Immunome database for marsupials and monotremes.

abstract：BACKGROUND:Impaired diabetic wound healing occurs as a consequence of excessive reactive oxygen species (ROS) and inflammatory cytokine production. We previously found that whey protein (WP) was able to normally regulate the ROS and inflammatory cytokines during the inflammatory phase (first day) in streptozotocin (STZ...

journal_title：BMC immunology

authors： Ebaid H,Ahmed OM,Mahmoud AM,Ahmed RR

更新日期：2013-07-25 00:00:00

abstract：BACKGROUND:The lymphatic vascular pattern in the head of mice has rarely been studied, due to problems of sectioning and immunostaining of complex bony structures. Therefore, the association of head lymphoid tissues with the lymphatics has remained unknown although the mouse is the most often used species in immunology...

journal_title：BMC immunology

authors： Lohrberg M,Pabst R,Wilting J

更新日期：2018-01-25 00:00:00

abstract：BACKGROUND:Besides their prominent role in the elimination of infected or malignantly transformed cells, natural killer (NK) cells serve as modulators of adaptive immune responses. Enhancing bidirectional crosstalk between NK cells and dendritic cells (DC) is considered a promising tool to potentiate cancer vaccines. W...

journal_title：BMC immunology

authors： Oth T,Habets THPM,Germeraad WTV,Zonneveld MI,Bos GMJ,Vanderlocht J

更新日期：2018-02-13 00:00:00

abstract：BACKGROUND:Adenoviral vectors have provided effective methods for in vivo gene delivery in therapeutic applications. However, these vectors can induce immune responses that may severely affect the ability of vector re-application. There is limited information about the mechanisms and signal transduction pathways involv...

journal_title：BMC immunology

authors： Steinstraesser L,Sorkin M,Jacobsen F,Al-Benna S,Kesting MR,Niederbichler AD,Otte JM,Hirsch T,Stupka J,Steinau HU,Schulte M

更新日期：2011-01-21 00:00:00

abstract：BACKGROUND:Inappropriate activation of T lymphocytes plays an important role in perinatal complications. However, data on T lymphocyte activation markers of preterm infants is scarce. We investigated the association between gender, gestational and postnatal age, preeclampsia (PE), premature rupture of membranes (PROM) ...

journal_title：BMC immunology

authors： Sava F,Toldi G,Treszl A,Hajdú J,Harmath Á,Tulassay T,Vásárhelyi B

更新日期：2016-06-21 00:00:00

abstract：BACKGROUND:Inappropriate responses to normal intestinal bacteria may be involved in the development of Inflammatory Bowel Diseases (IBD, e.g. Crohn's Disease (CD), Ulcerative Colitis (UC)) and variations in the host genome may mediate this process. IL-10 gene-deficient (Il10-/-) mice develop CD-like colitis mainly in t...

journal_title：BMC immunology

authors： Barnett MP,McNabb WC,Cookson AL,Zhu S,Davy M,Knoch B,Nones K,Hodgkinson AJ,Roy NC

更新日期：2010-07-15 00:00:00

abstract：BACKGROUND:Some chemicals, including some phthalate plasticizers, have been shown to have an adjuvant effect in mice. However, an adjuvant effect, defined as an inherent ability to stimulate the humoral immune response, was only observed after exposure to a limited number of the phthalates. An adjuvant effect may be du...

journal_title：BMC immunology

authors： Larsen ST,Nielsen GD

更新日期：2008-10-31 00:00:00

abstract：BACKGROUND:We have developed a 12-parameter/10-color flow cytometric staining method for the simultaneous detection and characterization of 21 mouse thymocyte subpopulations that represent discreet stages of T cell development. To demonstrate the utility of this method, we assessed cytokine receptor expression on mouse...

journal_title：BMC immunology

authors： Tan C,Taylor AA,Coburn MZ,Marino JH,Van De Wiele CJ,Teague TK

更新日期：2011-06-20 00:00:00

abstract：BACKGROUND:We have previously reported that interleukin-10 (IL-10) deficient dendritic cells (DCs) are potent antigen presenting cells that induced elevated protective immunity against Chlamydia. To further investigate the molecular and biochemical mechanism underlying the superior immunostimulatory property of IL-10 d...

journal_title：BMC immunology

authors： Ryans K,Omosun Y,McKeithen DN,Simoneaux T,Mills CC,Bowen N,Eko FO,Black CM,Igietseme JU,He Q

更新日期：2017-05-19 00:00:00

abstract：BACKGROUND:The new JAK3 inhibitor, CP690,550, has shown efficacy in the treatment of rheumatoid arthritis. The present study was undertaken to assess the effects of CP690,550 on cytokine production and cellular signaling in human CD4(+) T cells. RESULTS:CD4(+) T cells produced IL-2, IL-4, IL-17, IL-22 and IFN-γ in fol...

journal_title：BMC immunology

authors： Migita K,Miyashita T,Izumi Y,Koga T,Komori A,Maeda Y,Jiuchi Y,Aiba Y,Yamasaki S,Kawakami A,Nakamura M,Ishibashi H

