The pathology of familial breast cancer: Morphological aspects.

Abstract:

:A small proportion of breast cancers are due to a heritable predisposition. Recently, two predisposition genes, BRCA1 and BRCA2, have been identified and cloned. The morphological features of tumours from patients harbouring mutations in the BRCA1 and BRCA2 genes differ from each other and from sporadic breast cancers. Both are of higher grade than are sporadic cases. An excess of medullary/atypical medullary carcinoma has been reported in patients with BRCA1 mutations. Multifactorial analysis, however, shows that the only features independently associated with BRCA1 mutations are a high mitotic count, pushing tumour margins and a lymphocytic infiltrate. For BRCA2 mutation, an association with tubular/lobular carcinoma has been suggested, but not substantiated in a larger Breast Cancer Linkage Consortium study. In multifactorial analysis, the independent features were a lack of tubule formation and pushing tumour margins only. The morphological analysis has implications for clinical management of patients.

journal_name

Breast Cancer Res

authors

Lakhani SR

doi

10.1186/bcr10

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

31-5

issue

1

eissn

1465-5411

issn

1465-542X

journal_volume

1

pub_type

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