2001-01-01 00:00:00

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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Mendoza-Villanueva D,Zeef L,Shore P

    更新日期:2011-10-27 00:00:00

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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,评审


    authors: Steinman RA,Brufsky AM,Oesterreich S

    更新日期:2012-09-21 00:00:00

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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,评审


    authors: LaMarca HL,Rosen JM

    更新日期:2007-01-01 00:00:00

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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Rostoker R,Abelson S,Genkin I,Ben-Shmuel S,Sachidanandam R,Scheinman EJ,Bitton-Worms K,Orr ZS,Caspi A,Tzukerman M,LeRoith D

    更新日期:2015-06-04 00:00:00

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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Têtu B,Brisson J,Wang CS,Lapointe H,Beaudry G,Blanchette C,Trudel D

    更新日期:2006-01-01 00:00:00

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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


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    更新日期:2006-01-01 00:00:00

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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,评审


    authors: Kesisis G,Makris A,Miles D

    更新日期:2009-01-01 00:00:00

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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Qin S,Ingle JN,Liu M,Yu J,Wickerham DL,Kubo M,Weinshilboum RM,Wang L

    更新日期:2017-08-18 00:00:00

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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,评审


    authors: Ho-Yen CM,Jones JL,Kermorgant S

    更新日期:2015-04-08 00:00:00

  • MicroRNAs: shortcuts in dealing with molecular complexity?

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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Dontu G,de Rinaldis E

    更新日期:2010-01-01 00:00:00

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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,评审


    authors: Kairouz R,Daly RJ

    更新日期:2000-01-01 00:00:00

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    abstract:INTRODUCTION:Breast cancer is the most common female malignancy worldwide and, despite improvements in treatment modalities, there are increased chances of recurrence and metastasis in a substantial number of cases and it remains one of the major causes of mortality among female cancer patients. Anaplastic lymphoma kin...

    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Siraj AK,Beg S,Jehan Z,Prabhakaran S,Ahmed M,R Hussain A,Al-Dayel F,Tulbah A,Ajarim D,Al-Kuraya KS

    更新日期:2015-09-17 00:00:00