更新日期：2011-08-31 00:00:00

abstract：BACKGROUND:Allergic skin inflammation such as atopic dermatitis (AD), which is characterized by pruritus and inflammation, is regulated partly through the activity of regulatory T cells (Tregs). Tregs play key roles in the immune response by preventing or suppressing the differentiation, proliferation and function of v...

journal_title：BMC immunology

authors： Han SC,Kang GJ,Ko YJ,Kang HK,Moon SW,Ann YS,Yoo ES

更新日期：2012-08-09 00:00:00

abstract：BACKGROUND:Most in vivo studies that have addressed the role of actin dynamics in NADPH oxidase function in phagocytes have used toxins to modulate the polymerization state of actin and mostly effects on actin has been evaluated by end point measurements of filamentous actin, which says little about actin dynamics, and...

journal_title：BMC immunology

authors： Rasmussen I,Pedersen LH,Byg L,Suzuki K,Sumimoto H,Vilhardt F

更新日期：2010-09-08 00:00:00

abstract：BACKGROUND:Regulatory T cells (Treg) play a crucial role in maintaining immune homeostasis and self-tolerance. The immune suppressive effects of Tregs should however be limited in case effective immunity is required against pathogens or cancer cells. We previously found that the Toll-like receptor 2 (TLR2) agonist, Pam...

journal_title：BMC immunology

authors： van Maren WW,Nierkens S,Toonen LW,Bolscher JM,Sutmuller RP,Adema GJ

更新日期：2011-03-24 00:00:00

abstract：BACKGROUND:Recognition of pathogens by dendritic cells (DCs) through interaction with pattern recognition receptors, including Toll like receptors (TLR), is crucial for the initiation of appropriate polarized T helper (Th) cell responses. Yet, the characteristics and differences in molecular profiles of DCs with differ...

journal_title：BMC immunology

authors： van Riet E,Everts B,Retra K,Phylipsen M,van Hellemond JJ,Tielens AG,van der Kleij D,Hartgers FC,Yazdanbakhsh M

更新日期：2009-02-04 00:00:00

abstract：BACKGROUND:Understanding immune mechanisms, particularly the role of innate immune markers during latent TB infection remains elusive. The main objective of this study was to evaluate mRNA gene expression patterns of toll-like receptors (TLRs) as correlates of immunity during latent TB infection and further infer their...

journal_title：BMC immunology

authors： Alemnew B,Hoff ST,Abebe T,Abebe M,Aseffa A,Howe R,Wassie L

更新日期：2021-01-28 00:00:00

abstract：BACKGROUND:There are three major B-cell compartments in peripheral lymphoid organs: the germinal center (GC), the mantle zone (MNZ) and the marginal zone (MGZ). Unique sets of B-cells reside in these compartments, and they have specific functional roles in humoral immune response. MNZ B cells are naive cells in a quies...

journal_title：BMC immunology

authors： Shen Y,Iqbal J,Xiao L,Lynch RC,Rosenwald A,Staudt LM,Sherman S,Dybkaer K,Zhou G,Eudy JD,Delabie J,McKeithan TW,Chan WC

更新日期：2004-09-15 00:00:00

abstract：BACKGROUND:Streptococcus sanguinis (S.sanguinis), a predominant bacterium in the human oral cavity, has been widely associated with the development of infective endocarditis. Platelets play both a haemostatic function and can influence both innate and adaptive immune responses. Previous studies have shown that S.sangui...

journal_title：BMC immunology

authors： Cognasse F,Hamzeh-Cognasse H,Chabert A,Jackson E,Arthaud CA,Garraud O,McNicol A

更新日期：2014-04-22 00:00:00

abstract：BACKGROUND:Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been performed on macrophages derived from bone marrow, spleen and peritoneum. However, differences among macrophages from these particular sources remain ...

journal_title：BMC immunology

authors： Wang C,Yu X,Cao Q,Wang Y,Zheng G,Tan TK,Zhao H,Zhao Y,Wang Y,Harris DCh

更新日期：2013-02-05 00:00:00

abstract：BACKGROUND:Eosinophils are innate immune cells present in the intestine during steady state conditions. An intestinal eosinophilia is a hallmark of many infections and an accumulation of eosinophils is also observed in the intestine during inflammatory disorders. Classically the function of eosinophils has been associa...

journal_title：BMC immunology

authors： Forman R,Bramhall M,Logunova L,Svensson-Frej M,Cruickshank SM,Else KJ

更新日期：2016-05-31 00:00:00

abstract：BACKGROUND:The extracellular domains of cytokine receptors are released during inflammation, but little is known about the shedding of Toll-like receptors (TLR) and whether they can be used as diagnostic biomarkers. METHODS:The release of sTLR2 and sTLR4 was studied in in-vitro stimulations, as well as in-vivo during ...

journal_title：BMC immunology

authors： Ten Oever J,Kox M,van de Veerdonk FL,Mothapo KM,Slavcovici A,Jansen TL,Tweehuysen L,Giamarellos-Bourboulis EJ,Schneeberger PM,Wever PC,Stoffels M,Simon A,van der Meer JW,Johnson MD,Kullberg BJ,Pickkers P,Pachot A,Jooste

