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Mortality among infants born with orofacial clefts in a single cleft network.

Abstract：

OBJECTIVE:To determine mortality rate and cause of death in infants born with orofacial clefts. METHODS:Retrospective case note review of all children with orofacial clefts within the East of England Cleft Network who have died. RESULTS:Between 2002 and 2010, of 638 children born with orofacial clefts, 23 died at a median age of 5 months (range, 1 day to 4 years). The overall mortality rate was 36 per 1000 cleft births. A total of 21 deaths were in the isolated cleft palate group, with a calculated death rate of 68.1 per 1000. One child each from the cleft lip and the cleft lip and palate groups died. Of the children who died, 21 (91%) had other structural abnormalities. Of these children, 19 (83%) died before their first birthday. The causes of death were mainly due to associated congenital anomalies (61%) and infection (17%). CONCLUSIONS:Children born with cleft palate have a 15-fold increase in mortality compared with the regional East of England infant mortality rate and at least a 10-fold increase when compared with other clefts. Pediatricians should be involved in the care of these complicated patients.

journal_name

Cleft Palate Craniofac J

journal_title

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

authors

Kang SL,Narayanan CS,Kelsall W

doi

10.1597/10-179

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

508-11

issue

4

eissn

1055-6656

issn

1545-1569

journal_volume

49

pub_type

杂志文章

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