更新日期：2014-11-19 00:00:00

abstract：BACKGROUND:The adaptive immune system maintains a diversity of T cells capable of recognizing a broad array of antigens. Each T cell's specificity for antigens is determined by its T cell receptors (TCRs), which together across all T cells form a repertoire of millions of unique receptors in each individual. Although m...

journal_title：BMC immunology

authors： Chu ND,Bi HS,Emerson RO,Sherwood AM,Birnbaum ME,Robins HS,Alm EJ

更新日期：2019-06-21 00:00:00

abstract：BACKGROUND:Extracellular vesicles (EVs) are nano-sized particles secreted by most cells. EVs carry nucleic acids that hold promise as potential biomarkers in various diseases. Human immunodeficiency virus type 1 (HIV) infects CD4+ T cells and induces immune dysfunction, inflammation, and EV secretion, but little is kno...

journal_title：BMC immunology

authors： Chettimada S,Lorenz DR,Misra V,Wolinsky SM,Gabuzda D

更新日期：2020-11-11 00:00:00

abstract：BACKGROUND:While dendritic cells (DCs) can induce tolerance in T cells, little is known about tolerance induction in DCs themselves. We have analysed tolerance induced in human in-vitro generated DCs by repeated stimulation with ligands for TLR4 and TLR2. RESULTS:DCs stimulated with the TLR4 ligand LPS did show a rapi...

journal_title：BMC immunology

authors： Albrecht V,Hofer TP,Foxwell B,Frankenberger M,Ziegler-Heitbrock L

更新日期：2008-11-24 00:00:00

abstract：BACKGROUND:Human memory CD4+ T cells can be either CD300a/c+ or CD300a/c- and subsequent analyses showed that CD4+ effector memory T (T(EM)) cells are mostly CD300a/c+, whereas CD4+ central memory T (T(CM)) cells have similar frequencies of CD300a/c+ and CD300a/c- cells. RESULTS:Extensive phenotypical and functional c...

journal_title：BMC immunology

authors： Simhadri VR,Mariano JL,Zhou Q,DeBell KE,Borrego F

更新日期：2011-11-02 00:00:00

abstract：BACKGROUND:Respiratory burst function resulting in the release of reactive oxygen species such as superoxide anion (O2-) from neutrophils is one of the key mechanisms of the innate immune system, and maladaptive control of this mechanism is thought to play a pivotal role in the development of pathologies such as acute ...

journal_title：BMC immunology

authors： Tung JP,Fraser JF,Wood P,Fung YL

更新日期：2009-05-08 00:00:00

abstract：BACKGROUND:Dysregulation of the immune system has been shown to occur during spaceflight, although the detailed nature of the phenomenon and the clinical risks for exploration class missions have yet to be established. Also, the growing clinical significance of immune system evaluation combined with epidemic infectious...

journal_title：BMC immunology

authors： Crucian B,Lee P,Stowe R,Jones J,Effenhauser R,Widen R,Sams C

更新日期：2007-05-23 00:00:00

abstract：BACKGROUND:An ideal tumor vaccine should activate both effector and memory immune response against tumor-specific antigens. Beside the CD8+ T cells that play a central role in the generation of a protective immune response and of long-term memory, dendritic cells (DCs) are important for the induction, coordination and ...

journal_title：BMC immunology

authors： Cerkovnik P,Novakovic BJ,Stegel V,Novakovic S

更新日期：2010-09-13 00:00:00

abstract：BACKGROUND:In genetically modified (GM) crops there is a risk that the inserted genes may introduce new allergens and/or adjuvants into the food and feed chain. The MON810 maize, expressing the insecticidal Cry1Ab toxin, is grown in many countries worldwide. In animal models, intranasal and intraperitoneal immunisation...

journal_title：BMC immunology

authors： Andreassen M,Bøhn T,Wikmark OG,Bodin J,Traavik T,Løvik M,Nygaard UC

更新日期：2016-05-04 00:00:00

abstract：BACKGROUND:Myeloid cells, especially mononuclear phagocytes, which include monocytes, macrophages and dendritic cells (DC), play vital roles in innate immunity, and in the initiation and maintenance of adaptive immunity. While T cell-associated activation pathways and cytokines have been identified and evaluated in inf...

journal_title：BMC immunology

authors： Liu H,Dasgupta S,Fu Y,Bailey B,Roy C,Lightcap E,Faustin B

更新日期：2019-11-12 00:00:00

abstract：BACKGROUND:Recent studies have shown that early growth response 2 (EGR2) is highly induced in activated T cells and regulates T cell functions. In normal C57BL/6 (B6) mice, deletion of EGR2 in lymphocytes results in the development of lupus-like systemic autoimmune disease, which implies indirectly an autoimmune protec...

journal_title：BMC immunology

authors： Dai R,Heid B,Xu X,Xie H,Reilly CM,Ahmed SA

更新日期：2020-07-09 00:00:00